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The role of radical prostatectomy and definitive external beam radiotherapy in combined treatment for high-risk prostate cancer:a systematic review and meta-analysis

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Asian Journal of Andrology 2020年第4期22卷 383-389页

作者： Xu Cheng Zhi-Hui wang Mou Peng Zhi-Chao Huang Lu Yi Yi-Jian Li Lei Yi Wen-Zhi Luo Jia-Wen Chen yin-huai wang Department of Urology The Second Xiangya Hospital of Central South UniversityChangsha 410011China T.H.Chan School of Public Health Harvard UniversityBostonMA 02115USA

The first-line treatment options for high-risk prostate cancer(PCa)are definitive external beam radiotherapy(EBRT)with or without androgen deprivation therapy(ADT)and radical prostatectomy(RP)with or without adjuvant ***,few randomized trials have compared the survival outcomes of these two *** systematically evaluate the survival outcomes of high-risk PCa patients treated with EBRT-or RP-based therapy,a comprehensive and up-to-date meta-analysis was performed.A systematic online search was conducted for randomized or observational studies that investigated biochemical relapse-free survival(bRFS),cancer-specific survival(CSS),and/or overall survival(OS),in relation to the use of RP or EBRT in patients with high-risk *** summary hazard ratios(HRs)were estimated under the random effects *** identified heterogeneity between studies using Q tests and measured it using I2 *** evaluated publication bias using funnel plots and Egger's regression asymmetry *** studies(including one randomized controlled trial[RCT])of low risk of bias were selected and up to 9504 patients were *** comparing EBRT-based treatment with RP-based treatment,the pooled HRs for bRFS,CSS,and OS were 0.40(95%confidence interval[CI]:0.24–0.67),1.36(95%CI:0.94–1.97),and 1.39(95%CI:1.18–1.62),*** OS for RP-based treatment and better bRFS for EBRT-based treatment have been identified,and there was no significant difference in CSS between the two ***-based treatment is recommended for high-risk PCa patients who value long-term survival,and EBRT-based treatment might be a promising alternative for elderly patients.

关键词： high risk prostatectomy prostatic neoplasms radiotherapy survival

FedCLCC:A personalized federated learning algorithm for edge cloud collaboration based on contrastive learning and conditional computing

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Defence Technology(防务技术) 2025年第1期43卷 80-93页

作者： Kangning yin Xinhui Ji Yan wang Zhiguo wang School of Information and Software Engineering University of Electronic Science and Technology of ChinaChengdu611731China Institute of Public Security Kash Institute of Electronics and Information IndustryKashi844000China

Federated learning(FL)is a distributed machine learning paradigm for edge cloud *** can facilitate data-driven decision-making in tactical scenarios,effectively addressing both data volume and infrastructure challenges in edge ***,the diversity of clients in edge cloud computing presents significant challenges for *** federated learning(pFL)received considerable attention in recent *** example of pFL involves exploiting the global and local information in the local *** pFL algorithms experience limitations such as slow convergence speed,catastrophic forgetting,and poor performance in complex tasks,which still have significant shortcomings compared to the centralized *** achieve high pFL performance,we propose FedCLCC:Federated Contrastive Learning and Conditional *** core of FedCLCC is the use of contrastive learning and conditional *** learning determines the feature representation similarity to adjust the local *** computing separates the global and local information and feeds it to their corresponding heads for global and local *** comprehensive experiments demonstrate that FedCLCC outperforms other state-of-the-art FL algorithms.

关键词： Federated learning Statistical heterogeneity Personalized model Conditional computing Contrastive learning

Adsorption of typical NDMA precursors by superfine powdered activated carbon:Critical role of particle size reduction

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Journal of Environmental Sciences 2025年第1期147卷 101-113页

作者： ying wang Zhichen Zhang Zhihang yin Jun wang Xiaojian Zhang Chao Chen State Key Joint Laboratory of Environmental Simulation and Pollution Control School of EnvironmentTsinghua UniversityBeijing 100084China Research Institute for Environmental Innovation(Suzhou) TsinghuaSuzhou 215163China

Control of N-nitrosodimethylamine(NDMA)in drinking water could be achieved by removing its precursors as one practical ***,superfine powdered activated carbons with a diameter of about 1μm(SPACs)were successfully prepared by grinding powdered activated carbon(PAC,D50=24.3μm)and applied to remove model NDMA precursors,***(RAN)and nizatidine(NIZ).Results fromgrain diameter experiments demonstrated that the absorption velocity increased dramatically with decreasing particle size,and the maximum increase in k2 was 26.8-folds for RAN and 33.4-folds for ***,kinetic experiments explained that rapid absorption could be attributed to the acceleration of intraparticle diffusion due to the shortening of the diffusion ***,performance comparison experiments suggested that the removal of RAN and NIZ(C_(0)=0.5 mg/L)could reach 61.3%and 60%,respectively,within 5 min,when the dosage of SAPC-1.1(D_(50)=1.1μm)was merely 5 mg/L,while PAC-24.3 could only eliminate 17.5%and 18.6%.The adsorption isotherm was well defined by Langmuir isotherm model,indicating that the adsorption of RAN/NIZ was a monolayer coverage *** adsorption of RAN or NIZ by SAPC-1.1 and PAC-24.3 was strongly pH dependent,and high adsorption capacity could be observed under the condition of pH>pk_(a)+*** coexistence of humic acid(HA)had no significant effect on the adsorption performance because RAN/NIZ may be coupled with HA and removed *** coexistence of anions had little effect on the adsorption *** study is expected to provide an alternative strategy for drinking water safety triggered by NDMA.

关键词： Adsorption NDMA Kinetics Superfine powdered activated carbon Intraparticle diffusion Drinking water

Toxicity variability in Alexandrium pacificum isolated from East China Sea:impact of temperature and light intensity

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Journal of Oceanology and Limnology 2025年第1期43卷 147-158页

作者： Xuexia ZHU Tianchi yin Min PANG Jun wang The First Institute of Oceanography Ministry of Natural Resources of the People’s Republic of ChinaQingdao 266061China College of Animal Science and Technology Yangzhou UniversityYangzhou 225009China College of Oceanography Hohai UniversityNanjing 210098China

Suitable temperature and light intensity play important roles in the formation of harmful algae blooms(HABs),which can pose serious threats to aquatic ecosystems and human *** this study,we measured the growth,physiological function,and paralytic shellfish toxins(PSTs)production of Alexandrium pacificum(CCMA-272),a strain isolated from East China Sea,at different temperatures(15,20,and 25℃)and light intensities(30,60,and 90μmol photons/(m^(2)·s)).Results indicate that temperature and light intensity significantly affected the growth,physiology,and toxigenic potentials of *** optimal conditions for the growth of *** were observed at 20℃ under60μmol photons/(m^(2)·s).Regarding the production of PSTs,this strain of *** produced 12 PSTs,including carbamate toxins:saxitoxin(STX),neosaxitoxin(NEO),and gonyautoxin 1–4(GTX1,GTX2,GTX3,GTX4);dicarbamoyl toxins:dicarbamoylsaxitoxin(dcSTX),dicarbamoylgonyautoxin 2,3(dcGTX2,dcGTX3);and N-sulfocarbamoyl toxins:N-sulfocarbamoylgonyautoxin 1,2(C1,C2),and gonyautoxin 5(GTX5).Among all the PSTs,C2 was the most *** temperature(15℃)and high light intensity(90μmol photons/(m^(2)·s))were beneficial for the production of PSTs in *** cultured at 20 and 25℃,*** generated comparable total quantities of PSTs,yet the toxicity levels were lower at 25℃.Intra-cellular PSTs contents were greater than extra-cellular PSTs contents,except those under the condition of 25℃ with 30μmol photons/(m^(2)·s).However,as the increase of temperature,*** released more amounts of analogues with higher toxicity levels(e.g.,STX and dcGTX_(2))into the environment than *** findings emphasize the significant sensitivity of *** to temperature and light intensity,highlighting the importance of evaluating both intra-cellular and extra-cellular PSTs for assessing its toxicity and aiding in the prediction and management of HABs.

关键词： temperature light intensity Alexandrium pacificum paralytic shellfish toxin harmful algal bloom

Effect of pouring time on microstructure and mechanical properties of centrifugal cast Ti-46Al alloy tubes

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China Foundry 2025年第1期22卷 65-74页

作者： Gang Huang Qian Dang Cong-cong Su Jing Zhao Chi Zhang Guo-huai Liu Zhao-dong wang The State Key Laboratory of Rolling and Automation Northeastern UniversityShenyang 110819China School of Materials Science and Engineering Shenyang University of TechnologyShenyang 110870China

The grain size of TiAl alloy castings prepared by traditional casting process is coarse,thus showing poor mechanical *** this study,a new type of high performance Ti-46Al alloy tube prepared by vacuum centrifugal casting technology was *** research comprehensively examined the influence of pouring time on the microstructure and mechanical performance of the castings,employing both experimental approaches and ProCast simulation *** findings indicate that prolonging the pouring time facilitates a microstructural evolution from coarse columnar grains to refined equiaxed *** the condition of pouring temperature of 1,600℃,rotation speed of 800 r·min^(-1) and pouring time of 6 s,the tensile strength of Ti-46Al alloy at room temperature reaches 650 MPa,and the tensile strength at 800℃ reaches 705 MPa,which is significantly higher than that of traditional as-cast Ti-Al alloy.

关键词： vacuum induction melting centrifugal casting Ti-46Al alloy pouring time Ti-Al alloy tubes

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Assessing microcatheter-assisted 360-degree trabeculotomy combined with trabeculectomy for refractory glaucoma:1-year results

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International Journal of Ophthalmology(English edition) 2025年第1期18卷 94-102页

作者： Jia-yin Qin Yan Liu Tao wang Department of Ophthalmology Peking University International HospitalBeijing 102206China Beijing Key Laboratory of Ophthalmology and Visual Science Beijing Tongren Eye CenterBeijing Tongren HospitalCapital Medical UniversityBeijing 100730China

AIM:To evaluate the efficacy and safety of microcatheterassisted 360-degree trabeculotomy combined with trabeculectomy(MATT-Trab)for treating refractory ***:Patients with refractory glaucoma who underwent MATT-Trab were retrospectively *** indicators for research statistics included the intraocular pressure(IOP)level,degree of decrease,changes in medication dosage,and success *** indicators included the best-corrected visual acuity and incidence of ***:This study comprised 31 patients,including 11 males and 20 females,with ages ranging from 8mo to 67y(mean age:29.40±22.10y).The average postoperative IOP at 1d,1wk,1mo,3mo,6mo,1y,and the last followup was significantly lower than the average preoperative IOP(31.33±9.24 mm Hg,P<0.05).The average number of postoperative medications at 1y was 0.48±1.51,which was significantly reduced compared to that used preoperatively(3.77±0.99,P=0.00).The absolute and qualified success rates were 45.16% and 83.87%,*** acuity exhibited no statistically significant difference between the postoperative and preoperative follow-up time points,except for the first day after *** most common postoperative complications were anterior chamber hemorrhage(25 cases,86.21%)and high IOP(10 cases,34.48%).CONCLUSION:Our results indicate that MATT-Trab is effective and safe for treating refractory glaucoma.

关键词： glaucoma refractor y glaucoma trabeculotomy trabeculectomy microcatheter

Vibration safety assessment and parameter analysis of buried oil pipelines based on vibration isolation holes under strong surface impact

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Earthquake Engineering and Engineering Vibration 2025年第1期24卷 69-82页

作者： wang Guobo Mei Hua wang Jianning He Wei yin Yao Zhai Yuxin Zuo Pengfei College of Civil Engineering and Architecture Wenzhou UniversityWenzhou 325035China Zhejiang Engineering Research Center of Disaster Prevention and Mitigation for Coastal Soft Soil Foundation WenZhou 325035China China National Machinery Industry Co. Ltd.Beijing 100080China Faculty of Engineering China University of GeosciencesWuhan 430074China China Railway Construction Group Co. Ltd.Beijing 100072China School of Civil Engineering and Architecture Wuhan University of TechnologyWuhan 430070China

Strong surface impact will produce strong vibration,which will pose a threat to the safety of nearby buried pipelines and other important lifeline *** on the verified numerical method,a comprehensive numerical parameter analysis is conducted on the key influencing factors of the vibration isolation hole(VIH),which include hole diameter,hole net spacing,hole depth,hole number,hole arrangement,and soil *** results indicate that a smaller ratio of net spacing to hole diameter,the deeper the hole,the multi-row hole,the hole adoption of staggered arrangements,and better site soil conditions can enhance the efficiency of the VIH *** average maximum vibration reduction efficiency within the vibration isolation area can reach 42.2%.The vibration safety of adjacent oil pipelines during a dynamic compaction projection was evaluated according to existing standards,and the measurement of the VIH was recommended to reduce excessive *** single-row vibration isolation scheme and three-row staggered arrangement with the same hole parameters are suggested according to different *** research findings can serve as a reference for the vibration safety analysis,assessment,and control of adjacent underground facilities under the influence of strong surface impact loads.

关键词： vibration isolation hole buried oil pipeline strong surface impact vibration velocity vibration safety assessment

A robust statistical prediction model for late-summer heavy precipitation days in North China

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Science China Earth Sciences 2025年第1期68卷 158-171页

作者： Shunli JIANG Tingting HAN Xin ZHOU Huijun wang Zhicong yin Xiaolei SONG Collaborative Innovation Center on Forecast and Evaluation of Meteorological Disasters/Key Laboratory of Meteorological Disaster Ministry of EducationNanjing University for Information Science and TechnologyNanjing210044China Nansen-Zhu International Research Centre Institute of Atmospheric PhysicsChinese Academy of SciencesBeijing100029China Southern Marine Science and Engineering Guangdong Laboratory(Zhuhai) Zhuhai519080China

Recently,heavy precipitation(HP)events have occurred frequently in North China(NC),causing devastating economic losses and human ***,the short-term climate prediction of HP is quite *** year-to-year increment(DY)method and sliding correlations,we developed a robust seasonal prediction model for late-summer HP days(HPDs)in NC during 1982–2022,utilizing three independent predictors—February sea surface temperature(SST)in the Indian Ocean(SST_IO),February snow depth over North Asia(SDE_NA),and May melted snow depth in NC(MSDE_NC).The SST_IO anomalies affect NC's precipitation through the Pacific-Japan *** SDE_NA anomalies are associated with East Asian anomalous anticyclone by southeastern propagation of Rossby wave at *** MSDE_NC anomalies are followed by vertical motion and moisture anomalies in situ and thereby cause precipitation *** prediction model can well simulate the variations of the HPDs,with a correlation coefficient(CC)of 0.81(0.65)between the observed and predicted HPDs_DY(HPDs_anomaly).The percentage with the same sign for 15 extreme HPDs_anomaly years(PSSE)is 100%.Moreover,in the cross-validation test during 1982–2022,the PSSE for HPDs_anomaly is as high as 100%,along with a low rootmean-square error of *** independent hindcasts during 2013–2022,the CC between the observed and predicted HPDs_DY(HPDs_anomaly)is 0.93(0.83),together with high Nash-Sutcliffe efficiency(0.82)and agreement index(0.89).Specifically,the predictions are broadly consistent with the observations for 2015,2016,2017,2021,and 2022,reflecting excellent performance of this prediction model of HPDs in NC.

关键词： Heavy precipitation at North China Year-to-year increment approach Robust seasonal prediction Sea surface temperature Snow depth

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Rapid and specific fluorescent probe visualizes dynamic correlation of Cys and HClO in OGD/R

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Chinese Chemical Letters 2025年第1期36卷 437-441页

作者： Pei Huang Weijie Zhang Junping wang Fangjun Huo Caixia yin Institute of Molecular Science Key Laboratory of Chemical Biology and Molecular Engineering of Ministry of EducationShanxi UniversityTaiyuan 030006China Research Institute of Applied Chemistry Shanxi UniversityTaiyuan 030006China

Intracellular redox homeostasis is of indispensable importance in *** order to maintain the balance of the redox state within the cell,reactive oxygen species(ROS)and reactive sulfur species(RSS)react and transform with each other,and their levels also directly reflect the degree of oxidative stress and *** acid(HClO)and cysteine(Cys)usually co-exist in organisms,interacting with each other in many important physiological processes and synergistically maintaining the dynamic redox balance in the *** understand the relevance and pathophysiological effects of these two signaling molecules in oxidative stress,unique fluorescence imaging tools are ***,we designed and developed a dual-channel fluorescent probe HP,for the individual and continuous detection of HClO and *** probe could simultaneously monitor the changes in the concentrations of HClO and Cys in cells,and was characterized by a fast response,high sensitivity and high selectivity,especially compared with glutathione(GSH)and homocysteine(Hcy),the probe had a good specificity for ***,probe HP successfully observed dynamic changes in HCl O-and Cys-mediated redox status in the oxygenglucose deprivation/reperfusion(OGD/R)model of HeLa cells and dynamically monitored fluctuations in endogenous HClO levels in lipopolysaccharides(LPS)-induced peritonitis mice.

关键词： Redox homeostasis Dual-channel OGD/R Fluctuations Peritonitis