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Harnessing innate immune pathways for therapeutic advancement in cancer

Signal Transduction and Targeted Therapy 2024年第4期9卷 1506-1564页

作者： Ankang Hu Li Sun Hao Lin Yuheng Liao Hui Yang ying mao Department of Neurosurgery Huashan HospitalFudan UniversityShanghaiP.R.China Institute for Translational Brain Research Shanghai Medical CollegeFudan University ShanghaiPR.China National Center for Neurological Disorders Huashan HospitalShanghai Medical CollegeFudan UniversityShanghaiP.R.China Shanghai Key Laboratory of Brain Function Restoration and Neural Regeneration Shanghai Clinical Medical Center of NeurosurgeryNeurosurgical Institute of Fudan UniversityHuashan HospitalShanghai Medical CollegeFudan UniversityShanghaiP.R.China State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science and MOE Frontiers Center for Brain Science Institutes of Brain ScienceShanghai Medical CollegeFudan UniversityShanghaiP.R.China Shanghai Key Laboratory of Medical Epigenetics International Co-laboratory of Medical Epigenetics and Metabolism(Ministry of Science and Technology)and Key Laboratory of Metabolism and Molecular Medicine(Ministry of Education)and Molecular and Cell Biology LabInstitutes of Biomedical SciencesShanghai Medical College of Fudan UniversityShanghaiP.R.China

The innate immune pathway is receiving increasing attention in cancer *** pathway is ubiquitous across various cell types,not only in innate immune cells but also in adaptive immune cells,tumor cells,and stromal *** targeting the innate immune pathway have shown profound changes in the tumor microenvironment(TME)and improved tumor prognosis in preclinical ***,to date,the clinical success of drugs targeting the innate immune pathway remains ***,recent studies have shown that activation of the innate immune pathway can paradoxically promote tumor *** uncertainty surrounding the therapeutic effectiveness of targeted drugs for the innate immune pathway is a critical issue that needs immediate *** this review,we observe that the role of the innate immune pathway demonstrates heterogeneity,linked to the tumor development stage,pathway status,and specific cell *** propose that within the TME,the innate immune pathway exhibits multidimensional *** diversity is fundamentally rooted in cellular heterogeneity and is manifested as a variety of signaling *** pro-tumor effect of innate immune pathway activation essentially reflects the suppression of classical pathways and the activation of potential pro-tumor alternative *** our understanding of the tumor's innate immune pathway network and employing appropriate targeting strategies can enhance our ability to harness the anti-tumor potential of the innate immune pathway and ultimately bridge the gap from preclinical to clinicalapplication.

关键词： drugs therapeutic innate

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Fusion of Ground-Based and Spaceborne Radar Precipitation Based on Spatial Domain Regularization

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Journal of Meteorological Research 2024年第2期38卷 285-302页

作者： Anfan HUANG Leilei KOU Yanzhi LIANG ying mao Haiyang GAO Zhigang CHU School of Atmospheric Physics Nanjing University of Information Science&TechnologyNanjing 210044 Collaborative Innovation Center on Forecast and Evaluation of Meteorological Disasters Nanjing University of Information Science&TechnologyNanjing 210044

High-quality and accurate precipitation estimations can be obtained by integrating precipitation information measures using ground-based and spaceborne radars in the same target *** the true precipitation state is a typical inverse problem for a given set of noisy radar precipitation *** regularization method can appropriately constrain the inverse problem to obtain a unique and stable *** different types of precipitation with different prior distributions,the L_(1) and L_(2) norms were more effective in constraining stratiform and convective precipitation,*** a combination of L_(1) and L_(2) norms,the Huber norm is more suitable for mixed precipitation *** study uses different regularization norms to combine precipitation data from the C-band dual-polarization ground radar(CDP)and dual-frequency precipitation radar(DPR)on the Global Precipitation Measurement(GPM)mission core *** to single-source radar data,the fused figures contain more information and present a comprehensive precipitation structure encompassing the reflectivity and precipitation *** 27 precipitation cases,the fusion results utilizing the Huber norm achieved a structural similarity index measure(SSIM)and a peak signal-to-noise ratio(PSNR)of 0.8378 and 30.9322,respectively,compared with the CDP *** fusion results showed that the Huber norm effectively amalgamate the features of convective and stratiform precipitation,with a reduction in the mean absolute error(MAE;16.1%and 22.6%,respectively)and root-mean-square error(RMSE;11.7%and 13.6%,respectively)compared to the 1-norm and ***,in contrast to the fusion results of scale recursive estimation(SRE),the Huber norm exhibits superior capability in capturing the localized precipitation intensity and reconstructing the detailed features of precipitation.

关键词： dual-frequency precipitation radar(DPR) dual-polarization radar data fusion regularization Huber norm

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Federated Dynamic Client Selection for Fairness Guarantee in Heterogeneous Edge Computing

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Journal of Computer Science & Technology 2024年第1期39卷 139-158页

作者：毛莺池沈莉娟吴俊平萍吴杰 Key Laboratory of Water Big Data Technology of Ministry of Water Resources Hohai UniversityNanjing 211100China College of Computer and Information Hohai UniversityNanjing 211100China Center of Networked Computing Temple UniversityPhiladelphiaPA 19122-6096U.S.A

Federated learning has emerged as a distributed learning paradigm by training at each client and aggregat-ing at a parameter *** heterogeneity hinders stragglers from responding to the server in time with huge com-munication *** client grouping in federated learning can solve the straggler problem,the stochastic selection strategy in client grouping neglects the impact of data distribution within each ***,current client grouping ap-proaches make clients suffer unfair participation,leading to biased performances for different *** order to guaran-tee the fairness of client participation and mitigate biased local performances,we propose a federated dynamic client selec-tion method based on data representativity(FedSDR).FedSDR clusters clients into groups correlated with their own lo-cal computational *** estimate the significance of client datasets,we design a novel data representativity evalua-tion scheme based on local data ***,the two most representative clients in each group are selected to optimize the global ***,the DYNAMIC-SELECT algorithm updates local computational efficiency and data representativity states to regroup clients after periodic average *** on real datasets show that FedS-DR improves client participation by 27.4%,37.9%,and 23.3%compared with FedAvg,TiFL,and FedSS,respectively,tak-ing fairness into account in federated *** addition,FedSDR surpasses FedAvg,FedGS,and FedMS by 21.32%,20.4%,and 6.90%,respectively,in local test accuracy variance,balancing the performance bias of the global model across clients.

关键词： federated learning fairness computational efficiency data distribution client selection client grouping

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注册制、法律实验与学习型监管

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新疆师范大学学报（哲学社会科学版） 2024年第5期45卷 125-136页

作者：唐应茂复旦大学法学院上海200438

法律实验范式强调,揭示试点变化幅度大、效果差异大的法律规则(激进规则)的试点效果信息,有助于发现更优法律规则。采用法律实验范式立法应具备两个前提:一是被实验的法律规则具备可逆性,存在制度纠错机制,能够及时终止负面效果明显的... 详细信息

法律实验范式强调,揭示试点变化幅度大、效果差异大的法律规则(激进规则)的试点效果信息,有助于发现更优法律规则。采用法律实验范式立法应具备两个前提:一是被实验的法律规则具备可逆性,存在制度纠错机制,能够及时终止负面效果明显的法律规则;二是实验者具备学习能力,能够通过法律实验获得信息、发现更优规则。从法律实验角度观察,我国股票发行注册制改革存在三个突出特点:法律规则的激进程度高、由外力助推实现激进规则的可逆性、学习型监管能力有待提升。未来注册制改革取得成效的关键在于加强党中央对金融工作的集中统一领导,对尝试法律规则保持更高容忍度以及金融监管部际协调,不断提升监管机构的学习能力。

关键词：注册制法律实验学习型监管激进规则可逆性

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Distinct immune escape and microenvironment between RG-like and pri-OPC-like glioma revealed by single-cell RNA-seq analysis

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Frontiers of Medicine 2024年第1期18卷 147-168页

作者： Weiwei Xian Mohammad Asad Shuai Wu Zhixin Bai Fengjiao Li Junfeng Lu Gaoyu Zu Erin Brintnell Hong Chen ying mao Guomin Zhou Bo Liao Jinsong Wu Edwin Wang Linya You Department of Human Anatomy&Histoembryology School of Basic Medical SciencesFudan UniversityShanghai200032China Cumming School of Medicine University of CalgaryCalgaryAlbertaT2N 4N1Canada Glioma Surgery Division Department of NeurosurgeryHuashan HospitalFudan UniversityShanghai200040China Department of Pathology Huashan HospitalFudan UniversityShanghai200040China Department of Neurosurgery Huashan HospitalFudan UniversityShanghai200040China Shanghai Key Laboratory of Medical Imaging Computing and Computer Assisted Intervention Fudan UniversityShanghai200040China School of Mathematics and Statistics Hainan Normal UniversityHaikou570100China

The association of neurogenesis and gliogenesis with glioma remains *** conducting single-cell RNA-seq analyses on 26 gliomas,we reported their classification into primitive oligodendrocyte precursor cell(pri-OPC)-like and radial glia(RG)-like tumors and validated it in a public cohort and TCGA *** RG-like tumors exhibited wild-type isocitrate dehydrogenase and tended to carry EGFR mutations,and the pri-OPC-like ones were prone to carrying TP53 *** subclones only in pri-OPC-like tumors showed substantially down-regulated MHC-I genes,suggesting their distinct immune evasion ***,the two subgroups appeared to extensively modulate glioma-infiltrating lymphocytes in distinct *** specific genes not expressed in normal immune cells were found in glioma-infiltrating *** example,glial/glioma stem cell markers OLIG1/PTPRZ1 and B cell-specific receptors IGLC2/IGKC were expressed in pri-OPC-like and RG-like glioma-infiltrating lymphocytes,*** expression was positively correlated with those of immune checkpoint genes(e.g.,LGALS33)and poor survivals as validated by the increased expression of LGALS3 upon IGKC overexpression in Jurkat *** finding indicated a potential inhibitory role in tumor-infiltrating lymphocytes and could provide a new way of cancer immune evasion.

关键词： single-cell RNA-seq glioma radial glia primitive oligodendrocyte precursor cell immune escape

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Consensus of Chinese experts on glioma multidisciplinary team management(2nd edition)

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Chinese Medical Journal 2024年第11期137卷 1267-1270页

作者： Jinsong Wu Zhirui Zhou Zanyi Wu Zhiwei Tang Ming Li Siyuan Yin Xufei Luo Ling Wang Yaolong Chen Guoguang Zhao Tao Jiang ying mao The National Glioma MDT Alliance of National Center for Neurological Diseases Department of Neurosurgery Huashan HospitalShanghai Medical CollegeFudan UniversityShanghai 200040China Department of Radiation Oncology Huashan HospitalShanghai Medical CollegeFudan UniversityShanghai 200040China Department of Neurosurgery The First Affiliated Hospital of Fujian Medical UniversityFuzhouFujian 350005China Neurosurgery Department The First Affiliated Hospital of Kunming Medical UniversityKunmingYunnan 650032China Department of Neurosurgery Henan Provincial People’s HospitalPeople’s Hospital of Zhengzhou UniversityZhengzhouHenan 463599China State Key Laboratory of Pharmaceutical Biotechnology Institute for Brain SciencesAdvanced Institute for Life SciencesSchool of Life SciencesNanjing UniversityNanjingJiangsu 210023China Evidence-Based Medicine Center School of Basic Medical SciencesLanzhou UniversityLanzhouGansu 730000China School of Public Health Lanzhou UniversityLanzhouGansu 730000China Department of Neurosurgery Xuanwu HospitalCapital Medical UniversityBeijing 100053China Department of Neurosurgery Beijing Tiantan HospitalCapital Medical UniversityBeijing 100050China 不详

To increase the consistency of glioma multidisciplinary team(MDT)management across different regions and hospitals at varying levels,we have updated the Expert Consensus on MDT of Glioma in China based on the currently available *** version has revised and updated the process-management rules and quality-control standards for a glioma MDT,providing reference and guidance for relevant clinical disciplines and *** members of the Consensus Expert Group,abstract,background,and prospects can be seen in supplementaryle,http://***/CM9/B999.

关键词： glioma MDT Expert

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神经外科诊疗新技术与研究的最新进展

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中华外科杂志 2024年第1期62卷 31-38页

作者：庄骐源陈亮毛颖复旦大学附属华山医院神经外科、国家神经疾病医学中心上海200040

神经外科领域临床需求的快速增长推动了技术的不断创新迭代,从精细手术到个体医疗,从分子可视化到数字智能化,从延长患者生存时间到恢复神经功能,不断涌现的新发现、新知识、新技术和新器械拓宽了诊疗窗口,提升了治疗效能,也给神经外科... 详细信息

神经外科领域临床需求的快速增长推动了技术的不断创新迭代,从精细手术到个体医疗,从分子可视化到数字智能化,从延长患者生存时间到恢复神经功能,不断涌现的新发现、新知识、新技术和新器械拓宽了诊疗窗口,提升了治疗效能,也给神经外科医师带来了机遇与挑战。本文从神经影像、神经导航、机器人手术辅助系统等新技术的应用出发,围绕中枢神经系统肿瘤、脑血管病外科治疗、功能神经外科、神经损伤与神经修复等多个亚专科的实际临床问题,详细总结了影像技术创新应用、精细手术发展、个体化神经功能替代治疗及多维信息数字化等研究热点,并对未来研究方向进行展望。

关键词：神经外科手术机器人神经影像神经肿瘤脑血管病功能神经外科神经修复数字化

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黄河流域虚拟水贸易核算及影响因素研究

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人民黄河 2024年第4期46卷 68-72,85页

作者：邓光耀毛颖兰州财经大学统计与数据科学学院甘肃兰州730020

为了量化贸易伴随的虚拟水流动,评价其对区域水资源系统的影响,运用多区域投入产出模型揭示2012年、2015年、2017年黄河流域内、外部虚拟水贸易格局与结构,采用对数平均迪氏指数法(LMDI)对黄河流域各省区相对于中国其他省区的净输出虚... 详细信息

为了量化贸易伴随的虚拟水流动,评价其对区域水资源系统的影响,运用多区域投入产出模型揭示2012年、2015年、2017年黄河流域内、外部虚拟水贸易格局与结构,采用对数平均迪氏指数法(LMDI)对黄河流域各省区相对于中国其他省区的净输出虚拟水进行影响效应分析,用QAP回归模型分析黄河流域各省区之间虚拟水贸易的影响因素。研究结果表明:1)黄河流域整体呈虚拟水净输入状态,但向北京、天津、河北等12个省区净输出虚拟水。2)黄河流域虚拟水贸易输出行业主要是农业及电力、燃气和水的生产和供应业。3)结构效应和强度效应是黄河流域虚拟水净输出的重要驱动因素。4)经济发展水平、地理空间距离及用水强度是影响黄河流域内部虚拟水贸易的主要因素。

关键词：虚拟水贸易对数平均迪氏指数法 QAP模型黄河流域

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人工智能背景下环境治理与社会保障的协同推进研究

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中国工业经济 2024年第6期 42-60页

作者：杜雯翠毛赢首都经济贸易大学经济学院

在人口老龄化背景下,提升老年群体福利离不开社会保障与环境治理的协同推进。本文通过构建包含人工智能、老龄化、社会保障与环境治理支出的动态一般均衡模型,将税额分配内生化,分析老龄化冲击下社会保障与环境治理两项职能的关系,并讨... 详细信息

在人口老龄化背景下,提升老年群体福利离不开社会保障与环境治理的协同推进。本文通过构建包含人工智能、老龄化、社会保障与环境治理支出的动态一般均衡模型,将税额分配内生化,分析老龄化冲击下社会保障与环境治理两项职能的关系,并讨论人工智能对社会保障与环境治理职能协同推进的“政策正外部性”。研究发现,在福利最大化条件下,老龄化加速使社会保障支出比例提高,环境治理支出比例下降,进而对产出、环境质量与居民福利造成不利影响。然而,人工智能可以在提升经济增长活力的前提下进一步实现社会保障与环境治理的协同推进,带来产出水平与环境质量齐升。具体来讲,人工智能除了实现资本替代劳动、提升生产效率外,还从动态视角对社会保障与环境治理的职能履行进行了时序上的重新分配:人工智能发展初期,智能生产过程的清洁化为大幅增加的社会保障支出提供了“绿色平台期”;人工智能发展后期,社会保障支出的长期持续增加使政策逐渐放松社会保障职能,加大环境治理支出,这种政策职能的时序重新分配实现了社会保障与环境治理的协同推进。本文提供了老龄化背景下解决政府多项公共服务职能冲突的新视角,对于政府如何利用人工智能发展实现环境治理与社会保障的协同共进具有重要的政策启示。

关键词：人工智能老龄化政策正外部性动态一般均衡模型

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生活方式评分与非酒精性脂肪肝的关联性研究

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现代预防医学 2024年第4期51卷 742-747页

作者：陈颖徐柳红毛盈颖叶丁浙江中医药大学公共卫生学院

目的基于美国健康与营养调查(NHANES)数据库，探讨生活方式评分与非酒精性脂肪肝(NAFLD)患病之间的关联，为预防和治疗NAFLD提供新思路。方法本研究基于2007—2018年的美国NHANES人群数据，通过logistic回归分析评估生活方式对NAFLD... 详细信息

目的基于美国健康与营养调查(NHANES)数据库，探讨生活方式评分与非酒精性脂肪肝(NAFLD)患病之间的关联，为预防和治疗NAFLD提供新思路。方法本研究基于2007—2018年的美国NHANES人群数据，通过logistic回归分析评估生活方式对NAFLD的影响。进一步通过分层分析，探讨性别、年龄、种族、婚姻状态、教育程度等不同分层之间的差异。结果本研究共纳入4 105名参与者，其中1 284名NAFLD(24.64%),2 821名非NAFLD(75.36%)。研究发现相较于低生活方式评分，生活方式评分中等(OR=0.372,95%CI:0.25～0.56,P=9.15×10-6)和较高(OR=0.091,95%CI:0.06～0.14,P=1.50×10-17)的人群发生NAFLD的风险更低。分层分析显示，该效应在男性和60岁以上人群中更强。结论健康生活方式与较低的NAFLD发生风险有关，通过干预生活方式可以有效防治NAFLD。

关键词：生活方式评分非酒精性脂肪肝 NHANES

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