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Effects of medical adhesives in prevention of complications after endoscopic submucosal dissection

World Journal of Gastroenterology 2013年第17期19卷 2704-2708页

作者： Yi Zhang ying Chen Chun-ying Qu Min zhou Qian-Wen Ni Lei-Ming Xu Department of Digestive Endoscopy Xinhua Hospital School of Medicine Shanghai Jiaotong University Shanghai Key Laboratory of Pediatric Digestion and Nutrition

AIM:To evaluate the use of medical adhesive spray in endoscopic submucosal dissection (ESD). METHODS:Patients who underwent ESD between January 2009 and June 2012 (n = 173) were enrolled in the prospective randomized study. Two patients undergoing surgery due to severe intraoperative hemorrhage and failed hemostasis were excluded, and the remaining 171 patients were randomly divided into two groups:group A (medical adhesive group, n = 89) and group B (control group, n = 82). In group A, a medical adhesive spray was evenly applied after routine electrocoagulation and hemostasis using hemostatic clip after ESD. Patients in group B only treated with routine wound management. Intraoperative and postoperative data were collected and compared. RESULTS:In all 171 patients, ESD was successfully completed. There was no significant difference in the average treatment time between groups A and B (59.4 min vs 55.0 min, respectively). The average length of hospital stay was significantly different between group A and B (8.89 d vs 9.90 d, respectively). The incidence of intraoperative perforation was 10.1% in group A and 9.8% in group B, and was not significantly different between the two groups. In all cases, perforations were successfully managed endoscopically and with conservative treatment. The incidence of postoperative delayed bleeding in group A was significantly lower than that in group B (0.00% vs 4.88%, respectively). CONCLUSION:ESD is an effective minimally invasive treatment for gastrointestinal precancerous lesions or early-stage gastrointestinal cancer. Medical adhesive spray is effective in preventing delayed bleeding after ESD, and can thus reduce the average length of hospital stay.

关键词： Endoscopic submucosal dissection Medical adhesive Early-stage gastrointestinal cancer Postoperative delayed bleeding Intraoperative hemorrhage

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Value of bevacizumab in treatment of colorectal cancer: A meta-analysis

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World Journal of Gastroenterology 2015年第16期21卷 5072-5080页

作者： Chun-ying Qu ying Zheng Min zhou Yi Zhang Feng Shen Jia Cao Lei-Ming Xu Department of Digestive Diseases Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine Shanghai Key Laboratory of Pediatric Gastroenterology and Nutrition Shanghai Institute of Pediatric Research Department of Oncology Branch of Shanghai First People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine

AIM:To assess the efficacy and safety of bevacizumab in the treatment of colorectal ***:All randomized controlled trials of bevacizumab for the treatment of colorectal cancer from January 2003 to June 2013 were collected by searching the Cochrane Library, Pub Med, Chinese National Knowledge Infrastructure and Wanfang *** primary endpoint was overall survival(OS), and the secondary endpoints were progression-free survival, overall response rate and adverse *** reviewers extracted data *** analyses were performed with Stata *** degree of bias was assessed using funnel plots for the effect size of OS at the primary ***:Following the inclusion criteria and exclusion criteria, ten studies comprising 6977 cases were finally included, of which nine were considered to be of high quality(4-7 points) and one of low quality(1-3 points).Our meta-analysis revealed the efficacy of bevacizumab in patients with colorectal cancer in terms of OS(HR = 0.848, 95%CI:0.747-0.963), progressionfree survival(HR = 0.617, 95%CI:0.530-0.719), and overall response rate(OR = 1.627, 95%CI:1.199-2.207).Regarding safety, higher rates of grade ≥ 3 hypertension, proteinuria, bleeding, thrombosis, and gastrointestinal perforation were observed in the bevacizumab treatment group(P < 0.05); however, the incidence of serious toxicity was very *** was no publication bias in the 10 reports included in this ***:The clinical application of bevacizumab in colorectal cancer is effective with good safety.

关键词： Bevacizumab Colorectal cancer Clinicalapplication Randomized controlled trials Meta-analysis

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0~6岁听力正常儿童听性脑干反应演化规律及声传导功能异常儿童的特征

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临床耳鼻咽喉头颈外科杂志 2023年第3期37卷 225-230页

作者：李颖王雪瑶周怡金欣郑之芃史吉峰刘海红国家儿童医学中心(北京)首都医科大学附属北京儿童医院耳鼻咽喉头颈外科、儿童耳鼻咽喉头颈外科疾病北京市重点实验室北京100045

目的:探索0~6岁儿童短声诱发听性脑干反应(Click-ABR)潜伏期及波间期的正常参考范围,分析声传导功能异常儿童Click-ABR的临床特征。方法:分别对1791例(3582耳)0~6岁听力正常儿童及176例(258耳)声传导功能异常儿童进行Click-ABR。分析不... 详细信息

目的:探索0~6岁儿童短声诱发听性脑干反应(Click-ABR)潜伏期及波间期的正常参考范围,分析声传导功能异常儿童Click-ABR的临床特征。方法:分别对1791例(3582耳)0~6岁听力正常儿童及176例(258耳)声传导功能异常儿童进行Click-ABR。分析不同月龄听力正常儿童Click-ABR各项参数的差异,同时比较声传导功能异常儿童Click-ABR波Ⅴ反应阈与潜伏期及波间期的相关性。结果:波Ⅰ潜伏期与月龄不相关,波Ⅲ潜伏期、波Ⅴ潜伏期、波Ⅰ-Ⅲ间期和波Ⅰ-Ⅴ间期均与月龄呈明显负相关;波Ⅲ潜伏期自25个月起不随年龄增长而缩短,波Ⅴ潜伏期自37个月起不随年龄增长而缩短。声传导功能异常儿童在80 dB nHL刺激声下波Ⅰ潜伏期与听阈呈正相关,波Ⅰ-Ⅲ、Ⅰ-Ⅴ间期与听力正常儿童标准值无差异。结论:0~6岁儿童Click-ABR波Ⅲ、Ⅴ潜伏期及波Ⅰ-Ⅲ、Ⅰ-Ⅴ间期随年龄增长而缩短,本研究建立了本实验室0~6岁不同年龄段儿童Click-ABR潜伏期及波间期的正常参考范围;结合Click-ABR听阈以及80 dB nHL刺激声下波Ⅰ潜伏期,可初步筛选出声传导功能异常儿童,同时应进一步补充其他听力诊断组合。

关键词：儿童听性脑干反应传导性听力损失

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三种抗生素对土壤呼吸和硝化作用的影响

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生态环境学报 2014年第6期23卷 1050-1056页

作者：杨基峰应光国赖华杰赵建亮刘珊周丽君中国科学院广州地球化学研究所有机地球化学国家重点实验室广东广州510640 湖南文理学院化学化工学院湖南常德415000 湖南大学化学化工学院湖南长沙410082

抗生素广泛用于人体和动物疾病治疗,但使用后大部分以母体形式排除体外,通过污泥还田、污灌及其他各种途径进入土壤环境,对陆生生态环境产生潜在威胁。为评价抗生素对土壤微生物活性和功能的影响,以3种不同抗生素(磺胺嘧啶、氧四环素和... 详细信息

抗生素广泛用于人体和动物疾病治疗,但使用后大部分以母体形式排除体外,通过污泥还田、污灌及其他各种途径进入土壤环境,对陆生生态环境产生潜在威胁。为评价抗生素对土壤微生物活性和功能的影响,以3种不同抗生素(磺胺嘧啶、氧四环素和诺氟沙星)为靶标化合物,采用OECD标准土壤呼吸实验和氮硝化实验方法,运用SPSS软件对实验结果进行统计分析,考察抗生素对土壤微生物活性和氮转化功能的影响。实验结果显示:在呼吸实验中,磺胺嘧啶和氧四环素在初始阶段对土壤呼吸具有一定的抑制作用,并且氧四环素的抑制强度低于磺胺嘧啶,其最高抑制率分别为76.8%和20.7%;在实验后期则出现一定激活作用,最高激活率分别为343%和218%,随着时间的推移激活效应减弱。诺氟沙星在呼吸实验初期对微生物活性出现激活作用,最高激活率为15.4%;后期则出现一定的抑制作用,最高抑制率为21.9%。在硝化实验中,磺胺嘧啶对土壤A的微生物硝化作用在各处理之间未出现显著性差异,而对土壤B则具有一定抑制作用,最高抑制率为20%;氧四环素和诺氟沙星则相反,在土壤A中对微生物硝化作用的抑制率分别为50%和19%,这种硝化作用差别性可能是由于土壤pH值和抗生素本身的抗菌谱所引起。通过以上实验结果可得出如下结论:3种不同类型的抗生素对土壤的微生物活性和氮转化功能会产生不同的作用,这种不同主要来自于抗生素种类、土壤类型及抗生素的浓度等因素的影响。因此,土壤中抗生素的引入将可对陆生生态环境造成一定影响,在实际粪便还田过程中应开展风险评估。

关键词：抗生素土壤呼吸作用硝化作用

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基于统计参数图的fMRI图像空间平滑技术的研究

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生物医学工程研究 2015年第3期34卷 148-151,157页

作者：周蕾蕾胡颖郁芸胡新华杨坤南京医科大学基础医学院江苏南京210029 南京医科大学脑科医院江苏南京210029

探讨并分析用统计参数图(statistical parametric mapping,SPM)进行脑功能磁共振图像空间平滑处理的技术原理及其程序实现。采用医用磁共振机对正常人脑进行脑功能磁共振成像扫描,获得相关的脑功能图像。利用SPM软件对图像进行空间平滑... 详细信息

探讨并分析用统计参数图(statistical parametric mapping,SPM)进行脑功能磁共振图像空间平滑处理的技术原理及其程序实现。采用医用磁共振机对正常人脑进行脑功能磁共振成像扫描,获得相关的脑功能图像。利用SPM软件对图像进行空间平滑处理,并分析其算法及程序实现,在此基础上对SPM算法进行改进并仿真。通过分析和改进算法,得到了更好的空间平滑效果,从而获得更高质量的脑功能磁共振图像,便于临床诊断。SPM软件包在脑功能磁共振图像处理与分析中有着重要应用,但仍需改进和提高。

关键词：功能核磁共振成像统计参数图空间平滑卷积滤波

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水性双组分聚氨酯在石材防护中的应用研究

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新型建筑材料 2007年第11期34卷 81-84页

作者：周新华廖列文尹国强崔英德广东工业大学博士后流动站广东广州510006 仲恺农业技术学院化学与化工系广东广州510225

以亲水性多异氰酸酯(Bayhydur XP 2487/1)为甲组分,丙烯酸多元醇乳液(Bayhydrol-XP 2427)为乙组分,研究了水性双组分聚氨酯乳液对石材的防护性。结果表明,水性双组分聚氨酯乳液属渗透型防护剂对石材的润湿性好,石材对乳液的吸液率为水的... 详细信息

以亲水性多异氰酸酯(Bayhydur XP 2487/1)为甲组分,丙烯酸多元醇乳液(Bayhydrol-XP 2427)为乙组分,研究了水性双组分聚氨酯乳液对石材的防护性。结果表明,水性双组分聚氨酯乳液属渗透型防护剂对石材的润湿性好,石材对乳液的吸液率为水的3倍以上。润湿性和乳液黏度是影响双组分聚氨酯乳液在石材中的渗透量的2个主要因素,其对石材的防护性取决于乳液在石材孔隙中的渗透量和交联密度。双组分聚氨酯对石材具有较好的防水性、抗污染性、防风化性、耐老化性以及抗渗性,可制成多功能石材防护剂。

关键词：水性双组分聚氨酯石材防护剂

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肝内胆管结石的完全腹腔镜下肝切除术

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中国现代医生 2015年第1期53卷 144-146页

作者：应东建周新华宁波市医疗中心李惠利医院腹部微创外科浙江宁波315041

目的分析研究全腹腔镜肝切除术与传统肝切除术治疗肝内胆管结石的效果。方法将124例肝内胆管结石患者按照治疗方式的不同分为观察组和对照组各62例,观察组行腹腔镜下规则性左半肝切除术,对照组行常规开腹手术进行治疗。观察两组临床效... 详细信息

目的分析研究全腹腔镜肝切除术与传统肝切除术治疗肝内胆管结石的效果。方法将124例肝内胆管结石患者按照治疗方式的不同分为观察组和对照组各62例,观察组行腹腔镜下规则性左半肝切除术,对照组行常规开腹手术进行治疗。观察两组临床效果及不良反应情况。结果观察组手术时间、术中出血量、术后下床时间均优于对照组(P<0.05);观察组总有效率明显高于对照组(χ2=3.815,P<0.05);观察组术后转氨酶升高程度显著低于对照组,白蛋白水平显著高于对照组(P<0.05);两组在术后并发症发生率方面比较差异有统计学意义(χ2=5.128,P<0.05)。两组均无围手术期死亡病例。结论行腹腔镜肝切除术治疗肝内胆管结石安全、微创,可作为治疗肝胆管结石的一种较好的选择在临床上使用。

关键词：腹腔镜肝切除肝胆管结石临床应用

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Petrology and geochemistry of Zijinshan alkaline intrusive complex in Shanxi Province,western North China Craton:Implication for magma mixing of different sources in an extensional regime

Petrology and geochemistry of Zijinshan alkaline intrusive c...

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中国科学院地质与地球物理研究所2007学术年会

作者： jifeng ying~(a,*),Hongfu Zhang~a,Min Sun~b,Yanjie Tang~a, xinhua zhou~a,Xiaoming Liu~c a State Key Laboratory of Lithospheric Evolution,Institute of Geology and Geophysics,Chinese Academy of Sciences, P.O.Box 9825.Beijing 100029,China b Department of Earth Sciences,The University of Hong Kong,Porkfulam road,Hong Kong,China c Department of Geology,Northwest University,Xi’an 710069,China

In situ zircon U-Pb ages and Hf isotopic compositions and whole rock geochemical and Sr-Nd-Pb isotopic data are presented for the Zijinshan alkaline intrusive complex from the Shanxi Province,western North China *** rocks dominate the complex with the monzonite occurring in the outermost and pseudoleucite phonolitic breccia in the *** intrusion took place 127 Ma ago with the earliest emplacement of monzonite and the termination of cryptoexplosive pseudoleucite phonolitic *** rocks from this complex show LREE enrichment and HFSE depletion and exhibit enriched to depleted Sr-Nd isotopic *** presence of inherited zircons and enriched Hf isotopic compositions in zircon rims,along with the enriched whole rock Sr-Nd isotopic compositions,indicate that the monzonite was formed through the mixing of lithospheric mantle-derived magma with lower crustderived *** diopside syenite and nepheline-bearing diopside syenite are more depleted than the monzonite in terms of the Sr and Nd isotopes,together with their very high concentrations of LILE,we proposed that they originated from a mixed mantle source of enriched lithospheric mantle and depleted *** nepheline syenite has very low concentrations of MgO,Ni,Cr, suggesting that the magma underwent significant crystal *** most depleted Sr and Nd isotopic compositions ((Sr/Sr)=0.7036-0.7042,ε(t)=-0.2-0.3) among all rock types indicate a great contribution of asthenosphere to the nepheline *** Zijinshan complex and its related crust-mantle interaction occurred in an extensional environment which resulted in continuously asthenospheric *** an extensional environment might have been developed during the post-orogenic stage of the Late Paleozoic amalgamation of North China Craton with Mongolian continents and subsequent Mongol-Okhotsk ocean closure.

关键词： Alkaline complex Crust-mantle interaction Monzonite Nepheline syenite North China Craton

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Current management of chemotherapy-induced neutropenia in adults:key points and new challenges

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Cancer Biology & Medicine 2020年第4期17卷 896-909页

作者： Committee of Neoplastic Supportive-Care(CONS),China Anti-Cancer Association Committee of Clinical Chemotherapy,China Anti-Cancer Association Yi Ba Yuankai Shi Wenqi Jiang jifeng Feng ying Cheng Li Xiao Qingyuan Zhang Wensheng Qiu Binghe Xu Ruihua Xu Bo Shen Zhiguo Luo Xiaodong Xie Jianhua Chang Mengzhao Wang Yufu Li Yuerong Shuang Zuoxing Niu Bo Liu Jun Zhang Li Zhang Herui Yao Conghua Xie Huiqiang Huang Wangjun Liao Gongyan Chen Xiaotian Zhang Hanxiang An Yanhong Deng Ping Gong Jianping Xiong Qinghua Yao Xin An Cheng Chen Yanxia Shi Jialei Wang Xiaohua Wang Zhiqiang Wang Puyuan Xing Sheng Yang Chenfei zhou 不详 Department of Gastrointestinal Medical Oncology Tianjin Medical University Cancer Institute and HospitalNational Clinical Research Center for CancerKey Laboratory of Cancer Prevention and TherapyTianjinTianjin's Clinical Research Center for CancerTianjin 300060China Department of Medical Oncology National Cancer CenterCancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China Department of Medical Oncology Sun Yat-sen University Cancer CenterGuangzhou 510060China Department of Medical Oncology Jiangsu Cancer HospitalNanjing 210009China Department of Oncology Jilin Province Cancer HospitalChangchun 130012China Department of Oncology Zhongshan Hospital Affiliated to Xiamen UniversityXiamen 361004China Department of Oncology Cancer Hospital Harbin Medical UniversityHarbin 150081China Department of Oncology Affiliated Hospital of Qingdao UniversityQingdao 266003China Department of Medical Oncology Fudan University Shanghai Cancer CenterShanghai 200032China Department of Oncology General Hospital of Shenyang Military RegionShenyang 110016China Department of Pulmonary and Critical Care Medicine Peking Union Medical College HospitalBeijing 100730China Department of Hematology Affiliated Cancer Hospital of Zhengzhou UniversityHenan Cancer HospitalZhengzhou 450008China Lymphoma and Myeloma Department Jiangxi Cancer HospitalNanchang 330029China Department of Medical Oncology Shandong Cancer HospitalShandong Academy of Medical SciencesJinan 250117China Department of Oncology Ruijin HospitalShanghai Jiao Tong University School of MedicineShanghai 200025China MSun Yat-sen Memorial Hospital Sun Yat-sen UniversityGuangzhou 510120China Department of Radiation and Medical Oncology Zhongnan Hospital of Wuhan UniversityWuhan 430070China Department of Oncology Nanfang HospitalSouthern Medical UniversityGuangzhou 510515China Department of Gastrointestinal Oncology Peki ng University Cancer Hospital&InstituteBeijing 100142China Department of

Chemotherapy-induced neutropenia(CIN)is a potentially fatal and common complication in myelosuppressive *** timing and grade of CIN may play prognostic and predictive roles in cancer *** is associated with older age,poor functional and nutritional status,the presence of significant comorbidities,the type of cancer,previous chemotherapy cycles,the stage of the disease,specific chemotherapy regimens,and combined *** are many key points and new challenges in the management of CIN in adults including:(1)Genetic risk factors to evaluate the patient’s risk for CIN remain ***,these risk factors urgently need to be identified.(2)Febrile neutropenia(FN)remains one of the most common reasons for oncological *** consensus nomogram for FN risk assessment has been established.(3)Different assessment tools[e.g.,Multinational Association for Supportive Care in Cancer(MASCC),the Clinical Index of Stable Febrile Neutropenia(CISNE)score model,and other tools]have been suggested to help stratify the risk of complications in patients with ***,current tools have *** CISNE score model is useful to support decision-making,especially for patients with stable FN.(4)There are still some challenges,including the benefits of granulocyte colony stimulating factor treatment and the optimal antibiotic regimen in emergency management of *** view of the current reports,our group discusses the key points,new challenges,and management of CIN.

关键词： Chemotherapy-induced neutropenia(CIN) febrile neutropenia cancer risk stratification granulocyte-colony stimulating factor(G-CSF)

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超低氧弹簧钢硫容量计算及硫脱除分析

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北京科技大学学报 2008年第9期30卷 986-992页

作者：王郢王新华周红霞郭佳王万军北京科技大学冶金与生态工程学院北京100083 北京科技大学材料科学与工程学院北京100083

采用KTH模型、Young光学碱度模型、Tsao硫容量经验公式等方法对超低氧弹簧生产过程的硫容量进行了计算,并使用Turkdogan、Hino等提出的公式预测了生产过程中硫的分配比(LS).对比预测与实测的硫分配比,找到了比较准确的超低氧弹簧钢的LS... 详细信息

采用KTH模型、Young光学碱度模型、Tsao硫容量经验公式等方法对超低氧弹簧生产过程的硫容量进行了计算,并使用Turkdogan、Hino等提出的公式预测了生产过程中硫的分配比(LS).对比预测与实测的硫分配比,找到了比较准确的超低氧弹簧钢的LS预测模型.

关键词：弹簧钢超低氧脱硫硫容量硫分配比

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