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Granulomatous mastitis in a 50-year-old male:A case report and review of literature

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World Journal of Clinical Cases 2024年第2期12卷 451-459页

作者： Le-yin Cui chen-ping Sun Yun-Yuan Li Sheng Liu Department of Breast Surgery Longhua Hospital Shanghai University of Traditional Chinese MedicineShanghai 200032China Department of Pathology Longhua Hospital Shanghai University of Traditional Chinese MedicineShanghai 200032China Graduate School Shanghai University of Traditional Chinese MedicineShanghai 201203China

BACKGROUND Granulomatous mastitis(GM)an inflammatory disease of the breast that usually affects women of childbearing age,occurs very rarely in males.CASE SUMMARY We present a case study of a 50-year-old male patient with GM.The patient developed a breast lump following the cleaning of a previously embedded dirtfilled nipple.While an initial improvement was noted with antibiotic therapy,a recurrence occurred a year later,showing resistance to the previously effective antibiotics.Subsequently,the lesion was excised.The histopathological examination confirmed the diagnosis of GM.CONCLUSION GM should be considered a possible diagnosis of male breast masses.

关键词： Granulomatous mastitis Male Pathology Differential diagnosis Case report

Quantum Neural Network for Quantum Neural Computing

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Research 2024年第1期2023卷 71-80页

作者： Min-Gang Zhou Zhi-ping Liu Hua-Lei yin chen-Long Li Tong-Kai Xu Zeng-Bing chen National Laboratory of Solid State Microstructures School of PhysicsCollaborative Innovation Center of Advanced MicrostructuresNanjing UniversityNanjing 210093China MatricTime Digital Technology Co.Ltd. Nanjing 211899China

Neural networks have achieved impressive breakthroughs in both industry and academia.How to effectively develop neural networks on quantum computing devices is a challenging open problem.Here,we propose a new quantum neural network model for quantum neural computing using(classically controlled)single-qubit operations and measurements on real-world quantum systems with naturally occurring environment-induced decoherence,which greatly reduces the difficulties of physical implementations.Our model circumvents the problem that the state-space size grows exponentially with the number of neurons,thereby greatly reducing memory requirements and allowing for fast optimization with traditional optimization algorithms.We benchmark our model for handwritten digit recognition and other nonlinear classification tasks.The results show that our model has an amazing nonlinear classification ability and robustness to noise.Furthermore,our model allows quantum computing to be applied in a wider context and inspires the earlier development of a quantum neural computer than standard quantum computers.

关键词： quantum thereby breakthrough

Moyamoya syndrome may result from psoriasis: Four case reports

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World Journal of Clinical Cases 2024年第10期12卷 1830-1836页

作者： Zhi-ying chen Xiao-Qin Yu Yuan-Yuan Xiang Ling-Hua Liu Xiao-ping yin Department of Neurology The Affiliated Hospital of Jiujiang UniversityJiujiang 332000Jiangxi ProvinceChina Department of Dermatology The Affiliated Hospital of Jiujiang UniversityJiujiang 332000Jiangxi ProvinceChina

BACKGROUND Moyamoya syndrome(MMS)is a group of diseases that involves more than one underlying disease and is accompanied by moyamoya vascular phenomena.Psoriasis is a chronic immune skin disease closely linked to high blood pressure and heart disease.However,psoriasis-related MMS has not been reported.CASE SUMMARY We collected data on patients with stroke due to MMS between January 2017 and December 2019 and identified four cases of psoriasis.Case histories,imaging,and hematological data were collected.The average age of the initial stroke onset was 58.25±11.52 years;three cases of hemorrhagic and one case of ischemic stroke were included.The average duration from psoriasis confirmation to the initial MMS-mediated stroke onset was 17±3.56 years.All MMS-related stenoses involved the bilateral cerebral arteries:Suzuki grade III in one case,grade IV in two cases,and grade V in one case.Abnormally elevated plasma interleukin-6 levels were observed in four patients.Two patients had abnormally elevated immunoglobulin E levels,and two had thrombocytosis.All four patients received medication instead of surgery.With an average follow-up time of 2 years,two causing transient ischemic attacks occurred in two patients,and no hemorrhagic events occurred.CONCLUSION Psoriasis may be a potential risk factor for MMS.Patients with psoriasis should be screened for MMS when they present with neurological symptoms.

关键词： Moyamoya syndrome Psoriasis Stroke Interleukin-6 Immune Hypertension Case report

Manipulating submolecular-scale phototautomerization

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Science China Materials 2024年第6期67卷 2048-2050页

作者： ping Zhou Hongliang chen Stoddart Institute of Molecular Science Department of ChemistryZhejiang UniversityHangzhou 310058China Zhejiang-Israel Joint Laboratory of Self-Assembling Functional Materials ZJU-Hangzhou Global Scientific and Technological Innovation CenterZhejiang UniversityHangzhou 311215China

A recent study on the submolecular-scale control of phototautomerization methods and the underlying reaction mechanisms was reported in Nature Nanotechnology by Guillaume and co-workers[1],elucidating how the field confinement effect generated by the scanning tunneling microscope(STM)tip precisely triggers the phototautomerization of a free-base phthalocyanine at the submolecular level and demonstrating that the reaction process can be finely controlled by adjusting either the laser excitation wavelength or the position of the tip.

关键词： tunneling excitation phthalocyanine

Chemoselective and Living/Controlled Polymerization of Alkenyl Methacrylates by the Phosphonium Ylide/Organoaluminum Lewis Pairs

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Chinese Journal of Polymer Science 2024年第2期42卷 159-167,I0005页

作者： Zhi-Kang chen Wu-Chao Zhao Yi-Ling Zhao Cong-Lei Liu Liu-yin Jiang Yue-Tao Zhang Hong-ping Zhu State Key Laboratory of Physical Chemistry of Solid Surfaces College of Chemistry and Chemical EngineeringXiamen UniversityXiamen361005China State Key Laboratory of Supramolecular Structure and Materials College of ChemistryJilin UniversityChangchun130012China

Chemoselective,living/controlled polymerizations of allyl methacrylate(AMA) and vinyl methacrylate(VMA) with/without methyl methacrylate(MMA) by using the phosphonium ylide/organoaluminum based Lewis pairs(LPs) have been realized.The P-ylide-2/AIMe(BHT)_(2)(Pylide-2=Ph_(3)P=CHMe and BHT=2,6-iBu_(2)-4-MeC_(6)H_(2)O) was demonstrated to be superior by which homopolymers PAMAs(M_(n)=27.6-111.5kg/mol and ■=1.14-1.25) and PVMAs(M_(n)=28.4-78.4 kg/mol and ■=1.12-1.18) and block copolymers PMMA-b-PAMA,PAMA-b-PVMA,PAMA-bPMMA,PMMA-b-PAMA-b-PMMA,PAMA-b-PMMA-b-PAMA,and PAMA-b-PVMA-b-PAMA were synthesized.In the polymerizations,all of the monomers were reacted by the conjugated ester vinyl groups leaving intactly the nonconjugated acryloxy groups.The pendant acryloxy groups attached to the main chain enable further to post-functionalization by the AIBN-induced radical "thiol-ene" reaction using PhCH_(2)SH.The thiolether side group-containing polymers PAMA-SCH_(2)Ph and PAMA-SCH_(2)Ph-b-PMMA-b-PAMA-SCH_(2)Ph were thus prepared.

关键词： Phosphonium ylide Alkenyl methacrylate Chemoselectivity Living/controlled polymerization Post-functionalization

Identification and characterization of camptothecin tailoring enzymes in Nothapodytes tomentosa

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Journal of Integrative Plant Biology 2024年第6期66卷 1158-1169页

作者： yin chen Jian-ping Huang Yong-Jiang Wang Meng-Ling Tu Junheng Li Bingyan Xu Guoqing Peng Jing Yang Sheng-Xiong Huang State Key Laboratory of Phytochemistry and Plant Resources in West China and Yunnan Key Laboratory of Natural Medicinal Chemistry Kunming Institute of BotanyChinese Academy of SciencesKunming 650201China University of Chinese Academy of Sciences Beijing 100049China Key Laboratory for Economic Plants and Biotechnology Kunming Institute of BotanyChinese Academy of SciencesKunming 650201China

Camptothecin is a complex monoterpenoid indole alkaloid with remarkable antitumor activity.Given that two C-10 modified camptothecin derivatives,topotecan and irinotecan,have been approved as potent anticancer agents,there is a critical need for methods to access other aromatic ringfunctionalized congeners(e.g.,C-9,C-10,etc.).However,contemporary methods for chemical oxidation are generally harsh and low-yielding when applied to the camptothecin scaffold,thereby limiting the development of modified derivatives.Reported herein,we have identified four tailoring enzymes responsible for C-9 modifications of camptothecin from Nothapodytes tomentosa,via metabolomic and transcriptomic analysis.These consist of a cytochrome P450(Nt CPT9H)which catalyzes the regioselective oxidation of camptothecin to 9-hydroxycamptothecin,as well as two methyltransferases(Nt OMT1/2,converting 9-hydroxycamptothecin to 9-methoxycamptothecin),and a uridine diphosphate-glycosyltransferase(Nt UGT5,decorating 9-hydroxycamptothecin to9-β-D-glucosyloxycamptothecin).Importantly,the critical residues that contribute to the specific catalytic activity of Nt CPT9H have been elucidated through molecular docking and mutagenesis experiments.This work provides a genetic basis for producing camptothecin derivatives through metabolic engineering.This will hasten the discovery of novel C-9 modified camptothecin derivatives,with profound implications for pharmaceutical manufacture.

关键词： camptothecin biosynthesis enzymatic assay Nothapodytes tomentosa tailoring enzyme transcriptomic analysis

Effect of biochar application on rice,wheat,and corn seedlings in hydroponic culture

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Journal of Environmental Sciences 2024年第1期135卷 379-390页

作者： yingjie yin Jikai Li Sihang Zhu Qing chen Chong chen Yukui Rui Jianying Shang College of Land Science and Technology China Agricultural UniversityKey Laboratory of Plant-Soil InteractionsMinistry of Educationand Key Laboratory of Arable Land Conservation in North ChinaMinistry of Agriculture and Rural AffairsBeijing 100193China Agricultural Management Institute Ministry of Agriculture and Rural AffairsBeijing 102208China College of Resources and Environmental Sciences China Agricultural UniversityBeijing Key Laboratory of Farmland Soil Pollution Prevention and RemediationBeijing 100193China

In recent years,biochar has attracted considerable attention for soil quality improvement and carbon sequestration due to its unique physicochemical properties.However,the mechanism by which biochar application negatively affects the growth of crop seedlings has not been fully investigated.In this study,a hydroponic experiment was conducted to evaluate the response of rice,wheat,and corn seedlings to biochar application(CK,0 g/L;BC1,0.5 g/L;and BC2,1.0 g/L).Compared with the CK treatment,the BC1 and BC2 treatments decreased the fresh shoot and root weights of rice and corn seedlings(P0.05).For the contents of nutrient elements in seedlings,both BC1 and BC2 treatments hindered the roots from absorbing Fe and Cu and increased the uptake of Ca and Mn.Compared with the CK treatment,the translocation factor(TF)values of Ca,Mn,and Zn were significantly decreased especially in rice seedlings(35.3%-36.8%,68.7%-76.5%,and 29.8%-22.0%,respectively)under the BC1 and BC2 treatments,while only Mn was significantly decreased in wheat and corn seedlings(P<0.05).Transmission electron microscope(TEM)analysis of root cross-sections showed that nano-sized biochar particles(10~23 nm)were found in the root cells under BC2 treatment conditions.Our findings reveal that a large amount of biochar application can reduce nutrient absorption and translocation,and hinder rice,wheat,and corn seedlings,particularly rice seedling,in hydroponic system.

关键词： Biochar Toxicity Seedling growth Hydroponic cultivation

Privacy-Preserving Consensus-Based Distributed Economic Dispatch of Smart Grids via State Decomposition

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IEEE/CAA Journal of Automatica Sinica 2024年第5期11卷 1250-1261页

作者： Wei chen Guo-ping Liu The authors are with the Center for Control Science and Technology Southern University of Science and TechnologyShenzhen 518055China

This paper studies the privacy-preserving distributed economic dispatch(DED)problem of smart grids.An autonomous consensus-based algorithm is developed via local data exchange with neighboring nodes,which covers both the islanded mode and the grid-connected mode of smart grids.To prevent power-sensitive information from being disclosed,a privacy-preserving mechanism is integrated into the proposed DED algorithm by randomly decomposing the state into two parts,where only partial data is transmitted.Our objective is to develop a privacy-preserving DED algorithm to achieve optimal power dispatch with the lowest generation cost under physical constraints while preventing sensitive information from being eavesdropped.To this end,a comprehensive analysis framework is established to ensure that the proposed algorithm can converge to the optimal solution of the concerned optimization problem by means of the consensus theory and the eigenvalue perturbation approach.In particular,the proposed autonomous algorithm can achieve a smooth transition between the islanded mode and the grid-connected mode.Furthermore,rigorous analysis is given to show privacy-preserving performance against internal and external eavesdroppers.Finally,case studies illustrate the feasibility and validity of the developed algorithm.

关键词： preserving autonomous mode

A Blade Altering Toolbox for Automating Rotor Design Optimization

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Communications on Applied Mathematics and Computation 2024年第1期6卷 688-704页

作者： Akiva Wernick Jen-ping chen Mechanical and Aerospace Engineering The Ohio State University201 W.19th Ave.ColumbusOH43210USA

The Blade Altering Toolbox(BAT)described in this paper is a tool designed for fast reconstruction of an altered blade geometry for design optimization purposes.The BAT algorithm is capable of twisting a given rotor’s angle of attack and stretching the chord length along the span of the rotor.Several test cases were run using the BAT’s algorithm.The BAT code’s twisting,stretching,and mesh reconstruction capabilities proved to be able to handle reasonably large geometric alterations to a provided input rotor geometry.The test examples showed that the toolbox’s algorithm could handle any stretching of the blade’s chord as long as the blade remained within the original bounds of the unaltered mesh.The algorithm appears to fail when the net twist angle applied the geometry exceeds approximately 30 degrees,however this limitation is dependent on the initial geometry and other input parameters.Overall,the algorithm is a very powerful tool for automating a design optimization procedure.

关键词： Mesh reconstruction Mesh alteration Rotor alteration Design optimization