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World Journal of Gastrointestinal Oncology 2025年第1期17卷 143-157页

作者： Xian-Rang Cao yin-long xu Jia-Wei Chai Kai Zheng Jun-Jie Kong Jun Liu Shun-Zhen Zheng Department of Liver Transplantation and Hepatobiliary Surgery Shandong Provincial Hospital Affiliated to Shandong First Medical UniversityJinan 250021Shandong ProvinceChina Department of Breast and Thyroid Surgery Shandong Provincial Maternal and Child Health Care HospitalJinan 250014Shandong ProvinceChina

BACKGROUND Red blood cell distribution width(RDW)is associated with the development and progression of various *** To explore the association between pretreatment RDW and short-term outcomes after laparoscopic pancreatoduodenectomy(LPD).METHODS A total of 804 consecutive patients who underwent LPD at our hospital between March 2017 and November 2021 were retrospectively *** between pretreatment RDW and clinicopathological characteristics and short-term outcomes were *** Patients with higher pretreatment RDW were older,had higher Eastern Cooperative Oncology Group scores and were associated with poorer short-term outcomes than those with normal *** pretreatment RDW was an independent risk factor for postoperative complications(POCs)(hazard ratio=2.973,95%confidence interval:2.032-4.350,Pying patients who were at high risk of developing POCs after LPD.

关键词： Biomarker Laparoscopic pancreatoduodenectomy Postoperative complication Red blood cell distribution width Short-term outcomes

Approximation Algorithms for Steiner Connected Dominating Set

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Journal of Computer Science & Technology 2005年第5期20卷 713-716页

作者： Ya-Feng Wu yin-long xu Guo-Liang Chen National High Performance Computing Center at Hefei Department of Computer Science and Technology University of Science and Technology of China Hefei 230027 P.R. China

Steiner connected dominating set （SCDS） is a generalization of the famous connected dominating set problem, where only a specified set of required vertices has to be dominated by a connected dominating set, and known to be NP- hard. This paper firstly modifies the SCDS algorithm of Guha and Khuller and achieves a worst case approximation ratio of （2 ＋ 1/（m - 1））H（min（△, k））＋O（1）, which outperforms the previous best result （c ＋ 1）H（min（△, k））＋ O（1） in the case of m ≥ 1 ＋1/（c - 1）, where c is the best approximation ratio for Steiner tree, A is the maximum degree of the graph, k is the cardinality of the set of required vertices, m is an optional integer satisfying 0 ≤ m ≤ min（△, k） and H is the harmonic function. This paper also proposes another approximation algorithm which is based on a greedy approach. The second algorithm can establish a worst case approximation ratio of 2 ln（min（△, k））＋ O（1）, which can also be improved to 2 lnk if the optimal solution is greater than c·e^2c＋1/2（c＋1）.

关键词： approximation algorithm Steiner connected dominated set graph algorithm NP-hard

Dual-property blue and red emission carbon dots for Fe(Ⅲ)ions detection and cellular imaging

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Rare Metals 2021年第7期40卷 1957-1965页

作者： yin-long xu Rui-xue Mo Cai-Yu Qi Zeng Ren Xiu-Zhi Jia Zi-Gui Kan Cao-long Li Fei Wang Key Laboratory of Biomedical Functional Materials School of Basic ScienceChina Pharmaceutical UniversityNanjing 211198China Tibetan Medicine Research Institute Tibetan Traditional Medical CollegeLasa 850000China School of Basic Medical Science Harbin Medical UniversityHarbin 150081China

The excitation wavelength-dependent and-independent emissions are two crucial fluorescent properties of carbon dots(CDs).However,CDs reported till date exhibit only one of these properties,which limits their practical ***,dual-property carbon dots(DCDs)with both the excitation wavelength-dependent and-independent emissions were synthesized via a facile onestep solvothermal method using 4-(2-pyridylazo)-resorcinol as the carbon *** multi-functional applications of the resulting DCDs were also *** asprepared DCDs exhibited not only excellent monodispersity,high photostability,and storage stability,but also low toxicity,good biocompatibility,and cellular bioimaging *** addition,the DCDs exhibited excitation-dependent emission photoluminescence under low excitation *** DCDs exhibited good Fe3+detection by quenching the blue emission fluorescence and showed a relatively low Fe3+detection limit of 0.067 lmol·L-1 based on three times signal-to-noise criteria(R2=0.99).Furthermore,the DCDs showed excitation-independent emission at low excitation wavelengths and exhibited red emission at about 598 nm to avoid damage to the *** results demonstrate the excellent bioimaging properties of the *** to their dual PL properties,the as-prepared DCDs exhibited multi-functional applications:Fe3+detection and A549 cell *** results will be helpful in developing novel CDs for applications in various fields.

关键词： Carbon dots Solvothermal Dual properties Fe3+ions detection Bioimaging

ECO-HYDRAULICS TECHNIQUES FOR CONTROLLING EUTROPHICATION OF SMALL SCENERY LAKES-A CASE STUDY OF LUDAO LAKE IN SHANGHAI

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Journal of Hydrodynamics 2007年第6期19卷 776-783页

作者： yin Hai-long xu Zu-xin YAO Yi-jun HUANG Shen-fa College of Environmental Science and Engineering Tongji University Shanghai 200092 China Shanghai Academy of Environmental Sciences Shanghai 200233 China

The Ludao Lake with an area of 0.86 km2 and 50% water surface ratio, was taken as an example to study the eco-hydraulics techniques for preventing lake eutrophication. Besides external water inflow and outflow, the term related to internal local flow circulation was added in the continuity equation of two-dimensional horizontal hydrodynamic model, and further the hydrodynamic model was calibrated by the scenario of no water exchange. The velocity of 0.2 m/s was suggested to be the critical velocity of controlling algal bloom. To achieve the critical velocity in the whole lake, three factors were analyzed, which are wind, artificial external inflow augmentation and internal local flow disturbance by pump circulation. It is found that the role of wind can be disregarded. For the eco-hydraulics technique of external lake water inflow augmentation, the water flowing route should be firstly optimized, further, the lake inflow has a critical value under specified water level due to the narrow inlets, so the whole lake is difficult to reach the critical velocity to prevent algal bloom, and a combination of external inflow augmentation and internal local flowing disturbance should be considered. Simulation results show that the combination of external water inflow augmentation and internal local flow disturbance requires less eco-flow to achieve the global critical velocity than the sole internal local flow disturbance, for the Ludao Lake, the former requires total eco-flow of 25 m3/s, which reduces by 50% than the latter requiring total eco-flow of 52 m3/s.

关键词： eutrophication eco-hydraulics algal bloom,hydrodynamic model

Carbon footprint and carbon neutrality pathway of green tea in China

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Advances in Climate Change Research 2022年第3期13卷 443-453页

作者： Ming-Bao HE Shi-Xiang ZONG ying-Chun LI Ming-Ming MA Xin MA Kuo LI xue HAN Ming-Yue ZHAO Li-Ping GUO yin-long xu Institute of Environment and Sustainable Development in Agriculture Chinese Academy of Agricultural SciencesBeijing 100081China Beijing Key Laboratory for Forest Pest Control Beijing Forestry UniversityBeijing 100083China

With the rising popularity of the concept of“carbon neutralization”,low-carbon products are likely to gain more *** to this,green tea-an important beverage that is widely consumed in China-along with emissions from planting,processing,and use phase should be given ***,quantifying the carbon footprint(CF)of green tea is an essential task in developing the pathway to carbon *** this study,we quantified the CF and mitigation potential of green tea through life cycle assessment,after which we investigated the pathway toward carbon neutrality in 16 major tea-producing regions(except Hainan and Taiwan)in *** system boundary was divided into six subsystems from cradle to grave:cultivation,processing,transport,packaging,consumption,and *** results showed that the total carbon emissions of green tea reached 44.13 Mt CO_(2)eq in 2019,of which 43%came from consumption and 28%from *** were 18.78 Mt CO_(2)eq emissions from fertilizer production and application,while there was a 7.71 Mt CO_(2)eq carbon sink of tea *** average carbon intensity was 24.30 kg CO_(2)eq kg−1 tea,while Shandong and Guizhou ranked as the top two ***,Hubei,and Yunnan Provinces had the largest amounts of carbon emissions at 6.79,6.14,and 5.96 Mt CO_(2)eq,*** 2030,2050 and 2060,total carbon emissions would be reduced by 46%,63%,and 86%,respectively,under carbon neutrality assumption.A small amount of 6.14 Mt CO_(2)eq carbon emissions was retained to be offset by carbon trading or zero-carbon ***,the results indicate that adopting low-carbon fertilizers and clean energies will be a key entry point for carbon-neutral green tea.

关键词： Carbon neutrality Pathway Life cycle assessment Carbon footprint Green tea China

The On-Vehicle Inspection System Based on Passive UHF RFID

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微计算机信息 2010年第32期26卷 133-134,198页

作者： HUANG yin-long xu xu TAN Guang-yun The Third Institute of Ministry of Public Security Shanghai200031 China

This article introduces a design theory of vehicle-related management in forms of system linkage in a certain close *** analyses the technology advantages,working principles,system structures and design solutions of the scene inspection system based on passive UHF RFID technology,which has functions of data capturing,image collection,wireless data transmission and provision of warning *** system enables scene disposal of vehicle-related management in a specific environment,people management in large-scale events and management of important *** system has the capability of rapid network connection and scene inspection especially in emergencies and public security affairs,in which advance deployment is normally *** system has been successfully applied in the vehicle safety monitoring system in the 2010 Shanghai World Expo Park.

关键词： mobile network on-vehicle system RFID image identification

Investigating Müller glia reprogramming in mice: a retrospective of the last decade, and a look to the future

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Neural Regeneration Research 2025年第4期20卷 946-959页

作者： Zhiyuan yin Jiahui Kang xuan Cheng Hui Gao Shujia Huo Haiwei xu Key Lab of Visual Damage and Regeneration&Restoration of Chongqing Southwest Eye HospitalSouthwest HospitalThird Military Medical University(Army Medical University)ChongqingChina

Müller glia,as prominent glial cells within the retina,plays a significant role in maintaining retinal homeostasis in both healthy and diseased *** lower vertebrates like zebrafish,these cells assume responsibility for spontaneous retinal regeneration,wherein endogenous Müller glia undergo proliferation,transform into Müller glia-derived progenitor cells,and subsequently regenerate the entire retina with restored ***,Müller glia in the mouse and human retina exhibit limited neural reprogramming.Müller glia reprogramming is thus a promising strategy for treating neurodegenerative ocular disorders.Müller glia reprogramming in mice has been accomplished with remarkable success,through various *** in molecular,genetic,epigenetic,morphological,and physiological evaluations have made it easier to document and investigate the Müller glia programming process in ***,there remain issues that hinder improving reprogramming efficiency and ***,understanding the reprogramming mechanism is crucial toward exploring factors that will improve Müller glia reprogramming efficiency,and for developing novel Müller glia reprogramming *** review describes recent progress in relatively successful Müller glia reprogramming *** also provides a basis for developing new Müller glia reprogramming strategies in mice,including epigenetic remodeling,metabolic modulation,immune regulation,chemical small-molecules regulation,extracellular matrix remodeling,and cell-cell fusion,to achieve Müller glia reprogramming in mice.

关键词： cell fusion chemical small-molecules epigenetic extracellular matrix immune metabolic mice Müller glia neurodegenerative diseases reprogramming retina regeneration

一种鲁棒的Multi-Egocentric视频中的多目标检测及匹配算法

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智能系统学报 2016年第5期11卷 619-626页

作者：李龙尹辉许宏丽欧伟奇北京交通大学计算机与信息技术学院北京100044 北京交通大学交通数据分析与挖掘北京市重点实验室北京100044

针对视频中的背景变化剧烈、目标尺度差异明显和视角时变性强的特点,提出一种鲁棒的针对multi-egocentric视频的多目标检测及匹配算法。首先,构建基于boosting方法的多目标检测模型对各视频序列中的显著目标进行粗检测,并提出一种基于... 详细信息

针对视频中的背景变化剧烈、目标尺度差异明显和视角时变性强的特点,提出一种鲁棒的针对multi-egocentric视频的多目标检测及匹配算法。首先,构建基于boosting方法的多目标检测模型对各视频序列中的显著目标进行粗检测,并提出一种基于局部相似度的区域优化算法对粗检测显著目标的轮廓进行优化,提高Egocentric视频中显著目标轮廓检测和定位的准确性。在显著目标检测基础上,对不同视角中的显著目标构建基于HOG特征的SVM分类器,实现多视角的多目标匹配。在Party Scene数据集上的实验验证了本文算法的有效性。

关键词： Multi-Egocentric视频多目标检测多目标匹配

CNKSR2 interactome analysis indicates its association with the centrosome/microtubule system

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Neural Regeneration Research 2025年第8期20卷 2420-2432页

作者： Lin yin Yalan xu Jie Mu Yu Leng Lei Ma Yu Zheng Ruizhi Li yin Wang Peifeng Li Hai Zhu Dong Wang Jing Li Institute for Translational Medicine The Affiliated Hospital of Qingdao UniversityMedical CollegeQingdao UniversityQingdaoShandong ProvinceChina School of Basic Medicine Qingdao UniversityQingdaoShandong ProvinceChina College of Life Sciences and School of PharmacyMedical CollegeQingdao UniversityQingdaoShandong ProvinceChina Department of Urology Qingdao Municipal Hospital Affiliated to Qingdao UniversityQingdaoShandong ProvinceChina

The protein connector enhancer of kinase suppressor of Ras 2(CNKSR2),present in both the postsynaptic density and cytoplasm of neurons,is a scaffolding protein with several protein-binding *** of the CNKSR2 gene have been implicated in neurodevelopmental disorders,particularly intellectual disability,although the precise mechanism involved has not yet been fully *** has demonstrated that CNKSR2 plays a role in facilitating the localization of postsynaptic density protein complexes to the membrane,thereby influencing synaptic signaling and the morphogenesis of dendritic ***,the function of CNKSR2 in the cytoplasm remains to be *** this study,we used immunoprecipitation and high-resolution liquid chromatography-mass spectrometry to identify the interactors of *** a combination of bioinformatic analysis and cytological experiments,we found that the CNKSR2 interactors were significantly enriched in the proteome of the *** also showed that CNKSR2 interacted with the microtubule protein DYNC1H1 and with the centrosome marker *** colocalization analysis confirmed the centrosomal localization of *** we downregulated CNKSR2 expression in mouse neuroblastoma cells(Neuro 2A),we observed significant changes in the expression of numerous centrosomal *** manipulation also affected centrosome-related functions,including cell size and shape,cell proliferation,and ***,we found that CNKSR2 interactors were highly enriched in de novo variants associated with intellectual disability and autism spectrum *** findings establish a connection between CNKSR2 and the centrosome,and offer new insights into the underlying mechanisms of neurodevelopmental disorders.

关键词： autism spectrum disorder centrosome CNKSR2 intellectual disability interactome mass spectrometry microtubule neurodevelopmental disease protein complexes protein-protein interactions

Small extracellular vesicles derived from human induced pluripotent stem cell-differentiated neural progenitor cells mitigate retinal ganglion cell degeneration in a mouse model of optic nerve injury

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Neural Regeneration Research 2025年第2期20卷 587-597页

作者： Tong Li Hui-Min Xing Hai-Dong Qian Qiao Gao Sheng-Lan xu Hua Ma Zai-long Chi State Key Laboratory of Ophthalmology Optometry and Visual ScienceEye HospitalWenzhou Medical UniversityWenzhouZhejiang ProvinceChina National Clinical Research Center for Ocular Diseases Eye HospitalWenzhou Medical UniversityWenzhouZhejiang ProvinceChina

Several studies have found that transplantation of neural progenitor cells(NPCs)promotes the survival of injured ***,a poor integration rate and high risk of tumorigenicity after cell transplantation limits their clinical *** extracellular vesicles(sEVs)contain bioactive molecules for neuronal protection and *** studies have shown that stem/progenitor cell-derived sEVs can promote neuronal survival and recovery of neurological function in neurodegenerative eye diseases and other eye *** this study,we intravitreally transplanted sEVs derived from human induced pluripotent stem cells(hiPSCs)and hiPSCs-differentiated NPCs(hiPSC-NPC)in a mouse model of optic nerve *** results show that these intravitreally injected sEVs were ingested by retinal cells,especially those localized in the ganglion cell *** with hiPSC-NPC-derived sEVs mitigated optic nerve crush-induced retinal ganglion cell degeneration,and regulated the retinal microenvironment by inhibiting excessive activation of *** analysis further revealed that hiPSC-NPC derived sEVs transported neuroprotective and anti-inflammatory miRNA cargos to target cells,which had protective effects on RGCs after optic nerve *** findings suggest that sEVs derived from hiPSC-NPC are a promising cell-free therapeutic strategy for optic neuropathy.

关键词： exosome miRNA neural progenitor cell neurodegeneration neuroinflammation neuroprotection optic nerve crush optic neuropathy retinal ganglion cell small extracellular vesicles