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Science Bulletin 2016年第24期61卷 1844-1854页

作者： Yang Hu Jijun wang Chunbo Li yin-shan wang Zhi Yang Xi-Nian Zuo Key Laboratory of Behavioral Science Laboratory for HumanConnectome and Development Magnetic Resonance ResearchCenter Institute of Psychology Chinese Academy of SciencesBeijing 100101 China University of Chinese Academy of Sciences Beijing 100049China shanghai Key Laboratory of Psychotic Disorders Shanghai Mental Health Center Shanghai Jiao Tong University School of Medicine Shanghai 200030 China

Abstract A brain network consisting of two key parietal nodes, the precuneus and the posterior cingulate cortex, has emerged from recent fMRI studies. Though it is anatomically adjacent to and spatially overlaps with the default mode network （DMN）, its function has been associated with memory processing, and it has been referred to as the parietal memory network （PMN）. Independent component analysis （ICA） is the most common data-driven method used to extract PMN and DMN simultaneously. However, the effects of data preprocessing and parameter determi- nation in ICA on PMN-DMN segregation are completely unknown. Here, we employ three typical algorithms of group ICA to assess how spatial smoothing and model order influence the degree of PMN-DMN segregation. Our findings indicate that PMN and DMN can only be stably separated using a combination of low-level spatial smoothing and high model order across the three ICA algorithms. We thus argue for more considerations on parametric settings for interpreting DMN data.

关键词： Default mode network Parietal memory network Independent component analysis Model order Resting-state fMRI Spatial smoothing

Functional brain network mapping with dual regression

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Science China(Life Sciences) 2017年第12期60卷 1450-1452页

作者： Hui-Jie Li yin-shan wang Xuequan Su Xi-Nian Zuo CAS Key Laboratory of Behavioral Science Institute of PsychologyBeijing 100101China Department of Psychology University of Chinese Academy of SciencesBeijing 100049China Research Center for Lifespan Development of Mind and Brain Institute of PsychologyChinese Academy of SciencesBeijing 100101China Key Laboratory for Brain and Education Sciences Guangxi Teachers Education UniversityNanning 530001China

Functional magnetic resonance imaging（fMRI）is an in-vivo non-invasive technique for measuring brain activity with excellent spatial and good temporal *** performing explicit tasks,resting-state fMRI（rfMRI）is widely used to map the functional connectivity network（FCN）,which refers to a large-scale network of interdependent or functionally connected brain regions and it could be detected by using different algorithms（Zuo and Xing, 2014）.ciation CAS （2016084）, Guangxi Bagui Scholarship, the Natural Science Foundation of China （81471740, 81220108014）, the Major Project of National Social Science Foundation of China （14ZDB161）, Beijing Municipal Science and Tech Commission （Z161100002616023, Z161100000216152） and the National R＆D Infrastructure and Facility Development Program ＂Fundamental Science Data Sharing Platform＂（DKA2017-12-02-21）.

关键词： Functional brain network mapping dual regression

Connectome Computation System:2015–2021 updates

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Science Bulletin 2022年第5期67卷 448-451页

作者： Xiu-Xia Xing Ting Xu Chao Jiang yin-shan wang Xi-Nian Zuo Department of Applied Mathematics College of MathematicsFaculty of ScienceBeijing University of TechnologyBeijing 100124China Center for the Developing Brain Child Mind InstituteNY 10022USA School of Psychology Capital Normal UniversityBeijing 100048China State Key Laboratory of Cognitive Neuroscience and Learning Beijing Normal UniversityBeijing 100875China National Basic Science Data Center Beijing 100190China Developmental Population Neuroscience Research Center IDG/McGovern Institute for Brain ResearchBeijing Normal UniversityBeijing 100875China

The Connectome Computation System(CCS)was previously reported in the Science Bulletin[1].Here,we describe a summary of the 6-year CCS updates(2015–2021),which are accessible at https://***/zuoxinian/*** updates contain many utilities of mining developmental neuroimaging ***,H1 module covers the data cleaning and preprocessing and refines the implementations of face-masking,brain extraction,denoising,and frequency banding.

关键词： Bulletin cleaning mining

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重组人胰岛素类似物研发进展和安全性特点

中国新药杂志 2018年第21期27卷 2578-2583页

作者：尹华静余珊珊尹茂山王寅吴爽李峥胡晓敏国家药品监督管理局药品审评中心北京100022

胰岛素是目前治疗糖尿病的首选药物之一,而利用重组DNA技术研制生产的胰岛素类似物,在临床应用上更加接近人体的正常分泌状态,从而具有更好的安全性。研究者们一方面在临床实践中不断优化胰岛素的治疗方案,另一方面在新型胰岛素类似物... 详细信息

胰岛素是目前治疗糖尿病的首选药物之一,而利用重组DNA技术研制生产的胰岛素类似物,在临床应用上更加接近人体的正常分泌状态,从而具有更好的安全性。研究者们一方面在临床实践中不断优化胰岛素的治疗方案,另一方面在新型胰岛素类似物和非注射胰岛素制剂的研发方面取得新进展。本文着重讨论重组人胰岛素类似物的研发进展及潜在致癌性和生殖毒性等方面的安全性问题。

关键词：胰岛素类似物非注射制剂生物类似药安全性评价

P2Y1 receptor in Alzheimer’s disease

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Neural Regeneration Research 2025年第2期20卷 440-453页

作者： shan Luo Yifei wang Tatsuhiro Hisatsune Department of Integrated Biosciences The University of TokyoKashiwaJapan

Alzheimer’s disease is the most frequent form of dementia characterized by the deposition of amyloid-beta plaques and neurofibrillary tangles consisting of hyperphosphorylated *** amyloid-beta plaques has been a primary direction for developing Alzheimer’s disease treatments in the last ***,existing drugs targeting amyloid-beta plaques have not fully yielded the expected results in the clinic,necessitating the exploration of alternative therapeutic *** evidence unravels that astrocyte morphology and function alter in the brain of Alzheimer’s disease patients,with dysregulated astrocytic purinergic receptors,particularly the P2Y1 receptor,all of which constitute the pathophysiology of Alzheimer’s *** receptors are not only crucial for maintaining normal astrocyte function but are also highly implicated in neuroinflammation in Alzheimer’s *** review delves into recent insights into the association between P2Y1 receptor and Alzheimer’s disease to underscore the potential neuroprotective role of P2Y1 receptor in Alzheimer’s disease by mitigating neuroinflammation,thus offering promising avenues for developing drugs for Alzheimer’s disease and potentially contributing to the development of more effective treatments.

关键词： astrocytes neuroinflammation P2Y1 receptor purinergic receptor

Multiple liver metastases of unknown origin:A case report

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World Journal of Gastrointestinal Oncology 2025年第1期17卷 233-238页

作者： ying-Jin wang Ze-Chuan Liu Jian wang yin-Mo Yang Department of Hepatobiliary Pancreatic Surgery Peking University First HospitalBeijing 100034China Department of Interventional and Vascular Surgery Peking University First HospitalBeijing 100034China

BACKGROUND The liver is the most common site of digestive system tumor metastasis,but not all liver metastases can be traced back to the primary *** it is unusual,syphilis can impact the liver,manifesting as syphilitic hepatitis with inflammatory nodules,which might be misdiagnosed as *** SUMMARY This case report involves a 46-year-old female who developed right upper abdominal pain and intermittent low fever that persisted for more than three *** definitive diagnosis of a tumor had been made in the past decades,but signs of multiple liver metastases were recognized after a computed tomo-graphy scan without evidence of primary *** positive serological tests for syphilis and a biopsy of the liver nodules,a diagnosis of hepatic syphilis was made and confirmed with follow-up nodule reduction after anti-syphilis *** Clinicians must be aware of the possibility that syphilis can cause hepatic inflam-matory masses,especially when liver metastasis is suspected without evidence of primary lesions.A definitive diagnosis should be established in conjunction with a review of the patient’s medical history for accurate therapeutic intervention.

关键词： Syphilitic hepatitis Liver nodules Liver metastasis Treponema pallidum Case report

Successful emergency surgical intervention in acute non-STsegment elevation myocardial infarction with rupture:A case report

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World Journal of Clinical Cases 2025年第4期13卷 41-47页

作者： Xing-Po Li Zi-shan wang Hong-Xia Yu shan-shan wang Department of Cardiovascular Medicine Huantai County Hospital of Traditional Chinese MedicineZibo 256400Shandong ProvinceChina Department of Cardiovascular Medicine Zibo Hospital of Integrated Traditional Chinese and Western MedicineZibo 255500Shandong ProvinceChina

BACKGROUND The incidence of acute myocardial infarction(AMI)is rising,with cardiac rupture accounting for approximately 2%of deaths in patients with acute ST-segment elevation myocardial infarction(STEMI).Ventricular free wall rupture(FWR)occurs in approximately 2%of AMI patients and is notably rare in patients with *** of cardiac rupture include left ventricular FWR,ventricular septal rupture,and papillary muscle *** FWR usually leads to acute cardiac tamponade or electromechanical dissociation,where standard resuscitation efforts may not be *** septal rupture and papillary muscle rupture often result in refractory heart failure,with mortality rates over 50%,even with surgical or percutaneous repair *** SUMMARY We present a rare case of an acute non-STEMI patient who suffered sudden FWR causing cardiac tamponade and loss of consciousness immediate before undergoing coronary *** resuscitation and emergency open-heart repair along with coronary artery bypass grafting resulted in successful patient *** This case emphasizes the risks of AMI complications,shares a successful treatment scenario,and discusses measures to prevent such complications.

关键词： Acute non-ST segment elevation myocardial infarction Cardiac rupture Acute myocardial infarction Free wall rupture Case report

Unleashing the Potential of Electroactive Hybrid Biomaterials and Self‑Powered Systems for Bone Therapeutics

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Nano-Micro Letters 2025年第2期17卷 463-497页

作者： Shichang Liu Farid Manshaii Jinmiao Chen Xinfei wang Shaolei wang Junyi yin Ming Yang Xuxu Chen Xinhua yin Yunlei Zhou Honghui Hospital Xi’an Jiaotong UniversityXi’an 710018People’s Republic of China Department of Bioengineering Henry Samueli School of Engineering and Applied ScienceUniversity of California Los AngelesLos Angeles 90095USA Hangzhou Institute of Technology Xidian UniversityHangzhou 311231People’s Republic of China

The incidence of large bone defects caused by traumatic injury is increasing worldwide,and the tissue regeneration process requires a long recovery time due to limited self-healing *** bioelectrical phenomena have been well recognized as critical biophysical factors in bone remodeling and *** by bioelectricity,electrical stimulation has been widely considered an external intervention to induce the osteogenic lineage of cells and enhance the synthesis of the extracellular matrix,thereby accelerating bone *** ongoing advances in biomaterials and energy-harvesting techniques,electroactive biomaterials and self-powered systems have been considered biomimetic approaches to ensure functional recovery by recapitulating the natural electrophysiological microenvironment of healthy bone *** this review,we first introduce the role of bioelectricity and the endogenous electric field in bone tissue and summarize different techniques to electrically stimulate cells and ***,we highlight the latest progress in exploring electroactive hybrid biomaterials as well as self-powered systems such as triboelectric and piezoelectric-based nanogenerators and photovoltaic cell-based devices and their implementation in bone tissue ***,we emphasize the significance of simulating the target tissue’s electrophysiological microenvironment and propose the opportunities and challenges faced by electroactive hybrid biomaterials and self-powered bioelectronics for bone repair strategies.

关键词： Electroactive biomaterials Self-powered bioelectronics Bone regeneration Bone tissue

CNKSR2 interactome analysis indicates its association with the centrosome/microtubule system

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Neural Regeneration Research 2025年第8期20卷 2420-2432页

作者： Lin yin Yalan Xu Jie Mu Yu Leng Lei Ma Yu Zheng Ruizhi Li yin wang Peifeng Li Hai Zhu Dong wang Jing Li Institute for Translational Medicine The Affiliated Hospital of Qingdao UniversityMedical CollegeQingdao UniversityQingdaoShandong ProvinceChina School of Basic Medicine Qingdao UniversityQingdaoShandong ProvinceChina College of Life Sciences and School of PharmacyMedical CollegeQingdao UniversityQingdaoShandong ProvinceChina Department of Urology Qingdao Municipal Hospital Affiliated to Qingdao UniversityQingdaoShandong ProvinceChina

The protein connector enhancer of kinase suppressor of Ras 2(CNKSR2),present in both the postsynaptic density and cytoplasm of neurons,is a scaffolding protein with several protein-binding *** of the CNKSR2 gene have been implicated in neurodevelopmental disorders,particularly intellectual disability,although the precise mechanism involved has not yet been fully *** has demonstrated that CNKSR2 plays a role in facilitating the localization of postsynaptic density protein complexes to the membrane,thereby influencing synaptic signaling and the morphogenesis of dendritic ***,the function of CNKSR2 in the cytoplasm remains to be *** this study,we used immunoprecipitation and high-resolution liquid chromatography-mass spectrometry to identify the interactors of *** a combination of bioinformatic analysis and cytological experiments,we found that the CNKSR2 interactors were significantly enriched in the proteome of the *** also showed that CNKSR2 interacted with the microtubule protein DYNC1H1 and with the centrosome marker *** colocalization analysis confirmed the centrosomal localization of *** we downregulated CNKSR2 expression in mouse neuroblastoma cells(Neuro 2A),we observed significant changes in the expression of numerous centrosomal *** manipulation also affected centrosome-related functions,including cell size and shape,cell proliferation,and ***,we found that CNKSR2 interactors were highly enriched in de novo variants associated with intellectual disability and autism spectrum *** findings establish a connection between CNKSR2 and the centrosome,and offer new insights into the underlying mechanisms of neurodevelopmental disorders.

关键词： autism spectrum disorder centrosome CNKSR2 intellectual disability interactome mass spectrometry microtubule neurodevelopmental disease protein complexes protein-protein interactions

Local-to-remote cortical connectivity in amnestic mild cognitive impairment

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Local-to-remote cortical connectivity in amnestic mild cogni...