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Research 2024年第1期2023卷 81-95页

作者： Fangxuan chu Ruxin Tan Xin Wang Xiaoqing Zhou Ren Ma Xiaoxu Ma ying Li Ruixu Liu chunlan Zhang Xu Liu Tao Yin Zhipeng Liu Institute of Biomedical Engineering Chinese Academy of Medical Sciences and Peking Union Medical CollegeTianjin300192China Tianjin Institutes of Health Science Tianjin301600China Neuroscience Center Chinese Academy of Medical Science&Peking Union Medical CollegeBeijing100730China

The neuropathological features of Alzheimer’s disease include amyloid *** emerging evidence suggests that Piezo1,a mechanosensitive cation channel,plays a critical role in transforming ultrasound-related mechanical stimuli through its trimeric propeller-like structure,but the importance of Piezo1-mediated mechanotransduction in brain functions is less ***,apart from mechanical stimulation,Piezo1 channels are strongly modulated by *** assume that Piezo1 may play a role in converting mechanical and electrical signals,which could induce the phagocytosis and degradation of Aβ,and the combined effect of mechanical and electrical stimulation is superior to single mechanical ***,we design a transcranial magneto-acoustic stimulation(TMAS)system,based on transcranial ultrasound stimulation(TUS)within a magnetic field that combines a magnetoacoustic coupling effect electric field and the mechanical force of ultrasound,and applied it to test the above hypothesis in 5xFAD *** tests,in vivo electrophysiological recordings,Golgi–Cox staining,enzyme-linked immunosorbent assay,immunofluorescence,immunohistochemistry,real-time quantitative PCR,Western blotting,RNA sequencing,and cerebral blood flow monitoring were used to assess whether TMAS can alleviate the symptoms of AD mouse model by activating Piezo1.

关键词： stimulation Alzheimer Piezo1

Actinidia chinensis *** extract downregulates the Wnt/β-catenin pathway to treat gastric cancer:a mechanism study based on network pharmacology

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Traditional Medicine Research 2023年第7期8卷 35-46页

作者： ying-Ming chu Qiu-Yue Huang Ting-Xin Wang Nan Yang Xiao-Fen Jia Zong-Ming Shi Hui Ye Xue-Zhi Zhang Department of Integrated Traditional Chinese and Western Medicine Peking University First HospitalBeijing 100034China Institute of Integrated Traditional Chinese and Western Medicine Peking UniversityBeijing 100191China Institute(College)of Integrative Medicine Dalian Medical UniversityDalian 116000China

Background:Actinidia chinensis ***(AcRoots)have been applied as an anti-inflammatory and antitumor drug in the treatment of gastric cancer(GC).However,their mechanisms against GC cells remain *** investigate the anticancer effect of AcRoots in GC and the possible underlying mechanism by using network ***:Differentially expressed genes between gastric precancerous lesions and cancer were analyzed in Gene Expression Omnibus datasets,and these genes were overlapped with potential targets of *** targets and pathways for AcRoots treatment of GC predicted by network ***,we used the GC cell line HGC27 to explore the molecular mechanisms in the context of hub genes in apoptosis,invasion,metastasis,and epithelial to mesenchymal transition-promoting *** docking between hub targets and active drug components was also ***:Network pharmacological analysis suggested that the potential mechanism was related to the Wnt pathway and predicted nine hub *** in vitro studies,AcRoots significantly decreased HGC27 cell viability and promoted apoptosis by upregulating caspase3 and downregulating ***,it suppressed invasion and metastasis as well as the expression of epithelial to mesenchymal transition-related *** addition,AcRoots affected the phosphorylation level of GSK3β(Ser9)in the Wnt pathway to promote the degradation ofβ-catenin,resulting in the downregulation of the downstream target genes c-myc,cyclin D1 and *** the experimental results were consistent with the network pharmacology ***:This study combined network pharmacology with in vitro experiments to provide valid evidence for the clinical promotion of AcRoots.

关键词： gastric cancer Actinidia chinensis Planch.root network pharmacology Wnt/β-catenin pathway traditional Chinese medicine bioinformatics

Configurational entropy-induced phase transition in spinel LiMn_(2)O_(4)

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Chinese Physics B 2022年第9期31卷 592-596页

作者： Wei Hu Wen-Wei Luo Mu-Sheng Wu Bo Xu chu-ying Ouyang Department of Physics Laboratory of Computational Materials PhysicsJiangxi Normal UniversityNanchang 330022China School of Ecology and Environment Yuzhang Normal UniversityNanchang 330103China

The spinel-type LiMn_(2)O_(4) is a promising candidate as cathode material for rechargeable Li-ion batteries due to its good thermal stability and ***,it is observed that in this compound there occur the structural phase transitions from cubic(Fd3m)to tetragonal(I4_(1)/amd)phase at slightly below room *** understand the phase transition mechanism,we compare the Gibbs free energy between cubic phase and tetragonal phase by including the configurational *** results show that the configurational entropy contributes substantially to the stability of the cubic phase at room temperature due to the disordered Mn^(3+)/Mn^(4+)distribution as well as the orientation of the Jahn-Teller elongation of the Mn^(3+)O_(6) octahedron in the the spinel ***,the phase transition temperature is predicted to be 267.8 K,which is comparable to the experimentally observed *** results serve as a good complement to the experimental study,and are beneficial to the improving of the electrochemical performance of LiMn_(2)O_(4) cathode.

关键词： configurational entropy LiMn_(2)O_(4) phase transition Jahn-Teller distortion

以SiCl_4/H_2为气源低温制备pc-Si薄膜的稳恒光电导特性

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功能材料 2007年第5期38卷 711-713页

作者：余楚迎林璇英黄锐汕头大学物理系广东汕头515063

研究了以SiCl4/H2为气源、用等离子体增强化学气相沉积方法,在低于300℃温度下所制备的pc-Si薄膜在长时间的光照下电导率的变化情况。实验结果表明,所制备的多晶硅薄膜具有类稳恒光电导效应,而且薄膜的稳恒光电导特性依赖于薄膜的晶化... 详细信息

研究了以SiCl4/H2为气源、用等离子体增强化学气相沉积方法,在低于300℃温度下所制备的pc-Si薄膜在长时间的光照下电导率的变化情况。实验结果表明,所制备的多晶硅薄膜具有类稳恒光电导效应,而且薄膜的稳恒光电导特性依赖于薄膜的晶化率和晶粒尺寸,随晶化率的增加和晶粒尺寸的增大而增大。

关键词：多晶硅薄膜稳恒光电导效应晶化率晶粒尺寸

Effects of a Care Workshop on Caring Behaviors as Measured by Patients and Patient Satisfaction

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Open Journal of Nursing 2015年第2期5卷 89-95页

作者： Hui-Shan Chan Hui-ying chu Hsiang Yen Li-Na Chou Department of Applied Cosmetology National Tainan Junior College of Nursing Tainan Taiwan Department of Living Services Industry Tainan University of Technology Tainan Taiwan Department of Nursing Chang Gung University of Science and Technology Taoyuan Taiwan Department of Nursing National Tainan Junior College of Nursing Tainan Taiwan

Caring is a central focus of nursing, and patient satisfaction is a critical indicator of nursing care quality. The aim of this study was to determine the effects that a care workshop exerted on nurse caring behaviors as perceived by patients and reflected by patient satisfaction. A quasi-experimental, pretest-posttest design without a control group was applied. The intervention consisted of several facets: 1) formal educational sessions twice a week for six weeks, 2) an angel-master mentorship activity, and 3) posts of exemplary caring behavior and stories. A demographic questionnaire, the Modified Nurse Caring Behaviors Inventory, and the Hartford Hospital Satisfaction Survey were used in this study. Descriptive statistics were analyzed to evaluate participant demographic characteristics. Paired t tests were used to determine the effects of a care workshop on nurse caring behaviors as perceived by patients and reflected by patient satisfaction. Of the 236 patients enrolled, 49.6% were women and 57.2% were admitted to medical-surgical units. Female patients rated nurse caring behaviors higher and reported greater patient satisfaction than did male patients on the pretest (p p p p p p = 0.000). Caring educational programs for nurses are commonly regarded to be an essential strategy for promoting care knowledge and practice and improving patient satisfaction. According to the favorable results of this study, care workshops must be provides to nurses in other units or hospitals in future studies.

关键词： Quasi-Experimental Design Nurse Caring Patient Satisfaction Nursing Education Quality of Care

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安全壳整体泄漏率计算方法的比较分析

核动力工程 2010年第6期31卷 33-37页

作者：褚英杰欧阳钦福建宁德核电有限公司福建福鼎355200 江苏核电有限公司江苏连云港222000

对国际上常用的3种安全壳整体试验泄漏率计算方法进行了系统介绍。分别应用上述3种方法对田湾核电厂安全壳整体试验数据进行计算分析,同时对各计算方法的差异以及对结果的影响进行了探讨。结果表明,试验工况下应用3种计算方法所得到的... 详细信息

对国际上常用的3种安全壳整体试验泄漏率计算方法进行了系统介绍。分别应用上述3种方法对田湾核电厂安全壳整体试验数据进行计算分析,同时对各计算方法的差异以及对结果的影响进行了探讨。结果表明,试验工况下应用3种计算方法所得到的泄漏率计算结果基本相同。

关键词： ANSI/ANS-56.8 RCC-G ПНАЭГ-10-021-90 安全壳泄漏率

MicroRNA signature in response to nutrient restriction and re-feeding in fast skeletal muscle of grass carp （Ctenopharyngodon idella）

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Zoological Research 2014年第5期35卷 404-410页

作者： Xin ZHU Wu-ying chu Ping WU Tan YI Tao CHEN Jian-She ZHANG College of Veterinary Medicine Hunan Agriculture University Changsha Hunan 410128 China Department of Bioengineering and Environmental Science Changsha University Changsha Hunan 410003 China

The grass carp(Ctenopharyngodon idella) is one of the most important cultivated fish species in *** evidences suggests that microRNAs(miRNAs) may be key regulators of skeletal muscle among the grass carp,but the knowledge of the identity of myogenic miRNAs and role of miRNAs during skeletal muscle anabolic state remains *** the present study,we choose 8 miRNAs previously reported to act as muscle growth-related miRNAs for fasting-refeeding *** investigated postprandial changes in the expression of 8 miRNAs following a single satiating meal in grass carp juveniles who had been fasting for one week and found that 7 miRNAs were sharply up-regulated within 1 or 3 h after refeeding,suggesting that they may be promising candidate miRNAs involved in a fast-response signaling system that regulates fish skeletal muscle growth.

关键词： MicroRNA Grass carp Fasting Refeeding Skeletal muscle

锂离子电池正极材料Li2MnO3稀土掺杂的第一性原理研究

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物理学报 2019年第13期68卷 278-286页

作者：郑路敏钟淑英徐波欧阳楚英江西师范大学物理与通信电子学院

掺杂是锂离子电池电极材料优化改性的一种有效的方法.稀土元素因其具有高的电子电荷、大的离子半径以及强的自极化能力,成为掺杂改性的重要选择.本文利用基于密度泛函理论的第一性原理方法研究了稀土元素(La,Ce,Pr,Sm)掺杂的锂离子电池... 详细信息

掺杂是锂离子电池电极材料优化改性的一种有效的方法.稀土元素因其具有高的电子电荷、大的离子半径以及强的自极化能力,成为掺杂改性的重要选择.本文利用基于密度泛函理论的第一性原理方法研究了稀土元素(La,Ce,Pr,Sm)掺杂的锂离子电池正极材料Li2MnO3的性质.通过稀土元素的掺杂,Li2MnO3材料的晶格常数和晶胞体积都有不同程度的增大.由于稀土原子的价态不同,导致掺杂后的Li2MnO3的电子结构性质不同.La掺杂的Li2MnO3表现出金属性,而Ce,Pr,Sm掺杂的结构为半导体性质,但带隙与未掺杂情况下相比有所减小.Li2MnO3中的Li离子迁移在La和Ce掺杂后展示出复杂的能垒变化.在远离稀土离子处,Li离子迁移势垒比未掺杂时减小,但在靠近稀土离子处则表现为势垒变化的多样性.当Li离子在离稀土离子最近的位置处进行迁移,势垒有明显的增加,这一结果与稀土离子周围的局域结构变化大密切相关.

关键词：第一性原理计算稀土掺杂锂离子电池正极材料

Problems and countermeasures on main mineral resource sustainable supply in northeastern China

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Global Geology 2008年第3期11卷 150-155页

作者： Chang LIU Shouyi LI Jian GUAN Tingting ZHANG ying chu Jing ZHANG College of Earth Sciences Jilin University Changchun 130061 China English Department Jilin Agricultural University Changchun 130118 China

northeastern China is an important old industrial base in China. Mineral resources are the foundation of industry development. However, because of long-term exploitation of mineral resources in northeastern China, the mineral resources reserves decrease gradually and some mineral resources are nearly exhausted, which restricts revitalization and sustainable development of the northeast old industrial base. On the basis of the comprehensive analysis of development and utilization status of mineral resources and supply and demand situation of main mineral resources in northeastern China, the authors put forward countermeasures on main mineral resources sustainable supply in northeastern China.

关键词： Northeast China mineral resources sustainable countermeasures

A Novel ATM Antisense Transcript ATM-AS Positively Regulates ATM Expression in Normal and Breast Cancer Cells

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Current Medical Science 2022年第4期42卷 681-691页

作者： He CHENG Er-shao ZHANG Xiao SHI Ping-ping CAO Bei-jing PAN Xin-xin SI Yue LIU Nan YANG ying chu Xu-chun WANG Xiao HAN Zhi-hong ZHANG Yu-jie SUN Key Laboratory of Human Functional Genomics of Jiangsu Province Nanjing Medical UniversityNanjing 210000China Department of Pathology the First Affiliated Hospital of Nanjing Medical UniversityNanjing 210000China Key Laboratory of Cancer Biomarkers Prevention and TreatmentCollaborative Innovation Center for Personalized Cancer MedicineNanjing Medical UniversityNanjing 210000China Department of Cell Biology Nanjing Medical UniversityNanjing 210000China

Objective:The ataxia telangiectasia mutated(ATM)gene is a master regulator in cellular DNA damage *** dysregulation of ATM expression is frequent in breast cancer,and is known to be involved in the carcinogenesis and prognosis of ***,the underlying mechanism remains *** bioinformatic analysis predicted a potential antisense transcript ATM-antisense(AS)from the opposite strand of the ATM *** purpose of this study was to identify ATM-AS and investigate the possible effect of ATM-AS on the ATM gene ***:Single strand-specific RT-PCR was performed to verify the predicted antisense transcript ATM-AS within the ATM gene ***-PCR and Western blotting were used to detect the expression levels of ATM-AS and ATM in normal and breast cancer cell lines as well as in tissue *** reporter gene assays,biological mass spectrometry,ChIP-qPCR and RIP were used to explore the function of ATM-AS in regulating the ATM *** and host-cell reactivation(HCR)assay were performed to evaluate the biological significance of ATM-AS in ATM-mediated DNA damage *** cancer tissue samples were used for evaluating the correlation of the ATM-AS level with the ATM expression as well as prognosis of the ***:The ATM-AS significantly upregulated the ATM gene activity by recruiting KAT5 histone acetyltransferase to the gene *** reduced ATM-AS level led to the abnormal downregulation of ATM expression,and impaired the ATM-mediated DNA damage repair in normal breast cells in *** ATM-AS level was positively correlated with the ATM expression in the examined breast cancer tissue samples,and the patient ***:The present study demonstrated that ATM-AS,an antisense transcript located within the ATM gene body,is an essential positive regulator of ATM expression,and functions by mediating the binding of KAT5 to the ATM *** findings uncover the novel mechanism und

关键词： antisense transcript ataxia telangiectasia mutated ataxia telangiectasia mutatedantisense breast cancer KAT5