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Chinese breast cancer surgery:clinical practice and research

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Chinese Medical Journal 2020年第19期133卷 2269-2270页

作者： Ling Xin Jia-Yi Li Zhi-Gang Yu yin-hua liu Breast Disease Center Peking University First HospitalBeijing 100034China Breast Surgical Department The Second Hospital of Shandong UniversityJinanShandong 250000China

According to GLOBOCAN 2018,the global cancer statistic database by the International Agency for Research on Cancer,breast cancer is the most commonly diagnosed cancer in women.[1]In 2018,more than 2 million new breast cancer cases were reported,with an age standardized rate(ASR)of 46.3 per 100,000,and over 600,000 deaths from breast cancer were estimated,with an ASR of 13.0 per 100,000,*** number of breast cancer cases continues to *** China,more than 270,000 new cases were diagnosed in 2015,with 70,000 reported deaths.[2]In 2018,the number of new cases in the country increased to 367,900.[1]Thus,we urgently need more clinical researches and expert consensus on optimal therapies for breast cancer.

关键词： breast clinical cancer

Synthesis and Structure of 3-Aryl-5-cyano-6-methylthio pyrimidine2,4-diones

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Chinese Chemical Letters 1999年第3期10卷 191-192页

作者： hua yin liu Guang Fu YANG hua Zheng YANG(State Key Laboratory of Elemento-Organic Chemistry, Institute of Elemento-Organic Chemistry,Nankai University, Tianjin 300071)

The title compounds of 3-aryl-5-cyano-6-methylthiopyrimidine2.4-diones weresynthesized by the reaction of ethy1 2-cyano-3.3'dimethylthioacrylate with arylureas. The compound(Ar＝p-CH_3OC_6H_4) was recrystallized in acetone/petroleum in space group P2_(1/n) with a＝1. 1602 (2).b=1.5921(3), c＝1.3918 (3)um. β=94.38 (3)°for Z=8. R=*** X-ray analysis showedthat there is H-bond interaction among molecules.

关键词： Synthesis crystalline structure

Prognostic value of tumor-infiltrating lymphocyte subtypes in residual tumors of patients with triple-negative breast cancer after neoadjuvant chemotherapy

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Chinese Medical Journal 2020年第5期133卷 552-560页

作者： Yu-Ge Bai Guo-Xuan Gao Hong Zhang Shuang Zhang yin-hua liu Xue-Ning Duan Ling Xu Breast Disease Center Peking University First HospitalBeijing 100034China Department of General Surgery Beijing Friendship HospitalCapital Medical UniversityBeijing 100050China Pathology Department Peking University First HospitalBeijing 100034China

Background:After neoadjuvant chemotherapy(NAC),non-pathological complete response of breast cancer patients can benefit from tailored adjuvant ***,it is difficult to select patients with poorer prognosis for additional adjuvant chemotherapy to maximize the *** study aimed to explore whether the subtypes of tumor-infiltrating lymphocytes(TILs)in residual tumors(RT)is related to the prognosis of triple-negative breast cancer(TNBC)after ***:Data from patients with primary TNBC consecutively diagnosed at the Breast Disease Center of Peking University First Hospital from 2008 to 2014 were retrieved,and the cases with RT in the breast after NAC were *** subtypes in RT were observed by double-staining immunohistochemistry,and counted with the median TILs value per square millimeter as the cut-off to define high versus low TILs density in each *** relationships between the TIL density of each subgroup and the clinicopathological characteristics of the RT after NAC patients were analyzed by Fisher exact ***-free survival(DFS)and overall survival(OS)were analyzed by the Kaplan-Meier method and log-rank ***:A total of 37 eligible patients were included in this study,and the median follow-up period was 50 months(range 17–106 months).There was no significant correlation between the infiltrate density of CD4^+,CD8^+,CD20^+,and CD68^+lymphocytes and clinic-pathological *** better prognosis was observed in patients with high CD4^+-TILs(DFS:P=0.005,OS:P=0.021)and high CD8^+-TILs(DFS:P=0.018)and low CD20^+-TILs(OS:P=0.042).Further analysis showed that patients with CD4^+/CD20^+ratio greater than 1(DFS:P=0.001,OS:P=0.002)or CD8^+/CD20^+ratio greater than 1(DFS:P=0.009,OS:P=0.022)had a better ***:Subtypes of TILs in RT is a potential predictive biomarker of survival in TNBC patients after NAC.

关键词： Triple-negative breast cancer Neoadjuvant chemotherapy Residual tumors Tumor-infiltrating lymphocyte subtypes

A Retrospective Survival Analysis of Anatomic and Prognostic Stage Group Based on the American Joint Committee on Cancer 8th Edition Cancer Staging Manual in Luminal B Human Epidermal Growth Factor Receptor 2-negative Breast Cancer

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Chinese Medical Journal 2017年第16期130卷 1945-1952页

作者： Ling Xu Jiang-Hong Li Jing-Ming Ye Xue-Ning Duan Yuan-Jia Cheng Ling Xin Qian liu Bin Zhou yin-hua liu Breast Disease Center Peking University First Hospital Beijing 100034 China Department of General Surgery The Third Hospital of Shijiazhuang Shijiazhuang Hebei 050011 China

Background： Current understanding of tumor biology suggests that breast cancer is a group of diseases with different intrinsic molecular subtypes. Anatomic staging system alone is insufficient to provide future outcome information. The American Joint Committee on Cancer （AJCC） expert panel updated the 8th edition of the staging manual with prognostic stage groups by incorporating biomarkers into the anatomic stage groups. In this study, we retrospectively analyzed the data from our center in China using the anatomic and prognostic staging system based on the AJCC 8th edition staging manual. Methods： We reviewed the data from January 2008 to December 2014 for cases with Luminal B Human Epidermal Growth Factor Receptor 2 （HER2）-negative breast cancer in our center. All cases were restaged using the AJCC 8th edition anatomic and prognostic staging system. The Kaplan-Meier method and log-rank test were used to compare the survival differences between different subgroups. SPSS software version 19.0 （IBM Corp., Armonk, NY, USA） was used for the statistical analyses. Results： This study consisted of 796 patients with Luminal B HER-negative breast cancer. The 5-year disease-free survival （DFS） of 769 Stage I-III patients was 89.7%, and the 5-year overall survival （OS） of all 796 patients was 91.7%. Both 5-year DFS and 5-year OS were significantly different in the different anatomic and prognostic stage groups, There were 372 cases （46.7%） assigned to a different group. The prognostic Stage II and III patients restaged from anatomic Stage III had significant differences in 5-year DFS （v2 = 11.319; P = 0.001） and 5-year OS （χ2 = 5.225, P = 0.022）. In addition, cases restaged as prognostic Stage I, II, or III from the anatomic Stage II group had statistically significant differences in 5-year DFS （χ2 = 6.510, P = 0.039） but no significant differences in 5-year OS （χ2 = 5.087, P = 0.079）. However, the restaged prognostic Stage I and II cases from anatomic Stage I had no statist

关键词： American Joint Committee on Cancer Biomarker Breast Cancer Cancer Stage Luminal B Human EpidermalGrowth Factor Receptor 2-negative Prognostic Factors

Clinicopathologic analysis of 722 breast cancer patients who met the inclusion criteria of the TAILORx trial

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Chinese Medical Journal 2019年第24期132卷 2914-2919页

作者： Hong-Yu Xiang yin-hua liu Hong Zhang Shuang Zhang Ling Xin Ling Xu Jing-Ming Ye Ting Li Xue-Ning Duan Qian liu Breast Disease Center Peking University First HospitalBeijing 100034China Department of Pathology Peking University First HospitalBeijing 100034China

Background:The results of the Trial Assigning IndividuaLized Options for Treatment(TAILORx)suggested that approximately 70%of T1-2N0M0,hormone receptor-positive,human epidermal growth factor receptor 2(HER2)-negative breast cancer patients can avoid chemotherapy and receive only adjuvant endocrine *** conducted a retrospective analysis of the clinicopathologic features and prognostic factors of patients with breast cancer who met the inclusion criteria of the TAILORx ***:According to the enrollment criteria of the TAILORx trial,a retrospective analysis was performed on patients with breast cancer who were treated from January 2008 to December 2015 at Peking University First *** clinicopathologic characteristics of all patients were analyzed,and prognoses were calculated using the Kaplan-Meier method and a Cox proportionate hazards ***:A total of 2430 patients with early stage breast cancer who were admitted at our hospital had complete clinicopathologic data and follow-up *** these patients,722 met the inclusion criteria and were enrolled in the present study,accounting for 29.7%of all *** them,417(57.8%)patients received only adjuvant endocrine therapy(the non-chemo group),and 305(42.2%)patients received adjuvant chemotherapy followed by adjuvant endocrine therapy(the chemo group).No statistically significant difference was observed in overall survival(OS)between the two groups(non-chemo ***:5-year OS:97.9%vs.97.9%,χ^2=1.00,P=0.995;hazard ratio[HR]=1.00,95%confidence interval[CI]:0.46–2.21).A significant difference was observed in disease-free survival(DFS)between the two groups(non-chemo ***:5-year DFS:97.9%vs.94.7%,χ^2=8.65,P=0.003;HR=3.05,95%CI:1.40–6.67).The choice of adjuvant therapy was associated with clinicopathologic factors,such as the age at diagnosis,T stage,histologic grade,the Ki67 index,the presence of intravascular tumor thrombus(P<0.001),pathologic type,and menstrual status(P=0.014

关键词： Adjuvant therapy Early stage breast cancer Multigene detection Prognosis TAILORx trial

Retrospective analysis of sentinel lymph node biopsy using methylene blue dye for early breast cancer

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Chinese Medical Journal 2021年第3期134卷 318-325页

作者： Shan Yang Hong-Yu Xiang Ling Xin Hong Zhang Shuang Zhang Yuan-Jia Cheng Qian liu Ling Xu Ting Li Xue-Ning Duan Jing-Ming Ye yin-hua liu Breast Disease Center Peking University First HospitalBeijing 100034China Department of Pathology Peking University First HospitalBeijing 100034China

Background:Methylene blue is the most commonly used tracer for sentinel lymph node(SLN)biopsy(SLNB)in *** study aimed to investigate the feasibility of clinical application of SLNB using methylene blue dye(MBD)for early breast cancer and the prognosis of patients with different SLN and non-SLN ***:We retrospectively analyzed the clinicopathological data of patients with early breast cancer treated at the Peking University First Hospital between 2013 and *** calculated the SLN identification rate(IR)in SLNB with MBD and the false-negative rate(FNR),and analyzed the prognosis of patients with different SLN and non-SLN statuses using Kaplan-Meier ***:Between January 2013 and December 2018,1603 patients with early breast cancer underwent SLNB with *** SLN IR was 95.8%(1536/1603).Two SLNs(median)were detected per *** were significant differences in FNR between patients with SLN micrometastasis and macrometastasis(19.0%vs.4.5%,χ^(2)=12.771,P<0.001).Chi-square test showed that there were significant differences in SLN successful detection rates among patients with different vascular tumor embolism status(96.3%vs.90.8%,χ^(2)=9.013,P=0.003)and tumor(T)stages(96.6%vs.94.1%,χ^(2)=5.189,P=0.023).Multivariate analysis showed that vascular tumor embolism was the only independent factor for SLN successful detection(odds ratio:0.440,95%confidence interval:0.224-0.862,P=0.017).Survival analysis showed a significant difference in disease-free survival(DFS)between patients with non-SLN metastasis and patients without non-SLN metastasis(P=0.006).Conclusion:Our single-center data show that,as a commonly used tracer in SLNB in China,MBD has an acceptable SLN IR and a low FNR in frozen *** finding is consistent with reports of dual tracer-guided *** SLNs with non-SLN metastasis are associated with DFS.

关键词： Breast cancer Identification rate Methylene blue dye Prognosis Sentinel lymph node biopsy

Clinical practice guidelines for sentinel lymph node biopsy in patients with early-stage breast cancer: Chinese Society of Breast Surgery (CSBrS) practice guidelines 2021

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Chinese Medical Journal 2021年第8期134卷 886-894页

作者： Jing-Ming Ye Bao-Liang Guo Qian liu Fei Ma Hong-Jin liu Qian Wu Ling Xin Yuan-Jia Cheng Hong Zhang Shuang Zhang Xue-Ning Duan Jian-Guo Zhang yin-hua liu Breast Disease Center Peking University First HospitalBeijing 100034China Department of General Surgery The Second Affiliated Hospital of Harbin Medical UniversityHarbinHeilongjiang 150001China Department of Pathology Peking University First HospitalBeijing 100034China.

Axillary lymph node assessment is one of the important indicators in the clinical pathological staging of breast *** have shown that sentinel lymph node biopsy(SLNB)has the advantages of fewer complications and less trauma than conventional axillary lymph node dissection(ALND)/[1] Common mapping methods for SLNB include blue dye,radioisotopes,a combination of blue dye and radioisotopes,and fluorescence imaging.

关键词： Surgery lymph biopsy

Advancements and Challenges in Organic–Inorganic Composite Solid Electrolytes for All‑Solid‑State Lithium Batteries

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Nano-Micro Letters 2025年第1期17卷 46-97页

作者： Xueyan Zhang Shichao Cheng Chuankai Fu Geping yin Liguang Wang Yongmin Wu hua Huo State Key Laboratory of Space Power‑Sources School of Chemistry and Chemical EngineeringHarbin Institute of TechnologyHarbin 150001People’s Republic of China College of Chemical and Biological Engineering Zhejiang UniversityHangzhou 310058People’s Republic of China State Key Laboratory of Space Power-Sources 2965 Dongchuan RoadMinhang DistrictShanghai 200240People’s Republic of China

To address the limitations of contemporary lithium-ion batteries,particularly their low energy density and safety concerns,all-solid-state lithium batteries equipped with solid-state electrolytes have been identified as an up-and-coming *** the various SEs,organic–inorganic composite solid electrolytes(OICSEs)that combine the advantages of both polymer and inorganic materials demonstrate promising potential for large-scale ***,OICSEs still face many challenges in practical applications,such as low ionic conductivity and poor interfacial stability,which severely limit their *** review provides a comprehensive overview of recent research advancements in ***,the influence of inorganic fillers on the main functional parameters of OICSEs,including ionic conductivity,Li+transfer number,mechanical strength,electrochemical stability,electronic conductivity,and thermal stability are systematically *** lithium-ion conduction mechanism of OICSE is thoroughly analyzed and concluded from the microscopic ***,the classic inorganic filler types,including both inert and active fillers,are categorized with special emphasis on the relationship between inorganic filler structure design and the electrochemical performance of ***,the advanced characterization techniques relevant to OICSEs are summarized,and the challenges and perspectives on the future development of OICSEs are also highlighted for constructing superior ASSLBs.

关键词： Composite solid electrolytes Inorganic filler Interfacial stability Li-ion conduction mechanism Characterization techniques

3-(4-羟基苯基)丙酸在酿酒酵母中的生物合成

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生物技术通报 2017年第9期33卷 184-190页

作者：江晶洁庄以彬殷华刘涛刘少伟华东理工大学上海200237 中国科学院天津工业生物技术研究所天津300308

3-(4-羟基苯基)丙酸(HPPA)是一种芳香类化合物,作为中间体主要应用于医药、食品、化学领域,具有重要的经济价值。旨在实现HPPA在酿酒酵母中的从头合成,通过在酿酒酵母中过表达约氏黄杆菌来源的酪氨酸转移酶(Fj TAL)、拟南芥来源的对香... 详细信息

3-(4-羟基苯基)丙酸(HPPA)是一种芳香类化合物,作为中间体主要应用于医药、食品、化学领域,具有重要的经济价值。旨在实现HPPA在酿酒酵母中的从头合成,通过在酿酒酵母中过表达约氏黄杆菌来源的酪氨酸转移酶(Fj TAL)、拟南芥来源的对香豆酰辅酶A连接酶(At4CL),同时利用酿酒酵母BY4742自身来源的超长链烯酰辅酶A还原酶(Sc TSC13)、硫酯水解酶,实现了在酿酒酵母中从头合成HPPA,产量约为70 mg/L左右。在以4 mmol/L酪氨酸为前体、半乳糖诱导Fj TAL过表达、30℃发酵培养72 h的条件下,约36%的酪氨酸转化生成对香豆酸;在以4 mmol/L对香豆酸或咖啡酸为前体,半乳糖诱导At4CL过表达,同时利用酵母内源Sc TSC13、硫酯水解酶,30℃发酵培养72 h的条件下,约94%的对香豆酸被还原成HPPA,约91%的咖啡酸被还原成3,4-二羟基苯丙酸(DHPPA),为进一步生物合成HPPA及其衍生物奠定了基础。

关键词：酿酒酵母 3-(4-羟基苯基)丙酸(HPPA) 生物合成酪氨酸氨基转移酶对香豆酰辅酶A连接酶