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Bufferless Epitaxial Growth of GaAs on Step-Free Ge(001)Mesa

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Chinese Physics Letters 2021年第6期38卷 67-71页

作者： Ding-Ming Huang jie-yin zhang Jian-Huan Wang Wen-Qi Wei Zi-Hao Wang Ting Wang Jian-Jun zhang Beijing National Laboratory for Condensed Matter Physics Institute of PhysicsChinese Academy of SciencesBeijing 100190China School of Physical Sciences University of Chinese Academy of SciencesBeijing 100190China Songshan Lake Materials Laboratory Dongguan 523808China

GaAs/Ge heterostructures have been employed in various semiconductor devices such as solar cells,high-performance CMOS transistors,andⅢ-Ⅴ/Ⅳheterogeneous optoelectronic *** performance of these devices is directly dependent on the material quality of the GaAs/Ge heterostructure,while the material quality of the epitaxial GaAs layer on the Ge is limited by issues such as the antiphase domain(APD),and stacking-fault pyramids(SFP).We investigate the epitaxial growth of high-quality GaAs on a Ge(001)mesa array,via molecular beam *** a systematic study of the Ge terrace via an in situ scanning tunneling microscope,an atomically step-free terrace on the Ge mesa measuring up to 5×5μm^(2) is obtained,under optimized growth *** step-free terrace has a single-phase c(4×2)surface *** deposition of a high-quality GaAs layer with no APD and SFP is then achieved on this step-free Ge ***-resolution transmission electron microscopy and electron channel contrast image characterizations reveal the defect-free growth of the GaAs layer on the step-free Ge ***,InAs quantum dots on this GaAs/Ge mesa reveal photoluminescent intensity comparable to that achieved on a GaAs substrate,which further confirms the high quality of the GaAs layer on Ge.

关键词： GaAs/Ge optoelectronic tunneling

A CMOS Compatible Si Template with (111) Facets for Direct Epitaxial Growth of Ⅲ–Ⅴ Materials

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Chinese Physics Letters 2020年第2期37卷 30-34页

作者： Wen-Qi Wei Jian-Huan Wang jie-yin zhang Qi Feng Zihao Wang Hong-Xing Xu Ting Wang Jian-Jun zhang Wuhan University School of Physics and Technology Wuhan UniversityWuhan 430072 Beijing National Laboratory for Condensed Matter Physics and Institute of Physics Chinese Academy of SciencesBeijing 100190 College of Materials Science and Opto-electronic Technology University of Chinese Academy of SciencesBeijing 100049 Songshan Lake Materials Laboratory Dongguan 523808

Ⅲ-Ⅴ quantum dot(QD) lasers monolithically grown on CMOS-compatible Si substrates are considered as essential components for integrated silicon photonic ***,epitaxial growth of Ⅲ-Ⅴ materials on Si substrates encounters three obstacles:mismatch defects,antiphase boundaries(APBs),and thermal *** study the evolution of the structures on U-shaped trench-patterned Si(001) substrates with various trench orientations by homoepitaxy and the subsequent heteroepitaxial growth of GaAs *** results show that the formation of(111)-faceted hollow structures on patterned Si(001) substrates with trenches oriented along [110] direction can effectively reduce the defect density and thermal stress in the GaAs/Si ***(111)-faceted silicon hollow structure can act as a promising platform for the direct growth of Ⅲ-Ⅴ materials for silicon based optoelectronic applications.

关键词： III–V trench optoelectronic

A multicenter study assessing the prevalence of germline genetic alterations in Chinese gastric-cancer patients

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Gastroenterology Report 2021年第4期9卷 339-349,I0002页

作者： yin-jie zhang Yang Yang Qing Wei Ting Xu Xiao-Tian zhang Jing Gao Si-Yi Tan Bao-Rui Liu Jing-Dong zhang Xiao-Bing Chen Zhao-jie Wang Meng Qiu Xin Wang Lin Shen Xi-Cheng Wang Department of Gastrointestinal Oncology Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education/Beijing)Peking University Cancer Hospital&InstituteBeijingP.R.China Department of Medical Oncology Sichuan Cancer Hospital&InstituteSichuan Cancer CenterSchool of MedicineUniversity of Electronic Science and Technology of ChinaChengduSichuanP.R.China Comprehensive Cancer Center of Drum Tower Hospital Medical School of Nanjing University&Clinical Cancer Institute of Nanjing UniversityNanjingJiangsuP.R.China Department of Medical Oncology Zhejiang Cancer HospitalHangzhouZhejiangP.R.China Department of Medical Oncology Cancer Hospital of China Medical UniversityLiaoning Cancer Hospital&InstituteShenyangLiaoningP.R.China Department of Gastroenterology and Medical Oncology Henan Cancer Hospital(Affiliated Cancer Hospital of Zhengzhou University)ZhengzhouHenanP.R.China Department of Oncology Henan Provincial People’s HospitalZhengzhouHenanP.R.China Department of Medical Oncology Cancer Centerthe State Key Laboratory of BiotherapyWest China HospitalWest China Medical SchoolSichuan UniversityChengduSichuanP.R.China State Key Laboratory of Cancer Biology Xijing Hospital of Digestive DiseaseFourth Military Medical UniversityXi’anShaanxiP.R.China

Background Approximately 10%of patients with gastric cancer(GC)have a genetic predisposition toward the ***,there is scant knowledge regarding germline mutations in predisposing genes in the Chinese GC *** study aimed to determine the spectrum and distribution of predisposing gene mutations among Chinese GC patients known to have hereditary high-risk factors for *** A total of 40 GC patients from 40 families were recruited from seven medical institutions in ***-generation sequencing was performed on 171 genes associated with cancer *** probands carrying pathogenic/likely pathogenic germline variants,Sanger sequencing was applied to validate the variants in the probands as well as their *** According to sequencing results,25.0%(10/40)of the patients carried a combined total of 10 pathogenic or likely pathogenic germline variants involving nine different genes:CDH1(n=1),MLH1(n=1),MSH2(n=1),CHEK2(n=1),BLM(n=1),EXT2(n=1),PALB2(n=1),ERCC2(n=1),and SPINK1(n=2).In addition,129 variants of uncertain significance were identified in 27 *** This study indicates that approximately one in every four Chinese GC patients with hereditary high risk factors may harbor pathogenic/likely pathogenic germline alterations in cancer-susceptibility *** results further indicate a unique genetic background for GC among Chinese patients.

关键词： familial gastric cancer next-generation sequencing germline mutation cancer-predisposition gene

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身体与道德发生机制的认知维度探析

科学技术哲学研究 2018年第2期35卷 7-12页

作者：殷杰张祯山西大学科学技术哲学研究中心太原030006

道德发生机制是一个从抽象道德概念表征,到具体道德行为发生,再上升到抽象道德意识构建的演变过程,在这一过程中产生的道德概念、道德行为和道德意识都离不开身体的参与。纵向来看,随着认知科学的发展,当代具身认知突破传统离身认知的局... 详细信息

道德发生机制是一个从抽象道德概念表征,到具体道德行为发生,再上升到抽象道德意识构建的演变过程,在这一过程中产生的道德概念、道德行为和道德意识都离不开身体的参与。纵向来看,随着认知科学的发展,当代具身认知突破传统离身认知的局限,从身心二元走向身心一体,强调身体参与道德发生机制的重要作用。横向来看,道德发生机制是在具身认知范式下,以道德心理学和神经科学等多学科视角展开研究,强调身体经验是道德概念表征的基础,肢体语言是道德行为产生的重要因素,以及身体与环境的交互是道德意识构建的基本条件。文章以具身认知视角探析道德发生机制的动态构建过程,旨在论证身体对道德发生机制的重要性。

关键词：具身认知道德发生机制具身道德

Nanomaterials-mediated lysosomal regulation:a robust protein-clearance approach for the treatment of Alzheimer’s disease

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Neural Regeneration Research 2025年第2期20卷 424-439页

作者： Mengqi Hao Jianjian Chu Tinglin zhang Tong yin Yuankai Gu Wendanqi Liang Wenbo Ji Jianhua Zhuang Yan Liu jie Gao You yin Department of Neurology Second Affiliated Hospital of Naval Medical University(Shanghai Changzheng Hospital)ShanghaiChina School of Health Science and Engineering University of Shanghai for Science and TechnologyShanghaiChina Changhai Clinical Research Unit Shanghai Changhai HospitalNaval Medical UniversityShanghaiChina Department of Clinical Pharmacy Xinhua HospitalShanghai Jiao Tong University School of MedicineShanghaiChina Department of Neurology Shanghai East HospitalSchool of MedicineTongji UniversityShanghaiChina

Alzheimer’s disease is a debilitating,progressive neurodegenerative disorder characterized by the progressive accumulation of abnormal proteins,including amyloid plaques and intracellular tau tangles,primarily within the ***,crucial intracellular organelles responsible for protein degradation,play a key role in maintaining cellular *** studies have suggested a link between the dysregulation of the lysosomal system and pathogenesis of neurodegenerative diseases,including Alzheimer’s *** the normal physiological function of lysosomes hold the potential to reduce the pathological burden and improve the symptoms of Alzheimer’s ***,the efficacy of drugs in treating Alzheimer’s disease is limited,with major challenges in drug delivery efficiency and ***,nanomaterials have gained widespread use in Alzheimer’s disease drug research owing to their favorable physical and chemical *** review aims to provide a comprehensive overview of recent advances in using nanomaterials(polymeric nanomaterials,nanoemulsions,and carbon-based nanomaterials)to enhance lysosomal function in treating Alzheimer’s *** review also explores new concepts and potential therapeutic strategies for Alzheimer’s disease through the integration of nanomaterials and modulation of lysosomal *** conclusion,this review emphasizes the potential of nanomaterials in modulating lysosomal function to improve the pathological features of Alzheimer’s *** application of nanotechnology to the development of Alzheimer’s disease drugs brings new ideas and approaches for future treatment of this disease.

关键词： Alzheimer’s disease autophagy dysfunction lysosomal acidification lysosomal system nanomaterials neurodegenerative diseases

山东滨海盐渍区植物群落与土壤化学因子的关系

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应用生态学报 2018年第11期29卷 3521-3529页

作者：尹德洁张洁荆瑞董丽国家花卉工程技术研究中心/城乡生态环境北京实验室/北京林业大学园林学院北京100083

在山东滨海盐渍区选取81个样方进行植物群落调查,对土壤化学性质进行分析,研究耐盐植物分布与土壤pH、可溶性盐总量、全氮、全磷、有机质、K^+、Na^+、Ca^(2+)、Mg^(2+)、Cl^-、SO_4^(2-)和HCO_3^-12个土壤化学因子之间的关系.结果表明... 详细信息

在山东滨海盐渍区选取81个样方进行植物群落调查,对土壤化学性质进行分析,研究耐盐植物分布与土壤pH、可溶性盐总量、全氮、全磷、有机质、K^+、Na^+、Ca^(2+)、Mg^(2+)、Cl^-、SO_4^(2-)和HCO_3^-12个土壤化学因子之间的关系.结果表明:共记录耐盐植物30科67属85种,排名前三的优势科为菊科、禾本科、藜科.群落类型分为4类,分别是芦苇-白茅+茵陈蒿群落、盐地碱蓬+芦苇-茵陈蒿+地肤群落、芦苇-香蒲+罗布麻群落和芦苇-罗布麻群落.CCA排序表明,土壤可溶性盐总量和水溶性离子含量是影响该区域耐盐植被分布的关键土壤化学因子,其次是土壤全氮含量.优势种为芦苇,同时伴生白茅和茵陈蒿的群落在4个群落类型中具有较丰富的物种多样性,所蕴含的耐盐植物资源丰富.群落的物种多样性与土壤可溶性盐总量和水溶性盐离子含量呈显著负相关,高盐分土壤会降低群落的物种多样性指数,影响群落的物种多样性.

关键词：滨海盐渍区土壤化学因子空间异质性耐盐植物

Dynamic behaviors of graphene platelets-reinforced metal foam piezoelectric beams with velocity feedback control

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Applied Mathematics and Mechanics(English Edition) 2025年第1期46卷 63-80页

作者： jie CHEN Xinyue zhang Mingyang FAN School of Mathematics Statistics and Mechanics Beijing University of Technology College of Mechanical & Energy Engineering Beijing University of Technology

Graphene platelets(GPLs)-reinforced metal foam structures enhance the mechanical properties while maintaining the lightweight characteristics of metal foams. Further bonding piezoelectric actuator and sensor layers on the surfaces of GPLs-reinforced metal foam beams enables active vibration control, greatly expanding their applications in the aerospace industry. For the first time, this paper investigates the vibration characteristics and active vibration control of GPLs-reinforced metal foam beams with surfacebonded piezoelectric layers. The constant velocity feedback scheme is used to design the closed-loop controller including piezoelectric actuators and sensors. The effects of the GPLs on the linear and nonlinear free vibrations of the beams are numerically *** Newmark-β method combined with Newton's iteration technique is used to calculate the nonlinear responses of the beams under different load forms including harmonic loads,impact loads, and moving loads. Additionally, special attention is given to the vibration reduction performance of the velocity feedback control on the responses of the beam.

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诱变技术在落叶果树育种中的应用

园艺学报 2016年第9期43卷 1633-1652页

作者：吴潇齐开杰殷豪张绍铃南京农业大学梨工程技术研究中心南京210095

对利用诱变技术开展落叶果树育种的研究进展,包括诱变方法、诱变育种取得的成果及发展趋势等进行了综述,指出目前诱变育种中存在的问题,并对诱变技术与杂交、离体培养及基因组学研究结合用于育种进行了展望。

关键词：落叶果树诱变育种突变体

CNKSR2 interactome analysis indicates its association with the centrosome/microtubule system

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Neural Regeneration Research 2025年第8期20卷 2420-2432页

作者： Lin yin Yalan Xu jie Mu Yu Leng Lei Ma Yu Zheng Ruizhi Li yin Wang Peifeng Li Hai Zhu Dong Wang Jing Li Institute for Translational Medicine The Affiliated Hospital of Qingdao UniversityMedical CollegeQingdao UniversityQingdaoShandong ProvinceChina School of Basic Medicine Qingdao UniversityQingdaoShandong ProvinceChina College of Life Sciences and School of PharmacyMedical CollegeQingdao UniversityQingdaoShandong ProvinceChina Department of Urology Qingdao Municipal Hospital Affiliated to Qingdao UniversityQingdaoShandong ProvinceChina

The protein connector enhancer of kinase suppressor of Ras 2(CNKSR2),present in both the postsynaptic density and cytoplasm of neurons,is a scaffolding protein with several protein-binding *** of the CNKSR2 gene have been implicated in neurodevelopmental disorders,particularly intellectual disability,although the precise mechanism involved has not yet been fully *** has demonstrated that CNKSR2 plays a role in facilitating the localization of postsynaptic density protein complexes to the membrane,thereby influencing synaptic signaling and the morphogenesis of dendritic ***,the function of CNKSR2 in the cytoplasm remains to be *** this study,we used immunoprecipitation and high-resolution liquid chromatography-mass spectrometry to identify the interactors of *** a combination of bioinformatic analysis and cytological experiments,we found that the CNKSR2 interactors were significantly enriched in the proteome of the *** also showed that CNKSR2 interacted with the microtubule protein DYNC1H1 and with the centrosome marker *** colocalization analysis confirmed the centrosomal localization of *** we downregulated CNKSR2 expression in mouse neuroblastoma cells(Neuro 2A),we observed significant changes in the expression of numerous centrosomal *** manipulation also affected centrosome-related functions,including cell size and shape,cell proliferation,and ***,we found that CNKSR2 interactors were highly enriched in de novo variants associated with intellectual disability and autism spectrum *** findings establish a connection between CNKSR2 and the centrosome,and offer new insights into the underlying mechanisms of neurodevelopmental disorders.

关键词： autism spectrum disorder centrosome CNKSR2 intellectual disability interactome mass spectrometry microtubule neurodevelopmental disease protein complexes protein-protein interactions