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Color Vision Defects with Variation in the Exon 5 of Red and Green Pigment Genes

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眼科学报 1998年第3期14卷 130-133页

作者： Huangxuan Shen, qingjiong Zhang, Xueshan Xiao, Shiqiang Li, Li Guo, Futian Jiangzhongshan ophthalmic center, sun yat-sen university of medical sciences , guangzhou 510060, china zhongshan ophthalmic center Sun Yat-sen University of Medical Sciences Guangzhou 510060 China

Purpose : To investigate correlation of variation in the exon 5 of red and green pigment genes with color vision *** : Exon 5 of the red and green pigment genes in 11 protans, 19 deutans and 38 normal controls were analyzed by heteroduplux-SSCP *** : In all 11 protans and 8 of the 19 deutans, defects of the red or green pigment gene could be identified. The C polymorphism (A/C at codon 283) in green pigment gene was present in 8 of 44 trichromats and 5 of 24 dichromats. Specific electrophoretic bands were found in 2 normal controls and a ***: Variation in the exon 5 of the red and green pigment genes is the most common cause for color vision defects. Heteroduplex-SSCP analysis is a suitable way in screening specific variation in visual pigment genes. Eye Science 1998; 14 : 130 - 133.

关键词：色觉缺陷视色素基因 SSCP 遗传多态性红色素绿色素

Retinoma and Phthisis Bulbi of Retinoblastoma *** and genetic Analysis

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眼科学报 1992年第3期8卷 117-121页

作者： qingjiong Zhang Youzhao chen Zhongyao Wu Qiaoyun Ma Ruiping Zeng Xiangming Guo Danyang Li National Ophthalmological Laboratories,Ministry of Public Health,china zhongshan ophthalmic center,sun yat-sen university of medical sciences,guangzhou 510060,china National Ophthalmological Laboratories Ministry of Public Health China.

Retinoma and phthisis bulbi of retinoblastoma are rare entitiesfound in retinoblastoma patients and their *** cases of phthisisbulbi of retinoblastoma and 9 cases of retinoma were identified from 1966 to1991 in our *** clinic data show that retinoma and phthisis bulbi areclosely related to the retinoblastoma *** should be carried outas soon as possible without hesitation for the phthisis of eyes with *** counseling and frequent observation should be p...

关键词： Retinoma Retinoblastoma phthisis bulbi spontaneous regression

细胞因子Ⅱ在遗传性视网膜色素变性的转基因小鼠视网膜的表达研究

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眼科研究 2001年第3期19卷 229-231页

作者：陈颖 Zhang qingjiong 张清炯谭智群中山医科大学中山眼科中心广州 Lab.of Ocular genetic and molecular biology Zhongshan Ophthalmic CenterSun Yat-san University of Medical SciencesGuangzhou 510060 美国南加州大学神经科

目的探讨细胞因子Ⅱ（ｃａｌｐａｉｎ Ⅱ）在视网膜色素变性过程中表达的变化，以此窥视遗传性视网膜色素变性的转基因小鼠（ｒｄｓ小鼠）发病的某些可能因素。方法以Ｃ３Ｂ小鼠为对照，选择不同生长时期的ｒｄｓ小鼠的视网膜组织... 详细信息

目的探讨细胞因子Ⅱ（ｃａｌｐａｉｎ Ⅱ）在视网膜色素变性过程中表达的变化，以此窥视遗传性视网膜色素变性的转基因小鼠（ｒｄｓ小鼠）发病的某些可能因素。方法以Ｃ３Ｂ小鼠为对照，选择不同生长时期的ｒｄｓ小鼠的视网膜组织，用免疫组化方法检测Ｃａｌｐａｉｎ Ⅱ在不同生长阶段的小鼠模型视网膜中的是否表达及表达情况。结果１周即可见Ｃａｌｐａｉｎ Ⅱ在ｒｄｓ小鼠视网膜神经节细胞层的表达，２周左右内核层也见表达，４周后外核层也开始出现由强至弱的ｃａｌｐａｉｎ Ⅱ强阳性表达，最终至全部视网膜剩余组织中均可见ｃａｌｐａｉｎ Ⅱ的表达。结论只有高钙才能激活ｃａｌｐａｉｎ Ⅱ的表达，研究中ｃａｌｐａｉｎ Ⅱ参与了ｒｄｓ小鼠视网膜细胞的变性死亡。因此，高钙是ｒｄｓ小鼠视网膜变性的一个可能因素。

关键词：视网膜色素变性细胞因子Ⅱ rds小鼠

VEGF-B prevents excessive angiogenesis by inhibiting FGF2/FGFR1 pathway

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Signal Transduction and Targeted Therapy 2023年第9期8卷 4380-4393页

作者： Chunsik Lee Rongyuan chen Guangli sun Xialin Liu Xianchai Lin Chang He Liying Xing Lixian Liu Lasse DJensen Anil Kumar Harald FLanger Xiangrong Ren Jianing Zhang Lijuan Huang Xiangke Yin JongKyong Kim Juanhua Zhu Guanqun Huang Jiani Li Weiwei Lu Wei chen Juanxi Liu Jiaxin Hu Qihang sun Weisi Lu Lekun Fang Shasha Wang Haiqing Kuang Yihan Zhang Geng Tian Jia Mi Bi-Ang Kang Masashi Narazaki Aaron Prodeus Luc Schoonjans David MOrnitz Jean Gariepy Guy Eelen Mieke Dewerchin Yunlong Yang Jing-Song Ou Antonio Mora Jin Yao chen Zhao Yizhi Liu Peter Carmeliet Yihai Cao Xuri Li State Key Laboratory of Ophthalmology Zhongshan Ophthalmic CenterSun Yat-sen University and Guangdong Provincial Key Laboratory of Ophthalmology and Visual ScienceGuangzhou 510060P.R.China Affiliated Eye Hospital of Nanjing medical university Nanjing 210000China Department of Obstetrics and Gynecology Guangdong Provincial Key Laboratory of Major Obstetric DiseasesGuangdong Provincial Clinical Research Center for Obstetrics and GynecologyThe Third Affiliated Hospital of Guangzhou Medical UniversityGuangzhouChina Shenzhen Eye Hospital Jinan UniversityShenzhen Eye InstituteShenzhenChina Department of Health Medical and Caring SciencesDivision of Diagnostics and Specialist MedicineLinköping University58183 LinköpingSweden Department of Cardiology AngiologyHaemostaseology and Medical Intensive CareUniversity Medical Centre MannheimMedical Faculty MannheimHeidelberg UniversityMannheimGermany DZHK(German Research Centre for Cardiovascular Research) partner site Mannheim/HeidelbergMannheimGermany European center for Angioscience Medical Faculty MannheimHeidelberg UniversityMannheimGermany Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Disease Guangdong Research Institute of GastroenterologyDepartment of Colorectal SurgeryThe Sixth Affiliated Hospital of Sun Yat-sen UniversityGuangzhouChina Eye Institute Eye and ENT HospitalShanghai Medical CollegeFudan UniversityKey Laboratory of Myopia of State Health Ministry(Fudan University)and Shanghai Key Laboratory of Visual Impairment and Restoration200031 ShanghaiChina Shandong Technology Innovation center of molecular Targeting and Intelligent Diagnosis and Treatment Binzhou Medical UniversityYantai 264003P.R.China Division of Cardiac Surgery National-Guangdong Joint Engineering Laboratory for Diagnosis and Treatment of Vascular DiseasesNHC key Laboratory of Assisted Circulation(Sun Yat-sen University)The First Affiliated HospitalSun Yat-sen UniversityGuangzhouChina Department of Respiratory Medicine and Clinical Imm

Although VEGF-B was discovered as a VEGF-A homolog a long time ago,the angiogenic effect of VEGF-B remains poorly understood with limited and diverse findings from different ***,drugs that inhibit VEGF-B together with other VEGF family members are being used to treat patients with various neovascular *** is therefore critical to have a better understanding of the angiogenic effect of VEGF-B and the underlying *** comprehensive in vitro and in vivo methods and models,we reveal here for the first time an unexpected and surprising function of VEGF-B as an endogenous inhibitor of angiogenesis by inhibiting the FGF2/FGFR1 pathway when the latter is abundantly ***,we unveil that VEGF-B binds to FGFR1,induces FGFR1/VEGFR1 complex formation,and suppresses FGF2-induced Erk activation,and inhibits FGF2-driven angiogenesis and tumor *** work uncovers a previously unrecognized novel function of VEGF-B in tethering the FGF2/FGFR1 *** the anti-angiogenic nature of VEGF-B under conditions of high FGF2/FGFR1 levels,caution is warranted when modulating VEGF-B activity to treat neovascular diseases.

关键词： FGFR1 FGF2 drugs