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Immune rebalancing at the maternal-fetal interface of maternal SARS-CoV-2.infection during early pregnancy

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Protein & Cell 2024年第6期15卷 460-473页

作者： Chenxiang Xi Zihui Yan Dandan Bai Yalin Zhang Beiying Wang Xiaoxiao Han Li Wu Xiaohui Shi Zhiyi Hu ming Tang Zhongqu Su yingdong Liu Binya Liu Jiqing yin Hong Wang Xiaocui Li Yanping Zhang Shaorong Gao Wenqiang Liu Shanghai Key Laboratory of Maternal Fetal Medicine Clinical and Translational Research Center of Shanghai First Maternity and Infant HospitalShanghai Institute of Maternal-Fetal Medicine and Gynecologic OncologyFrontier Science Center for Stem Cell ResearchSchool of Life Sciences and TechnologyTongji UniversityShanghai 200092China Jiaxing Maternity and Child Health Care Hospital Jiaxing 314050China

The current coronavirus disease 2.19(COVID-19)pandemic caused by severe acute respiratory syndrome coronavirus(SARS-CoV-2.remains a threat to pregnant ***,the impact of early pregnancy SARS-CoV-2.infection on the maternal-fetal interface remains poorly ***,we present a comprehensive analysis of single-cell transcriptomics and metabolomics in placental samples infected with SARS-CoV-2.during early *** to control placentas,SARS-CoV-2.infection elicited immune responses at the maternal-fetal interface and induced metabolic alterations in amino acid and phospholipid profiles during the initial weeks ***,subsequent immune cell activation and heightened immune tolerance in trophoblast cells established a novel dynamic equilibrium that mitigated the impact on the maternal-fetal ***,the immune response and metabolic alterations at the maternal-fetal interface exhibited a gradual decline during the second *** study underscores the adaptive immune tolerance mechanisms and establishment of immunological balance during the first two trimesters following maternal SARS-CoV-2.infection.

关键词： fetal alterations pregnancy

套管式CO_(2.蒸发器的性能模拟与优化计算

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化学工程 2024年第2期52卷 50-55页

作者：杨俊兰殷明天津城建大学能源与安全工程学院天津300384

为优化设计套管式CO_(2.蒸发器,达到提高换热器效率的目的,采用稳态分布参数法对其建立仿真模型,并对模型精度进行实验验证。分析蒸发器内外部条件、结构参数对换热性能的影响,并分析干涸现象与管长的关系。结果表明:蒸发温度和质量通... 详细信息

为优化设计套管式CO_(2.蒸发器,达到提高换热器效率的目的,采用稳态分布参数法对其建立仿真模型,并对模型精度进行实验验证。分析蒸发器内外部条件、结构参数对换热性能的影响,并分析干涸现象与管长的关系。结果表明:蒸发温度和质量通量对换热性能影响较大,蒸发温度由4℃降至-4℃,制冷量下降4 500 W/(m^(2.·K);质量通量每升高100 kg/(m^(2.·s),换热系数平均升高约1 000 W/(m^(2.·K);在设计工况下,干涸前CO_(2.流体所行进管路长度先下降再升高,且在蒸发温度为0℃达到最低点。在结构参数方面,外管管径为2. mm时,蒸发器换热效果较好。当冷冻水温度从11℃降至10℃时,压降下降3.5 kPa,明显低于其他温度情况下的压降情况。

关键词：套管式CO_(2.蒸发器稳态分布参数法模拟计算换热性能

Abnormal adipose tissue-derived microbes drive metabolic disorder and exacerbate postnatal growth retardation in piglet

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Life Metabolism 2024年第2期3卷 55-69页

作者： Tongxing Song ming Qi Yucheng Zhu Nan Wang Zhibo Liu Na Li Jiacheng Yang Yanxu Han Jing Wang Shiyu Tao Zhuqing Ren Yulong yin Jinshui Zheng Bie Tan College of Animal Science and Technology Huazhong Agricultural UniversityWuhanHubei 430070China College of Animal Science and Technology Hunan Agricultural UniversityChangshaHunan 410000China Laboratory of Animal Nutritional Physiology and Metabolic Process CAS Key Laboratory of Agro-ecological Processes in Subtropical RegionNational Engineering Laboratory for Pollution Control and Waste Utilization in Livestock and Poultry ProductionInstitute of Subtropical AgricultureChinese Academy of SciencesChangshaHunan 410125China State Key Laboratory of Agricultural Microbiology Huazhong Agricultural UniversityWuhanHubei 430070China Hubei Key Laboratory of Agricultural Bioinformatics Huazhong Agricultural UniversityWuhanHubei 430070China

Postnatal growth retardation(PGR)frequently occurs during early postnatal development of piglets and induces high *** date,the mechanism of PGR remains poorly *** tissue-derived microbes have been documented to be associated with several disorders of metabolism and body ***,the connection between microbial disturbance of adipose tissue and pig PGR remains ***,we investigated piglets with PGR and found that the adipose tissue of PGR piglets was charac-terized by metabolism impairment,adipose abnormality,and specific enrichment of culturable bacteria from *** of Sphingomonas paucimobilis,a species of Sphingomonas genus from the alphaproteobacteria,induced PGR in ***,this bacterium could also lead to metabolic disorders and susceptibility to acute stress,resulting in weight loss in ***,multi-omics analysis indicated the changes in lipid metabolism as a response of adipose tissue to abnormal microbial *** experimental tests proved that one of the altered lipids phosphatidylethanolamines could rescue the metabolism disorder and growth retardation,thereby suppressing the amount of Sphingomonas in the adipose ***,these results highlight that the microbe–host crosstalk may regulate the metabolic function of adipose tissue in response to PGR.

关键词： adipose tissue microbe metabolic disorder postnatal growth retardation piglet

Coupling Analysis of Multiple Machine Learning Models for Human Activity Recognition

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Computers, Materials & Continua 2024年第6期79卷 3783-3803页

作者： Yi-Chun Lai Shu-yin Chiang Yao-Chiang Kan Hsueh-Chun Lin Department of Public Health China Medical UniversityTaichung406040Taiwan Department of Information and Telecommunications Engineering Ming Chuan UniversityGui-ShanTaoyuan333Taiwan Department of Electrical Engineering Yuan Ze UniversityChung-Li32003Taiwan Department and Institute of Health Service Administrations China Medical UniversityTaichung406040Taiwan

Artificial intelligence(AI)technology has become integral in the realm of medicine and healthcare,particularly in human activity recognition(HAR)applications such as fitness and rehabilitation *** study introduces a robust coupling analysis framework that integrates four AI-enabled models,combining both machine learning(ML)and deep learning(DL)approaches to evaluate their effectiveness in *** analytical dataset comprises 561 features sourced from the UCI-HAR database,forming the foundation for training the ***,the MHEALTH database is employed to replicate the modeling process for comparative purposes,while inclusion of the WISDM database,renowned for its challenging features,supports the framework’s resilience and *** ML-based models employ the methodologies including adaptive neuro-fuzzy inference system(ANFIS),support vector machine(SVM),and random forest(RF),for data *** contrast,a DL-based model utilizes one-dimensional convolution neural network(1dCNN)to automate feature ***,the recursive feature elimination(RFE)algorithm,which drives an ML-based estimator to eliminate low-participation features,helps identify the optimal features for enhancing model *** best accuracies of the ANFIS,SVM,RF,and 1dCNN models with meticulous featuring process achieve around 90%,96%,91%,and 93%,*** analysis using the MHEALTH dataset showcases the 1dCNN model’s remarkable perfect accuracy(100%),while the RF,SVM,and ANFIS models equipped with selected features achieve accuracies of 99.8%,99.7%,and 96.5%,***,when applied to the WISDM dataset,the DL-based and ML-based models attain accuracies of 91.4%and 87.3%,respectively,aligning with prior research *** conclusion,the proposed framework yields HAR models with commendable performance metrics,exhibiting its suitability for integration into the healthcare services system through AI-driven applications.

关键词： Human activity recognition artificial intelligence support vector machine random forest adaptive neuro-fuzzy inference system convolution neural network recursive feature elimination

Effect of L-theanine combined with geniposide on depression-like behavior induced by the chronic unpredictable mild stress(CUMS) in mice

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Food Science and Human Wellness 2024年

作者： Qi-ming Yu Yan Zhu Tao Jiang ying Gao Nan Ling Na Wang John Shi Wei-Chun Pan Qi-Zhen Du Jun-Feng yin Tea Research Institute Chinese Academy of Agricultural Sciences， Key Laboratory of Tea Biology and Resources Utilization， Ministry of Agriculture College of Food and Health Sciences， Zhejiang A & F University Zhejiang Gongshang University Guelph Food Research Center， Agriculture and Agri-Food Canada College of Public Health， Guilin Medical University

Depression is a prevalent mental disorder with limited effective treatments， posing a significant global issue. This study explored L-theanine and geniposide， key components in "food-medicine homology" materials， to determine if their combination (TG) could alleviate depression-like behaviors and hippocampal neuronal damage in a chronic unpredictable mild stress (CUMS) mouse model. Male C57BL/6J mice were divided into control， CUMS model， and CUMS+TG groups with varying doses. The CUMS group displayed depression-like behaviors， including reduced activity and sucrose preference. TG treatment partially reversed these changes， significantly increasing antioxidant enzyme activities， decreasing pro-inflammatory cytokine levels， and improving neuromodulator levels. RNA-seq analysis identified the transthyretin (TTR) gene， upregulated in the model group but downregulated after TG treatment. TG treatment modulated intestinal microbiota composition compared to the CUMS group， including increased Firmicutes， reduced Bacteroidetes and Prevotella， and variable changes in Bifidobacterium abundance. In conclusion， our study indicates that CUMS exposure upregulates stress hormones and TTR expression， associated with neuroinflammation， oxidative stress， monoamine depletion， depression-like behaviors， and intestinal microbiota dysbiosis. TG treatment alleviates these effects and modulates intestinal microbiota， suggesting L-theanine and geniposide’s potential as a novel depression therapy.

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试论中医诊疗中病、证、症的离合关系及其应用

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中华中医药杂志 2024年第2期39卷 636-641页

作者：尹笑玉陈明北京中医药大学北京100029

中医临床中,病名、证型与主症的确立对于理法方药的裁定具有各自不同的指导意义,三者合而相参则能够相互补充,从时空序列中较为精确地定位当前的疾病状态与预后转归发展,从而指导处方用药;三者相离则各彰所长,只要把握其不同的临床适用... 详细信息

中医临床中,病名、证型与主症的确立对于理法方药的裁定具有各自不同的指导意义,三者合而相参则能够相互补充,从时空序列中较为精确地定位当前的疾病状态与预后转归发展,从而指导处方用药;三者相离则各彰所长,只要把握其不同的临床适用范围即可高效准确地掌握病情之机要,从而确立治法选定方药。文章结合临床实际情况,分类论述临证中定病名、辨病证与抓主症的内涵与外延及其间的相互联系,阐明了三者在不同的离合作用下的应用方法及意义,并例举验案验方为佐,力图说明其各自的适用范围及临床诊疗应用的方法与思路。

关键词：诊疗思路辨证论治抓主症方证相对专病专方离合关系

优先切开腱鞘的全内镜下手术与传统开放手术治疗腓骨肌腱滑脱症的临床效果比较

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中华外科杂志 2024年第6期62卷 556-564页

作者：李明李杨殷睿桂鉴超南京医科大学附属南京医院(南京市第一医院)运动关节科南京210006 南京市高淳人民医院关节外科南京211300

目的比较优先切开腱鞘的全内镜下手术与传统开放手术治疗腓骨肌腱滑脱症的临床效果。方法本研究为回顾性队列研究。回顾性分析2.16年7月至2.2.年6月南京医科大学附属南京医院运动关节科收治的45例腓骨肌腱滑脱症患者的临床资料。男性2.... 详细信息

目的比较优先切开腱鞘的全内镜下手术与传统开放手术治疗腓骨肌腱滑脱症的临床效果。方法本研究为回顾性队列研究。回顾性分析2.16年7月至2.2.年6月南京医科大学附属南京医院运动关节科收治的45例腓骨肌腱滑脱症患者的临床资料。男性2.例,女性19例,年龄(31.2.9.3)岁(范围:17~45岁)。其中行改良腓骨肌沟加深联合腱鞘修补术2.例(传统手术组),行优先切开腱鞘的全内镜下腓骨肌沟加深联合腱鞘修补术2.例(全内镜组)。收集患者围手术期资料,采用疼痛视觉模拟评分(VAS)、美国足踝外科协会踝与后足评分(AOFAS-AH)、踝关节跖屈-背伸活动度(ROM)、健康调查简表(SF)-36及自制患者满意度调查问卷对患者术后疗效进行全面评估。术后行影像学检查,观察术后腓骨沟加深情况和肌腱及腱鞘愈合情况。定量资料的组间比较采用独立样本t检验、Wilcoxon秩和检验,组内比较采用配对样本t检验、重复测量方差分析;分类资料的比较采用χ2.验、Mann-whitney U检验或Fisher确切概率法。结果两组患者的性别、年龄、病程、损伤侧别、损伤分型的差异无统计学意义(P值均>0.05)。全内镜组手术时间为(47.9±5.4)min,传统手术组为(47.2.6.3)min,差异无统计学意义(t=0.402.P=0.690)。全内镜组与传统手术组相比,切口长度[(2.2.0.4)cm比(6.0±0.4)cm;t=32.892.P2.9,P2.月以上随访,随访时间(19.2.3.9)个月(范围:12.2.个月)。术后3个月及末次随访时,全内镜组患者的VAS、AOFAS-AH、SF-36评分及患者满意度评分均高于传统手术组(P值均2.14±1.46)°比(53.13±1.52.°;t=2..315,P2.43)°;t=0.531,P=0.599]。影像学检查结果显示,全内镜组腓骨沟加深情况优于传统手术组。结论优先切开腱鞘的全内镜下手术与传统开放手术相比具有微创的优势,患者术后恢复快,短期效果良好。

关键词：肌腱病腓骨腓骨肌腱滑脱关节镜踝关节腓骨肌腱微创肌腱镜

高职课程学业表现性评价的任务框架设计与评分量规设计

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中国职业技术教育 2024年第11期 76-85页

作者：殷明季琼广东白云学院北京劳动保障职业学院

高等职业教育侧重于培养职业性、应用型的高素质技术技能人才,在课程教学中注重能力本位与工作任务情境,传授“功能性知识”,课程学业更适合采用表现性评价以衡量学生的认知思维与推理技能,以及运用知识解决现实、有意义的问题的能力。... 详细信息

高等职业教育侧重于培养职业性、应用型的高素质技术技能人才,在课程教学中注重能力本位与工作任务情境,传授“功能性知识”,课程学业更适合采用表现性评价以衡量学生的认知思维与推理技能,以及运用知识解决现实、有意义的问题的能力。表现性评价设计的核心包括评价任务设计与评分量规设计。评价任务设计框架包括主题内容、行动或实践、情境、意义,以有效地引发学生“证明其习得功能性知识”的表现。评分量规设计框架包括评分指标、指标权重、质量水平层次、水平分值、标准描述,可作为表现性评价设计具体步骤的参考,最终促进高职课程教学实践更好实现育人效果。

关键词：高职课程学业表现性评价任务框架设计评分量规设计

Quantum synchronization with correlated baths

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Chinese Physics B 2024年第2期33卷 152-157页

作者：李磊王春辉尹洪浩王如泉刘伍明 School of Physical Science and Technology Inner Mongolia UniversityHohhot 010021China Beijing National Laboratory for Condensed Matter Physics Institute of PhysicsChinese Academy of SciencesBeijing 100190China

We study quantum synchronization under the nonequilibrium *** consider a two-qubit XXZ chain coupled independently to their own reservoirs modeled by the collisional *** reservoir particles,initially prepared in a thermal state or a state with coherence,are correlated through a unitary transformation and afterward interact locally with the two quantum *** study the quantum effect of reservoir on synchronous dynamics of *** preparing different reservoir initial states or manipulating the reservoir particles coupling and the temperature gradient,we find that quantum entanglement of reservoir is the key to control quantum synchronization of system qubits.

关键词： quantum synchronization entanglement quantum coherence nonequilibrium reservoir