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^(18)氟-氟代脱氧葡萄糖正电子发射体层摄影/CT显像联合MRI高分辨成像在局灶性皮质发育不良合并难治性癫痫中的诊断价值

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中华神经科杂志 2024年第4期57卷 326-332页

作者：党娜孙英张谷青董有文艾慧芳济宁医学院附属医院医学影像科济宁272001 济宁医学院附属医院妇产科济宁272001

目的探讨^(18)氟-氟代脱氧葡萄糖(^(18)F-FDG)正电子发射体层摄影(PET)/CT与MRI高分辨成像在局灶性皮质发育不良(FCD)合并难治性癫痫患者中的诊断价值及显像特点。方法回顾性分析2017年1月至2022年12月于济宁医学院附属医院就诊的42例FC... 详细信息

目的探讨^(18)氟-氟代脱氧葡萄糖(^(18)F-FDG)正电子发射体层摄影(PET)/CT与MRI高分辨成像在局灶性皮质发育不良(FCD)合并难治性癫痫患者中的诊断价值及显像特点。方法回顾性分析2017年1月至2022年12月于济宁医学院附属医院就诊的42例FCD合并难治性癫痫患者的临床资料,所有患者术前均行头颅^(18)F-FDG PET/CT显像及MRI高分辨成像,并对图像进行PET/MRI异机融合。采用卡方检验、Kappa一致性检验比较PET/CT、MRI、PET/MRI异机融合对患者癫痫灶的定位效能;根据患者性别、病灶部位、癫痫灶病理类型、癫痫发作类型、疗效进行分组,采用独立样本t检验、方差分析比较不同亚组间FCD合并难治性癫痫患者的最大标准摄取值(SUVmax)、放射性分布不对称指数(AI)之间的差异。结果在42例患者中,MRI、PET/CT、PET/MRI异机融合检查的阳性率分别为85.7%(36/42)、95.2%(40/42)、100.0%(42/42),致痫灶定侧率分别为71.4%(30/42)、92.9%(39/42)、95.2%(40/42),定位率分别为57.1%(24/42)、81.0%(34/42)、88.1%(37/42)。MRI与PET/CT对致痫灶的定侧率及定位率差异(χ^(2)=6.574、5.570;P=0.010、0.018)及与PET/MRI异机融合的病灶阳性率、致痫灶定侧率及定位率差异(χ^(2)=6.385、8.571、10.118;P=0.012、0.003、0.001)均有统计学意义。MRI与PET/CT的病灶阳性率及PET/CT与PET/MRI异机融合的病灶阳性率、致痫灶定侧率及定位率差异均无统计学意义(χ^(2)=2.184、2.024、0.210、0.819;P=0.139、0.155、0.647、0.365)。将PET/CT、PET/MRI异机融合显像对致痫灶的定位情况行Kappa一致性检验,得出Kappa=0.721,提示两者在致痫灶定位上较为一致。颞叶型癫痫患者的SUVmax值低于、AI值高于颞叶外型患者(分别为7.4±1.3比9.6±1.6、15.5±2.6比12.9±2.4;t=5.154、6.083;P=0.001、0.001)。疗效良好组(根据Engel疗效分级系统,Ⅰ~Ⅱ级为疗效良好)患者的SUVmax值高于、AI值低于疗效不佳组(Engel疗效分级系统,Ⅲ~Ⅳ级为疗效不佳)患者(分别为9.5±1.9比7.9±2.1、13.5±3.3比14.8±3.0;t=2.789、3.722;P=0.042、0.029)。不同性别、病理类型、发作类型患者间的SUVmax值、AI值差异均无统计学意义(均P>0.05)。结论不同类型FCD合并难治性癫痫患者的影像学显像特征存在差异,PET/MRI异机融合在FCD合并难治性癫痫患者中的诊断效能优于MRI,且与PET/CT在致痫灶定位上较为一致。

关键词：局灶性皮质发育不良癫痫,难治性正电子发射断层显像术葡萄糖磁共振成像

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环面上外可平面图的最小圈基

华东师范大学学报（自然科学版） 2006年第5期 72-75页

作者：徐梅任韩党英淮阴师范学院数学系华东师范大学数学系上海200062

研究环面上2-连通外可平面图G在嵌入Π的面宽fw(G)≥2时的圈基理论;给出在面宽fw(G)≥2和边宽ew(G)>m,m=max{li|1≤i≤f}时外可平面图G的最小圈基的结构,其中f记为Π的除Hamilton圈外的面迹数,l1,…,lf,为Π的对应面迹的长;并证明了G的... 详细信息

研究环面上2-连通外可平面图G在嵌入Π的面宽fw(G)≥2时的圈基理论;给出在面宽fw(G)≥2和边宽ew(G)>m,m=max{li|1≤i≤f}时外可平面图G的最小圈基的结构,其中f记为Π的除Hamilton圈外的面迹数,l1,…,lf,为Π的对应面迹的长;并证明了G的最小圈基与其不同伦的两条长度之和最短的不可收缩圈之间存在一一对应．

关键词：外可平面图不可收缩圈最小圈基

Development and Application of Comprehensive Platform of Operation in Professional Meteorological Station

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Meteorological and Environmental Research 2011年第7期2卷 5-8,46页

作者： dang ying-na,GUO Qing-li,HUANG Ben-feng Yantai Meteorological Bureau,Yantai 264003,China

[Objective] The aim was to study the development and application of operation in comprehensive platform of professional meteorological station.[Method] Taking the operation platform of professional meteorological station in Yantai City as an example,and by dint of VB language and Mysql database technology,the ideas of comprehensive platform development of operation in professional meteorological station,main contents of the platform and its main functions were introduced.[Result] The platform mainly used VB language and Mysql database *** together the forecast making,forecast inventory and check,surveillance of data uploading and machine operation and records of shifts,the interface was simple,visual and easy to *** reduced reporters’ workload,improved their work efficiency and was the favorite of majority reporters.[Conclusion] The study provided reference for the improvement of work efficiency of each professional meteorological station.

关键词： Operation comprehensive platform Professional meteorological station Development Application China

Clinical manifestation,lifestyle,and treatment patterns of chronic erosive gastritis:A multicenter real-world study in China

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World Journal of Gastroenterology 2024年第9期30卷 1108-1120页

作者： ying-Yun Yang Ke-Min Li Gui-Fang Xu Cheng-dang Wang Hua Xiong Xiao-Zhong Wang Chun-Hui Wang Bing-Yong Zhang Hai-Xing Jiang Jing Sun Yan Xu Li-Juan Zhang Hao-Xuan Zheng Xiang-Bin Xing Liang-Jing Wang Xiu-Li Zuo Shi-Gang Ding Rong Lin Chun-Xiao Chen Xing-Wei Wang Jing-Nan Li Department of Gastroenterology Peking Union Medical College HospitalPeking Union Medical CollegeChinese Academy of Medical SciencesBeijing 100730China Department of Gastroenterology Nanjing Drum Tower HospitalNanjing 21000Jiangsu ProvinceChina Department of Gastroenterology The First Affiliated Hospital of Fujian Medical UniversityFuzhou 350005Fujian ProvinceChina Department of Gastroenterology Renji HospitalShanghai 200127China Department of Gastroenterology Union Hospital of Fujian Medical UniversityFuzhou 350000Fujian ProvinceChina Department of Gastroenterology West China Hospital of Sichuan UniversityChengdu 610041Sichuan ProvinceChina Department of Gastroenterology and Hepatology The People’s Hospital of Zhengzhou UniversityThe Henan Provincial People’s HospitalZhengzhou 450003Henan ProvinceChina Department of Gastroenterology The First Affiliated Hospital of Guangxi Medical UniversityNanning 530021Guangxi Zhuang Autonomous RegionChina Ruijin Hospital Shanghai Jiaotong University School of Medicine Shanghai Jiao Tong UnivesrityRuijin HospitalSchool MedicineShanghai 200025China Department of Gastroenterology and Hepatology China-Japan Union Hospital of Jilin UniversityChangchun 130033Jilin ProvinceChina Department of Gastroenterology Fujian Medical University Union HospitalFuzhou 350001Fujian ProvinceChina Department of Gastroenterology Nanfang HospitalGuangzhou 510080Guangdong ProvinceChina Department of Gastroenterology The First Affiliated HospitalSun Yat-sen UniversityGuangzhou 510080Guangdong ProvinceChina Department of Gastroenterology The Second Affiliated Hospital Zhejiang University School of MedicineHangzhou 310000Zhejiang ProvinceChina Department of Gastroenterology Shandong University Qilu HospitalJinan 250012Shandong ProvinceChina Department of Gastroenterology Peking University Third HospitalBeijing 100191China Department of Gastroenterology Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022Hubei Pr

BACKGROUND Although chronic erosive gastritis(CEG)is common,its clinical characteristics have not been fully *** lack of consensus regarding its treatment has resulted in varied treatment *** To explore the clinical characteristics,treatment patterns,and short-term outcomes in CEG patients in *** We recruited patients with chronic non-atrophic or mild-to-moderate atrophic gastritis with erosion based on endoscopy and *** and treating physicians completed a questionnaire regarding history,endoscopic findings,and treatment plans as well as a follow-up questionnaire to investigate changes in symptoms after 4 wk of *** Three thousand five hundred sixty-three patients from 42 centers across 24 cities in China were *** pain(68.0%),abdominal distension(62.6%),and postprandial fullness(47.5%)were the most common presenting *** was classified as chronic non-atrophic in 69.9%of *** those with erosive lesions,72.1%of patients had lesions in the antrum,51.0%had multiple lesions,and 67.3%had superficial flat *** patients with epigastric pain,the combination of a mucosal protective agent(MPA)and proton pump inhibitor was more *** those with postprandial fullness,acid regurgitation,early satiety,or nausea,a MPA appeared more *** CEG is a multifactorial disease which is common in Asian patients and has non-specific *** may play a major role in its detection and *** should be individualized based on symptom profile.

关键词： Chronic erosive gastritis Symptom Endoscopic findings Treatment pattern Real-world

Tuning the ferroelectricity of HfZrOwith alloy electrodes

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Science China(Information Sciences) 2024年

作者： Keqin LIU Bingjie dang Zhiyu YANG Teng ZHANG Zhen YANG Jinxuan BAI Zelun PAN Ru HUANG Yuchao YANG Beijing Advanced Innovation Center for Integrated Circuits School of Integrated Circuits Peking University School of Electronic and Computer Engineering Peking University Center for Brain Inspired Chips Institute for Artificial Intelligence Peking University Center for Brain Inspired Intelligence Chinese Institute for Brain Research

Tuning ferroelectricity of Hf0.5Zr0.5O2 is crucial for facilitating its practical applications in various fields, including in-memory and neuromorphic computing. Previous studies have revealed that the electrodes have a significant influence on ferroelectricity, and changing electrode materials can realize different but discrete ferroelectric polarization values. Here, we introduce an alloy-electrode method, in order to achieve gradual and accurate modulation of ferroelectric polarization, especially useful for matching the polarization charges at the interface of ferroelectric insulators and ferroelectric semiconductors. Au and W electrodes are chosen as baselines for realizing weak and strong ferroelectric polarization, where the intermediate states can be achieved by adjusting the ratio of metals in the Au-W alloy. To demonstrate the generality of this approach, the Cu-W alloy electrode is also realized for tuning ferroelectric polarization. The effect of alloy electrodes on device leakage current, endurance, and retention is evaluated. In addition, the temperature stability of ferroelectric capacitors is tested, where limited changes in both remnant polarization and coercive voltages are observed, showing the great potential of the ferroelectric hafnium oxide. Such gradual modulation of ferroelectric polarization could facilitate the application of Hf0.5Zr0.5O2 in in-memory and neuromorphic computing.

关键词：

在乳腺癌细胞MCF-7中紫杉醇诱导硫氧还蛋白结合蛋白-2的表达

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昆明理工大学学报（理工版） 2009年第4期34卷 73-77页

作者：党英男白洁昆明理工大学生命科学与技术学院云南昆明650224

探讨紫杉醇在人乳腺癌细胞株MCF-7中诱导硫氧还蛋白结合蛋白-2表达及与其诱导的相关途径.用不同浓度的紫杉醇刺激MCF-7细胞,MCF-7细胞生长受抑制.通过荧光实时定量PCR检测,发现紫杉醇刺激MCF-7细胞后硫氧还蛋白结合蛋白-2mRNA的表达升高... 详细信息

探讨紫杉醇在人乳腺癌细胞株MCF-7中诱导硫氧还蛋白结合蛋白-2表达及与其诱导的相关途径.用不同浓度的紫杉醇刺激MCF-7细胞,MCF-7细胞生长受抑制.通过荧光实时定量PCR检测,发现紫杉醇刺激MCF-7细胞后硫氧还蛋白结合蛋白-2mRNA的表达升高.经荧光素酶活性检测,得出紫杉醇诱导硫氧还蛋白结合蛋白-2基因启动子活性的增高.p38丝裂原激活蛋白激酶(p38 MAPK)抑制剂,SB203580抑制了紫杉醇诱导的硫氧还蛋白结合蛋白-2mRNA的表达.因此,紫杉醇抑制MCF-7细胞生长,并通过p38丝裂原激活蛋白激酶途径诱导硫氧还蛋白结合蛋白-2表达.

关键词：乳腺癌硫氧还蛋白结合蛋白-2 紫杉醇癌细胞

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MEMS加速度传感器的数据采集和预处理

仪表技术与传感器 2015年第2期 16-19页

作者：韩盈党李哲西安邮电大学电子工程学院陕西西安710061

设计了一种基于微机电系统(MEMS)加速度传感器的数据采集单元,用微处理器通过内部集成电路(I2C)总线采集加速度传感器ADXL345的数据,对数据进行低通滤波、零偏误差修正以及去除重力加速度等,从而得到载体的运动加速度,并对加速度进行二... 详细信息

设计了一种基于微机电系统(MEMS)加速度传感器的数据采集单元,用微处理器通过内部集成电路(I2C)总线采集加速度传感器ADXL345的数据,对数据进行低通滤波、零偏误差修正以及去除重力加速度等,从而得到载体的运动加速度,并对加速度进行二次积分得到位移,在100 m范围内实测多次,仿真计算位移误差在2%以内。

关键词：微机电系统(MEMS) 加速度传感器内部集成电路(I2C) 数据预处理

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带内表面缺陷TA16管的高周疲劳性能研究

核动力工程 2016年第1期37卷 48-51页

作者：何琨赵宇翔党莹王理蒋帆中国核动力研究设计院反应堆燃料与材料重点实验室成都610041

采用无损探伤方法，选取新旧2种工艺带内表面缺陷的TA16钛合金管管材进行轴向应力控制的高周疲劳试验。新工艺管内壁缺陷宽而平滑，旧工艺管内壁缺陷呈裂纹或锯齿状。超声检测结果表明，25%-90％的旧工艺TA16管的疲劳寿命在1×105^次～6... 详细信息

采用无损探伤方法，选取新旧2种工艺带内表面缺陷的TA16钛合金管管材进行轴向应力控制的高周疲劳试验。新工艺管内壁缺陷宽而平滑，旧工艺管内壁缺陷呈裂纹或锯齿状。超声检测结果表明，25%-90％的旧工艺TA16管的疲劳寿命在1×105^次～6X105^次；新工艺管材的疲劳寿命均在10‘次以上。分析表明，高周疲劳断口无法直接观察疲劳裂纹源，但裂纹扩展方向由管内壁向外壁发展，说明管的表面状态对材料的疲劳性能有一定的影响。

关键词： TA16钛合金管高周疲劳缺陷

紧凑型折反式制冷型中波红外成像光学系统设计

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光学学报 2024年第9期44卷 219-230页

作者：胡晨霞刘英王成龙周广鹏于晨党博石中国科学院长春光学精密机械与物理研究所吉林长春130033 中国科学院大学北京100049

为解决长焦距大口径红外成像光学系统长筒长、大体积、高成本的问题,设计了基于卡塞格林结构(卡式结构)的折反式制冷型中波红外成像光学系统。鉴于该类系统初始结构的确定缺乏充分的理论指导,推导了由拦光系数α、副镜放大率β_(sec)和... 详细信息

为解决长焦距大口径红外成像光学系统长筒长、大体积、高成本的问题,设计了基于卡塞格林结构(卡式结构)的折反式制冷型中波红外成像光学系统。鉴于该类系统初始结构的确定缺乏充分的理论指导,推导了由拦光系数α、副镜放大率β_(sec)和中继镜组垂轴放大率β_(relay)三个关键参数表示的计算公式,包括光学系统初始结构参数、系统长度T值、卡式结构初级球差和初级彗差计算公式,分析了系统像差校正难度和紧凑性随α、β_(sec)、β_(relay)的变化规律。基于像差校正难度与结构紧凑性之间的相互矛盾关系,提出了关键参数的最佳取值方法,为确定系统初始结构提供了重要的理论指导。使用ZEMAX软件对初始结构进行设计优化,完成了一款焦距为-600 mm、F数为2的紧凑型折反式制冷型中波红外成像光学系统,系统实现了100%冷光阑效率,总长为428 mm,各视场调制传递函数(MTF)值在奈奎斯特频率处均大于0.4,并对系统进行了公差分析,验证了理论的正确性和系统可加工性。

关键词：折反式光学系统二次成像中波红外像差理论光学系统设计