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Systematical identification of regulatory GPCRs by single-cell trajectory inference reveals the role of ADGRD1 and GPR39 in adipogenesis

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Science China Life Sciences 2025年

作者： Chuan Ye Xuemei Wang Jun Lin Chenyang Wu Yuhua Gao Chenghao Guo Yunxi Liao Ziyan Rao Shaodong huang Weixuan Chen ying huang Jinpeng Sun Dongyu Zhao Changtao Jiang Center of Basic Medical Research Institute of Medical Innovation and ResearchPeking University Third Hospital Department of Physiology and Pathophysiology School of Basic Medical SciencesPeking University Department of Biomedical Informatics School of Basic Medical SciencesPeking University State Key Laboratory of Vascular Homeostasis and Remodeling Peking University Center for Obesity and Metabolic Disease Research School of Basic Medical SciencesPeking University State Key Laboratory of Female Fertility Promotion Center for Reproductive MedicineDepartment of Obstetrics and GynecologyPeking University Third Hospital National Clinical Research Center for Obstetrics and Gynecology Peking University Third Hospital Department of Endocrinology and Metabolism Peking University Third Hospital Key Laboratory Experimental Teratology of the Ministry of Education Department of Biochemistry and Molecular BiologySchool of Basic Medical SciencesCheeloo College of MedicineShandong University Department of Immunology School of Basic Medical SciencesPeking University

Adipogenesis is the healthy expansion of white adipose tissue (WAT),serving as a compensatory response to maintain metabolic homeostasis in the presence of excess energy in the ***,the identification of novel regulatory molecules in adipogenesis,specifically membrane receptors such as G protein-coupled receptors (GPCRs),holds significant clinical *** receptors can serve as viable targets for pharmaceuticals,offering potential for restoring metabolic homeostasis in individuals with *** utilized trajectory inference methods to analyze three distinct single-nucleus sequencing (sNuc-seq) datasets of adipose tissue and systematically identified GPCRs with the potential to regulate *** verification in primary adipose progenitor cells (APCs) of mice,we discovered that ADGRD1 promoted the differentiation of APCs,while GPR39 inhibits this *** the obese mouse model induced by a high-fat diet(HFD),both gain-of-function and loss-of-function studies validated that ADGRD1 promoted adipogenesis,thereby improving metabolic homeostasis,while GPR39 inhibited adipogenesis,leading to metabolic ***,through the analysis of 2,400 ChIP-seq data and 1,204 bulk RNA-seq data,we found that the transcription factors (TFs) MEF2D and TCF12 regulated the expression of ADGRD1and GPR39,*** study revealed the regulatory role of GPCRs in adipogenesis,providing novel targets for clinical intervention of metabolic dysfunction in obese patients.

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基于反应气混合物的ICP-MS/MS测定原油中的钒和镍

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光谱学与光谱分析 2025年第1期45卷 101-106页

作者：蔡松韬黄莹秀袁亮代宇宣莫垚坤黄建华湖南工学院材料科学与工程学院湖南衡阳421002 湖南省中医药研究院中药研究所湖南长沙410013

原油中金属元素钒和镍(V和Ni)的含量和比值可为深入了解原油的沉积环境特征和有机质类型发挥重要作用。在原油炼制过程中,V和Ni作为原油催化裂化过程中的有害金属元素,会降低催化剂的活性,严重时会导致催化剂中毒,会严重腐蚀设备,在精... 详细信息

原油中金属元素钒和镍(V和Ni)的含量和比值可为深入了解原油的沉积环境特征和有机质类型发挥重要作用。在原油炼制过程中,V和Ni作为原油催化裂化过程中的有害金属元素,会降低催化剂的活性,严重时会导致催化剂中毒,会严重腐蚀设备,在精炼之前必须对原油中的V和Ni进行脱除处理。V和Ni具有致突变性和致癌性,识别或监测原油中V和Ni进入环境的潜在危险变得越来越重要,对原油中V和Ni的含量进行高灵敏精准测定具有重要意义。采用电感耦合等离子体串联质谱(ICP-MS/MS)测定原油中V和Ni的新策略。原油样品经航空煤油简单稀释后直接采用ICP-MS/MS进行分析,针对V和Ni受到的质谱干扰,在MS/MS模式下,采用由NH_(3)/He(He为缓冲气)和H_(2)组成的反应气混合物(NH_(3)/He/H_(2))作为反应气,基于V^(+)与NH_(3)/He/H_(2)不发生反应,而V^(+)的干扰离子与NH_(3)/He/H_(2)发生反应,采用原位质量法消除干扰,选择V^(+)进行测定;基于Ni^(+)与NH_(3)/He/H_(2)发生反应,采用质量转移法消除干扰,选择无干扰团簇离子Ni(NH_(3))_(3)^(+)进行测定。通过与NH_(3)/He反应模式进行对比研究发现,对于V的测定,加入H_(2)为反应气能快速去除氩基离子的干扰,并能协同NH_(3)消除氧化物离子的干扰;对于Ni的测定,加入H_(2)为反应气能促进全氢加合物(-NH_(3))的形成,从而提高生成Ni(NH_(3))_(3)^(+)的产率。在NH_(3)/He/H_(2)反应模式下,V和Ni的背景等效浓度(BEC)更低,Ni的灵敏度更高,V和Ni的检出限(LOD)分别低至0.83和3.76 ng·kg^(-1),定量限(LOQ)分别为2.77和12.5 ng·kg^(-1)。通过分析标准参考物质NIST SRM 1634c并进行加标回收实验评价方法的准确度和精密度,结果显示,方法的测定结果与标准参考物质的认证值基本一致,V和Ni的加标回收率分别为97.7%和103%,相对标准偏差(RSD)分别为1.8%和1.9%。所建立的分析方法避免了繁琐的样品预处理过程,具有操作简单快速、灵敏度高、准确度和精密度好的特点,适用于原油中V和Ni的检测,能为原油深加工中V和Ni的脱除提供理论依据。

关键词：原油电感耦合等离子体串联质谱钒(V) 镍(Ni) 氨气/氦气/氢气(NH_(3)/He/H_(2))

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Solvent extraction equilibrium of dysprosium(Ⅲ) from nitric acid solutions with 2-ethylhexylphosphonic acid mono-2-ethylhexyl ester

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Transactions of Nonferrous Metals Society of China 2010年第4期20卷 707-711页

作者： huang ying TANAKA Mikiya Research Institute for Environmental Management Technology National Institute of Advanced Industrial Science and Technology （AIST） 16-10nogawa Tsukuba Ibaraki 305-8569 Japan School of Energy and Environment Southeast University Nanjing 210096 China

In view of the importance of solvent extraction of rare earth metals with the acidic organophosphorous reagent,the development of a chemically based model applicable to high concentration is *** the present study,the equilibrium distribution of dysprosium(Ⅲ)between an aqueous nitric acid solution and 2-ethylhexylphosphonic acid mono-2-ethylhexyl ester (PC88A)was measured in the range of an initial aqueous dysprosium(Ⅲ)concentration from 1.0×10-3to 1.0×10-1kmol/m 3and PC88A concentration from 0.16 to 0.65 kmol/m3in Shellsol D70 as the *** obtained data were analyzed using the chemically based model in order to correlate the equilibrium distribution *** this model,dysprosium(Ⅲ)was assumed to be extracted with the PC88A dimer as a 1:3 complex,the activities were considered for the aqueous species,and the effective concentration of the PC88A dimer was calculated using Alstad's empirical *** a result,the apparent extraction equilibrium constant was determined to be 253(kmol·m- 3)-2with an excellent correlation between the experiment and calculation results in the wide range of the logarithm of the distribution ratio from-2 to *** conclusion,the methodology in this model would be effective for quantitative description of solvent extraction behavior of general rare earth elements as well as dysprosium.

关键词： solvent extraction dysprosium 2-ethylhexylphosphonic acid mono-2-ethylhexyl ester(PC88A) nitric acid equilibrium

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The Climate Response to Global Forest Area Changes under Different Warming Scenarios in China

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Advances in Atmospheric Sciences 2023年第6期40卷 1073-1088页

作者： ying huang Anning huang Jie TAN School of Atmospheric Sciences Nanjing UniversityNanjing 210023China Frontiers Science Center for Critical Earth Material Cycling Nanjing UniversityNanjing 210023China Glarun Technology Co. Ltd.Nanjing 211106China

Human activities have notably affected the Earth’s climate through greenhouse gases(GHG), aerosol, and land use/land cover change(LULCC). To investigate the impact of forest changes on regional climate under different shared socioeconomic pathways(SSPs), changes in surface air temperature and precipitation over China under low and medium/high radiative forcing scenarios from 2021 to 2099 are analyzed using multimodel climate simulations from the Coupled Model Intercomparison Project Phase 6(CMIP6). Results show that the climate responses to forest changes are more significant under the low radiative forcing scenario. Deforestation would increase the mean, interannual variability, and the trend of surface air temperature under the low radiative forcing scenario, but it would decrease those indices under the medium/high radiative forcing scenario. The changes in temperature show significant spatial heterogeneity. For precipitation, under the low radiative forcing scenario, deforestation would lead to a significant increase in northern China and a significant decrease in southern China, and the effects are persistent in the near term(2021–40), middle term(2041–70), and long term(2071–99). In contrast, under the medium/high radiative forcing scenario, precipitation increases in the near term and long term over most parts of China, but it decreases in the middle term, especially in southern, northern,and northeast China. The magnitude of precipitation response to deforestation remains comparatively small.

关键词： land use/land cover change deforestation radiative forcing scenario regional climate

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Cooperative-Guided Ant Colony Optimization with Knowledge Learning for Job Shop Scheduling Problem

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Tsinghua Science and Technology 2024年第5期29卷 1283-1299页

作者： Wei Li Xiangfang Yan ying huang School of Information Engineering Jiangxi University of Science and TechnologyGanzhou 341000China School of Mathematics and Computer Science Gannan Normal UniversityGanzhou 341000China

With the advancement of the manufacturing industry,the investigation of the shop floor scheduling problem has gained increasing *** Job shop Scheduling Problem(JSP),as a fundamental scheduling problem,holds considerable theoretical research ***,finding a satisfactory solution within a given time is difficult due to the NP-hard nature of the JSP.A co-operative-guided ant colony optimization algorithm with knowledge learning(namely KLCACO)is proposed to address this *** algorithm integrates a data-based swarm intelligence optimization algorithm with model-based JSP schedule knowledge.A solution construction scheme based on scheduling knowledge learning is proposed for *** problem model and algorithm data are fused by merging scheduling and planning knowledge with individual scheme construction to enhance the quality of the generated individual solutions.A pheromone guidance mechanism,which is based on a collaborative machine strategy,is used to simplify information learning and the problem space by collaborating with different machine processing ***,the KLCACO algorithm utilizes the classical neighborhood structure to optimize the solution,expanding the search space of the algorithm and accelerating its *** KLCACO algorithm is compared with other highperformance intelligent optimization algorithms on four public benchmark datasets,comprising 48 benchmark test cases in *** effectiveness of the proposed algorithm in addressing JSPs is validated,demonstrating the feasibility of the KLCACO algorithm for knowledge and data fusion in complex combinatorial optimization problems.

关键词： Ant Colony Optimization(ACO) Job shop Scheduling Problem(JSP) knowledge learning cooperative guidance

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NATURAL BOUNDARY ELEMENT METHOD FOR THREE DIMENSIONAL EXTERIOR HARMONIC PROBLEM WITH AN INNER PROLATE SPHEROID BOUNDARY

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Journal of Computational Mathematics 2006年第2期24卷 193-208页

作者： Hong-ying huang De-hao Yu LSEC ICMSEC Academy of Mathematics and System Sciences Chinese Academy of Sciences Beijing 100080 China

In this paper, we study natural boundary reduction for Laplace equation with Dirichlet or Neumann boundary condition in a three-dimensional unbounded domain, which is the outside domain of a prolate spheroid. We express the Poisson integral formula and natural integral operator in a series form explicitly. Thus the original problem is reduced to a boundary integral equation on a prolate spheroid. The variational formula for the reduced problem and its well-posedness are discussed. Boundary element approximation for the variational problem and its error estimates, which have relation to the mesh size and the terms after the series is truncated, are also presented. Two numerical examples are presented to demonstrate the effectiveness and error estimates of this method.

关键词： Natural boundary reduction Prolate spheroid boundary Finite element Exterior harmonic problem.

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Diagnosabilities of exchanged hypercube networks under the pessimistic one-step diagnosis strategy

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Journal of Systems Engineering and Electronics 2015年第2期26卷 415-420页

作者： Jiarong Liang ying huang Liangcheng Ye School of Computer Electronics and Information Guangxi University

The exchanged hypercube EH（s, t）（where s ≥ 1 and t ≥ 1） is obtained by systematically reducing links from a regular hypercube Q,＋t＋l. One-step diagnosis of exchanged hypercubes which involves only one testing phase during which processors test each other is discussed. The diagnosabilities of exchanged hypercubes are studied by using the pessimistic one-step diagno- sis strategy under two kinds of diagnosis models： the PMC model and the MM model. The main results presented here are the two proofs that the degree of diagnosability of the EH（s, t） under pessimistic one-step tl/tl fault diagnosis strategy is 2s where I ≤ s ≤ t （respectively, 2t, where 1 ≤ t ≤ s） based on the PMC model and that it is also 2s where 1 ≤ s ≤ t （respectively, 2t, where 1 ≤ t ≤ s） based on the MM＊ model.

关键词： pessimistic diagnosis strategy exchanged hypercube network PMC model M M*model interconnection networks

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A balanced decomposition approach to real-time visualization of large vector maps in CyberGIS

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Frontiers of Computer Science 2015年第3期9卷 442-455页

作者： Mingqiang GUO ying huang Zhong XIE Faculty of Information and Engineering China University of Geosciences Wuhan 430074 China Geographic Information Systems Software and Application Project Research Center of the Educational Department China University of Geosciences Wuhan 430074 China

With the dramatic development of spatial data in- frastructure, CyberGIS has become significant for geospatial data sharing. Due to the large number of concurrent users and large volume of vector data, CyberGIS faces a great chal- lenge in how to improve performance. The real-time visual- ization of vector maps is the most common function in Cyber- GIS applications, and it is time-consuming especially when the data volume becomes large. So, how to improve the effi- ciency of visualization of large vector maps is still a signif- icant research direction for GIScience scientists. In this re- search, we review the existing three optimization strategies, and determine that the third category strategy （i.e., parallel optimization） is appropriate for the real-time visualization of large vector maps. One of the key issues of parallel optimiza- tion is how to decompose the real-time visualization tasks into balanced sub tasks while taking into consideration the spatial heterogeneous characteristics. We put forward some rules that the decomposition should conform to, and design a real-time visualization framework for large vector maps. We focus on a balanced decomposition approach that can assure efficiency and effectiveness. Considering the spatial hetero- geneous characteristic of vector data, we use a ＂horizontal grid, vertical multistage＂ approach to construct a spatial point distribution information grid. The load balancer analyzes the spatial characteristics of the map requests and decomposes the real-time viewshed into multiple balanced sub ***, all the sub viewsheds are distributed to multiple server nodes to be executed in parallel, so as to improve the real- time visualization efficiency of large vector maps. A group of experiments have been conducted by us. The analysis results demonstrate that the approach proposed in this research has the ability of balanced decomposition, and it is efficient and effective for all geometry types of vector data.

关键词： real-time visualization large vector map bal-anced decomposition CyberGIS load balance

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Effect of Carboxymethyl Cellulose(CMC) Functionalization on Dispersion, Mechanical, and Corrosion Properties of CNT/Epoxy Nanocomposites

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Chinese Journal of Polymer Science 2023年第8期41卷 1277-1286,I0010页

作者： Da-Wei Zhang Leonard Chia ying huang Department of Civil Construction and Environmental EngineeringNorth Dakota State UniversityFargo 58108USA

Carbon nanotube(CNT)/epoxy nanocomposites have a great potential of possessing many advanced ***,the homogenization of CNT dispersion is still a great challenge in the research field of *** study applied a novel dispersion agent,carboxymethyl cellulose(CMC),to functionalize CNTs and improve CNT dispersion in *** effectiveness of the CMC functionalization was compared with mechanical mixing and a commonly used surfactant,sodium dodecylbenzene sulfonate(Na DDBS),regarding dispersion,mechanical and corrosion properties of CNT/epoxy nanocomposites with three different CNT concentrations(0.1%,0.3%and 0.5%).The experimental results of Raman spectroscopy,particle size analysis and transmission electron microscopy showed that CMC functionalized CNTs reduced CNT cluster sizes more efficiently than Na DDBS functionalized and mechanically mixed CNTs,indicating a better CNT *** peak particle size of CMC functionalized CNTs reduced as much as 54%(0.1%CNT concentration)and 16%(0.3%CNT concentration),compared to mechanical mixed and Na DDBS functionalized *** of the better dispersion,it was found by compressive tests that CNT/epoxy nanocomposites with CMC functionalization resulted in 189%and 66%higher compressive strength,224%and 50%higher modulus of elasticity than those with mechanical mixing and Na DDBS functionalization respectively(0.1%CNT cencentration).In addition,electrochemical corrosion tests also showed that CNT/epoxy nanocomposites with CMC functionalization achieved lowest corrosion rate(0.214 mpy),the highest corrosion resistance(201.031Ω·cm^(2)),and the lowest porosity density(0.011%).

关键词： CNT/epoxy composites Carboxymethyl cellulose Dispersion Mechanical properties Corrosion properties

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Anti -monopoly Thoughts by Qiu Jun in the Ming Dynasty

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学术界 2017年第5期 279-288页

作者： huang ying Chongqing University Chongqing 400045 Chongqing Jiaotong University Chongqing 400074

Qiu Jun in the Ming Dynasty was one of the most outstanding figures to systematically illustrate anti-monopoly thoughts in the 15th ***'s thoughts include three aspects:***,he was not for the Monarch's expropriation of the country;***,he opposed the government's encroachment of merchants'interest;and ***,he was against merchant's embezzlement of the interest of the *** criticism largely focuses on the Monarch and the government in order to rectify the unhealthy tendency of the unjustified interference and monopoly over the industry and business by the government *** called for the return of the market to the society and the government's role of public ***'s thoughts in anti-monopoly are the specific illustration of classic Confucianism and a great achievement in Man's war a—gainst anti-monopoly.

关键词：金六月反垄断帝王政府

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