检索结果-南通市图书馆

T cell interactions with microglia in immune-inflammatory processes of ischemic stroke

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第5期20卷 1277-1292页

作者： Yuxiao Zheng Zilin Ren ying liu Juntang Yan Congai Chen Yanhui He Yuyu Shi Fafeng Cheng Qingguo Wang Changxiang Li Xueqian Wang School of Traditional Chinese Medicine Beijing University of Chinese MedicineBeijingChina Library Beijing University of Chinese MedicineBeijingChina Dongzhimen Hospital Beijing University of Chinese MedicineBeijingChina

The primary mechanism of secondary injury after cerebral ischemia may be the brain inflammation that emerges after an ischemic stroke,which promotes neuronal death and inhibits nerve tissue *** the first immune cells to be activated after an ischemic stroke,microglia play an important immunomodulatory role in the progression of the *** an ischemic stroke,peripheral blood immune cells(mainly T cells)are recruited to the central nervous system by chemokines secreted by immune cells in the brain,where they interact with central nervous system cells(mainly microglia)to trigger a secondary neuroimmune *** review summarizes the interactions between T cells and microglia in the immune-inflammatory processes of ischemic *** found that,during ischemic stroke,T cells and microglia demonstrate a more pronounced synergistic ***1,Th17,and M1 microglia can co-secrete proinflammatory factors,such as interferon-γ,tumor necrosis factor-α,and interleukin-1β,to promote neuroinflammation and exacerbate brain ***2,Treg,and M2 microglia jointly secrete anti-inflammatory factors,such as interleukin-4,interleukin-10,and transforming growth factor-β,to inhibit the progression of neuroinflammation,as well as growth factors such as brain-derived neurotrophic factor to promote nerve regeneration and repair brain *** interactions between microglia and T cells influence the direction of the subsequent neuroinflammation,which in turn determines the prognosis of ischemic stroke *** trials have been conducted on the ways to modulate the interactions between T cells and microglia toward anti-inflammatory communication using the immunosuppressant fingolimod or overdosing with Treg cells to promote neural tissue repair and reduce the damage caused by ischemic ***,such studies have been relatively infrequent,and clinical experience is still *** summary,in ischemic stroke,T cell subsets and activated micro

关键词： brain immune inflammation interaction ischemic stroke mechanism microglia neuron secondary injury T cells

Persistent alterations in gray matter in COVID-19 patients experiencing sleep disturbances:a 3-month longitudinal study

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第10期20卷 3013-3024页

作者： Kaixuan Zhou Gaoxiong Duan ying liu Bei Peng Xiaoyan Zhou Lixia Qin Lingyan Liang Yichen Wei Qingping Zhang Xiaocheng Li Haixia Qin Yinqi Lai Yian Lu Yan Zhang Jiazhu Huang Jinli Huang Yinfei Ouyang Bolin Bin Mingming Zhao Jun liu Jianrong Yang Demao Deng Guangxi Key Laboratory of Special Biomedicine School of MedicineGuangxi UniversityNanningGuangxi Zhuang Autonomous RegionChina Department of Radiology the People’s Hospital of Guangxi Zhuang Autonomous RegionGuangxi Academy of Medical SciencesNanningGuangxi Zhuang Autonomous RegionChina Department of Sleep Medicine the People’s Hospital of Guangxi Zhuang Autonomous RegionNanningGuangxi Zhuang Autonomous RegionChina Department of Radiology The Second Xiangya HospitalCentral South UniversityChangshaHunan ProvinceChina Guangxi Clinical Research Center for Sleep Medicine the People’s Hospital of Guangxi Zhuang Autonomous RegionNanningGuangxi Zhuang Autonomous RegionChina

Sleep disturbances are among the most prevalent neuropsychiatric symptoms in individuals who have recovered from severe acute respiratory syndrome coronavirus 2 *** studies have demonstrated abnormal brain structures in patients with sleep disturbances who have recovered from coronavirus disease 2019(COVID-19).However,neuroimaging studies on sleep disturbances caused by COVID-19 are scarce,and existing studies have primarily focused on the long-term effects of the virus,with minimal acute phase *** a result,little is known about the pathophysiology of sleep disturbances in the acute phase of *** address this issue,we designed a longitudinal study to investigate whether alterations in brain structure occur during the acute phase of infection,and verified the results using 3-month follow-up data.A total of 26 COVID-19 patients with sleep disturbances(aged 51.5±13.57 years,8 women and 18 men),27 COVID-19 patients without sleep disturbances(aged 47.33±15.98 years,9 women and 18 men),and 31 age-and gender-matched healthy controls(aged 49.19±17.51 years,9 women and 22 men)were included in this *** COVID-19 patients with sleep disturbances were included in a longitudinal *** found that COVID-19 patients with sleep disturbances exhibited brain structural changes in almost all brain *** cortical thicknesses of the left pars opercularis and left precuneus were significantly negatively correlated with Pittsburgh Sleep Quality Index ***,we observed changes in the volume of the hippocampus and its subfield regions in COVID-19 patients compared with the healthy *** 3-month follow-up data revealed indices of altered cerebral structure(cortical thickness,cortical grey matter volume,and cortical surface area)in the frontal-parietal cortex compared with the baseline in COVID-19 patients with sleep *** findings indicate that the sleep disturbances patients had altered morphology in the cortical an

关键词： brain structure cortical gray matter volume cortical surface area cortical thickness hippocampus magnetic resonance imaging Pittsburgh Sleep Quality Index severe acute respiratory syndrome coronavirus 2 infections sleep disturbances sub-cortical volume

Transformation behaviors of Ti_(48.5)Ni_(48)Fe_2Nb_(1.5) dependence of annealing and thermomechanical cycling

在线全文

学校读者我要写书评

暂无评论

Rare Metals 2012年第3期31卷 231-236页

作者： liu, ying liu, Fushun School of Materials Science and Engineering Beijing University of Aeronautics and Astronautics Beijing 100191 China

The effect of annealing treatments and thermomechanical cycling on the transformation behaviors and shape memory effect of Ti48.5Ni48Fe2Nb1.5 shape memory alloys were investigated using electrical resistivity measurement and tensile testing. It is found that the transformation behaviors are influenced considerably by the annealing treatments. Both Ms and As increase with increasing annealing temperature and cooling rate. Martensite stabilization occurs during thermomechanical cycles, thus resulting in lower Ms and recovery ratio. Moreover, thermomechanical cycling leads to pseudo-elasticity. The yield point of stress-induced martensite (σSIM) increases with increasing cycles and pre-formation.

关键词： thermomechanical annealing transformation behavior shape memory alloys

Review of vanadium-based electrode materials for rechargeable aqueous zinc ion batteries

在线全文

学校读者我要写书评

暂无评论

Journal of Energy Chemistry 2021年第5期30卷 223-237页

作者： ying liu Xiang Wu School of Materials Science and Engineering Shenyang University of TechnologyShenyang 110870LiaoningChina Wuhan National Laboratory for Optoelectronics Huazhong University of Science and TechnologyWuhan 430074HubeiChina

In recent years,rechargeable aqueous zinc ion batteries(ZIBs),as emerging energy storage devices,stand out from numerous metal ion *** to the advantages of low cost,environmentally friendly characteristic and safety,ZIBs can be considered as alternatives to lithium-ion batteries(LIBs).Vanadiumbased compounds with various structures and large layer spacings are considered as suitable cathode candidates for *** this review,the recent research advances of vanadium-based electrode materials are systematically *** electrode design strategy,electrochemical performances and energy storage mechanisms are ***,we point out the limitation of vanadium-based materials at present and the future prospect.

关键词： Aqueous zinc ion batteries Vanadium-base compounds Cathode materials Energy storage mechanism

Upper Bounds of the Rates of Decay for Solutions of the Boussinesq Equations

在线全文

学校读者我要写书评

暂无评论

Acta Mathematicae Applicatae Sinica 2011年第1期27卷 105-114页

作者： ying liu Fundamental Department of the Academy of Armored Force Engineering Bejing 100072 China

In this paper, upper bounds of the L2-decay rate for the Boussinesq equations are considered. Using the L2 decay rate of solutions for the heat equation, and assuming that the solutions of the Boussinesq equations are smooth, we obtain the upper bounds of L2 decay rate for the smooth solutions and difference between the solutions of the Boussinesq equations and those of the heat system with the same initial data. The decay results may then be obtained by passing to the limit of approximating sequences of solutions. The main tool is the Fourier splitting method.

关键词： the Boussinesq equations L2 decay Fourier splitting method

Sponge:An Oversubscription Strategy Supporting Performance Interference Management in Cloud

在线全文

学校读者我要写书评

暂无评论

China Communications 2015年第11期12卷 196-209页

作者： liu ying Services Computing Technology and System Lab Cluster and Grid Computing LabSchool of Computer Science and TechnologyHuazhong University of Science and Technology

Resource oversubscription optimizes the utilization of the computing resources. Many well-known virtual machine monitors(VMMs)such as Xen and KVM,adopt this approach to help maximize the yield of the cloud datacenters That is,with proper resource oversubscription strategies,more virtual machines(VMs) can be supported by limited resources. However performance interference among VMs hosting in the same physical machines(PMs) exists in cloud environment,and probably aggravated by resource oversubscription strategies,which aims to put more VMs into the same PM. In this paper,we present a resource oversubscription strategy called Sponge targeting cloud platforms Sponge mitigates the issue of performance interference among the oversubscribed co-hosting VMs. Sponge also provides a VM association strategy for each PM to handle with its besteffort. We performed our evaluation on a virtua datacenter simulated by Xen. Our evaluation results show that Sponge improves the resources utilization and manages to make each VM mee its performance requirement even hosting with other VMs in the same PM.

关键词： resources oversubscription performance interference cloud computing resource management

Topology Adaptation for Robust Ad Hoc Cyberphysical Networks under Puncture-Style Attacks

在线全文

学校读者我要写书评

暂无评论

Tsinghua Science and Technology 2015年第4期20卷 364-375页

作者： ying liu Wade Trappe Department of Electrical and Computer Engineering Rutgers University

Many cyber physical networks will involve ad hoc deployments utilizing peer-to-peer communications. Examples include transportation systems where a group of moving cars communicate in order to avoid collisions, teams of robotic agents that work together in support of disaster recovery, and sensor networks deployed for health-care monitoring, monitoring the operation of a factory plant or to coordinate and actuate mechanisms for energy conservation in a building. These networks may face a variety of threats that puncture their connectivity and, should their performance degrade, the result could be catastrophic. Consider, for example, a vehicular ad hoc network where communication assists collision avoidance. In such a case, degradation could lead to vehicle accidents. Therefore, in order to overcome network performance degradations and the puncture of a network （such as blackhole or jamming） which is under attack, we propose an algorithm called the Fiedler Value Power Adjustment Topology Adaption （FVPATA）. FVPATA aims to dynamically adapt an ad hoc network＇s topology, even if the attacker varies its location and in the case of an interference-style attack by increasing the interference power. The algorithm utilizes the formulation from the graph theory which works with the Fiedler value to guide each node in wireless ad hoc network utilizing power adjustments to enhance the network＇s overall robustness. The advantage of the proposed mechanism is that it is a light-weight approach which is totally distributed, based on topology updates inherent in the Optimized Link State Routing （OLSR） protocol and, hence, it is unnecessary to introduce additional messages. Additionally, an algorithm was developed to resolve problems involving asymmetric links that arise in ad hoc networks by eliminating unnecessary energy consumption of Fiedler nodes. Simulation results using NS3 show that the proposed mechanism successfully decreases the average amount of hops used by 50% and the d

关键词： algebraic connectivity Fiedler value topology adaptation distributed power control ad hoc networks

A bottleneck-free model for P4P

在线全文

学校读者我要写书评

暂无评论

Science China(Information Sciences) 2015年第10期58卷 94-108页

作者： liu ying ZHANG ShengLin liu Hongying Institute for Network Sciences and Cyberspace Tsinghua University School of Mathematics and Systems Science Beihang University

Provider Portal for Applications(P4P) is a model aiming to incorporate(peer to peer) P2 P applications with Internet Service Providers(ISPs) and improve the performance of the both ISP and the P2 P applications. In this study, we have analyzed the relationship between the link traffic and the P-distance, which is the core interface of P4 P. In addition, the limitation of P4 P in dealing with network applications having bottleneck links is illustrated. Furthermore, taking link utility function as the optimization objective, we propose a Bottleneck-Free model for P4P(BFP), making the traffic produced by P2 P applications more homogeneous,which can reduce the peak link utilization, protect bottleneck links, and thereby improve both the network efficiency and the P2 P performance. We have built a simulation platform based on Bit Torrent and conducted extensive simulations. The simulation results demonstrate that BFP achieves a lower cost for ISPs and a better performance for P2 P applications than P4 P and native P2 P applications, both in intra-domain and inter-domain settings. BFP performs steadily in different topologies and swarm sizes, proving that it is scalable and easy to deploy.

关键词： subgradient method P2P traffic engineering cooperative model duality

Simulation of the Fate of Faecal Bacteria in Estuarine and Coastal Waters Based on A Fractionated Sediment Transport Model

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

China Ocean Engineering 2017年第4期31卷 389-395页

作者： YANG Chen liu ying College of Petroleum Engineering China University of Petroleum Beijing 102249 China China Institute of Water Resources and Hydropower Research Beijing 100038 China Research Center on Flood & Drought Disaster Reduction of the Ministry of Water Resources Beijing 100038 China

A two-dimensional depth-integrated numerical model is refined in this paper to simulate the hydrodynamics, graded sediment transport process and the fate of faecal bacteria in estuarine and coastal waters. The sediment mixture is divided into several fractions according to the grain size. A bed evolution model is adopted to simulate the processes of the bed elevation change and sediment grain size sorting. The faecal bacteria transport equation includes enhanced source and sink terms to represent bacterial kinetic transformation and disappearance or reappearance due to sediment deposition or re-suspension. A novel partition ratio and dynamic decay rates of faecal bacteria are adopted in the numerical model. The model has been applied to the turbid water environment in the Bristol Channel and Severn estuary, UK. The predictions by the present model are compared with field data and those by non-fractionated model.

关键词： bed evolution decay rate esmarine and coastal water faecal bacteria fractionated model sediment Wansport