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Association between glioblastoma cell-derived vessels and poor prognosis of the patients

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Cancer Communications 2020年第5期40卷 211-221页

作者： Xin Mei yin-sheng chen Qing-Ping Zhang Fu-Rong chen Shao-Yan Xi Ya-Kang Long Ji Zhang Hai-Ping Cai Chao Ke Jing Wang Zhong-Ping chen Department of Neurosurgery/Neuro-oncology State Key Laboratory of Oncology in South ChinaCollaborative Innovation Center for Cancer MedicineSun Yat-sen University Cancer CenterGuangzhouGuangdong 510060P.R.China Department of Neurosurgery Huazhong University of Science and Technology Union Shenzhen HospitalThe 6th Affiliated Hospital of Shenzhen University Health Science Center(Shenzhen Nanshan People’s Hospital)ShenzhenGuangdong 518052P.R.China Department of Molecular Diagnostics State Key Laboratory of Oncology in South ChinaCollaborative Innovation Center for Cancer MedicineSun Yat-sen University Cancer CenterGuangzhouGuangdong 510060P.R.China Department of Neurosurgery Sun Yat-sen Memorial HospitalGuangzhouGuangdong 510235P.R.China

Background:Vessels with different microcirculation patterns are required for glioblastoma(GBM)***,details of the microcirculation patterns in GBM remain ***,we examined the microcirculation patterns of GBM and analyzed their roles in patient prognosis together with two well-known GMB prognosis factors(O^(6)-methylguanine DNA methyltransferase[MGMT]promoter methylation status and isocitrate dehydrogenase[IDH]mutations).Methods:Eighty GBM clinical specimens were collected from patients diagnosed between January 2000 and December *** microcirculation patterns,including endothelium-dependent vessels(EDVs),extracellular matrix-dependent vessels(ECMDVs),GBM cell-derived vessels(GDVs),and mosaic vessels(MVs),were evaluated by immunohistochemistry(IHC)and immunofluorescence(IF)staining in both GBM clinical specimens and xenograft *** density assessments and three-dimensional reconstruction were *** promoter methylation status was determined by methylation-specific PCR,and IDH1/2 mutations were detected by Sanger *** relationship between the microcirculation patterns and patient prognosis was analyzed by Kaplan-Meier ***:All 4 microcirculation patterns were observed in both GBM clinical specimens and xenograft *** were detected in all tissue samples,while the other three patterns were observed in a small number of tissue samples(ECMDVs in 27.5%,GDVs in 43.8%,and MVs in 52.5%tissue samples).GDV-positive patients had a median survival of 9.56 months versus 13.60 months for GDV-negative patients(P=0.015).In MGMT promoter-methylated cohort,GDV-positive patients had a median survival of 6.76 months versus 14.23 months for GDV-negative patients(P=0.022).Conclusion:GDVs might be a negative predictor for the survival of GBM patients,even in those with MGMT promoter methylation.

关键词： endothelial differentiation endothelium-dependent vessel extracellular matrix-dependent vessel glioblastoma cell-derived vessel Glioblastoma MGMT promoter methylation microcirculation mosaic vessel prognosis vasculogenic mimicry

Longest survival with primary intracranial malignant melanoma:A case report and literature review

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World Journal of Clinical Cases 2022年第30期10卷 11162-11171页

作者： Tang-Fai Wong yin-sheng chen Xiang-Heng Zhang Wan-Ming Hu Xiao-Shi Zhang Yan-Chun Lv Dong-Cun Huang Mei-Ling Deng Zhong-Ping chen Department of Neurosurgery Macao Kiang Wu HospitalMacao 999078Sichuan ProvinceChina Department of Neurosurgery/Neuro-Oncology State Key Laboratory of Oncology in South ChinaCollaborative Innovation Center for Cancer MedicineSun Yat-Sen University Cancer CenterGuangzhou 510060Guangdong ProvinceChina Department of Pathology State Key Laboratory of Oncology in South ChinaCollaborative Innovation Center for Cancer MedicineSun Yat-Sen University Cancer CenterGuangzhou 510060Guangdong ProvinceChina Department of Biotherapy State Key Laboratory of Oncology in South ChinaCollaborative Innovation Center for Cancer MedicineSun Yat-Sen University Cancer CenterGuangzhou 510060Guangdong ProvinceChina Department of Medical Imaging Sun Yat-sen University Cancer CenterCollaborative Innovation Center for Cancer MedicineGuangzhou 510060Guangdong ProvinceChina Department of Radiotherapy State Key Laboratory of Oncology in South ChinaCollaborative Innovation Center for Cancer MedicineSun Yat-Sen University Cancer CenterGuangzhou 510060Guangdong ProvinceChina

BACKGROUND Primary intracranial malignant melanoma(PIMM)is rare,and its prognosis is very *** is not clear what systematic treatment strategy can achieve long-term *** case study attempted to identify the optimal strategy for long-term survival outcomes by reviewing the PIMM patient with the longest survival following comprehensive treatment and by reviewing the related *** SUMMARY The patient is a 47-year-old Chinese man who suffered from dizziness and gait *** underwent surgery for right cerebellum melanoma and was subsequently diagnosed by pathology in June *** the surgery,the patient received three cycles of chemotherapy but relapsed locally within 4 *** the second surgery for total tumor resection,the patient received an injection of Newcastle disease virus-modified tumor vaccine,interferon,andβ-elemene *** patient was tumor-free with a normal life for 21 years before the onset of the recurrence of melanoma without any symptoms in July 2021.A third gross-total resection with adjuvant radiotherapy and temozolomide therapy was *** magnetic resonance imaging showed no residual tumor or recurrence 3 mo after the 3rd operation,and the patient recovered well without neurological dysfunction until the last follow-up in June 2022,which was 22 years following the initial *** It is important for patients with PIMM to receive comprehensive treatment to enable the application of the most appropriate treatment ***-term survival is not impossible in patients with these malignancies.

关键词： Primary intracranial malignant melanoma Immunotherapy Newcastle disease virus-modified tumor vaccine β-elemene Long-term survival Case report

17α-methyltestosterone induced hepatocyte apoptosis through endoplasmic reticulum stress in Takifugu fasciatus

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Journal of Oceanology and Limnology 2025年第1期43卷 219-231页

作者： Xuanyin chen sheng LUO Yanfang LI Rui LI Xiaojun LI Zhengyang HU Shaowu yin Tao WANG College of Marine Science and Engineering Jiangsu Province Engineering Research Center for Aquatic Animals Breeding and Green Efficient Aquacultural TechnologyNanjing Normal UniversityNanjing 210023China Co-Innovation Center for Marine Bio-Industry Technology of Jiangsu Province Lianyungang 222005China

17α-methyltestosterone(17α-MT)is an emerging pollutant,which is harmful to the endocrine system and reproduction of *** investigated the effects of different concentrations of 17α-MT(0,5,30,60,and 100 mg/kg)on endoplasmic reticulum stress(ERS)and apoptosis in the liver of Takifugu *** show that:(1)with the increase of 17α-MT treatment concentration,liver transaminases(alanine aminotransferase;aspartate aminotransferase)and the mRNA expression of ERS marker genes(glucose-regulated protein 78;calreticulin)of *** were significantly increased compared with the control group(P<0.05);(2)the activity of succinate dehydrogenase(SDH),Caspase3 and Caspase9 in the liver of *** increased with the increase of 17α-MT concentration compared with the control group(P<0.05);(3)by using 4-phenylbutyricacid(4-PBA)inhibitors to stimulate ERS through in vitro experiments,the expression of ERS and apoptosis-related genes significantly decreased(P<0.05),and the apoptosis rate of *** hepatocytes was significantly inhibited(P<0.05)under 17α-MT *** study confirmed that ERS played an important role in the induction of apoptosis in the hepatocytes of ***,which enriched the ecotoxicological information of environmental androgens.

关键词： 17α-methyltestosterone Takifugu fasciatus liver endoplasmic reticulum stress apoptosis

Current research status on the distribution and transport of micro(nano)plastics in hyporheic zones and groundwater

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Journal of Environmental Sciences 2025年第5期151卷 387-409页

作者： Dongming Zhang Qiqing chen Ting Xu Daqiang yin Key Laboratory of Yangtze River Water Environment Ministry of EducationCollege of Environmental Science and EngineeringTongji UniversityShanghai 200092China Shanghai Institute of Pollution Control and Ecological Security Shanghai 200092China State Key Laboratory of Estuarine and Coastal Research East China Normal UniversityShanghai 200241China

Micro(nano)plastics,as an emerging environmental pollutant,are gradually discovered in hyporheic zones and *** studies have focused on the origin and spatial/temporal distribution of micro(nano)plastics in regional groundwater,together with the influence of their properties and effects of environmental factors on their ***,the transport of micro(nano)plastics in the whole hyporheic zone-groundwater system and the behavior of co-existing substances still lack a complete theoretical *** provide systematic theoretical support for that,this review summarizes the current pollution status of micro(nano)plastics in the hyporheic zone-groundwater system,provides a comprehensive introduction of their sources and fate,and classifies the transport mechanisms into mechanical transport,physicochemical transport and biological processes assisted transport fromthe perspectives ofmechanical stress,physicochemical reactions,and bioturbation,***,this review proposes to advance the understanding of the multi-dimensional hydrosphere transport of micro(nano)plastics centered on groundwater,themicroorganisms-mediated synergistic transformation and co-transport involving the intertidal ***,this review systematically dissects the presence and transport cycles of micro(nano)plastics within the hyporheic zone-groundwater system and proposes prospects for future studies based on the limitations of current studies.

关键词： Micro(nano)plastics Groundwater Hyporheic zone Transport mechanisms Abundance

Enhanced MGMT expression contributes to temozolomide resistance in glioma stem-like cells

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Chinese Journal of Cancer 2014年第2期33卷 115-122页

作者： Zhi-Kun Qiu Dong Shen yin-sheng chen Qun-ying Yang cheng-cheng Guo Bing-Hong Feng Zhong-Ping chen State Key Laboratory of Oncology in South China Department of Neurosurgery/Neuro-oncology Sun Yat-sen University Cancer Center Department of Pharmacology Guangdong Pharmaceutical University Department of Oncology The Affiliated Jiangyin Hospital of Southeast University Medical College

O6-methylguanine DNA methyltransferase(MGMT) can remove DNA alkylation adducts, thereby repairing damaged DNA and contributing to the drug resistance of gliomas to alkylating agents. In addition, glioma stem-like cells(GSCs) have been demonstrated to be involved in the recurrence and treatment resistance of gliomas. In this study, we aimed to investigate MGMT expression and regulatory mechanisms in GSCs and the association of MGMT with temozolomide(TMZ) sensitivity. GSCs were enriched from one MGMT-positive cell line(SF-767) and 7 MGMT-negative cell lines(U251, SKMG-4, SKMG-1, SF295, U87, MGR1, and MGR2) through serum-free clone culture. GSCs from the U251G, SKMG-4G, SF295G, and SKMG-1G cell lines became MGMT-positive, but those from the U87G, MGR1G, and MGR2G cell lines remained MGMT-negative. However, all the GSCs and their parental glioma cell lines were positive for nuclear factor-κB(NF-κB). In addition, GSCs were more resistant to TMZ than their parental glioma cell lines(P 0.05). When we treated the MGMT-positive GSCs with TMZ plus MG-132(an NF-κB inhibitor), the antitumor activity was significantly enhanced compared to that of GSCs treated with TMZ alone(P < 0.05). Furthermore, we found that MGMT expression decreased through the down-regulation of NF-κB expression by MG-132. Our results show that MG-132 may inhibit NF-κB expression and further decrease MGMT expression, resulting in a synergistic effect on MGMT-positive GSCs. These results indicate that enhanced MGMT expression contributes to TMZ resistance in MGMT-positive GSCs.

关键词：神经胶质瘤 MGMT 替莫唑胺干细胞耐药性 DNA甲基转移酶 NF-κB 核因子-κB

Unraveling the reaction mechanism of high reversible capacity CuP_(2)/C anode with native oxidation PO_(x) component for sodium-ion batteries

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Chinese Chemical Letters 2025年第1期36卷 574-578页

作者： Huixin chen chen Zhao Hongjun Yue Guiming Zhong Xiang Han Liang yin Ding chen State Key Laboratory of Advanced Design and Manufacturing for Vehicle Body College of Mechanical and Vehicle EngineeringHunan UniversityChangsha 410082China CAS key Laboratory of Design and Assembly of Functional Nanostructures and Fujian Provincial Key Laboratory of NanomaterialsFujian Institute of Research on the Structure of MatterChinese Academy of SciencesFuzhou 350002China College of Materials Science and Engineering Co-Innovation Center of Efficient Processing and Utilization of Forest ResourcesNanjing Forestry UniversityNanjing 210037China Laboratory of Advanced Spectro-electrochemistry and Li-ion Batteries Dalian Institute of Chemical PhysicsChinese Academy of SciencesDalian 116023China Institute of Physics Chinese Academy of SciencesBeijing 100190China Xiamen Key Laboratory of Rare Earth Photoelectric Functional Materials Xiamen Institute of Rare Earth MaterialsHaixi institutesChinese Academy of SciencesXiamen 361021China

Phosphorus-based anode is a promising anode for sodium-ion batteries(SIBs)due to its high specific capacity,however,suffers from poor electronic conductivity and unfavorable electrochemical *** metals such as copper(Cu)into phosphorus has been demonstrated to not only improve the electronic conductivity but also accommodate the volume change during cycling,yet the underline sodiation mechanism is not ***,take a copper phosphide and reduced graphene oxide(CuP_(2)/C)composite as an example,which delivers a high reversible capacity of>900 mAh/***,it is revealed that the native oxidation PO_(x)components of the CuP_(2)/C composite show higher electrochemical reversibility than the bulk Cu P_(2),based on a quantitative analysis of high-resolution solid-state^(31)P NMR,ex-situ XPS and synchrotron X-ray diffraction characterization *** sodiation products Na_(3)PO_(4) and Na_(4)P_(2)O_(7) derived from PO_(x) could react with Na-P alloys and regenerate to PO_(x) during charge process,which probably accounts for the high reversible capacity of the Cu P_(2)/C *** findings also illustrate that the phosphorus transforms into nanocrystalline Na_(3)P and Na_(x)P alloys,which laterally shows crystallization-amorphization evolution process during cycling.

关键词： CuP_(2)/C composite POx component Reaction mechanism Solid-state NMR Sodium-ion batteries

Metal-organic polyhedra as dynamic cross-linker for recyclable mixed matrix membranes with promising dimension stability

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Science China Chemistry 2025年第2期68卷 705-713页

作者： Linjie Lan Mingxin Zhang Haiyan Xiao Wei Liu-Fu Yuyan Lai Jiadong chen Jia-Fu yin Panchao yin State Key Laboratory of Luminescent Materials and Devices&South China Advanced Institute for Soft Matter Science and Technology Guangdong Basic Research Center of Excellence for Energy and Information Polymer MaterialsSouth China University of TechnologyGuangzhou 510641China State Key Laboratory of Marine Resource Utilization in South China Sea Hainan Provincial Key Lab of Fine ChemistrySchool of Chemical Engineering and TechnologyHainan UniversityHaikou 570228China

Mixed matrix membranes(MMMs)are designed by incorporating microporous inorganic fillers into polymer matrix for the integration of inorganics’excellent gas separation performance with polymers’promising ***,due to the complex interphase interaction,the prevention of long-term aging is still challenging and the poor processability/recyclability of MMMs hinders their extensive ***,a coordination assembly protocol is developed for the fabrication of MMMs with both excellent processability/recyclability upon thermal annealing and promising dimension stability even under high gas *** bearing isophthalic acid(IPA)as side chains are applied to coordinate with Cu^(2+)and the assembled 2.5 nm microporous metal-organic polyhedra(MOP),{Cu_(24)IPA_(24)},serves as multi-functional cross-linkers for the polymer network *** MOPs’well-defined microporosity grants MMMs the capability for O_(2)/N_(2) separation while their activated dynamics at high temperatures(>120℃)endows polymer networks with excellent *** contrast to conventional supramolecular units,the MOPs possess unique logarithmic ligand-exchange kinetics and they show nearly frozen bonding dynamics at room temperature,ensuring promising dimensional stability to overcome the long-term aging and high gas pressure *** work not only provides fundamental understanding of the unique relaxation dynamics of complex systems with intertwined dynamics of supramolecular bonds and polymer chains,but also paves new avenues for the fabrication of robust and recyclable MMMs and elastomers.

关键词： dynamic bonding metal-organic polyhedra mixed matrix membrane polymer recycling gas separation

Adsorption of typical NDMA precursors by superfine powdered activated carbon:Critical role of particle size reduction

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Journal of Environmental Sciences 2025年第1期147卷 101-113页

作者： ying Wang Zhichen Zhang Zhihang yin Jun Wang Xiaojian Zhang Chao chen State Key Joint Laboratory of Environmental Simulation and Pollution Control School of EnvironmentTsinghua UniversityBeijing 100084China Research Institute for Environmental Innovation(Suzhou) TsinghuaSuzhou 215163China

Control of N-nitrosodimethylamine(NDMA)in drinking water could be achieved by removing its precursors as one practical ***,superfine powdered activated carbons with a diameter of about 1μm(SPACs)were successfully prepared by grinding powdered activated carbon(PAC,D50=24.3μm)and applied to remove model NDMA precursors,***(RAN)and nizatidine(NIZ).Results fromgrain diameter experiments demonstrated that the absorption velocity increased dramatically with decreasing particle size,and the maximum increase in k2 was 26.8-folds for RAN and 33.4-folds for ***,kinetic experiments explained that rapid absorption could be attributed to the acceleration of intraparticle diffusion due to the shortening of the diffusion ***,performance comparison experiments suggested that the removal of RAN and NIZ(C_(0)=0.5 mg/L)could reach 61.3%and 60%,respectively,within 5 min,when the dosage of SAPC-1.1(D_(50)=1.1μm)was merely 5 mg/L,while PAC-24.3 could only eliminate 17.5%and 18.6%.The adsorption isotherm was well defined by Langmuir isotherm model,indicating that the adsorption of RAN/NIZ was a monolayer coverage *** adsorption of RAN or NIZ by SAPC-1.1 and PAC-24.3 was strongly pH dependent,and high adsorption capacity could be observed under the condition of pH>pk_(a)+*** coexistence of humic acid(HA)had no significant effect on the adsorption performance because RAN/NIZ may be coupled with HA and removed *** coexistence of anions had little effect on the adsorption *** study is expected to provide an alternative strategy for drinking water safety triggered by NDMA.

关键词： Adsorption NDMA Kinetics Superfine powdered activated carbon Intraparticle diffusion Drinking water

A Review on Thermal Management of Li-ion Battery:from Small-Scale Battery Module to Large-Scale Electrochemical Energy Storage Power Station

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Journal of Thermal Science 2025年第1期34卷 1-23页

作者： chen Zhifeng JIA Li yin Liaofei DANG Chao REN Honglei ZHANG Zhiqiang Beijing Key Laboratory of Flow and Heat Transfer of Phase Changing in Micro and Small Scale School of MechanicalElectronic and Control EngineeringBeijing Jiaotong UniversityBeijing 100044China

Li-ion battery is an essential component and energy storage unit for the evolution of electric vehicles and energy storage technology in the ***,in order to cope with the temperature sensitivity of Li-ion battery and maintain Li-ion battery safe operation,it is of great necessary to adopt an appropriate battery thermal management system(BTMS).In this paper,the current main BTM strategies and research hotspots were discussed from two aspects:small-scale battery module and large-scale electrochemical energy storage power station(EESPS).The practical application situation,advantages and disadvantages,and the future development trend of each heat dissipation method(air,liquid,PCM,heat pipe,hybrid cooling)were described in *** them,the air cooling and liquid cooling were reviewed in-depth based on the engineering *** PCM,heat pipe and hybrid cooling were reviewed extensively based on the latest *** research provides a comprehensive understanding for the BTMS in all scales.

关键词： battery thermal management cooling methods small-scale battery module large-scale electrochemical energy storage power station