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健康自我倾注在原发性高血压患者健康管理知信行建立过程中的作用初探

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中华全科医师杂志 2024年第1期23卷 33-40页

作者：陈荔萍蔡雨阳孔丽沈福来金迎上海市黄浦区打浦桥街道社区卫生服务中心上海200023 上海交通大学公共卫生学院社会医学与卫生事业管理系上海200025 上海师范大学教育学院心理系上海200233 上海交通大学健康长三角研究院健康强基研究中心上海200030

目的探讨健康自我倾注在原发性高血压患者健康管理知信行建立过程中的作用。方法该研究为横断面研究。于2021年10至12月在上海市黄浦区打浦桥街道社区卫生服务中心的4个卫生服务站点,采用随机数字表法抽取原发性高血压患者。通过调查问... 详细信息

目的探讨健康自我倾注在原发性高血压患者健康管理知信行建立过程中的作用。方法该研究为横断面研究。于2021年10至12月在上海市黄浦区打浦桥街道社区卫生服务中心的4个卫生服务站点,采用随机数字表法抽取原发性高血压患者。通过调查问卷收集入选患者的一般信息,高血压对生活、工作及家庭的影响程度,高血压相关知识与认知,高血压自我管理行为,健康自我倾注的情况,并对后4者进行评分。调查结束后测量患者血压,以此判断患者血压控制是否达标。采用Spearman秩相关分析及Pearson相关分析分析高血压对生活、工作及家庭的影响程度,高血压相关知识与认知,高血压自我管理行为,健康自我倾注,以及血压达标的两两相关性。采用AMOS 24.0软件构建“健康自我倾注-高血压相关知识与认知-高血压自我管理行为及高血压对生活、工作及家庭的影响程度”的结构方程模型,分析健康自我倾注对高血压相关知识与认知及自我管理行为的作用。结果纳入患者190例,年龄(71.2±8.5)岁,男性82例(43.2%),达标组119例、未达标组71例。调查问卷有效回收率100%(190/190)。达标组患者高血压自我管理行为总分和健康自我倾注总分均高于未达标组(均P<0.05)。高血压对生活、工作及家庭的影响程度与高血压相关知识与认知、高血压自我管理行为均呈负相关(r值分别为-0.39和-0.28,均P<0.01);高血压相关知识与认知与高血压自我管理行为、健康自我倾注均呈正相关(r值分别为0.29和0.27,均P<0.01);高血压自我管理行为与健康自我倾注呈正相关(r=0.28,P<0.01),与血压达标呈正相关(r=0.48,P<0.01);健康自我倾注与血压达标呈正相关(r=0.21,P<0.01)。结构方程模型分析结果显示健康自我倾注在原发性高血压患者认知和行为中具有驱动作用,其影响患者对高血压相关知识的掌握程度和正确认知的形成(路径系数为0.28),进而促进患者采取自我健康管理行为(路径系数为0.20)。此外,高血压对患者生活、工作和家庭的影响对患者接受并认同高血压相关知识及形成正确的认知、采取自我管理行为均具有负向调节作用,调节系数分别为-0.48、-0.22。结论健康自我倾注在原发性高血压患者健康管理知信行建立过程中可能具有驱动作用。

关键词：高血压知信行模式健康自我倾注

个旧市白云山国有林场天然次生林病虫害绿色防治效果分析

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林业科技情报 2024年第04期56卷 43-45页

作者：金樱尹信忠个旧市林业和草原勘察设计队个旧市白云山国有林场

目的分析个旧市白云山国有林场天然次生林病虫害绿色防治措施，总结防治效果。方法样地选择个旧市白云山国有林场，根据病虫害绿色防治措施差异分为不同处理，A1(农业防治)、A2(农业防治+生物防治)、A3(农业防治+生物防治+物理防治),... 详细信息

目的分析个旧市白云山国有林场天然次生林病虫害绿色防治措施，总结防治效果。方法样地选择个旧市白云山国有林场，根据病虫害绿色防治措施差异分为不同处理，A1(农业防治)、A2(农业防治+生物防治)、A3(农业防治+生物防治+物理防治),分析不同处理后的天然次生林病虫害绿色防治效果。结果 A3处理次生林健康度的优质和健康个数多于A1和A2处理，亚健康和不健康个数少于A1和A2处理；林下物种多样性表现为A3>A2>A1;A3处理的群落层次更复杂、郁闭度最高、叶面积更大，病虫害清除更为彻底。结论个旧市白云山国有林场天然次生林病虫害类型较多，不同的防治措施均能起到防治效果，以农业防治+生物防治+物理防治的综合防治效果最佳，因此在病虫害防治过程中需掌握区域的环境变化和气候变化特点，掌握动态变化因子，结合病虫害的类型、病虫害发生规律等制定符合实际要求的绿色防治对策。实践中应当提高森林病虫害防范意识，完善森防体系建设，并少量应用清除虫害的化学药剂，通过各种绿色防治措施以及营造混交林、对林木进行抚育间伐等措施获得更为理想的病虫害防治效果，从而促进林木生长。

关键词：国有林场天然次生林病虫害绿色防治防治效果

聚合离子液体设计及催化环己烷选择性氧化性能研究

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化工学报 2024年第4期75卷 1552-1564页

作者：王瑞瑞金颖刘玉梅李梦悦朱胜文闫瑞一刘瑞霞中国科学院过程工程研究所离子液体清洁过程北京市重点实验室北京100190 郑州大学河南先进技术研究院河南郑州450003

以乙烯基咪唑为单体,添加不同量的引发剂,采用常规热聚合中自由基聚合的方式,合成了不同分子量的聚乙烯基咪唑,热重(TG)分析表明该聚合物具有良好的热稳定性。采用季铵化反应,对最优聚合物进行1-氯代十八烷、1-氯代十二烷以及1-氯代正... 详细信息

以乙烯基咪唑为单体,添加不同量的引发剂,采用常规热聚合中自由基聚合的方式,合成了不同分子量的聚乙烯基咪唑,热重(TG)分析表明该聚合物具有良好的热稳定性。采用季铵化反应,对最优聚合物进行1-氯代十八烷、1-氯代十二烷以及1-氯代正己烷三种不同烷基链长度的取代,合成系列聚合离子液体(PIL)。通过傅里叶红外光谱(FT-IR)、扫描电子显微镜(SEM)、X射线光电子能谱(XPS)、接触角等表征手段分析了聚合离子液体的化学结构及形貌特征,并考察了PIL-C_(18)、PIL-C_(12)、PIL-C_(6)催化环己烷选择性氧化为己二酸的性能,进而选取PIL-C_(12)深入研究了离子率对催化性能的影响规律。结果表明,烷基链段长度以及离子率可以有效调控亲疏水性和反应活性位点,进而提高反应性能,使得反应生成己二酸的转化率达到21.8%,选择性为41.5%。

关键词：聚合离子液体离子率环己烷催化氧化

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High production of fatty alcohols in Yarrowia lipolytica by coordination with glycolysis

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Science China Chemistry 2019年第8期62卷 1007-1016页

作者： jin-Lai Zhang ying-Xiu Cao Yang-Zi Peng Cong-Cong jin Qiu-Yan Bai Ruo-Si Zhang Duo Liu ying-jin Yuan Frontier Science Center for Synthetic Biology and Key Laboratory of Systems Bioengineering (Ministry of Education) Tianjin University Tianjin 300072China Collaborative Innovation Center of Chemical Science and Engineering (Tianjin) School of Chemical Engineering and Technology Tianjin UniversityTianjin 300072China

Fatty alcohol biosynthesis by oleaginous microbes was a promising alternative to the petroleum or other non-renewable resources-based process. However, low titer and yield hamper the further industrial and commercial applications. Here, we developed an efficient strategy to coordinate fatty alcohol with glycolysis which achieved a ‘pull-and-push’ effect to improve fatty alcohol production. Transcript profiling indicated that genes in carbohydrate metabolism were up-regulated significantly in response to high fatty alcohol production. Based on it, 11 glycolysis promoters were screening to express fatty acyl-CoA reductase(FAR) to relate the fatty alcohol production with the up-regulated carbohydrate metabolism, and the fatty alcohol production reached 557 mg/L when FAR was expressed by the promoter of PFBAin. RNA-seq and qRT-PCR analysis demonstrated that a ‘pull-and-push’ effect caused by the coordination system dynamically enhanced the product synthesis flux from top to bottom, which was also testified and intensified by doubled glucose concentration. After manipulating structural and regulatory genes of lipid metabolism, the final strain achieved up to 5.75 g/L fatty alcohol production from modified YPD medium(containing 91 g/L glucose) in shake flasks, which represented the highest titer reported to date. This work offered a feasible and effective reference for dynamic manipulation of fatty acid-derived chemicals synthesis.

关键词： fatty alcohol biosynthesis coordinative expression Yarrowia lipolytica fatty acyl-CoA reductase(FAR) metabolic engineering

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炎症性肠病与牙周病的相关性及防治研究进展

中国实用口腔科杂志 2024年第5期17卷 603-608页

作者：应征米南南张苗苗靳赢中国医科大学附属盛京医院口腔科辽宁沈阳110004

炎症性肠病和牙周病均为微生物稳态失调与宿主免疫炎症反应相互作用导致的慢性炎症性疾病,二者之间可能通过直接或间接机制相互影响,进而促使另一种疾病发生或加重其原病变程度。直接机制为口腔微生物异位定植于肠道,并激活肠道免疫炎... 详细信息

炎症性肠病和牙周病均为微生物稳态失调与宿主免疫炎症反应相互作用导致的慢性炎症性疾病,二者之间可能通过直接或间接机制相互影响,进而促使另一种疾病发生或加重其原病变程度。直接机制为口腔微生物异位定植于肠道,并激活肠道免疫炎症反应;间接机制包括血液、淋巴循环在内的系统性免疫激活。由于二者存在相似的致病机制,或许可通过研究其共同靶点来探索针对这2种疾病的预防与治疗措施。因此,文章就炎症性肠病与牙周病的相关性及防治研究进展做一综述。

关键词：炎症性肠病牙周病微生物炎症反应信号通路

Mobile CRISPR-Cas9 based anti-phage system in E. coli

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Frontiers of Chemical Science and Engineering 2022年第8期16卷 1281-1289页

作者： Zhou Cao Yuxin Ma Bin Jia ying-jin Yuan Frontier Science Center for Synthetic Biology and Key Laboratory of Systems Bioengineering(Ministry of Education) Tianjin UniversityTianjin 300072China Collaborative Innovation Center of Chemical Science and Engineering(Tianjin) School of Chemical Engineering and TechnologyTianjin UniversityTianjin 300072China

Escherichia coli is one of the most important microbial cell factories,but infection by bacteriophages in the environment may have a huge impact on its application in industrial ***,we developed a mobile CRISPR-Cas9 based anti-phage system for bacteriophages defense in *** conjugative plasmids pGM1(phosphoglucomutase 1)and pGM2 carrying one and two guide RNAs,respectively,were designed to defend against a filamentous *** results showed that the pGM1 and pGM2 could decrease the phage infection rate to 1.6%and 0.2%respectively in infected *** preventing phage infection in ***,the pGM2 decreased the phage infection rate to 0.1%,while pGM1 failed to block phage *** verification revealed that point mutations in protospacer or protospacer adjacent motif sequences of the phage genome caused loss of the defense *** results support the potential application of MCBAS in *** cell factories to defend against phage infections.

关键词： phage infections anti-phage CRISPR-Cas9,conjugative transfer synthetic biology

Use of disposable graduated biopsy forceps improves accuracy of polyp size measurements during endoscopy

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World Journal of Gastroenterology 2015年第2期21卷 623-628页

作者： Hei-ying jin Qiang Leng National Center of Colorectal Surgery the Third Affiliated Hospital of Nanjing University of Traditional Chinese MedicineJiangsu Integrated Colorectal Oncology Center

AIM: To determine the accuracy of endoscopic polyp size measurements using disposable graduated biopsy forceps(DGBF). METHODS: Gradations accurate to 1 mm were assessed with the wire of disposable graduated biopsy forceps. When a polyp was noted, endoscopists determined the width of the polyp; then, the graduated biopsy forceps was inserted and the largest diameter of the tumor was measured. After excision, during surgery or endoscopy, the polyp was measured using the vernier ***: One hundred and thirty-three colorectal polyps from 119 patients were studied. The mean diameter, by post-polypectomy measurement, was 0.92 ± 0.69 cm; 83 were 2 cm. The mean diameter, by visual estimation, was 1.15 ± 0.88 cm; compared to the actual size measured using vernier calipers, the difference was statistically significant. The mean diameter measured using the DGBF was 0.93 ± 0.68 cm; compared to the actual size measured using vernier calipers, this difference was not statistically significant. The ratio between the mean size estimated by visual estimation and the actual size was significantly different from that between the mean size estimated using the DGBF and the actual size(1.26 ± 0.30 vs 1.02 ± 0.11).CONCLUSION: The accuracy of polyp size estimation was low by visual assessment; however, it improved when the DGBF was used.

关键词： Disposable graduated biopsy forceps Polyp size mea

仿真分析在热管理控制阀振动工装设计中的应用

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内燃机与配件 2024年第15期 67-69页

作者：金莹莹韩橙宋宏利上海飞龙新能源汽车部件有限公司上海201112

振动工装是新能源汽车热管理控制阀开展振动相关的试验时必备的配套产品,它的质量好坏将直接影响试验的测试结果。本文针对某汽车热管理控制阀在进行振动耐久试验时热管理控制阀支架在安装孔附近出现破坏的问题,采用有限元分析的方法对... 详细信息

振动工装是新能源汽车热管理控制阀开展振动相关的试验时必备的配套产品,它的质量好坏将直接影响试验的测试结果。本文针对某汽车热管理控制阀在进行振动耐久试验时热管理控制阀支架在安装孔附近出现破坏的问题,采用有限元分析的方法对振动工装进行了模态分析。结果表明,振动工装的固有频率太低,会导致其传递给支架的振动能量太大,因而造成支架破坏。将振动工装进行优化,支架没有发生破坏现象,试验顺利通过。这为后续新能源汽车热管理控制阀振动试验工装的设计和工程试验提供参考。

关键词：振动工装有限元模态分析热管理控制阀

The effect of Zhusha Anshen Wan decoction on states of the sleep-waking cycle in insomnic rats

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Neural Regeneration Research 2008年第4期3卷 398-401页

作者： ying Wang Yang jin Tingli Li Department of Pharmacology of Chinese Materia Medica Heilongjiang University of Traditional Chinese Medicine Harbin 150040Heilongjiang Province China

BACKGROUND： Sedative and hypnotic chemical drugs prolong the total-sleep time （TST） by a decrease in slow-wave sleep 2 （SWS2） and rapid-eye-movement sleep （REMS） and a relative increase in slow-wave sleep 1 （SWS1）. OBJECTIVE： To investigate the effect of the Chinese medicine Zhusha Anshen Wan at different doses on each sleeping state in insomnic rats, and to identify its mode of action in improving sleep. DESIGN, TIME AND SETTING： A randomized controlled study in rats. This study was performed in the Department of Pharmacology of Chinese Materia Medica, Heilongjiang University of Traditional Chinese Medicine during the period from January 2005 to July 2006. MATERIALS： Twenty-four male Wistar rats, weighing （220±5） g, were selected. The main components in Zhusha Anshen Wan, Cinnabaris, Rhizoma Coptidis, Radix Glycyrrhixae, Prepared Radix Glycyrhizae Radix Angelicae Sinensis, and Rehmannia Pride Rhizome, were authenticated by Dr Xiaowei Du, Professor of Pharmacology. ND-97 Digital Polysomnography was purchased from the Shanghai Medical Instrument High Technology Company and Footplate Electrical Stimulator from the Harbin Research Institute of Electrical Instruments. METHODS： Rats were deprived of sleep by using the Footplate Electrical Stimulator. Insomnic rats were randomized into high-, mid- and low-dose Zhusha Anshen Wan groups, eight rats in each group. Animals were administrated with different doses of Zhusha Anshen Wan （equal to crude drug 7.2, 3.6, 1.8 g/kg） consecutively for seven days. MAIN OUTCOME MEASURES： 30 minutes after the last administration, rats of each group suffered 8 hours foot-shocks while electroencephalography signals were recorded using Digital Polysomnography. Total time of waking （W）, SWS1, SWS2, REMS and TST were calculated for pre- and post-administration, respectively. RESULTS： All 24 rats were included in the statistical analysis of the results without any loss. In the low-dose Zhusha Anshen Wan group, SWS2 was increased significantly co

关键词： sleep electroencephalogram sleep stages Chinese traditional medicine