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An Evaluation Method of Human Gut Microbial Homeostasis by Testing Specific Fecal Microbiota

Engineering 2023年第10期29卷 110-119页

作者： Zhongwen Wu Xiaxia Pan yin Yuan Pengcheng Lou Lorina Gordejeva Shuo Ni Xiaofei zhu bowen Liu Lingyun Wu Lanjuan Li bo Li State Key Laboratory for Diagnosis and Treatment of Infectious Diseases National Clinical Research Center for Infectious DiseasesCollaborative Innovation Center for Diagnosis and Treatment of Infectious DiseasesThe First Affiliated HospitalCollege of MedicineZhejiang UniversityHangzhou 310003China Jinan Microecological Biomedicine Shandong Laboratory Jinan 250000China Research Units of Infectious Disease and Microecology Chinese Academy of Medical SciencesBeijing 100730China School of Medicine Zhejiang UniversityHangzhou 310000China Department of Orthopedic Surgery and Shanghai Institute of Microsurgery on Extremities Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiaotong University School of MedicineShanghai 200233China Department of Infectious Diseases Hangzhou Ninth People’s HospitalHangzhou 310003China Department of Radiation Oncology The First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China

Research on microecology has been carried out with broad perspectives in recent decades,which has enabled a better understanding of the gut microbiota and its roles in human health and *** is of great significance to routinely acquire the status of the human gut microbiota;however,there is no method to evaluate the gut microbiome through small amounts of fecal *** this study,we found ten predominant groups of gut bacteria that characterized the whole microbiome in the human gut from a large-sample Chinese cohort,constructed a real-time quantitative polymerase chain reaction(qPCR)method and developed a set of analytical approaches to detect these ten groups of predominant gut bacterial species with great maneuverability,efficiency,and quantitative *** ranges for the ten predominant gut bacterial groups were established,and we found that the concentration and pairwise ratios of the ten predominant gut bacterial groups varied with age,indicating gut microbial *** comparing the detection results of liver cirrhosis(LC)patients with those of healthy control subjects,differences were then analyzed,and a classification model for the two groups was built by machine *** the six established classification models,the model established by using the random forest algorithm achieved the highest area under the curve(AUC)value and sensitivity for predicting *** research enables easy,rapid,stable,and reliable testing and evaluation of the balance of the gut microbiota in the human body,which may contribute to clinical work.

关键词： Gut microbiota Machine learning Microbial dysbiosis Quantitative polymerase chain reaction Chinese cohort

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Particle mixing behavior of fine coal in density control of gas-solid separation fluidized bed

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Particuology 2020年第3期18卷 76-87页

作者： bo Lv Zhenfu Luo Yanhong Fu bo Zhang Xingzong Qin Xiangnan zhu College of Chemistry and Chemical Engineering Henan Polytechnic UniversityJiaozuo 454000China Key Laboratory of Coal Processing and Efficient Utilization of Ministry of Education China University of Mining&TechnologyXuzhou 221116China School of Chemical Engineering and Technology China University of Mining and TechnologyXuzhou 221116China School of Chemical&Environmental Engineering Shandong University of Science&TechnologyQingdao 266590China

In a gas-solid separation fluidized bed,mixing of fine coal is necessary to achieve a suitable bed density to enable effective separation of low rank *** the basis of a variety of mixture models,a gas-solid separation fluidized bed was judged,where fine coal particles of 0.6-1.0mm were uniformly mixed with magnetite ***-speed dynamic camera technology was combined with a slump-sampling method to study the mixing process of the fine coal in the fluidized *** results showed that limitations of the fluidized bed structure cause the mixing process to be dominated by lateral diffusion and supplemented by axial *** diffusion was mainly achieved through the ascension of bubbles,whereas lateral diffusion was determined by the bursting action of the gas bubbles at the surface of the bed and the undulating characteristics of the *** effective lateral diffusion coefficient increased exponentially with gas velocity but had no strong relationship with the bed *** the feed point moved toward the center,fine coal began to diffuse to both sides,which shortened the time for the bed density stabilization from 20 to 5 *** bed density of the layer was stabilized at approximately 1.75 g/*** separation efficiency of the gas-solid separation fluidized bed containing binary mixtures was more obvious for 6-50 mm raw coal,with a probable error E of 0.16.

关键词： Gas-solid separation fluidized bed Density control Fine coal Diffusion behavior Separation process

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Flow-field analysis of a continuous gas-solid separation fluidized bed equipped with a moving scraper

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Particuology 2021年第4期19卷 45-55页

作者： bo Lv Xiaowei Deng Chaojun Fang Xiangnan zhu College of Chemistry and Chemical Engineering Henan Polytechnic UniversityJiaozuo 454000China Henan Key Laboratory for Green and Efficient Mining&Comprehensive Utilization of Mineral Resources Henan Polytechnic UniversityJiaozuo 454000China School of Chemical&Environmental Engineering Shandong University of Science&TechnologyQingdao 266590China

Continuous gas-solid separation fluidized beds are one of the most widely used practical operation units for the dry separation of coal in China,particularly in Northwest China,and they can effectively promote the efficient and clean utilization of raw *** a continuous gas-solid separation fluidized bed,the bed flow field is the concrete manifestation of the fluidization ***,the complexity of the flow field increases under the action of a moving *** this study,a combination of computational fluid dynamics(CFD)simulations and experimental measurements was used to study the changes in the flow field of a fluidized *** results showed that when the scraper moved,the local flow field(mainly characterized by the movement of medium particles)near the scraper was affected not only by the common airflow or bubbles,but also by the lateral driving force of the *** the scraper speed was v_(l)<6.0 cm/s,it reduced the frequency of the formation of large bubbles and alleviated the random fluctuation of the nearby particle collision stress signals,which improved the fluidization stability of the ***,the movement of the scraper affected the global flow *** flow field shifted to the right near the scraper,with the direction of the scraper movement,while the flow field exhibited a leftward trend on the surface of the bed,accompanied by some vortices,in the middle and lower parts of the ***,the critical height of the area,directly affected by the scraper,increased from 52 to 54 mm with an increase in its operating speed from v_(l)=2.96 cm/s to v_(l)=4.44 cm/s,*** provides a theoretical basis for further understanding the hydrodynamic characteristics of fluidized beds.

关键词： Simulation analysis Moving scraper Flow-field Particle collision pressure Hydrodynamic characteristics

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Functionalized graphene oxide nanosheets with unique three-inone properties for efficient and tunable antibacterial applications

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Nano Research 2021年第1期14卷 185-190页

作者： bo-Yao Lu Guan-yin zhu Chen-Hao Yu Ge-Yun Chen Chao-Liang Zhang Xin Zeng Qian-Ming Chen Qiang Peng State Key Laboratory of Oral Diseases National Clinical Research Center for Oral DiseasesWest China Hospital of StomatologySichuan UntiversityChengdu 610041China

Developing antibiotics-independent antibacterial agents is of great importance since antibiotic therapy faces great challenges from drug *** oxide(GO)is a promising agent due to its natural antibacterial mechanisms,such as sharp edgemediated cutting ***,the antibacterial activity of GO is limited by its negative charge and low photothermal ***,the amino-functionalized GO nanosheets(AGO)with unique three-in-one properties were *** essential properties(positive charge,strong photothermal effect,and natural cutting effect)were integrated into *** positive charge(30 mV)rendered AGO a strong interaction force with model pathogen Streptococcus mutans(330 nN).The natural cutting effect of 100 ng·mL^(-1)AGO caused 27%loss of bacterial viability after incubation for 30 *** importantly,upon the near-infrared irradiation for just 5 min,the three-in-one properties of AGO caused 98%viability *** conclusion,the short irradiation period and the tunable antibacterial activity confer the three-in-one AGO a great potential for clinical use.

关键词： nanoparticles nanomaterials carbon nano-bio interaction dental caries antimicrobial

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SSUH model: A small-strain extension of the unified hardening model

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Science China(Technological Sciences) 2016年第2期59卷 225-240页

作者： YAO YangPing QU Shan yin ZhenYu zhu EnYang School of Transportation Science and Engineering Beihang University Key Laboratory of Geotechnical and Underground Engineering of Ministry of Education Tongji University LUNAM University Ecole Centrale de NantesUMR CNRS GeM School of Civil Engineering North China University of Technology

A small strain unified hardening(SSUH) model is proposed in the present study to tackle the small strain behavior of clay. The model is an extension of the unified hardening(UH) model for overconsolidated(OC) clays accounting for the small strain stiffness. The new features of the SSUH model over the UH model include:(a) a new elastic hysteretic stress-strain relationship to evaluate the stiffness degradation at small strains and to generate the hysteresis loop under cyclic loading condition;(b) a revised unified hardening parameter to enhance the plastic stiffness at small strains; and(c) a new overconsolidation parameter, which is crucial to make the UH model working with the elastic hysteretic stress-strain relationship effectively. With these enhancements, the SSUH model can describe a high initial stiffness and the highly nonlinear stress-strain relationship at small strains, in addition to the shear dilatancy and strain hardening/softening behaviors of OC clays at large strains. In comparison with the Modified Cam-clay(MCC) model, the proposed model needs two more small strain related parameters, which can be easily obtained from laboratory tests. Finally, some drained triaxial compression tests at large strains, drained triaxial compression/extension tests at small strains, an undrained compression test at small strains and a drained cyclic constant radial stress test are employed to validate the new model.

关键词： small strain overconsolidated clays constitutive model stiffness degradation nonlinearity

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Enhanced hydrogen storage performance of Mg-Cu-Ni system catalyzed by CeO2 additive

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Journal of Rare Earths 2020年第9期38卷 983-993,I0003页

作者： Yi yin bo Li Zeming Yuan Yan Qi Yanghuan Zhang Department of Functional Material Research Central Iron and Steel Research InstituteBeijing 100081China Key Laboratory of Integrated Exploitation of Baiyun Obo Multi-Metal Resources Inner Mongolia University of Science and TechnologyBaotou 014010China

In this paper,the as-cast Mg85Cu5Ni10 alloy and Mg85Cu5Ni10-x wt%CeO2(x=0,4,8)alloys were prepared successfully by vacuum induction smelting and ball *** microstructure,hydrogen absorption/desorption kinetics and thermodynamics performances of the alloys were studied in *** results show that the Mg85Cu5Ni10 alloys with CeO2 additive have faster hydrogenation/dehydrogenation kinetics and better thermodynamic *** dehydrogenation activation energy is reduced to 81.211 kJ/mol from 119.142 by adding 8 wt%***2 contributes to producing structural defects,nanocrystallines,grain boundaries,partial amorphous,lattice dislocations and cracks which are favorable to provide more hydrogen diffusion channels during hydriding/dehydriding ***,CeO2 additive weakens the bond energy of *** micro structural changes caused by CeO2 additive improve the hydrogen storage performance of Mg85Cu5Ni10 markedly.

关键词： Mg-Cu-Ni alloy CeO2 additive Ball milling Dehydrogenation activation energy Thermodynamic property

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Oxidization resistance of Ni76Cr19AlTi valve alloy at temperatures under operating mode of heavy-duty engines

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Rare Metals 2007年第1期26卷 45-50页

作者： zhu Yuanzhi yin Zhimin HUANG Jiwu TENG Hao School of Materials and Metallurgy Wuhan University of Science and Technology Wuhan 430081 China School of Materials Science and Engineering Central South University Changsha 410083 China

The oxidization resistance of the Ni76Cr19A1Ti alloy was studied by a static oxidization experiment at 600-800℃. The results show that the oxidation behavior of the alloy can be explained by a kinetic equation：（△m/S）2 = Kpt ＋ C, where Kp is a kinetic constant of the nickel-base alloy. The higher the experimental temperature, the higher the value of Kp. It is discovered that the microstructure of the oxide scales is compact and the thickness of it is less than 10 μm The oxidization of the alloy is in the first grade. It is also found that the oxide scales are mainly composed of Cr2O3 and TiO2. Chrome and titanium react more easily with oxygen at temperatures under the operating mode.

关键词： nickel-based alloy exhaust valve, heavy-duty engine, operating mode oxidation kinetics

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borophene–graphene heterostructure: Preparation and ultrasensitive humidity sensing

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Nano Research 2021年第7期14卷 2337-2344页

作者： Chuang Hou Guo'an Tai bo Liu Zenghui Wu Yonghe yin The State Key Laboratory of Mechanics and Control of Mechanical Structures and Laboratory of Intelligent Nano Materials and Devices of Ministry of Education College of Aerospace EngineeringNanjing University of Aeronautics and AstronauticsNanjing 210016China

Heterostructure has triggered a surge of interest due to its synergistic effects between two different layers,which contributes to desirable physical properties for extensive potential *** stable borophene is becoming a promising candidate for constructing two-dimensional(2D)heterostructures,but it is rarely prepared by suitable synthesis conditions ***,we demonstrate that a novel heterostructure composed of hydrogenated borophene and graphene can be prepared by heating the mixture of sodium borohydride and few-layered graphene followed by stepwise and in situ thermal decomposition of sodium borohydride under high-purity hydrogen as the carrier *** fabricated borophene–graphene heterostructure humidity sensor shows ultrahigh sensitivity,fast response,and long-time *** sensitivity of the fabricated borophene-based sensor is near 700 times higher than that of pristine graphene one at the relative humidity of 85%*** sensitivity of the sensor is highest among all the reported chemiresistive sensors based on 2D ***,the performance of the borophene–graphene flexible sensor maintains good stability after bending,which shows that the borophene-based heterostructures can be applied in wearable *** observed high performance can be ascribed to the well-established charge transfer mechanism upon H2O molecule *** study further promotes the fundamental studies of interfacial effects and interactions between boron-based 2D heterostructures and chemical species.

关键词： borophene graphene heterostructure humidity sensor two-dimensional materials

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Comprehensive utilization of solid waste resources: Development of wet shotcrete for mines

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International Journal of Minerals,Metallurgy and Materials 2023年第9期30卷 1692-1704页

作者： Yafei Hu Shenghua yin Keqing Li bo Zhang Bin Han School of Civil and Resource Engineering University of Science and Technology BeijingBeijing 100083China Key Laboratory of Ministry of Education of China for Efficient Mining and Safety of Metal Mines University of Science and Technology BeijingBeijing 100083China

The development of solid waste resources as constituent materials for wet shotcrete has significant economic and environmental advantages. In this study, the concept of using tailings as aggregate and fly ash and slag powder as auxiliary cementitious material is proposed and experiments are carried out by response surface methodology(RSM). Multivariate nonlinear response models are constructed to investigate the effect of factors on the uniaxial compressive strength(UCS) of tailings wet shotcrete(TWSC). The UCS of TWSC is predicted and optimized by constructing Gaussian process regression(GPR) and genetic algorithm(GA). The UCS of TWSC is gradually enhanced with the increase of slag powder dosage and fineness modulus, and it is enhanced first and then decreased with the increase of fly ash dosage. The microstructure of TWSC has the highest gray value and the highest UCS when the fly ash dosage is about 120 kg·m^(-3). The GPR–GA model constructed in this study achieves high accuracy prediction and optimization of the UCS of TWSC under multi-factor conditions.

关键词： tailings solid waste wet shotcrete machine learning mix proportion

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Numerical and Experimental Investigation on the Performance of Lean Burn Catalytic Combustion for Gas Turbine Application

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Journal of Thermal Science 2015年第2期24卷 185-193页

作者： Juan yin Yi-wu WENG Jun-qiang zhu Institute of Engineering Thermophysics Chinese Academy of Sciences Shanghai Jiao Tong University

This manuscript presents our numerical and experimental results regarding the performance characteristics of lean bum catalytic combustion for gas turbine application. The reactant transport was assumed to be controlled by both bulk diffusion as well as surface kinetics, implemented by means of an approximate reaction rate equation and empirical coefficients to incorporate reaction mechanism. Experimental and numerical results were compared to examine the effects of methane mole fraction, inlet temperature, operating pressure, velocity and hydrogen spe- cies on combustion intensity. The results indicate that inlet temperature is the most significant parameter that im- pacts operation of the catalytic combustor and the most effective methods for improving the methane conversion are increasing the inlet temperature and increasing the methane mole fraction. Simulations from ID heterogene- ous plug flow model can capture the trend of catalytic combustion and describe the behavior of the catalytic mo- nolith in detail. The addition of hydrogen will provide heat release by the exothermie combustion reaction so that the reactants reach a temperature at which methane oxidation can light-off.

关键词： Lean burn catalytic combustion performance gas turbine

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