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Clinical study of chemotherapy-related cognitive impairment in patients with non-Hodgkin lymphoma

World Journal of Psychiatry 2024年第7期14卷 1062-1067页

作者： Qiang-Li wang Hai-Yan Xu Yi wang yin-ling wang Pei-Nan Lin Zhong-Lei Chen Department of Oncology and Hematology Suzhou Kowloon HospitalShanghai Jiao Tong University School of MedicineSuzhou 215000Jiangsu ProvinceChina

BACKGROUND Chemotherapy for malignant tumors can cause brain changes and cognitive impairment,leading to chemotherapy-induced cognitive impairment(CICI).Current research on CICI has focused on breast cancer and Hodgkin’s *** patients with non-Hodgkin’s lymphoma(NHL)undergoing chemo-therapy have cognitive impairment has not been fully *** have cognitive impairment has not been fully *** To investigate whether NHL patients undergoing chemotherapy had cognitive *** The study included 100 NHL patients who were required to complete a compre-hensive psychological scale including the Brief Psychiatric Examination Scale(MMSE)at two time points:before chemotherapy and within 2 wk of two chemo-therapy courses.A language proficiency test(VFT),Symbol Number Pattern Test(SDMT),Clock Drawing Test(CDT),Abbreviated Daily Cognition Scale(ECog-12),Prospective and Retrospective Memory Questionnaire,and Karnofsky Perfor-mance Status were used to assess cognitive changes before and after *** The VFT scores for before treatment(BT)and after treatment(AT)groups were 45.20±15.62,and 42.30±17.53,respectively(t-2.16,P<0.05).The CDT scores were 8(3.5-9.25)for BT and 7(2.5-9)for AT groups(Z-2.1,P<0.05).Retrospective memory scores were 13.5(9-17)for BT and 15(13-18)for AT(Z-3.7,P<0.01).The prospective memory scores were 12.63±3.61 for BT and 14.43±4.32 for AT groups(t-4.97,P<0.01).The ECog-12 scores were 1.71(1.25-2.08)for BT and 1.79(1.42-2.08)for AT groups(Z-2.84,P<0.01).The SDMT and MMSE values did not show a significant difference between BT and AT *** Compared to the AT group,the BT group showed impaired language,memory,and subjective cognition,but objec-tive cognition and execution were not significantly affected.

关键词： Non-Hodgkin’s lymphoma Hodgkin lymphoma Lymphoma cognitive impairment Chemotherapy-related cogni-tive impairment Clinical study

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Efficient electroreduction of nitrate via enriched active phases on copper-cobalt oxides

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Chinese Chemical Letters 2024年第4期35卷 204-209页

作者： ling Fang Sha wang Shun Lu Fengjun yin Yujie Dai Lin Chang Hong Liu Chongqing Institute of Green and Intelligent Technology Chinese Academy of SciencesChongqing 400714China University of Chinese Academy of Sciences Beijing 100049China

Electrochemical conversion of nitrate(NO_(3)~-) to ammonia(NH_(3)) can target two birds with one stone well, in NO_(3)^(-)-containing sewage remediation and sustainable NH_(3) production. However, single metalbased catalysts are difficult to drive high-efficient NO_(3)~- removal due to the multi-electron transfer ***, we present a tandem catalyst with simple structure, Cu-Co binary metal oxides(Cu-Co-O), by engineering intermediate phases as catalytic active species for NO_(3)~- conversion. Electrochemical evaluation,X-ray photoelectron spectroscopy, and in situ Raman spectra together suggest that the newly-generated Cu-based phases was prone to NO_(3)~- to NO_(2)~- conversion, then NO_(2)~- was reduced to NH_(3) on Co-based species. At an applied potential of -1.1 V vs. saturated calomel electrode, the Cu-Co-O catalyst achieved NO_(3)~- -N removal of 90% and NH_(3) faradaic efficiency of 81% for 120 min in 100 m L of 50 mg/L NO_(3)~- -N,consuming only 0.69 k Wh/mol in a two-electrode system. This study provides a facile and efficient engineering strategy for developing high-performance catalysts for electrocatalytic nitrate conversion.

关键词： NO_(3)^(-)-containing sewage remediation Electrocatalytic reduction Copper-cobalt oxides Tandem reactivity Enriched active phases

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Inpatient disease spectrum and clinical characteristics of surgical disorders in pediatric and adolescent gynecology:A single-institute study of 12 years data from China

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Chinese Medical Journal 2024年第10期137卷 1240-1242页

作者： He Huang Siyun wang Ruixi Zhan ling yin Yongchun Hu Donglai Yang Yangyang Shi Department of Obstetrics and Gynecology Peking University First HospitalXicheng DistrictBeijing 100034China Department of Obstetrics and Gynecology Inner Mongolia Ulanqab Second HospitalUlanqabInner Mongolia 012000China Department of Obstetrics and Gynecology Jiujiang University Affiliated HospitalJiujiangJiangxi 332000China

To the Editor:Pediatric and adolescent gynecology(PAG)is a specialized branch of gynecology that focuses on reproductive health issues of women from infancy to adolescence.[1]In 1939,the Hungarian Dobszayrst established the new *** then,the PAG subject has begun to develop and gradually matured in the past 80 *** PAG has witnessed signicant development in western countries,a substantial unmet need persists in addressing specic health concerns among children and adolescents with gynecological disorders.

关键词： adolescent disorders branch

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Anti-epileptic and Neuroprotective Effects of Ultra-low Dose NADPH Oxidase Inhibitor Dextromethorphan on Kainic Acid-induced Chronic Temporal Lobe Epilepsy in Rats

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Neuroscience Bulletin 2024年第5期40卷 577-593页

作者： Jing-Jing Yang ying-Xin Liu Yan-Fang wang Bi-ying Ge ying wang Qing-Shan wang Sheng Li Jian-Jie Zhang ling-ling Jin Jau-Shyong Hong Sheng-Ming yin Jie Zhao College of Basic Medical Sciences Dalian Medical UniversityDalian116044China Department of Neurology The First Affiliated Hospital of Dalian Medical UniversityDalian116011China National and Local Joint Engineering Research Center for Drug Research and Development of Neurodegenerative Diseases Dalian116044China School of Public Health Dalian Medical UniversityDalian116044China Neurobiology Laboratory National Institute of Environmental Health SciencesNational Institutes of HealthResearch Triangle ParkDurhamNC27709USA

Neuroinflammation mediated by microglia and oxidative stress play pivotal roles in the development of chronic temporal lobe epilepsy(TLE).We postulated that kainic acid(KA)-Induced status epilepticus triggers microglia-dependent inflammation,leading to neuronal damage,a lowered seizure threshold,and the emergence of spontaneous recurrent seizures(SRS).Extensive evidence from our laboratory suggests that dextromethorphan(DM),even in ultra-low doses,has anti-inflammatory and neuroprotective effects in many animal models of neurodegenerative *** results showed that administration of DM(10 ng/kg per day;subcutaneously via osmotic minipump for 4 weeks)significantly mitigated the residual effects of KA,including the frequency of SRS and seizure *** addition,DM-treated rats showed improved cognitive function and reduced hippocampal neuronal *** found suppressed microglial activation-mediated neuroinflammation and decreased expression of hippocampal gp91^(phox) and p47^(phox) proteins in KA-induced chronic TLE ***,even after discontinuation of DM treatment,ultra-low doses of DM continued to confer long-term anti-seizure and neuroprotective effects,which were attributed to the inhibition of microglial NADPH oxidase 2 as revealed by mechanistic studies.

关键词： Temporal lobe epilepsy Dextromethorphan NADPH oxidase Ultra-low dose

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Energy band modulation of N-doped rutile/anatase TiO2 photoanode promoting charge separation toward prominent photoelectrochemical performance

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Rare Metals 2024年第8期43卷 3784-3797页

作者： Juan Gao Shi-Xuan wang Jia-Le Deng Ping-Ping Wei Fu-Zhang Chen ling-Cheng Zheng Yue-Qin wang Yang Li yin Liu Gang He School of Mechanics and Photoelectric Physics Anhui University of Science and Technology School of Materials Science and Engineering Anhui University Tianneng Battery (Wuhu) Co. Ltd. School of Materials Science and Engineering Anhui University of Science and Technology

To solve the problem of high photogenerated carrier recombination rate and low photoelectric conversion efficiency of TiO2-based materials,a simple N-doped anatase/rutile TiO2heterophase nanorod film was designed by a low-temperature hydrothermal method in this *** enhanced separation and transport of photogenerated charges were facilitated by the smaller contact barrier and appropriate band matching between anatase TiO2nanoparticles and rutile *** introduction of N doping in anatase TiO2resulted in an upward shift of the valence band and a narrowing of the band gap,consequently enhancing the efficiency of visible light *** combination of the heterophase junction and N-doping exhibited a synergistic effect,effectively suppressing the recombination of photogenerated charges and enhancing the photoelectric conversion efficiency of the *** AM 1.5G irradiation,the photocurrent density（J） of the A-TO（N）@R-TONR photoanode reached2.19 mA·cm-2(VRHE,1.23 eV).Additionally,the incident photon-electron conversion efficiency（IPCE） and the charge injection efficiency（η） reached 81.4% and 51.6% at320 ***,the J,IPCE,and η values of the A-TO（N）@R-TONR photoanode were 2.96,2.1 and 3.2times those of pure R-TONR photoanode,*** work presents a rational strategy for designing efficient TiO2-based photoanodes.

关键词： TiO 2 Heterophase junction Photoanode

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Evaluation of 3D crustal seismic velocity models in southwest China:Model performance,limitation,and prospects

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Science China Earth Sciences 2024年第2期67卷 604-619页

作者： Xin wang ling CHEN Qi-Fu CHEN Key Laboratory of Earth and Planetary Physics Institute of Geology and GeophysicsChinese Academy of SciencesBeijing100029China College of Earth and Planetary Sciences University of Chinese Academy of SciencesBeijing100049China State Key Laboratory of Lithospheric Evolution Institute of Geology and GeophysicsChinese Academy of SciencesBeijing100029China

Southwest China is a tectonically and seismically active region,witnessing strong deformation due to the collision between the Indian and Eurasian *** the subsurface velocity structure of this region is thus important in understanding the tectonics and geodynamic processes of continental collision and in mitigating seismic *** studies have provided various 3D seismic velocity models in southwest ***,discrepancies exist among these models,and less effort has been made to quantify the reliability and accuracy of these existing velocity *** this study,we use regional 3D waveform simulation to evaluate the performance of various regional crustal 3D velocity models in reproducing observed *** particularly focus on two recent earthquake sequence in the region,the 2021 Yunnan Yangbi MS_(6.4) earthquake sequence and the 2022 Sichuan Luding MS_(6.8) earthquake *** tested 3D velocity models include the Southwest China Community Velocity model V1.0,the Unified Seismic Tomography Models for Continental China Lithosphere V2.0,the adjoint full waveform tomography model of the crustal and upper mantle beneath Eastern Tibetan Plateau,and the shallow seismic structure model beneath continental *** results show that the tested 3D velocity models generally capture well long-period(<0.2 Hz)waveforms,indicating that the 3D models adequately resolve overall large-scale subsurface ***,the 3D synthetics show discrepancies in higher frequencies(0.05–0.3 Hz)and the performance of the 3D velocity models varies from region to region,suggesting that smaller scale heterogeneities are not well *** shallow velocity structures(<10 km)can improve the waveform fitting,emphasizing the importance of incorporating shallow structures in waveform *** full-waveform tomography model shows a slighter better performance than the other models,especially for the body-waves,highlighting the advantages

关键词： Southwest China Seismic tomography models Shallow Structures Waveform simulation Model evaluation

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Applications of mercury stable isotopes for tracing volcanism in the geologic record

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Science China Earth Sciences 2024年第5期67卷 1436-1458页

作者： Qing GONG Ming-Xing ling wang ZHENG State Key Laboratory of Nuclear Resources and Environment East China University of TechnologyNanchang 330013China School of Earth System Science Institute of Surface-Earth System ScienceTianjin UniversityTianjin 300072China

Mercury(Hg)enrichments in ancient sediments have been used as a proxy of volcanism,especially large igneous province(LIP)***,considering the existence of other potential Hg sources besides volcanoes and the diverse factors(e.g.,organic matters,clay minerals,sulfide minerals and Fe oxides)that can affect Hg sequestration,there are considerable uncertainties to simply regard sedimentary Hg anomalies as signatures of volcanic *** stable isotopes,a promising tool for tracing the origins and transformations of Hg,have been increasingly used for determining the causes of Hg spikes and understanding the geochemical behavior of Hg in the geologic *** date,lots of researches have applied Hg concentrations and Hg isotopes to identify LIP volcanisms linking with significant geological events such as mass extinctions,ocean anoxic events and other environmental perturbations that mainly occurred in the ***,the results in previous studies clearly show that not all Hg enrichments are derived from volcanic inputs,which emphasize the need for more caution in using Hg as a fingerprint of *** a better understanding of Hg isotopes in the future,there will be important implications for Hg isotopes to reconstruct volcanic activities in the rock records and their impacts on biological evolution.

关键词： Mercury stable isotopes Large igneous province Mass extinction event Ocean anoxic event

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Constrained Multi-Objective Optimization With Deep Reinforcement Learning Assisted Operator Selection

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IEEE/CAA Journal of Automatica Sinica 2024年第4期11卷 919-931页

作者： Fei Ming Wenyin Gong ling wang Yaochu Jin the School of Computer Science China University of GeosciencesWuhan 430074China the Department of Automation Tsinghua UniversityBeijing 100084China the Faculty of Technology Bielefeld UniversityNorth Rhine-Westphalia33619 BielefeldGermany

Solving constrained multi-objective optimization problems with evolutionary algorithms has attracted considerable *** constrained multi-objective optimization evolutionary algorithms(CMOEAs)have been developed with the use of different algorithmic strategies,evolutionary operators,and constraint-handling *** performance of CMOEAs may be heavily dependent on the operators used,however,it is usually difficult to select suitable operators for the problem at ***,improving operator selection is promising and necessary for *** work proposes an online operator selection framework assisted by Deep Reinforcement *** dynamics of the population,including convergence,diversity,and feasibility,are regarded as the state;the candidate operators are considered as actions;and the improvement of the population state is treated as the *** using a Q-network to learn a policy to estimate the Q-values of all actions,the proposed approach can adaptively select an operator that maximizes the improvement of the population according to the current state and thereby improve the algorithmic *** framework is embedded into four popular CMOEAs and assessed on 42 benchmark *** experimental results reveal that the proposed Deep Reinforcement Learning-assisted operator selection significantly improves the performance of these CMOEAs and the resulting algorithm obtains better versatility compared to nine state-of-the-art CMOEAs.

关键词： Constrained multi-objective optimization deep Qlearning deep reinforcement learning(DRL) evolutionary algorithms evolutionary operator selection

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Reinforcement Learning-Based Dynamic Order Recommendation for On-Demand Food Delivery

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Tsinghua Science and Technology 2024年第2期29卷 356-367页

作者： Xing wang ling wang Chenxin Dong Hao Ren Ke Xing Department of Automation Tsinghua UniversityBeijing 100080China School of Mechanical and Automotive Engineering Qingdao Hengxing University of Science and TechnologyQingdao 266100China Meituan Beijing 100015China

On-demand food delivery(OFD)is gaining more and more popularity in modern *** a kernel order assignment manner in OFD scenario,order recommendation directly influences the delivery efficiency of the platform and the delivery experience of *** paper addresses the dynamism of the order recommendation problem and proposes a reinforcement learning solution *** actor-critic network based on long short term memory(LSTM)unit is designed to deal with the order-grabbing conflict between different ***,three rider sequencing rules are accordingly proposed to match different time steps of the LSTM unit with different *** test the performance of the proposed method,extensive experiments are conducted based on real data from Meituan delivery *** results demonstrate that the proposed reinforcement learning based order recommendation method can significantly increase the number of grabbed orders and reduce the number of order-grabbing conflicts,resulting in better delivery efficiency and experience for the platform and riders.

关键词： on-demand food delivery order recommendation reinforcement learning actor-critic network long short term memory

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Ginsenoside Rd Induces Differentiation of Myeloid Leukemia Cells via Regulating ERK/GSK-3βSignaling Pathway

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Chinese Journal of Integrative Medicine 2024年第7期30卷 588-599页

作者： JIANG Yu-xia ZHAO Yan-na YU Xiao-ling yin Li-ming Department of Hematology Tongde Hospital of Zhejiang ProvinceHangzhou310012China Institute of Hematology Research the First Affiliated Hospital of Zhejiang Chinese Medical University(Zhejiang Provincial Hospital of Chinese Medicine)Hangzhou310006China

Objective To investigate the role of ginsenoside Rd(GRd)in acute myeloid leukemia(AML)cell *** AML cells were treated with GRd(25,50,100 and 200µg/mL),retinoic acid(RA,0.1g/L)and PD98059(20 mg/mL)for 72 h,cell survival was detected by methylthiazolyldiphenyl-tetrazolium bromide and colony formation assays,and cell cycle was detected by flow *** morphology and differentiation were observed by Wright-Giemsa staining,peroxidase chemical staining and cellular immunochemistry assay,*** protein expression levels of GATA binding protein 1(GATA-1),purine rich Box-1(PU.1),phosphorylated-extracellular signal-related kinase(p-ERK),ERK,phosphorylated-glycogen synthase kinase-3β(p-GSK3β),GSK3βand signal transducer and activator of transcription 1(STAT1)were detected by Western ***-six mice were randomly divided into 3 groups using a random number table:model control group(non-treated),GRd group[treated with 200 mg/(kg·d)GRd]and homoharringtonine(HTT)group[treated with 1 mg/(kg·d)HTT].A tumor-bearing nude mouse model was established,and tumor weight and volume were *** of subcutaneous tumor tissue were observed after hematoxylin and eosin ***1 and GATA-1 expressions were detected by immunohistochemical *** The cell survival was inhibited by GRd in a dose-dependent manner and GRd caused G0/G1 cell arrest(p<0.05).GRd treatment induced leukemia cell differentiation,showing increased expressions of peroxidase and specific proteins concerning erythrogenic or granulocytic differentiation(p<0.05).GRd treatment elicited upregulation of p-ERK,p-GSK-3βand STAT1 expressions in cells,and reversed the effects of PD98059 on inhibiting the expressions of peroxidase,GATA-1 and PU.1(P<0.05).After GRd treatment,tumor weight and volume of mice were decreased,and tumor cells underwent massive apoptosis and necrosis(P<0.05).WT1 level was decreased,and GATA-1 level was significantly increased in subcutaneous tumor ti

关键词： ginsenoside Rd myeloid leukemia survival differentiation extracellular signal-related kinase signaling pathway

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