检索结果-南通市图书馆

Characteristic changes in astrocyte properties during astrocyte-to-neuron conversion induced by NeuroD1/Ascl1/Dlx2

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第6期20卷 1801-1815页

作者： Qing He Zhen Wang Yuchen Wang Mengjie zhu Zhile Liang Kanghong Zhang Yuge Xu Gong Chen GHM Institute of CNS Regeneration Jinan UniversityGuangzhouGuangdong ProvinceChina

Direct in vivo conversion of astrocytes into functional new neurons induced by neural transcription factors has been recognized as a potential new therapeutic intervention for neural injury and degenerative disorders. However, a few recent studies have claimed that neural transcription factors cannot convert astrocytes into neurons, attributing the converted neurons to pre-existing neurons mis-expressing transgenes. In this study, we overexpressed three distinct neural transcription factors––NeuroD1, Ascl1, and Dlx2––in reactive astrocytes in mouse cortices subjected to stab injury, resulting in a series of significant changes in astrocyte properties. Initially, the three neural transcription factors were exclusively expressed in the nuclei of astrocytes. Over time, however, these astrocytes gradually adopted neuronal morphology, and the neural transcription factors was gradually observed in the nuclei of neuron-like cells instead of astrocytes. Furthermore,we noted that transcription factor-infected astrocytes showed a progressive decrease in the expression of astrocytic markers AQP4(astrocyte endfeet signal), CX43(gap junction signal), and S100β. Importantly, none of these changes could be attributed to transgene leakage into preexisting neurons. Therefore, our findings suggest that neural transcription factors such as NeuroD1, Ascl1, and Dlx2 can effectively convert reactive astrocytes into neurons in the adult mammalian brain.

关键词： aquaporin-4 Ascl1 astrocyte cortex Dlx2 gap junction glia-to-neuron conversion neural regeneration NeuroD1 reprogramming

Measurement of the Speed of Gravity

在线全文

学校读者我要写书评

暂无评论

Chinese Physics Letters 2011年第7期28卷 47-50页

作者： zhu yin Agriculture Department of Hubei Province Wuhan 430070

From the Liénard–Wiechert potential in both the gravitational field and the electromagnetic field,it is shown that the propagation speed of gravitational field(waves)can be tested by comparing the measured speed of ... 详细信息

关键词： force field gravitational

Boosting Photocatalytic Performance of Cu-Mn Co-doped CeO_(2) nanoparticles for Tetracycline Degradation

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Wuhan University of Technology(Materials Science) 2025年第1期40卷 42-48页

作者： XU Rongqi MI Jianxin WANG Shulin XU Man zhu Li BAI Lei TANG Dandan LEI Yu Engineering Research Center of Environmental Materials and Membrane Technology of Hubei Province School of Materials Science and EngineeringWuhan Institute of TechnologyWuhan 430205China Shaanxi Coal Chemical Industry Technology Research Institute Co. Ltd.Xi’an 710100China

Cu-Mn co-doped CeO_(2) photocatalyst was successfully synthesized by the sol-gel method to assess its capability in degrading *** and TEM results showed that Cu and Mn were successfully co-doped into CeO_(2) without forming heterostructure,XPS and photoelectrochemical results revealed that Mn ions doping amplified the generation of photo-induced charge carriers,while Cu ions doping significantly facilitated the interfacial charge transfer ***,the optimized Cu3Mn2CeO_(2) nanoparticles exhibited the highest TC removal efficiency,achieved a rate of 78.18%and maintained a stable cycling performance.

关键词： photocatalyst co-doped charge separation water treatment

Crustal deformation and dynamics of Early Cretaceous in the North China Craton

在线全文

学校读者我要写书评

暂无评论

Science China Earth Sciences 2021年第9期64卷 1428-1450页

作者： Guang zhu Yuanchao LU nan SU Xiaodong WU Hao yin Shuai ZHANG Chenglong XIE Manlan NIU School of Resource and Environmental Engineering Hefei University of TechnologyHefei230009China

The Early Cretaceous represents a peak period of the North China Craton(NCC)destruction.A comprehensive analysis of crustal deformation during this period can reveal processes and dynamics of the *** peak destruction of the NCC was associated with intense extension whose representative deformation products are metamorphic core complexes(MCCs),extensional domes and rifted *** MCCs occurred along both northern and southern margins of the NCC,and resulted from synchronous extension and magmatism,showing difference from the typical orogen-type MCCs in many *** MCCs of the Early Cretaceous were replaced by extensional domes under relatively weak extension and *** contrast to a major depression-type basin of the Early Cretaceous in the western NCC,rifted basins of the same age in the eastern NCC appeared as medium-to small-scale ones *** the eastern NCC,the rifted basins north of the Bohai Bay are characterized by a feature similar to an active rift whereas those south of the Bohai present similarity to a passive *** sorts of extensional structures developed during the peak destruction indicate a stable stress state of NE-SE extension over the entire central to eastern NCC,consistent with the plate margin-driven stress *** distribution of the extensional structures presents an 1800 km wide back-arc extension region in the central to eastern NCC,consistent with the Paleo-Pacific slab rollback model following flat ***-spatial variation of initial extension and volcanic activity during the peak period also supports the rollback model right after the flat oceanic *** crustal deformation evolution demonstrates that the peak destruction of the NCC took place after the B-episode compression of the Yanshan Movement of the earliest Early Cretaceous and terminated with onset of the C-episode compression of the earliest Late Cretaceous.

关键词： Peak period of craton destruction Metamorphic core complex Extensional domes Rifted basins Dynamic setting

Effect of Ti Additions on Mechanical and Thermodynamic Properties of W-Ti Alloys: A First-principles Study

在线全文

学校读者我要写书评

暂无评论

Journal of Wuhan University of Technology(Materials Science) 2025年第1期40卷 246-257页

作者： ZHANG Jian NIE Wei HUANG Jin zhu Ke LIU Ruxia ZHANG Ruizhi LUO Guoqiang SHEN Qiang State Key Laboratory of Advanced Technology for Materials Synthesis and Processing Wuhan University of TechnologyWuhan 430070China Institute for Carbon Neutrality University of Science and Technology BeijingBeijing 100083China

The mechanical and thermodynamic properties of W-Ti alloys(including W_(15)Ti_(1),W_(14)Ti_(2),W_(12)Ti_(4) and W_(8)Ti_(8) alloys)were investigated by the first-principles approach based on density functional *** results indicate that W-Ti alloys except W_(8)Ti_(8) are thermodynamically *** modulus and hardness of W-Ti alloys are smaller than those of pure tungsten and gradually decrease with increasing Ti ***,their B/G ratios and Poisson's ratios exceed those of pure tungsten,suggesting that the introduction of Ti decreases the mechanical strength while enhancing the ductility of W-Ti *** thermal expansion coefficients for W-Ti alloys all surpass those of pure tungsten,indicating that the introduction of titanium exacerbates the thermal expansion behavior of W-Ti ***,elevated pressure has the capacity to suppress the thermal expansion tendencies in titanium-doped tungsten *** study offers theoretical insights for the design of nuclear materials by exploring the mechanical and thermodynamic properties of W-Ti alloys.

关键词： first-principles mechanical properties thermodynamic properties tungsten-titanium alloys

Magnetic resonance imaging evaluation and nuclear receptor binding SET domain protein 1 mutation in the Sotos syndrome with attention-deficit/hyperactivity disorder

在线全文

学校读者我要写书评

暂无评论

World Journal of Clinical Cases 2025年第2期13卷 5-9页

作者： Wei zhu Shanghai XiRong Information Science and Technology Co. LtdNational Science and Technology ParkSchool of Life Sciences and TechnologyTongji UniversityShanghai 200092China

Sotos syndrome is characterized by overgrowth features and is caused by alterations in the nuclear receptor binding SET domain protein 1 ***/hyperactivity disorder(ADHD)is considered a neurodevelopment and psychiatric disorder in *** characteristics and clinical presentation could play an important role in the diagnosis of Sotos syndrome and *** resonance imaging(MRI)has been used to assess medical images in Sotos syndrome and *** images process is considered to display in MRI while wavelet fusion has been used to integrate distinct images for achieving more complete information in single image in this *** the future,genetic mechanisms and artificial intelligence related to medical images could be used in the clinical diagnosis of Sotos syndrome and ADHD.

关键词： Sotos syndrome Attention-deficit/hyperactivity disorder Genetic mutation Magnetic resonance imaging Wavelet fusion

Virtual and augmented reality technologies for emergency management in the built environments: A state-of-the-art review

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Safety Science and Resilience 2021年第1期2卷 1-10页

作者： Yiqing zhu nan Li Department of Construction Management Tsinghua UniversityBeijing 100084China

With the rapid technological advancements in recent decades,virtual reality(VR)and augmented reality(AR)technologies have been increasingly adopted to address various challenges in emergency management in the built *** paper presents a review of state-of-the-art applications in this rapidly evolving area.A total of 84 relevant articles are identified based on searching in the Web of Science Core Collection and *** papers are then organized based on a taxonomy developed in this ***,a range of VR/AR appli-cations presented in these papers that are aimed to enhance various processes associated with pre-emergency preparedness,responses during emergency and post-emergency recovery are reviewed in *** existing VR/AR applications are also described from a human-computer interaction ***,current research trends,knowledge gaps and directions for future research are *** findings presented in this paper are expected to provide a synthetic and critical review of state-of-the-art VR/AR applications for emergency management in the built environment and facilitate further advancements in both research and practice in this area.

关键词： Virtual reality Augmented reality Emergency management Built environment Literature review

Evolutionary Particle Swarm Optimization Algorithm Based on Collective Prediction for Deployment of Base Stations

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Computers, Materials & Continua 2025年第1期82卷 345-369页

作者： Jiaying Shen Donglin zhu Yujia Liu Leyi Wang Jialing Hu Zhaolong Ouyang Changjun Zhou Taiyong Li School of Computer Science and Technology Zhejiang Normal UniversityJinhua321004China School of Future Technologies Jiangxi Institute of Applied Science and TechnologyNanchang330000China School of Computing and Artificial Intelligence Southwestern University of Finance and EconomicsChengdu611130China

The wireless signals emitted by base stations serve as a vital link connecting people in today’s society and have been occupying an increasingly important role in real *** development of the Internet of Things(IoT)relies on the support of base stations,which provide a solid foundation for achieving a more intelligent way of *** a specific area,achieving higher signal coverage with fewer base stations has become an urgent ***,this article focuses on the effective coverage area of base station signals and proposes a novel Evolutionary Particle Swarm Optimization(EPSO)algorithm based on collective prediction,referred to herein as *** a new strategy called neighbor-based evolution prediction(NEP)addresses the issue of premature convergence often encountered by *** also employs a strengthening evolution(SE)strategy to enhance the algorithm’s global search capability and efficiency,ensuring enhanced robustness and a faster convergence speed when solving complex optimization *** better adapt to the actual communication needs of base stations,this article conducts simulation experiments by changing the number of base *** experimental results demonstrate thatunder the conditionof 50 ormore base stations,ECPPSOconsistently achieves the best coverage rate exceeding 95%,peaking at 99.4400%when the number of base stations reaches *** results validate the optimization capability of the ECPPSO algorithm,proving its feasibility and *** ablative experiments and comparisons with other algorithms highlight the advantages of ECPPSO.

关键词： Particle swarm optimization effective coverage area global optimization base station deployment

Ammonia-induced CuO/13X for H_(2)S removal from simulated blast furnace gas at low temperature

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Green Energy & Environment 2025年第1期10卷 139-149页

作者： Erping Cao Yuhua Zheng Hao Zhang Jianshan Wang Yuran Li Tingyu zhu Zhan-guo Zhang Guangwen Xu Yanbin Cui State Key Laboratory of Mesoscience and Engineering Institute of Process EngineeringChinese Academy of SciencesBeijing100190China State Key Laboratory of Vanadium and Titanium Resources Comprehensive Utilization PanGang Group Research Institute Co.Ltd.Panzhihua Sichuan617000China Shenyang University of Chemical Technology Shenyang110142China University of Chinese Academy of Sciences Beijing 100049China

Blast furnace gas(BFG)is an important by-product energy for the iron and steel industry and has been widely used for heating or electricity ***,the undesirable contaminants in BFG(especially H_(2)S)generate harmful environmental *** desulfurization of BFG is urgent for integrated steel plants due to the stringent ultra-low emission *** with other desulfurization materials,zeolite-based adsorbents represent a viable option with low costs and long service *** this study,an ammonia-induced CuO modified 13X adsorbent(NH3–CuO/13X)was prepared for H_(2)S removal from simulated BFG at low *** XRD,H_(2)-TPR and TEM analysis proved that smaller CuO particles were formed and the dispersion of Cu on the surface of 13X zeolite was improved via the induction of *** on H_(2)S adsorption performance of the adsorbent was carried out using simulated BFG,and the results showed that NH3–CuO/13X-3 has better breakthrough sulfur capacity,which was more than twice the sulfur capacity of CuO/*** is proposed that the enhanced desulfurization performance of NH3–CuO/13X is attributed to an abundant pore of 13X,and combined action of 13X and *** work provided an effective way to improve the sulfur capacity of zeolite-based adsorbents via impregnation method by ammonia induction.

关键词： Blast furnace gas Desulfurization Ammonia-induced CuO 13X zeolite