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Effect of moxibustion on expression profile of miRNAs in Tripterygium glycoside-induced decreased ovarian reserve

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Journal of Traditional Chinese Medicine 2024年第4期44卷 745-752页

作者： SHEN Jie yin Yaoli LI Hongxiao lu Ge ZHU Yaoyao QIN Yantong JIN Xun CHENG Jie SHEN Meihong College of Acupuncture and Tuina Nanjing University of Chinese MedicineNanjing 210023China

OBJECTIVE:To explore the possible regulatory mechanism of microRNA(miRNA)in moxibustion treatment for decreased ovarian reserve(DOR).METHODS:The DOR model was constructed by intragastrical Tripterygium glycoside suspension administration,and moxibustion therapy was simultaneously *** morphological ovarian changes were observed by hematoxylin and eosin *** miRNA expression profile was detected by RNA sequencing,and bioinformatics analysis was *** software 3.6.1 was used to establish a regulatory network and differentially expressed miRNAs were verified by reverse transcription quantitative polymerase chain reaction(RT-qPCR).RESULTS:Decreased number of mature follicles,increased atresia follicles,and abnormal granulosa cell morphology were observed in the model group compared with the control *** moxibustion group demonstrated increased mature follicles,decreased atretic follicles,and significantly decreased abnormal morphology of granulosa cells compared with the model ***,RNA sequencing results manifested significantly up-regulated miRNA expressions(miR-92b-3p,miR-26-5p_R+1_1ss10TC,miR-206-3p,miR-9993b-3p_1ss6GA,miR-7857-3p_R-1,miR-219a-2-3p_1ss10GC,miR-3968-p5_1ss10AT,and PC-5p-6478_1795)and down-regulated miR-664-2-5p_R+1 in the model group,compared with the control group,and the moxibustion group reversed abnormal disorder levels of these ***,these differentially expressed miRNAs were mainly involved in the phosphatidylinositol-3-kinase/protein kinase B signaling pathway and nuclear factor erythropoietin-2-related factor 2/heme oxygenase 1 signaling ***,network and RT-qPCR verification revealed miR-9993b-3p_1ss6GA as the most critical ***:This experiment proved the effectiveness of moxibustion in improving the ovarian reserve of rats by regulating miRNA expression,especially miR-9993b-3p_1ss6GA.

关键词： ovarian reserve moxibustion microRNAs mechanics

HHO optimized support vector machine classifier for traditional Chinese medicine syndrome differentiation of diabetic retinopathy

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International Journal of Ophthalmology(English edition) 2024年第6期17卷 991-1000页

作者： Li Xiao Cheng-Wu Wang ying Deng Yi-jing Yang jing lu Jun-Feng Yan Qing-Hua Peng School of Chinese Medicine Hunan University of Chinese MedicineChangsha 410208Hunan ProvinceChina School of Informatics Hunan University of Chinese MedicineChangsha 410208Hunan ProvinceChina Hunan Provincial Key Laboratory for Prevention and Treatment of Ophthalmology and Otolaryngology Diseases with Chinese Medicine Hunan University of Chinese MedicineChangsha 410208Hunan ProvinceChina Hunan Provincial Engineering and Technological Research Center for Prevention and Treatment of Ophthalmology and Otolaryngology Diseases with Chinese Medicine and Protecting Visual Function Hunan University of Chinese MedicineChangsha 410208Hunan ProvinceChina

AIM:To develop a classifier for traditional Chinese medicine(TCM)syndrome differentiation of diabetic retinopathy(DR),using optimized machine learning algorithms,which can provide the basis for TCM objective and intelligent syndrome ***:Collated data on real-world DR cases were collected.A variety of machine learning methods were used to construct TCM syndrome classification model,and the best performance was selected as the basic *** Algorithm(GA)was used for feature selection to obtain the optimal feature *** Hawk Optimization(HHO)was used for parameter optimization,and a classification model based on feature selection and parameter optimization was *** performance of the model was compared with other optimization *** models were evaluated with accuracy,precision,recall,and F1 score as ***:Data on 970 cases that met screening requirements were *** Vector Machine(SVM)was the best basic classification *** accuracy rate of the model was 82.05%,the precision rate was 82.34%,the recall rate was 81.81%,and the F1 value was 81.76%.After GA screening,the optimal feature combination contained 37 feature values,which was consistent with TCM clinical *** model based on optimal combination and SVM(GA_SVM)had an accuracy improvement of 1.92%compared to the basic *** model based on HHO and GA optimization(HHO_GA_SVM)had the best performance and convergence speed compared with other optimization *** with the basic classification model,the accuracy was improved by 3.51%.CONCluSION:HHO and GA optimization can improve the model performance of SVM in TCM syndrome differentiation of *** provides a new method and research idea for TCM intelligent assisted syndrome differentiation.

关键词： traditional Chinese medicine diabetic retinopathy Harris Hawk Optimization Support Vector Machine syndrome differentiation

Technical alternatives for coke oven gas utilization in China: A comparative analysis of environment-economic-strategic perspectives

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Environmental Science and Ecotechnology 2024年第5期21卷 168-177页

作者： Zichen Di Feixia Lei Jiankai jing Hao Peng Xi lu Fangqin Cheng Institute of Resources and Environmental Engineering Shanxi UniversityTaiyuan030006PR China School of Environment State Key Joint Laboratory of Environment Simulation and Pollution ControlTsinghua UniversityBeijing100084PR China Institute for Carbon Neutrality Tsinghua UniversityBeijing100084PR China

China is the largest coke producer and *** is a pressing need to address the high emissions of air pollutants and carbon dioxide associated with traditional coking *** the nation pursues a transition towards carbon neutrality,expanding supply chains for coking plants to produce hydrogen,methanol,and other green alternatives has garnered significant ***,the relative advantages of these strategies have remained *** this study,we integrate a life cycle assessmenteconomic analysis-scenario analysis model to evaluate various coke oven gas(COG)utilization routes(COGtM:COG-to-methanol,COGtLNG:COG-to-liquefied natural gas,COGtSA:COG-to-synthetic ammonia,and COGtH:COG-to-hydrogen).The results indicate that COGtSA emerges as the preferred option for balancing environmental and economic ***,COGtM demonstrates economic viability but is associated with higher environmental *** being recognized as a significant strategic direction under carbon neutrality initiatives,COGtH faces economic feasibility and risk resilience *** encounters both financial and environmental challenges,necessitating strategic development from an energy security *** projected coking capacity is anticipated to experience a slight increase in the mid-term yet a significant decline in the long term,influenced by steel production *** potential future markets,COGtM is estimated to potentially capture a maximum market share of 16e34%in the methanol ***,against the backdrop of continuously expanding potential demand for hydrogen,COGtH holds advantages as a transitional solution,but in the long run,it can only meet a small portion of the *** can meet 7e14%of market demand and emerges as the most viable pathway from the viewpoint of balancing environmental and economic aspects and covering future markets.

关键词： Coke oven gas Life cycle assessment Economic analysis Comprehensive benefits Transformation strategy

Coordinated Voltage Control of Distribution Network ConsideringMultiple Types of Electric Vehicles

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Energy Engineering 2024年第2期121卷 377-404页

作者： Liang Liu Guangda Xu Yuan Zhao Yi lu Yu Li jing Gao State Grid Jibei Electric Power Research Institute(North China Electric Power Research Institute Co. Ltd.)Beijing100045China

The couple between the power network and the transportation network(TN)is deepening gradually with the increasing penetration rate of electric vehicles(EV),which also poses a great challenge to the traditional voltage control *** this paper,we propose a coordinated voltage control strategy for the active distribution networks considering multiple types of *** the first stage,the action of on-load tap changer and capacitor banks,etc.,are determined by optimal power flow calculation,and the node electricity price is also determined based on dynamic time-of-use tariff *** the second stage,multiple operating scenarios of multiple types of EVs such as cabs,private cars and buses are considered,and the scheduling results of each EV are solved by building an optimization model based on constraints such as queuing theory,Floyd-Warshall algorithm and traffic flow *** the third stage,the output power of photovoltaic and energy storage systems is fine-tuned in the normal control *** charging power of EVs is also regulated in the emergency control mode to reduce the voltage deviation,and the amount of regulation is calculated based on the fair voltage control mode of ***,we test the modified IEEE 33-bus distribution system coupled with the 24-bus Beijing *** simulation results show that the proposed scheme can mitigate voltage violations well.

关键词： Electric vehicle transportation network voltage control queuing theory

First-principles study on the diffusion behavior of Cs and I in Cr coating

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Nuclear Science and Techniques 2024年第6期35卷 177-188页

作者： Shu-ying Lin Xiao-jing Li Lin-Bing Jiang Xi-Jun Wu Hui-Qin yin Yu Ma Wen-Guan Liu Sino-French Institute of Nuclear Engineering and Technology Sun Yat-Sen UniversityZhuhai 519082China School of Nuclear Science and Technology University of South ChinaHengyang 421001China

Cs and I can migrate through fuel-cladding interfaces and accelerate the cladding corrosion process induced by the fuel-cladding chemical *** coating has emerged as an important candidate for mitigating this chemical *** this study,first-principles calculations were employed to investigate the diffusion behavior of Cs and I in the Cr bulk and grain boundaries to reveal the microscopic interaction mitigation mechanisms at the fuel-cladding *** interaction between these two fission products and the Cr coating were studied systematically,and the Cs and I temperature-dependent diffusion coefficients in Cr were obtained using Bocquet’s oversized solute-atom model and Le Claire’s nine-frequency model,*** results showed that the Cs and I migration barriers were significantly lower than that of Cr,and the Cs and I diffusion coefficients were more than three orders of magnitude larger than the Cr self-diffusion coefficient within the temperature range of Generation-IV fast reactors(below 1000 K),demonstrating the strong penetration ability of Cs and ***,Cs and I are more likely to diffuse along the grain boundary because of the generally low migration barriers,indicating that the grain boundary serves as a fast diffusion channel for Cs and I.

关键词： First-principles calculation Fuel cladding chemical interaction Cr coating Fission product Diffusion Grain boundary

Non-contact gaseous microplasma electrode as anode for electrodeposition of metal and metal alloy in molten salt

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Chinese Chemical Letters 2024年第4期35卷 166-169页

作者： Junhan luo Qi Qing Liqin Huang Zhe Wang Shuang Liu jing Chen Yuexiang lu Institute of Nuclear and New Energy Technology Tsinghua UniversityBeijing 100084China The MOE Key Laboratory of Resources and Environmental System Optimization College of Environmental Science and EngineeringNorth China Electric Power UniversityBeijing 102206China Nuclear Research Institute for Future Technology and Policy Seoul National UniversitySeoul 08826Republic of Korea

Microplasma based on glow discharge could act as a non-contact gaseous electrode and has attracted much attention in both fundamental research and application. Herein, with microplasma as the anode,the electrodeposition process of a series of metal and metal alloys in molten salt has been systemically studied. Four metal cations with different valence states, silver(Ag~+), nickel(Ni^(2+)), copper(Cu^(2+)), and iron(Fe^(3+)), could all be reduced on the solid cathode with high current efficiency and the corresponding metal products were of high purity. The electrodeposition of aluminum-lanthanum(Al-Ln) alloy on the aluminum cathode was also successfully carried out with microplasma as the anode, and the same alloy was obtained by using the conventional anode electrode. These results indicated that microplasma anode based on non-contact direct-current(DC) glow discharge is a promising electrode to be applied in molten salt electrolysis.

关键词： Microplasma Anode Molten salt Electrodeposition Al-Ln alloy

An exo Probe-based Reverse Transcription and Recombinase Polymerase Amplification for Rapid Detection of Feline Calicivirus in Cats

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Biomedical and Environmental Sciences 2024年第3期37卷 325-330页

作者： MU Hong Yun ZHOU Hong Lei jing Zheng lu Wei ZHANG Jian Wei Jiangsu Agri-animal Husbandry Vocational College Taizhou 225300JiangsuChina Boehringer Ingelheim Animal Health(Shanghai)Co. LTD.Shanghai 200040China

Feline calicivirus(FCV)was a highly prevalent RNA virus causing upper respiratory tract infections in cats through the mouth and nose around the world,result in the death of cats especially under 1 year old with upper respiratory tract disease(URTD)and virulent systemic disease(FCV-VSD)[1].Infected cats usually presented with mouth ulcers,salivation and ***,both recovered cats and asymptomatic carriers can still carry and spread the FCV virus for extended periods of time,contributing to the potential for *** presented a significant threat to the health and lives of cats,and rare wildlife and took a heavy financial loss on the pet industry,making the prevention and control of the virus ***,rapid identification of FCV in clinical samples was necessary to prevent the spread of FCV and avoid financial loss.

关键词： prevention respiratory Probe

Highly efficient and stable electrocatalyst for hydrogen evolution by molybdenum doped Ni-Co phosphide nanoneedles at high current density

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Nano Research 2024年第3期17卷 1066-1074页

作者： Chengyu Huang Zhonghong Xia jing Wang jing Zhang Chenfei Zhao Xingli Zou Shichun Mu Jiujun Zhang Xionggang lu Hong Jin Fan Shengjuan Huo Yufeng Zhao College of Sciences&Institute for Sustainable Energy Shanghai UniversityShanghai 200444China State Key Laboratory of Metastable Materials Science and Technology Hebei Key Laboratory of Heavy Metal Deep-Remediation in Water and Resource ReuseYanshan UniversityQinhuangdao 066004China State Key Laboratory of Advanced Special Steel and Shanghai Key Laboratory of Advanced Ferrometallurgy School of Materials Science and EngineeringShanghai UniversityShanghai 200444China State Key Laboratory of Advanced Technology for Materials Synthesis and Processing Wuhan University of TechnologyWuhan 430070China School of Physical and Mathematical Sciences Nanyang Technological UniversitySingapore639798

There is an increasingly urgent need to develop cost-effective electrocatalysts with high catalytic activity and stability as alternatives to the traditional Pt/C in catalysts in water *** this study,microspheres composed of Mo-doped NiCoP nanoneedles supported on nickel foam were prepared to address this *** results show that the nanoneedles provide sufficient active sites for efficient electron transfer;the small-sized effect and the micro-scale roughness enhance the entry of reactants and the release of hydrogen bubbles;the Mo doping effectively improves the electrocatalytic performance of NiCoP in alkaline *** catalyst exhibits low hydrogen evolution overpotentials of 38.5 and 217.5 mV at a current density of 10 mA·cm^(-2) and high current density of 500 mA·cm^(-2),respectively,and only 1.978 V is required to achieve a current density of 1000 mA·cm^(-2) for overall water *** functional theory(DFT)calculations show that the improved hydrogen evolution performance can be explained as a result of the Mo doping,which serves to reduce the interaction between NiCoP and intermediates,optimize the Gibbs free energy of hydrogen adsorption(△G_(*H)),and accelerate the desorption rate of **** study provides a promising solution to the ongoing challenge of designing efficient electrocatalysts for high-current-density hydrogen production.

关键词： transition metal phosphides Mo-doped NiCoP hydrogen evolution reaction gradient hydrothermal water splitting

Machine learning-based predictions of current and future susceptibility to retrogressive thaw slumps across the Northern Hemisphere

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Advances in Climate Change Research 2024年第2期15卷 253-264页

作者： jing luO Guo-An yin Fu-Jun NIU Tian-Chun DONG Ze-Yong GAO Ming-Hao LIU Fan YU State Key Laboratory of Frozen Soil Engineering Northwest Institute of Eco-Environment and ResourcesChinese Academy of SciencesLanzhou 730000China China Railway Qinghai-Tibet Group Co. LtdXining 810000China University of Chinese Academy of Sciences Beijing 100049China

Retrogressive thaw slumps(RTSs)caused by the thawing of ground ice on permafrost slopes have dramatically increased and become a common permafrost hazard across the Northern Hemisphere during previous ***,a gap remains in our comprehensive understanding of the spatial controlling factors,including the climate and terrain,that are conducive to these RTSs at a global *** machine learning methodologies,we mapped the current and future RTSs susceptibility distributions by incorporating a range of environmental factors and RTSs *** identified freezing-degree days and maximum summer rainfall as the primary environmental factors affecting RTSs *** final ensemble susceptibility map suggests that regions with high to very high susceptibility could constitute(11.6±0.78)%of the Northern Hemisphere's permafrost *** juxtaposed with the current(2000-2020)RTSs susceptibility map,the total area with high to very high susceptibility could witness an increase ranging from(31.7±0.65)%(SSP585)to(51.9±0.73)%(SSP126)by the *** insights gleaned from this study not only offer valuable implications for engineering applications across the Northern Hemisphere,but also provide a long-term insight into the potential change of RTSs in permafrost regions in response to climate change.

关键词： Retrogressive thaw slump Machine learning Susceptibility map Permafrost Northern Hemisphere