检索结果-南通市图书馆

Ginsenoside Rd Induces Differentiation of Myeloid Leukemia Cells via Regulating ERK/GSK-3βSignaling Pathway

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Integrative Medicine 2024年第7期30卷 588-599页

作者： JIANG Yu-xia ZHAO Yan-na YU Xiao-ling yin li-ming Department of Hematology Tongde Hospital of Zhejiang ProvinceHangzhou310012China Institute of Hematology Research the First Affiliated Hospital of Zhejiang Chinese Medical University(Zhejiang Provincial Hospital of Chinese Medicine)Hangzhou310006China

Objective To investigate the role of ginsenoside Rd(GRd)in acute myeloid leukemia(AML)cell *** AML cells were treated with GRd(25,50,100 and 200µg/mL),retinoic acid(RA,0.1g/L)and PD98059(20 mg/mL)for 72 h,cell survival was detected by methylthiazolyldiphenyl-tetrazolium bromide and colony formation assays,and cell cycle was detected by flow *** morphology and differentiation were observed by Wright-Giemsa staining,peroxidase chemical staining and cellular immunochemistry assay,*** protein expression levels of GATA binding protein 1(GATA-1),purine rich Box-1(PU.1),phosphorylated-extracellular signal-related kinase(p-ERK),ERK,phosphorylated-glycogen synthase kinase-3β(p-GSK3β),GSK3βand signal transducer and activator of transcription 1(STAT1)were detected by Western ***-six mice were randomly divided into 3 groups using a random number table:model control group(non-treated),GRd group[treated with 200 mg/(kg·d)GRd]and homoharringtonine(HTT)group[treated with 1 mg/(kg·d)HTT].A tumor-bearing nude mouse model was established,and tumor weight and volume were *** of subcutaneous tumor tissue were observed after hematoxylin and eosin ***1 and GATA-1 expressions were detected by immunohistochemical *** The cell survival was inhibited by GRd in a dose-dependent manner and GRd caused G0/G1 cell arrest(plicited upregulation of p-ERK,p-GSK-3βand STAT1 expressions in cells,and reversed the effects of PD98059 on inhibiting the expressions of peroxidase,GATA-1 and PU.1(P<0.05).After GRd treatment,tumor weight and volume of mice were decreased,and tumor cells underwent massive apoptosis and necrosis(P<0.05).WT1 level was decreased,and GATA-1 level was significantly increased in subcutaneous tumor ti

关键词： ginsenoside Rd myeloid leukemia survival differentiation extracellular signal-related kinase signaling pathway

在线全文

学校读者我要写书评

暂无评论

基于文献计量的根际激发效应研究进展与趋势

土壤通报 2024年第3期55卷 876-885页

作者：姚忠凯刘丹阴黎明淳心林俊杰重庆三峡学院重庆市三峡库区水质演变与污染防治重点实验室重庆万州404100 重庆三峡职业学院农林科技学院重庆万州404000 中国科学院沈阳应用生态研究所辽宁沈阳110016

为了解根际激发效应(RPE)的研究进展和趋势,以Web of Science核心合集数据库中216篇RPE的研究论文为数据源,通过CiteSpace、VOS viewer对发文数量、平均/总被引频次及国家、机构、作者等进行了分析。结果表明:RPE研究大致可分为三个阶段... 详细信息

为了解根际激发效应(RPE)的研究进展和趋势,以Web of Science核心合集数据库中216篇RPE的研究论文为数据源,通过CiteSpace、VOS viewer对发文数量、平均/总被引频次及国家、机构、作者等进行了分析。结果表明:RPE研究大致可分为三个阶段:初始期(1984~1995年)、稳定发展期(1996~2014年)和快速增长期(2015~2022年)。美国总发文第一且中介中心性最高,国际影响力最大;中国在2018年后年均发文攀升至第一,在国际影响力方面次于德国,排在第三位。国际上主要以Cheng W、Kuzyakov Y为代表的核心作者群;就研究机构而言,中国科学院发文数量最多。研究热点主要集中在RPE的量化方法、影响因素及调控机制,且大多是采用植物幼苗和在室内盆栽条件下完成的。因此,亟需将室内研究拓展至野外原位条件,综合考虑全球气候变化的影响,改进CO_(2)同位素示踪技术和捕获方法,加强成年树种RPE的种间差异变幅研究,优化Earth-System模型参数,进而准确估算陆地生态系统碳循环对气候变化的响应。

关键词：根际激发效应文献计量土壤有机碳碳循环

同方期刊数据库

Unconventional Fluorescent and Multi-responsive Polyethyleneimine with LCST and UCST Behavior:Synthesis,Characterization and Biological Applications

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Polymer Science 2024年第6期42卷 826-837页

作者： Feng-ming yin li-li Wu Shu-Sheng li Xiao-Na Pan Xiao-li Zhu Xu-Bao Jiang Xiang Zheng Kong College of Chemistry and Chemical Engineering University of JinanJinan250022China Shandong Institute for Product Quality Inspection Jinan250102China College of Chemical Engineering Tianjin UniversityTianjin300072China

Non-aromatic fluorescent and multi-responsive materials,exhibiting inherent fluorescence emission and controlled phase change,have garnered significant attention in recent ***,the underlying interaction between their fluorescent properties and phase transition remains *** this study,we synthesized a series of catalyst-free aza-Michael addition-based polyethyleneimine(RFPEI)materials by reacting polyethyleneimine(PEI)with N-isopropyl acrylamide(NIPAM).The resulting RFPEI was comprehensively characterized,and demonstrated dual-phase transition behavior(LCST and UCST)in water,which could be finely tuned by adjusting its composition or external factors such as ***,upon UV irradiation(365 nm),RFPEI exhibited strong fluorescence *** further investigated the effects of NIPAM grafting percentage to PEI,polymer concentration,and pH on the LCST/UCST and fluorescent properties of RFPEI aqueous ***,we showcased the great potential of RFPEI as a versatile tool for physiological cell imaging,trace detection,and controlled release of *** study presents a novel class of stimuli-responsive fluorescent materials with promising applications in the field of biomedicine.

关键词： Polyethyleneimine Multi-responsiveness Intrinsic fluorescence emission Cell imaging Controlled drug release

KIM1、TIMP2及炎症指标与2型糖尿病肾病进展风险的相关性研究

在线全文

学校读者我要写书评

暂无评论

海南医学 2024年第14期35卷 2036-2041页

作者：孙小芳尹丽明包利文廖智威付文金王少波广东医科大学厚街临床医学院内分泌科广东东莞523960 广东医科大学厚街临床医学院检验科广东东莞523960

目的检测不同程度肾脏疾病的糖尿病患者中血清肾损伤分子-1(KIM-1)、金属基质蛋白酶抑制剂-2(TIMP2)、白介素6(IL-6)和C反应蛋白(CRP)的水平,并评估其与糖尿病肾脏进展风险的关系。方法选取2022年3月至2023年3月东莞厚街医院收治的65例... 详细信息

目的检测不同程度肾脏疾病的糖尿病患者中血清肾损伤分子-1(KIM-1)、金属基质蛋白酶抑制剂-2(TIMP2)、白介素6(IL-6)和C反应蛋白(CRP)的水平,并评估其与糖尿病肾脏进展风险的关系。方法选取2022年3月至2023年3月东莞厚街医院收治的65例2型糖尿病患者纳入研究,根据患者肾脏病变的严重程度,按照改善全球预后指南将糖尿病肾病(DKD)分为低风险组(n=19)、中风险组(n=22)和高风险组(n=24),同期选择20例体检健康者作为对照组。比较各组受试者血清KIM-1、TIMP-2、IL-6、CRP、糖化血红蛋白(HbAlc)、尿蛋白/肌酐比值(UACR)、低密度脂蛋白胆固醇(LDL-C)、空腹血糖(FPG)、血清总胆固醇(TC)、肾小球滤过率(eGFR)、高密度脂蛋白胆固醇(HDL-C)、25羟维生素D_(3)[(25(OH)D_(3))]和甘油三酯(TG)的水平,采用Pearson法分析血清TIMP-2、KIM-1与DKD糖脂代谢、肾功能指标的相关性,利用受试者工作(ROC)曲线分析血清KIM-1、TIMP-2、IL-6、CRP、KIM-1与TIMP-2联合检测对DKD疾病进展的预测价值。结果四组受检者血清LDL-C、HDL-C和CRP水平比较差异均无统计学意义(P>0.05);对照组血清FPG、HbAlc、TIMP2、KIM-1水平分别为(5.13±0.56)mmol/L、(5.56±0.30)%、(4.91±0.76)ng/mL、(0.46±0.33)ng/mL,明显低于低风险组的(12.17±9.82)mmol/L、(9.45±2.46)%、(11.51±25.01)ng/mL、(1.00±0.68)ng/mL及中风险组的(11.35±10.63)mmol/L、(9.73±2.82)%、(30.23±17.42)ng/mL、(1.26±1.31)ng/mL和高风险组的(8.04±7.69)mmol/L、(9.27±2.21)%、(30.51±46.01)ng/mL、(1.63±1.09)ng/mL,而低风险组的血清中TIMP2、KIM-1水平明显低于中风险组、高风险组,差异均有统计学意义(P<0.05);高风险组患者的血清CREA、IL-6水平分别为(122.00±79.23)μmmol/L、(3.51±5.92)pg/mL,明显高于低风险组的(77.00±42.70)μmmol/L、(0.50±2.79)pg/mL和中风险组的(74.00±32.25)μmmol/L、(1.34±3.61)pg/mL,差异均有统计学意义(P<0.05);经Spearman相关分析结果显示2型糖尿病肾病患者TIMP-2、KIM-1与HbA1c、IL-6、UACR均呈正相关(P<0.05),而TIMP-2、KIM-1与eGFR呈负相关(P<0.05);经ROC分析结果显示,KIM-1、TIMP-2、IL-6、CRP以及KIM-1联合TIMP-2预测2型糖尿病肾病进展风险的曲线下面积(AUC)分别为0.869、0.867、0.751、0.633和0.935,KIM-1联合TIMP-2预测较各单一指标预测的准确度更高。结论血清KIM-1、TIMP-2、IL-6、CRP水平升高与2型糖尿病肾病疾病进展密切相关,其中KIM-1联合TIMP-2预测2型糖尿病肾病进展风险的价值较高。

关键词：糖尿病肾病肾损伤分子-1 金属基质蛋白酶抑制剂-2 炎症因子相关性

A Potential Degree Sequence Problem of the Loebl-Komlós-Sós Conjecture

同方期刊数据库博看期刊评论

在线全文

学校读者我要写书评

暂无评论

Acta Mathematicae Applicatae Sinica 2024年

作者： Guang-ming li Jian-hua yin School of Mathematics and Statistics Hainan University

A non-increasing sequenceπ=(d1,..., dn) of nonnegative integers is said to be a graphic sequence if it is realizable by a simple graph G on n vertices. In this case, G is referred to as a realization ofπ. In terms of graphic sequences, the Loebl-Komlós-Sós conjecture states that for any integers k and n, if π=(d1,..., dn)is a graphic sequence with d「n/2」≥k, then every realization ofπcontains all trees with k edges as *** problem can be viewed as a forcible degree sequence problem. In this paper, we consider a potential degree sequence problem of the Loebl-Komlós-Sós conjecture, that is, we prove that for any integers k and n, ifπ=(d1,..., dn) is a graphic sequence with d「n/2」≥k, then there is a realization ofπcontaining all trees with k edges as subgraphs.

关键词：

Effect of the Filling liquid Ratio on the Thermal Performance of a Novel Thermal Diode with Wick

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Journal of Thermal Science 2024年第2期33卷 396-407页

作者： li Zhiyong ming Tingzhen ZHANG Heyu ZHAO Sitong WANG Qinggang CAI Cunjin yin Kui FANG Yueping WU Yongjia School of Civil Engineering and Architecture Wuhan University of TechnologyWuhan430070China Sanya Science and Education Innovation Park Wuhan University of TechnologySanya572004China Deparment of Four Station Logistics AcademyXuzhou221000China School of Energy Construction and EnvironmentCoventry UniversityPriory StreetCoventryCV15FBUK

The application of thermal diodes,which allow heat to flow more readily in one direction than the other,is an important way to reduce energy consumption in buildings and enhance the battery heat dissipation of electric *** on various factors including the specific design,materials used,and operating conditions,the convective thermal diode can exhibit the best thermal rectification effect in intended applications compared to the other thermal *** this study,a novel convective thermal diode with a wick was proposed based on the phase change heat transfer *** design takes advantage of both capillary forces provided by the wick and gravity to achieve enhanced unidirectional heat transfer performance for the designed convective thermal *** effect of the filling liquid ratio on the thermal performance of the thermal diode was experimentally investigated,which was in good agreement with the theoretical *** research findings showed that with an optimal liquid filling ratio of 140%,the thermal diode with a wick can achieve a better thermal rectification ratio when subjected to a lower heating power,and the maximum thermal rectification ratio of 21.76 was experimentally achieved when the heating power of the thermal diode was 40 W.

关键词： filling liquid ratio thermal diode wick structure gravity

Atomically Substitutional Engineering of Transition Metal Dichalcogenide Layers for Enhancing Tailored Properties and Superior Applications

在线全文

学校读者我要写书评

暂无评论

Nano-Micro Letters 2024年第5期16卷 248-284页

作者： Zhaosu liu Si yin Tee Guijian Guan ming‑Yong Han Institute of Molecular Plus Tianjin UniversityTianjin 300072People’s Republic of China Institute of Materials Research and Engineering A*STARSingapore 138634Singapore

Transition metal dichalcogenides(TMDs)are a promising class of layered materials in the post-graphene era,with extensive research attention due to their diverse alternative elements and fascinating semiconductor *** MX2 layers with different metal and/or chalcogen elements have similar structural parameters but varied optoelectronic properties,providing opportunities for atomically substitutional engineering via partial alteration of metal or/and chalcogenide atoms to produce ternary or quaternary *** resulting multinary TMD layers still maintain structural integrity and homogeneity while achieving tunable(opto)electronic properties across a full range of composition with arbitrary ratios of introduced metal or chalcogen to original counterparts(0–100%).Atomic substitution in TMD layers offers new adjustable degrees of freedom for tailoring crystal phase,band alignment/structure,carrier density,and surface reactive activity,enabling novel and promising *** review comprehensively elaborates on atomically substitutional engineering in TMD layers,including theoretical foundations,synthetic strategies,tailored properties,and superior *** emerging type of ternary TMDs,Janus TMDs,is presented specifically to highlight their typical compounds,fabrication methods,and potential ***,opportunities and challenges for further development of multinary TMDs are envisioned to expedite the evolution of this pivotal field.

关键词： Transition metal dichalcogenides Atomic substitution Tailored structure Tunable bandgap Enhanced applications

Dynamic modeling and RBF neural network compensation control for space flexible manipulator with an underactuated hand

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Aeronautics 2024年第3期37卷 417-439页

作者： Dongyang SHANG Xiaopeng li Meng yin Fanjie li School of Mechanical Engineering and Automation Northeastern UniversityShenyang 110819China Shenzhen Institute of Advanced Technology Chinese Academy of SciencesShenzhen 518055China

In space operation,flexible manipulators and gripper mechanisms have been widely used because of light weight and ***,the vibration caused by slender structures in manipulators and the parameter perturbation caused by the uncertainty derived from grasping mass variation cannot be *** existence of vibration and parameter perturbation makes the rotation control of flexible manipulators difficult,which seriously affects the operation accuracy of ***’s more,the complex dynamic coupling brings great challenges to the dynamics modeling and vibration *** solve this problem,this paper takes the space flexible manipulator with an underactuated hand(SFMUH)as the research *** dynamics model considering flexibility,multiple nonlinear elements and disturbance torque is established by the assumed modal method(AMM)and Hamilton’s principle.A dynamic modeling simplification method is proposed by analyzing the nonlinear ***’s more,a sliding mode control(SMC)method combined with the radial basis function(RBF)neural network compensation is ***,the control law is designed using a saturation function in the control method to weaken the chatter *** the help of neural networks to identify the uncertainty composition in the SFMUH,the tracking accuracy is *** results of ground control experiments verify the advantages of the control method for vibration suppression of the SFMUH.

关键词： Space flexible manipulator RBF neural network Underactuated hand Dynamic models Model simplification

cKBET:assessing goodness of batch effect correction for single-cell RNA-seq

在线全文

学校读者我要写书评

暂无评论

Frontiers of Computer Science 2024年第1期18卷 215-228页

作者： Yameng ZHAO yin GUO limin li School of Mathematics and Statistics Xi’an Jiaotong UniversityXi’an 710049China

Single-cell RNA sequencing reveals the gene structure and gene expression status of a single cell,which can reflect the heterogeneity between ***,batch effects caused by non-biological factors may hinder data integration and downstream *** the batch effect can be evaluated by visualizing the data,which actually is subjective and *** this work,we propose a quantitative method cKBET,which considers the batch and cell type information *** cKBET method accesses batch effects by comparing the global and local fraction of cells of different batches in different cell *** verify the performance of our cKBET method on simulated and real biological data *** experimental results show that our cKBET method is superior to existing methods in most *** general,our cKBET method can detect batch effect with either balanced or unbalanced cell types,and thus evaluate batch correction methods.

关键词： single-cell RNA-seq dataset b batch effect assessment cKBET method