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Predicting colorectal adenomatous polyps in patients with chronic liver disease: A novel nomogram

World Journal of Gastroenterology 2025年第2期31卷 71-84页

作者： Yu-Qin li Wen-Tao Kuai lin Chen Ming-Hui Zeng Xue-Mei Tao Jia-Xin Han Yue-Kui Wang lian-Xin Xu li-ying Ge Yong-Gang liu Shuang li liang Xu Yu-Qiang Mi Clinical School of the Second People’s Hospital Tianjin Medical UniversityTianjin 300192China Department of Hepatology Tianjin Second People’s HospitalTianjin 300192China Department of Pathology Clinical School of the Second People’s HospitalTianjin 300110China Endoscopy Center Tianjin Second People’s HospitalTianjin 300192China

BACKGROUND Colorectal polyps are commonly observed in patients with chronic liver disease(CLD)and pose a significant clinical concern because of their potential for *** To explore the clinical characteristics of colorectal polyps in patients with CLD,a nomogram was established to predict the presence of adenomatous polyps(AP).METHODS Patients with CLD who underwent colonoscopy at Tianjin Second People’s Hospital from January 2020 to May 2023 were *** data including laboratory results,colonoscopy findings,and pathology reports were *** variables for the nomogram were identified through least absolute shrinkage and selection operator regression,followed by multivariate logistic *** performance of the model was evaluated using the area under the receiver area under curve,as well as calibration curves and decision curve *** The study enrolled 870 participants who underwent colonoscopy,and the detection rate of AP in patients with CLD was 28.6%.Compared to individuals without polyps,six risk factors were identified as predictors for AP occurrence:Age,male sex,body mass index,alcohol consumption,overlapping metabolic dysfunction-associated steatotic liver disease,and serum ferritin *** novel nomogram(AP model)demonstrated an area under curve of 0.801(95%confidence interval:0.756-0.845)and 0.785(95%confidence interval:0.712-0.858)in the training and validation *** curves indicated good agreement among predicted and actual probabilities(training:χ^(2)=11.860,P=0.157;validation:χ^(2)=7.055,P=0.530).The decision curve analysis underscored the clinical utility of the nomogram for predicting the risk of *** The AP model showed reasonable accuracy and provided a clinical foundation for predicting the occurrence of AP in patients with CLD,which has a certain predictive value.

关键词： Metabolic dysfunction associated steatotic liver disease Fatty liver Chronic liver disease Colorectal adenomas Hepatitis Risk factors

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Branching fractions and direct C P asymmetries of ■_s →K^0h^+h′^-(h(′)=K,π) decays

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Science China(Physics,Mechanics & Astronomy) 2015年第3期58卷 16-24页

作者： li ying Department of Physics Yantai University

Motivated by the recent LHCb collaboration measurements of charmless three-body decays of Bs-0 meson, we calculate the branching fractions of Bs→K0h＋h＇-（h（＇）=K,π）decay modes using the factorization *** the resonant and nonresonant contributions are studied in detail. For the decays Bs→K0h＋h＇-（h（＇）=K,π） and Bs→K0h＋h＇-（h（＇）=K,π）our resultsagree well with experimental data, and the former is dominated by the K＊, while the latter one is dominated by the nonresonant con-tribution. Considering the flavor S U（3） symmetry violation, the sum of branching fractions of Bs→K0h＋h＇-（h（＇）=K,π）could accommodate the data well too. It should be noted that both branching fractions are sensitive to the scalar density （Kπ｜sq｜0））. Furthermore, the resonant contributions are dominated by the scalar K;（1430）. We hope that these branching fractions could be measured individually in the experiments so as to test the factorization approach and the flavor S U（3） asymmetry. Moreover, the direct CP asymmetries of these decays are also investigated, which could be measured in the running LHCb experiment and Super-b factory in the future.

关键词： Bs0 three-body decay factorization approach CP violation

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The Physical Chemistry for the Self-assembly of Peptide Hydrogels

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Chinese Journal of Polymer Science 2018年第3期36卷 366-378页

作者： ying li Yi Cao Collaborative Innovation Center of Atmospheric Environment and Equipment Technology School of Environmental Science and EngineeringJiangsu Engineering Technology Research Centre of Environmental Cleaning MaterialsJiangsu Key Laboratory of Atmospheric Environment Monitoring and Pollution ControlJiangsu Joint Laboratory of Atmaspheric Pollution ControlNanjing University of Information Science&TechnologyNanjing 210044China Collaborative Innovation Center of Advanced Microstrucures National Laboratony of Solid State MicrostrucureDepartment of PhysicsNanjing UniversityNanjing 210093China

Peptide hydrogels have been widely used for diverse biomedical applications. However, our current understanding of the physical principles underlying the self-assembly process is still limited. In this review, we summarize our current understanding on the physical chemistry principles from the basic interactions that drive the self-assembly process to the energy landscapes that dictate the thermodynamics and kinetics of the process. We discuss the effect of different factors that affect the kinetics of the self-assembly of peptide fibrils and how this is related to the macroscopic gelation process. We provide our understanding on the molecular origin of the complex and rugged energy landscape for the self-assembly of peptide hydrogels. The hierarchical self-assembled structures and the diverse self-assembling mechanism make it difficult and challenging to rationally design the physical and chemical properties of peptide hydrogels at the molecular revel. We also give our personal perspective to the potential future directions in this field.

关键词： Hydrogel Peptide Self-assembly Kinetics Thermodynamics

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^(18)F-Labeling techniques for positron emission tomography

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Science China Chemistry 2013年第12期56卷 1682-1692页

作者： li ying Jiangsu Key Laboratory of Atmospheric Environment Monitoring & Pollution Control Chemistry Department School of Environmental Science & Engineering Nanjing University of Information Science & Technology

Much research effort has been made to understand various biological processes at levels of molecules using molecular imaging techniques. Because of great sensitivity, high resolution, and rapid detection, positron emission tomography （PET） imaging is becoming one of the most used imaging techniques for medical diagnose and pre-clinical studies. Here we provide a review on molecular imaging and PET imaging. An introduction is also provided on ~SF-fluorine labeling techniques for the preparation of PET imaging probes. A summary and comparison of currently available ~SF-fluorine labeling methods is provided. The per- spectives for 18F-fluorine labeling techniques are also given.

关键词： molecular imaging positron emission tomography 18F-fluorine/fluoride specific activity radiochemical yield

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A stepwise optimal design of water network

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Chinese Journal of Chemical Engineering 2016年第6期24卷 787-794页

作者： ying li Jintao Guan Department of Environmental and Chemical Engineering Dalian Jiaotong University

In order to take full advantage of regeneration process to reduce fresh water consumption and avoid the accumulation of trace contaminants, regeneration reuse and regeneration recycle should be distinctive. A stepwise optimal design for water network is developed to simplify solution procedures for the formulated MINLP problem. In this paper, a feasible water reuse network framework is generated. Some heuristic rules from water reuse network are used to guide the placement of regeneration process. Then the outlet stream of regeneration process is considered as new water source. Regeneration reuse network structure is obtained through an iterative optimal procedure by taking the insights from reuse water network structure. Furthermore, regeneration recycle is only utilized to eliminate fresh water usage for processes in which regeneration reuse is impossible. Compared with the results obtained by relevant researches for the same example, the present method not only provides an appropriate regeneration reuse water network with minimum fresh water and regenerated water flow rate but also suggests a water network involving regeneration recycle with minimum recycle water flow rate. The design can utilize reuse, regeneration reuse and regeneration recycle step by step with minor water network structure change to achieve better flexibility. It can satisfy different demands for new plants and modernization of existing plants.

关键词： Water networkReuseRegeneration reuseRegeneration recycleStepwise

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Peptide hydrogelation triggered by enzymatic induced pH switch

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Science China(Physics,Mechanics & Astronomy) 2016年第7期59卷 76-81页

作者： Wei Cheng ying li Nanjing Stomatological Hospital Medical School of Nanjing University Jiangsu Engineering Technology Research Centre of Environmental Cleaning Materials Jiangsu Key Laboratory of Atmospheric Environment Monitoring and Pollution ControlJiangsu Joint Laboratory of Atmospheric Pollution ControlCollaborative Innovation Center of Atmospheric Environment and Equipment TechnologySchool of Environmental Science and EngineeringNanjing University of Information Science &Technology National Laboratory of Solid State Microstructures Nanjing University

It remains challenging to develop methods that can precisely control the self-assembling kinetics and thermodynamics of peptide hydrogelators to achieve hydrogels with optimal *** we report the hydrogelation of peptide hydrogelators by an enzymatically induced pH switch,which involves the combination of glucose oxidase and catalase with D-glucose as the substrate,in which both the gelation kinetics and thermodynamics can be controlled by the concentrations of *** novel hydrogelation method could result in hydrogels with higher mechanical stability and lower hydrogelation *** further illustrate the application of this hydrogelation method to differentiate different D-glucose levels.

关键词： glucose oxidase and catalase peptide hydrogel pH switch mechanical properties

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Segmental nature of the Red River fault revealed by seismic anisotropy and geological structures

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Science China Earth Sciences 2024年第8期67卷 2423-2443页

作者： ying li Yuan GAO School of Earth and Space Sciences University of Science and Technology of ChinaHefei 230026China Key Laboratory of Earthquake Prediction Institute of Earthquake ForecastingChina Earthquake AdministrationBeijing 100036China

As the western boundary of the Sichuan-Yunnan block(SYB),the Red River fault(RRF)is a major fault that controls deep crustal movement and deformation in the southeast margin of the Tibetan Plateau and regulates middle-lower crustal *** data suggest that the RRF is segmented and exhibits distinct variations in seismicity,velocity structure and crustal deformation from north to *** anisotropy reveals a complex pattern of lateral spatial and vertical stratified distributions.(1)From the perspective of crustal stratification,in the upper crust,the fast wave polarization in the north segment of the RRF is complex and possibly influenced by the Sanjiang lateral collision zone and adjacent faults with varying *** fast wave polarization in the middle segment is in the NW-SE direction,indicating a localized area of closed down or locked up with consistent *** in the south segment,it presents a disordered pattern,signifying complex deep tectonics and stress conditions at the wedged intersection *** the middle-lower crust in the north and south segments of the RRF,the azimuthal anisotropy is strong and consistent with the spatial strike of the weak zone characterized by low-velocity and *** suggests a connection between the anisotropy and the material migration.(2)In the whole crustal scale,the fast wave directions in two sides of the RRF are consistent with the NW-SE tectonic *** indicates that the RRF,as a large fault potentially cutting through the whole crust,strongly controls the surrounding media.(3)In the lithospheric scale,the fast wave polarizations are oriented nearly E-W and independent of the fault strike,consistent with the low P-and S-wave velocity structures and positive radial anisotropy in the upper *** fast wave directions could be related to lithospheric olivine deformation and asthenospheric *** paper suggests a decoupling of deformation between the crust and the lithospheri

关键词： Red River fault Seismic anisotropy Geological structures lithosphere Fault segmentation

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Advection and Thermal Diode

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Chinese Physics Letters 2021年第3期38卷 22-28页

作者： ying li Jiaxin li Interdisciplinary Center for Quantum Information State Key Laboratory of Modern Optical InstrumentationCollege of Information Science and Electronic EngineeringZhejiang UniversityHangzhou 310027China ZJU-Hangzhou Global Science and Technology Innovation Center Key Lab of Advanced Micro/Nano Electronic Devices&Smart Systems of ZhejiangZhejiang UniversityHangzhou 310027China International Joint Innovation Center Zhejiang UniversityHaining 314400China School of Mechatronics Engineering Harbin Institute of TechnologyHarbin 150001China

We prove that under the condition of closed boundary to mass flux, pure advection is not a valid mechanism to make a practical thermal diode. Among the various designs of thermal diodes, many of them involve circulating fluid flow, such as in thermosyphons. However, those designs often employ natural convection, which is basically a nonlinear process. It thus remains unclear how the pure advection of temperature field induced by a decoupled velocity field influences the symmetry of heat transfer. Here we study three typical models with pure advection:one with open boundary, one with closed boundary at unsteady state, and one with closed boundary at steady state. It is shown that only the last model is practical, while it cannot become a thermal diode. Finally, a general proof is given for our claim by analyzing the diffusive reciprocity.

关键词： process. state. boundary

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Determining Topographic Shielding from Digital Elevation Models for Cosmogenic Nuclide Analysis:a GIS Approach and Field Validation

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Journal of Mountain Science 2013年第3期10卷 355-362页

作者： li ying-kui Department of Geography University of Tennessee

Topographic shielding of cosmic radiation flux is a key parameter in using cosmogenic nuclides to determine surface exposure ages or erosion rates. Traditionally, this parameter is measured in the field and uncertainty and/or inconsistency may exist among different investigators. This paper provides an ArcGIS python code to determine topographic shielding factors using digital elevation models （DEMs）. This code can be imported into ArcGIS as a geoprocessing tool with a user-friendly graphical interface. The DEM-derived parameters using this method were validated with field measurements in central Tian Shan. Results indicate that DEM-derived shielding factors are consistent with field-measured values. It provides a valuable tool to save fieldwork efforts and has the potential to provide consistent results for different regions in the world to facilitate the comparison of cosmogenie nuclide results.

关键词： Cosmogenic nuclides Topographicshielding ArcGIS Python Digital elevation models(DEMs)

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Determining topographic shielding from digital elevation models for cosmogenic nuclide analysis: a GIS model for discrete sample sites

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Journal of Mountain Science 2018年第5期15卷 939-947页

作者： li ying-kui Department of Geography University of Tennessee

Topographic shielding(TS) is an important factor in cosmogenic nuclide surface exposure dating. The development of geographic information systems(GIS) and the availability of digital elevation models(DEMs) make it possible to derive this factor directly from a DEM. Most available GIS models derive the TS factors for an area(all cells in a DEM) without the consideration of surface conditions of individual sites, such as the strike, dip,and height above ground, into the calculation. This paper presents a new GIS model to derive the TS factors for discrete sample sites. This model uses the Skyline and Skyline Graph functions in ArcGIS to extract the set of azimuth and elevation angles of topographic obstructions around each site from a DEM(considering the sample height above ground)and then incorporates the strike and dip information of the sample surface to derive the TS factor. All processing tools and steps are streamlined in ArcGIS modelbuilder and this model can be run like a standard ArcGIS geoprocessing tool. It provides an easy and user-friendly means to derive the TS factors for discrete samples based on a DEM and the measured strike, dip and sample height for each site.

关键词： Cosmogenic nuclides Topographicshielding Digital elevation models (DEMs) ArcGISmodelbuilder

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