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Immediate implantation of ultrafine fiber slow-release system based on cell electrospinning to induce osteogenesis of mesenchymal stem cells

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Regenerative Biomaterials 2024年第2期3卷 76-87页

作者： Tao lu Long Yang Zhuoyang Li yin Liu Shun'en Xu Chuan Ye Department of Orthopaedics The Affliated Hospital of Guizhou Medical UniversityGuiyang 550004China Department of Orthopaedics The First People's Hospital of GuiyangGuiyang 550004China Center for Tissue Engineering and Stem Cell Research Guizhou Medical UniversityGuiyang 550004China Department of Otolaryngology Head and Neck Surgery Xinqiao HospitalArmy Medical University(Third Military Medical University)Chongqing 400037China Department of Dental implant Stomatological Hospital of GuiyangGuiyang 550000China

This study presents the development and evaluation of a poly(3-hydroxybutyrate-co-4-hydroxybutyrate)(P34HB)ultrafine fiber slow-release system for in vivo osteogenic induction of human umbilical cord mesenchymal stem cells(HUCMSCs).Utilizing dual-nozzle and cell electrospinning techniques,the system encapsulates L-ascorbic acid-2-phosphate magnesium(AsP),βB-glycerophosphate sodium and dexamethasone(DEX)within the'fbers,ensuring sustained osteogenic *** scaffold's morphology,characterization,hydrophilicity,mechanical properties and cellular behavior were *** subcutaneous implantation in rabbits was con-ducted to observe its ectopic osteogenic induction *** fabricated P34HB ultrafine fiber slow-release *** ization *** distribution of HUCMSCs and inducing components within the scaffold,with no chemical reactions affecting the active *** vitro tests showcased a prolonged release of DEX and ASP,while biocompatibility assays highlighted the scaffold's suitability for cellular *** Red,type I collagen,and osteopontin(OPN)staining verifed the scaffold's potent osteogenic induction effect on ***,immediate implantation into New Zealand White rabbits led to significant new bone formation within 8 *** findings underscore the system's potential for immediate in vivo implantation without prior in vitro induction,marking a promising advancement in bone tissue engineering.

关键词： bone tissue engineering cell electrospinning in vivo induction immediate implantation biomaterials

Chiral mesostructured hematite with temperature-independent magnetism due to spin confinement

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Nano Research 2024年第3期17卷 2019-2024页

作者： Baiwen Zhang jing Ai yingying Duan Te Bai lu Han Shunai Che School of Physics Science and Engineering Tongji UniversityShanghai 200092China School of Chemistry and Chemical Engineering Tongji UniversityShanghai 200092China Wuxi Vocational College of Science and Technology Wuxi 214028China School of Chemistry and Chemical Engineering Frontiers Science Center for Transformative MoleculesState Key Laboratory of Metal Matrix CompositesShanghai Jiao Tong UniversityShanghai 200240China

Hematite(α-Fe_(2)O_(3))is known to undergo conversion from weak ferromagnetic to antiferromagnetic as the temperature decreases below the Morin temperature(TM=250 K)due to spin moment rotation occurring during the Morin transition(MT).Herein,we endowed hematite with mesostructured chirality to maintain weak ferromagnetism without *** mesostructured hematite(CMH)nanoparticles were prepared by a hydrothermal method with glutamic acid(Glu)as the symmetry-breaking *** triangular bipyramidal CMH nanoparticles were composed of helically cleaved nanoflakes with twisted crystal ***-cooled(FC)magnetization measurements showed that the magnetic moments of CMH were stabilized without MT within the temperature range of 10–300 *** loop measurements confirmed the weak ferromagnetism of *** enhanced Dzyaloshinskii–Moriya interaction(DMI)was speculated to be responsible for the temperature-independent weak ferromagnetism,in which the spin configuration would be confined with canted antiferromagnetic coupling due to the mesostructured chirality of CMH.

关键词： hematite chiral mesostructure Dzyaloshinskii–Moriya interaction weak ferromagnetism antiferromagnetic material temperature-independent magnetism

Experimental and numerical investigations on micromixing performance of multi-orifice cross-flow jet mixers

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Chinese Journal of Chemical Engineering 2024年第6期70卷 63-72页

作者： Hang Yang Zhaojin lu Likun Ma Wei yin Bingjie Wang Zhishan Bai Xiaoyong Yang School of Mechanical and Power Engineering East China University of Science and TechnologyShanghai 200237China

Multi-orifice cross-flow jet mixers(MOCJMs)are used in various industrial applications due to their excellent mixing efficiency,but few studies have focused on the micromixing performance of ***,the flow characteristics and micromixing performance inside the MOCJM were investigated using experiments and computational fluid dynamics(CFD)simulations based on the Villermaux/Dushman system and the finite-rate/modified eddy-dissipation *** optimal A value was correlated with the characteristic parameters of MOCJMs to develop a CFD calculation method applicable to the study of the micromixing performance of the *** the micromixing efficiency was evaluated using the segregation index XS,and the effects of operational and geometric parameters such as mixing flow Reynolds number(ReM),flow ratio(RF),total jet area(ST),the number of jet orifices(n),and outlet configuration on the micromixing efficiency were *** was found that the intensive turbulent region generated by interactions between jets,as well as between jets and crossflows,facilitated rapid *** decreased with increasing ReM and decreasing ***,MOCJMs with lower ST,four jet orifices,and the narrower outlet configuration demonstrated a better micromixing *** study contributes to a deeper understanding of the micromixing performance of MOCJMs and provides valuable guidance for their design,optimization,and industrial application.

关键词： Multi-orifice cross-flow jet mixer Micromixing performance Finite-rate/modified eddy dissipation model Computational fluid dynamics Villermaux/Dushman reaction

Assessment of Crop Yield in China Simulated by Thirteen Global Gridded Crop Models

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Advances in Atmospheric Sciences 2024年第3期41卷 420-434页

作者： Dezhen yin Fang LI Yaqiong lu Xiaodong ZENG Zhongda LIN Yanqing ZHOU International Center for Climate and Environment Sciences Institute of Atmospheric PhysicsChinese Academy of SciencesBeijing 100029China University of Chinese Academy of Sciences Beijing 100049China Institute of Mountain Hazards and Environment Chinese Academy of SciencesChengdu 610041China State Key Laboratory of Numerical Modeling for Atmospheric Sciences and Geophysical Fluid Dynamics Institute of Atmospheric PhysicsChinese Academy of SciencesBeijing 100029China State Key Laboratory of Desert and Oasis Ecology Xinjiang Institute of Ecology and GeographyChinese Academy of SciencesUrumqi 830011China

Global gridded crop models(GGCMs) have been broadly applied to assess the impacts of climate and environmental change and adaptation on agricultural production. China is a major grain producing country, but thus far only a few studies have assessed the performance of GGCMs in China, and these studies mainly focused on the average and interannual variability of national and regional yields. Here, a systematic national-and provincial-scale evaluation of the simulations by13 GGCMs [12 from the GGCM Intercomparison(GGCMI) project, phase 1, and CLM5-crop] of the yields of four crops(wheat, maize, rice, and soybean) in China during 1980–2009 was carried out through comparison with crop yield statistics collected from the National Bureau of Statistics of China. Results showed that GGCMI models generally underestimate the national yield of rice but overestimate it for the other three crops, while CLM5-crop can reproduce the national yields of wheat, maize, and rice well. Most GGCMs struggle to simulate the spatial patterns of crop yields. In terms of temporal variability, GGCMI models generally fail to capture the observed significant increases, but some can skillfully simulate the interannual variability. Conversely, CLM5-crop can represent the increases in wheat, maize, and rice, but works less well in simulating the interannual variability. At least one model can skillfully reproduce the temporal variability of yields in the top-10 producing provinces in China, albeit with a few exceptions. This study, for the first time, provides a complete picture of GGCM performance in China, which is important for GGCM development and understanding the reliability and uncertainty of national-and provincial-scale crop yield prediction in China.

关键词： global gridded crop model historical crop yield China multi-model evaluation

Anti-atherosclerotic effects and molecular targets of ginkgolide B from Ginkgo biloba

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Acta Pharmaceutica Sinica B 2024年第1期14卷 1-19页

作者： Weile Ye Jiaojiao Wang Peter JLittle Jiami Zou Zhihua Zheng jing lu Yanjun yin Hao Liu Dongmei Zhang Peiqing Liu Suowen Xu Wencai Ye Zhiping Liu International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Development of Ministry of Education(MOE)of China Jinan UniversityGuangzhou 510632China Guangdong Province Key Laboratory of Pharmacodynamic Constituents of Traditional Chinese Medicine and New Drugs Research College of PharmacyJinan UniversityGuangzhou 510632China State Key Laboratory of Bioactive Molecules and Druggability Assessment Jinan UniversityGuangzhou 510632China Pharmacy Australia Centre of Excellence School of PharmacyUniversity of QueenslandWoolloongabba QLD 4102Australia Sunshine Coast Health Institute and School of Health and Behavioural Sciences University of the Sunshine CoastBirtinya QLD 4575Australia National-Local Joint Engineering Lab of Druggability and New Drugs Evaluation Guangdong Provincial Key Laboratory of New Drug Design and EvaluationSun Yat-sen UniversityGuangzhou 510006China School of Pharmacy Bengbu Medical CollegeBengbu 233030China Institute of Endocrine and Metabolic Diseases the First Affiliated Hospital of USTCDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefei 230026China

Bioactive compounds derived from herbal medicinal plants modulate various therapeutic targets and signaling pathways associated with cardiovascular diseases(CVDs),the world’s primary cause of *** biloba,a well-known traditional Chinese medicine with notable cardiovascular actions,has been used as a cardio-and cerebrovascular therapeutic drug and nutraceutical in Asian countries for *** studies have shown that ginkgolide B,a bioactive component in Ginkgo biloba,can ameliorate atherosclerosis in cultured vascular cells and disease *** clinical relevance,several clinical trials are ongoing or being completed to examine the efficacy and safety of ginkgolide B-related drug preparations in the prevention of cerebrovascular diseases,such as ischemia ***,we present a comprehensive review of the pharmacological activities,pharmacokinetic characteristics,and mechanisms of action of ginkgolide B in atherosclerosis prevention and *** highlight new molecular targets of ginkgolide B,including nicotinamide adenine dinucleotide phosphate oxidases(NADPH oxidase),lectin-like oxidized LDL receptor-1(LOX-1),sirtuin 1(SIRT1),platelet-activating factor(PAF),proprotein convertase subtilisin/kexin type 9(PCSK9)and ***,we provide an overview and discussion of the therapeutic potential of ginkgolide B and highlight the future perspective of developing ginkgolide B as an effective therapeutic agent for treating atherosclerosis.

关键词： Cardiovascular disease Atherosclerosis Ginkgo biloba Ginkgolide B Endothelial dysfunction LOX-1 PCSK9 PAF-R antagonist

Vein visualization enhancement by dual-wavelength phase-locked denoising technology

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Journal of Innovative Optical Health Sciences 2024年第3期17卷 73-83页

作者： Lihua Ruan Zhiqin yin Shibing Zhou Weibo Zheng Wei lu Tao Zhang Shaowei Wang Shanghai Institute of Technical Physics Chinese Academy of Sciences Shanghai 200083P.R.China State Key Laboratory of Infrared Physics Shanghai Institute of Technical PhysicsChinese Academy of SciencesShanghai 200083P.R.China Shanghai Engineering Research Center of Energy-Saving Coatings Shanghai 200083 P.R.China University of Chinese Academy of Sciences Beijing 100049P.R.China Shanghai Tech University Shanghai 201210P.R.China School of Physical Science and Technology ShanghaiTech UniversityShanghai 201210P.R.China School of Information Science and Technology ShanghaiTech UniversityShanghai 201210China

Visual near-infrared imaging equipment has broad applications in various fields such as venipuncture,facial injections,and safety verification due to its noncontact,compact,and portable ***,most studies utilize near-infrared single-wavelength for image acquisition of ***,many substances in the skin,including water,protein,and melanin can create significant background noise,which hinders accurate *** this paper,we developed a dual-wavelength imaging system with phase-locked denoising technology to acquire vein *** signals in the effective region are compared by using the absorption valley and peak of hemoglobin at 700nm and 940nm,*** phase-locked denoising algorithm is applied to decrease the noise and interference of complex surroundings from the *** imaging results of the vein are successfully extracted in complex noise *** is demonstrated that the denoising effect on hand veins imaging can be improved with 57.3%by using our dual-wavelength phase-locked denoising ***,this work proposes a novel approach for venous imaging with dual-wavelengths and phase-locked denoising algorithm to extract venous imaging results in complex noisy environment better.

关键词： Dual-wavelength phase-locked denoising vein visualization enhancement.

Effect of Blood Circulation in Veins on Resonance Suppression of the Dragonfly Wing Constructed by Numerical Method

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Journal of Bionic Engineering 2024年第2期21卷 877-891页

作者： Lijun Zhang Xu Zhang Kaifei Wang Zhenwei Gan Shibo Liu Xiao Liu Zhengjun jing Xudong Cui Jiahui lu jing Liu College of Mechanical and Electronic Engineering China University of PetroleumQingdao266580China

To reveal the resonance suppression mechanism of the blood circulation in dragonfly wings,a numerical modeling method of dragonfly wings based on Voronoi diagrams is proposed,and the changes in mass,aerodynamic damping,and natural frequencies caused by blood circulation in veins are *** equivalent mass of blood,boundary conditions,and aerodynamic damping are calculated *** analysis and harmonic response analysis of wing models with different blood circulation paths are performed using the finite-element method(FEM).The vibration reduction ratioδis introduced to compare the damping efficiency of different mass ***,a natural frequency testing device is constructed to measure the natural frequencies of dragonfly *** results indicate that the shape,mass,and natural frequencies of the dragonfly wing model constructed by numerical method agree well with *** mass distribution on the wing can be altered by blood circulation,thereby adjusting the natural frequencies and achieving resonance *** highestδof 1.013 is observed in the C region when blood circulates solely in secondary veins,but it is still lower than theδof 1.017 when blood circulates in complete *** aerodynamic damping ratio(1.19–1.79%)should not be neglected in the vibration analysis of the beating wing.

关键词： Dragonfly wings Blood circulation Resonance suppression Voronoi diagram FEM

FinTech Can Prevent the Formation of Zombie Firms:Evidence from China

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Social Sciences in China 2024年第1期45卷 111-133页

作者： Jiang Jiatong Yang lu yin Zhentao School of International Trade and Economics University of International Business and Economics School of Public Policy&Management Tsinghua University Institute of Finance and Banking Chinese Academy of Social Sciences

The interplay between financial technology(FinTech)and real economy firms has garnered considerable *** paper explores the relationship and mechanism between FinTech and corporate zombification using the data of Chinese A-share listed firms in China from 2011 to *** research findings reveal that FinTech significantly inhibits firm zombification,and FinTech breadth and depth both play a significant role in restraining firm *** exploration indicates that,on the one hand,FinTech reduces friction in the financial market,inhibiting firm zombification by improving firm investment efficiency,especially alleviating *** the other side,FinTech indirectly affects the technological investment,production,and operation of firms,thereby inhibiting firm zombification by increasing their total factor *** analysis suggests that the inhibitory effect of FinTech on corporate zombification is more pronounced for non-stateowned firms and small-sized firms,as well as those in manufacturing industries and highly competitive *** paper provides some novel evidence on evaluating the effect of FinTech on firms and also offers new insights for efficient governance of zombie firms.

关键词： FinTech zombie firms investment efficiency total factor productivity

A Novel Recovery Strategy to Suppress Subsequent Commutation Failure in an LCC-Based HVDC

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Protection and Control of Modern Power Systems 2024年第1期9卷 38-51页

作者： Changsheng Su Chunya yin Fengting Li lu Han 不详 School of Electrical Engineering Xinjiang UniversityUrumqi 830017China

A subsequent commutation failure(SCF)can easily occur during the recovery process after a first commutation failure(1st CF).This paper analyzes the interaction mechanism of extinction angle,AC voltage,DC current and firing angle,and reveals that the complex coupling relationship during the dynamic process after the 1st CF has a significant effect on the *** mathematical equations when considering different fault durations,fault severities and AC system strengths are then *** AC fault voltage detection method based on reactive power and fault duration is also proposed to measure the fault severity,and an SCF inhibition control strategy(SCFICS)based on AC fault detection and reactive power control is subsequently *** can not only inhibit the SCF,but also enhance the DC recovery speed ***,based on the SCFICS,a simulation model is built,and the simulation results with different cases indicate that the SCFICS can effectively inhibit the SCF with good recovery performance,for three-phase-to-ground(TPG)and single-phase-to-ground faults,and with a fault inductance range of 0.01 H to 1 H.

关键词： fault extinction angle