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Sequencing the landscape of cerebellar gene expression

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Journal of Molecular Cell Biology 2019年第8期11卷 633-635页

作者： ying shen Department of Neurobiology NHC Key Laboratory of Medical Neurobiology Zhejiang University School of Medicine Hangzhou China

The cerebellum plays critical roles in motor performance and non-motor functions such as cognition and emotion (Koziol et al., 2014;Baumann et al., 2015). These functions are encoded by canonical microcircuits that are composed of diversified cell types distributed in the cerebellar cortex and cerebellar nuclei (Buckner, 2013). The abnormality and dysfunction in cerebellar microcircuits cause a number of neurological and psychiatric symptoms, such as ataxia, tremor, autism spectrum disorder, and schizophrenia. Extensive morphologic and electrophysiological evidence has dem on strated the functional machinery of cerebellar microcircuits under physiological and pathological conditions. However, the gene expression framework for cerebellar development and dysfunction is poorly understood.

关键词： Sequencing landscape of cerebellar gene expression

PQBP1:A New Player in Metabotropic Glutamate Receptor Signaling and Synaptic Plasticity

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Neuroscience Bulletin 2021年第11期37卷 1637-1638页

作者： Li-Da Su ying shen Neuroscience Care Unit Second Affiliated Hospital of Zhejiang University School of MedicineHangzhou310009China Department of Physiology Zhejiang University School of MedicineHangzhou310058China

Group 1 metabotropic glutamate receptors(Gp1 mGluRs),comprising mGluR1 and mGluR5,are predominantly located at postsynaptic ***1 mGluRs induce the activation of phospholipase C-γ.

关键词： mGluR5 Metab Receptor

Flocculation properties of cohesive fine-grained sediment in the Three Gorges Reservoir under variable turbulent shear

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Journal of Mountain Science 2022年第8期19卷 2286-2296页

作者： LIU Jie shen ying WANG Xin National Inland Waterway Regulation Engineering Research Center Chongqing Jiaotong UniversityChongqing 400074China Tianjin Research Institute for Water Transport Engineering Tianjin 300000China National Key Laboratory of Hydraulic Engineering Simulation and Safety Tianjin UniversityTianjin 300072China

Sediment flocculation is a key process for the deposition of fine-grained sediments in the Three Gorges Reservoir(TGR)of *** flocculation influences the evolution of the river regime,but also hampers the smooth navigation in the long ***,the flocculation process and its controlling factors are poorly *** experimentally determined the flocculation properties of cohesive sediment of samples from the TGR(predominantly a mixture of clay and silt)over a range of turbulent shear rates and sediment *** experiments were conducted in an almost isotropic turbulence field,which was simulated by an array of horizontal oscillating grids in a water *** flocculation was recorded by a camera and investigated by image *** new data indicate that flocculation is generally a response in equilibrium median floc size(d_(f,50))to the increase of the shear rate *** peak value is attained at G=16.5 s^(-1),where d_(f,50) is 81.3μm(for the suspended sediment concentration(ssc)=0.4 g/L)and 107μm(for ssc=0.7 g/L),*** low shear rates(G<16.5 s^(-1)),the equilibrium floc sizes d_(f,50) increase with rising shear rate G and isinversely related to the Kolmogorov micro length scale η.We attribute this variability to an insufficient deposition time of the sediment flocs in the water *** velocities,calculated from our experimental data of the floc sizes,are almost consistent with in-situ measured settling velocities,and are ten times larger than the terminal settling velocity of primary particles as calculated from Stokes'law.

关键词： Cohesive sediment flocculation Floc properties Settling velocity Turbulent shear rate Three Gorges Reservoir(TGR)

Innovation for better health of children

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Science China(Life Sciences) 2019年第12期62卷 1561-1562页

作者： ying shen Tieliu Shi Beijing Key Laboratory for Chronic Renal Disease and Blood Purification Key Laboratory of Major Diseases in Children of Ministry of EducationNephrology DepartmentBeijing Children's HospitalCapital Medical UniversityNational Center for Children's HealthBeijing 100045China The Center for Bioinformatics and Computational Biology Shanghai Key Laboratory of Regulatory Biologythe Institute of Biomedical Sciences and School of Life SciencesEast China Normal UniversityShanghai 200241China

The past decades have witnessed a rapid development in the pediatric field along with the development of medical sciences in ***,the increasing demand for pediatric healthcare services still cannot be met owing to various *** shortage of pediatric medical resources and the limited access to medical care for pediatric patients have long been the priorities of healthcare reform in China.

关键词： China. pediatric patients

The Effect of Family Size on Children＇s Education： Evidence from the Fertility Control Policy in China

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Frontiers of Economics in China-Selected Publications from Chinese Universities 2017年第1期12卷 37-65页

作者： ying shen Institute for Economic and Social Research (IESR) Jinan University Guangzhou 510630 China Department of Economics University of Notre Dame Notre Dame IN 46556 USA

Empirical research on the effect of family size on child education is complicated by the endogeneity of family size. This study exploits plausibly exogenous changes in family size caused by China＇s population control policy to estimate the causal relationship between family size and child education outcomes. The results show that, compared to an only child, a person with an additional sibling will have an approximate seventeen percentage points lower likelihood of completing middle school in China. Separate regressions across individual characteristics reveal that much of this negative effect appears to be driven by the cohorts born in earlier years after the policy, and children with the highest birth order within a family.

关键词： education fertility control policy family size

Dramatic sediment load changes and sedimentation characteristics upstream of the Three Gorges Dam due to the large reservoirs construction

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Frontiers of Earth Science 2024年第3期18卷 565-578页

作者： Jie LIU Wenwu ZHANG ying shen Xin WANG National Inland Waterway Regulation Engineering Research Center Chongqing Jiaotong UniversityChongqing 400074China State Key Laboratory of Hydraulic Engineering Simulation and Safety Tianjin UniversityTianjin 300072China School of River&Ocean Engineering Chongqing Jiaotong UniversityChongqing 400074China Tianjin Research Institute for Water Transport Engineering Tianjin 300456China

After the construction of cascade reservoirs in the upper reaches of the Three Gorges Reservoir(TGR),the sediment load outflow of the upper Yangtze River Basin(YRB)has been significantly altered,decreasing from 491.8 Mt/yr(1956–2002)to 36.1 Mt/yr(2003–2017)at Yichang *** has widely affected river hydrology,suspended sediment grain size distribution,and channel *** study analyzed hydrological variations in water discharge and sediment load of the upper YRB over the past 62 years(1956–2017)by employing a double mass *** variations in the source areas of sediment yielding for the upper YRB were quantified,and field measurement data of the cross-channel profile were collected to investigate the sedimentation process in the TGR from 2003 to *** than 90%of the sediment load reduction in the upper YRB may be explained by human *** Jinshajiang River was no longer the largest sediment source area for the Zhutuo station(accounting for 5.23%)in the 2013–2017 time span,and the sediment rating rates for the inflow and outflow of the TGR shifted to negatively correlated.A longitudinal fining trend was revealed in the suspended sediment ***,the mean median grain size of suspended sediment in the TGR had an increasing trend in the 2013–2017 *** result may be closely related to sediment regulation in reservoirs and incoming sediment load *** in the TGR decreased sharply from 299.8 Mt/yr in 2003–2012 to 47.2 Mt/yr in 2013–2017,but the sedimentation rate of the TGR remained at>80%***,some cross sections in the fluctuating backwater zone experienced scouring.

关键词： cascade reservoirs sediment load sedimentation characteristics suspended sediment grain size Three Gorges Reservoir

Building 3D Cadastral System Based on 2D Survey Plans with SketchUp

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Geo-Spatial Information Science 2011年第2期14卷 129-136页

作者： ying shen LI Lin GUO Renzhong School of Resource and Environment Science Wuhan University 129 Luoyu Road Wuhan 430079 China Urban Planning Land and Resources Commission of Shenzhen Municipality Shenzhen 518034 China

Three-dimensional (3D) land development and utilization has become the trend for urban planning in the current *** paper presents a method for building a 3D cadastral management system from survey plans with *** concentrates on the geometric representation and topological consistent maintenance of 3D cadastral *** this system a complete topological model is built to express the body construction and spatial relationships among 3D property *** is used to automatically construct 3D models with attributes and thematic information from 2D survey *** topologic relationships and operations are analyzed with the programming and development of Ruby *** resulting system can manage 3D cadastral objects and manipulate them with spatial operations to support spatial analysis.

关键词： 3D cadastre topological model spatial operation

Glutamate and γ-aminobutyric acid receptors and their characteristics in retina

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Chinese Science Bulletin 1999年第17期44卷 1548-1556页

作者： Xiongli Yang ying shen Minghu Han Shanghai Institute of Physiology and Key Laboratory of Neurobiology Chinese Academy of Sciences Shanghai China Graduate student of Department of Biological Science and Technology Zhejiang University Hangzhou China

Glutamate and γ-aminobutyric acid (GABA) are important neurotransmitters in the retinal neuronal circuitry. Using the whole-cell patch clamp technique and a rapid solution changer, glutamate and GABA receptors in the retina have been extensively investigated. Results indicate that glutamate receptors on horizontal cells may be an AMPA preferring subtype,

关键词： retina glutamate γ-aminobutyric acid desensitization receptor patch clamp.

Exploring the factors affecting electric bicycle riders'working conditions and crash involvement in Ningbo,China

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Journal of Traffic and Transportation Engineering(English Edition) 2023年第4期10卷 633-646页

作者： Jibiao Zhou ying shen Yanyong Guo sheng Dong School of Civil and Transportation Engineering Ningbo University of TechnologyNingbo 315211China College of Transportation Engineering Tongji UniversityShanghai 201804China chool of Civil and Transportation Engineering Hebei University of TechnologyTianjin 300130China School of Transportation Southeast UniversityNanjing 211189China

The rapid development of the delivery industry brings convenience to modern ***,the high rates of crashes and the survival of electric bicycle(e-bike)riders in the delivery industry raise *** primary objective of this study is to explore the factors affecting delivery e-bike riders’stressful work pressure and crash involvement in *** were collected by a questionnaire survey administered in the city of Ningbo,China.A bivariate ordered probit(BOP)model was developed to simultaneously examine the factors associated with both the working conditions of delivery e-bike riders and their involvement in *** marginal effects for the contributory factors were calculated to quantify their impacts on the *** results showed that the BOP model can account for commonly unobserved characteristics of the working conditions and crash involvement of delivery e-bike *** BOP model results showed that the stressful working conditions of delivery e-bike riders were affected by the number of orders and delivery time and rider age and risky riding *** rider involvement in crashes was affected by the number of orders,strength of the punishment for traffic violations,and familiarity with traffic *** was also found that stressful working conditions and crash involvement were strongly and positively *** findings of this study can enhance our understanding of the factors that affect the working conditions and delivery rider crash *** on the results,some suggestions regarding public policy,risky riding behaviors,safety promotion,and stronger corporate governance rules were discussed to increase the targeted safety-related interventions for delivery ebike riders in Ningbo,China.

关键词： Traffic safety Stressful working conditions Bivariate ordered probit model Electric bicycleriders Crash involvement Delivery e-bike