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Observation of the effect of one-to-one education on high-risk cases of diabetic foot

World Journal of Clinical Cases 2021年第14期9卷 3265-3272页

作者： Xia-Jun Fu Shi-Di Hu yin-fang peng Ling-Yan Zhou Ting Shu Dan-Dan Song Department of Endocrinology and Metabolism The Third Affiliated HospitalSouthern Medical UniversityGuangzhou 510630Guangdong ProvinceChina

BACKGROUND Diabetes is a common chronic disease,and its global incidence is on the *** disease is directly attributed to insufficient insulin efficacy/secretion,and patients are often accompanied by multiple *** foot is one of the most common complications of *** feet have ulcers and infections,which can eventually lead to *** nursing care,such as lowering blood pressure and preventing foot skin infections in clinical nursing work,has positive significance for the prevention and control of diabetic *** To explore the positive significance of one-to-one education in high-risk cases of diabetic *** This observation included 98 high-risk cases of diabetic foot in our hospital during the period from August 2017 to October 2019,and these patients were randomly divided into the basic nursing group and the one-to-one education group with 49 patients per *** basic nursing group only received routine basic nursing,while the one-to-one education group gave patients one-to-one education on the basis of basic *** nursing,the self-care ability and compliance behavior of the two groups were evaluated and compared between these two *** knowledge mastery of the patient and the satisfaction of nursing were *** The assessment results of patients(self-care responsibility,self-care skills,selfconcept and self-care knowledge)were significantly higher in the one-to-one education group than in the basic nursing *** scores of compliance behaviors(foot bathing,shoes and socks selection,sports health care)in the oneto-one education group were significantly higher than those in the basic nursing *** in the one-to-one education group had a significantly higher level of knowledge mastery and satisfaction of nursing than the basic nursing *** One-to-one education for high-risk cases of diabetic foot is helpful to improve the cognition and self-care ability of patien

关键词： High risk cases of diabetic foot One-to-one education Contrastive research Basic care Ability of self-care Compliance behavior

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Engineered Cancer Nanovaccines:A New Frontier in Cancer Therapy

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Nano-Micro Letters 2025年第2期17卷 134-168页

作者： Yijie Wang Congrui Liu Chao fang Qiuxia peng Wen Qin Xuebing Yan Kun Zhang Central Laboratory and Department of Medical Ultrasound Sichuan Academy of Medical SciencesSichuan Provincial People’s HospitalSchool of MedicineUniversity of Electronic Science and Technology of ChinaNo.32West Second SectionFirst Ring RoadChengdu 610072People’s Republic of China Department of Stomatology and Central Laboratory School of MedicineShanghai Tenth People’s HospitalTongji UniversityNO.301 Yan‑Chang‑Zhong RoadShanghai 200072People’s Republic of China Jiangsu Provincial Innovation and Practice Base for Postdoctors Suining People’s HospitalAffiliated Hospital of Xuzhou Medical UniversityNo.2Bayi West RoadSuiningXu Zhou 221000Jiangsu ProvincePeople’s Republic of China

Vaccinations are essential for preventing and treating disease,especially cancer nanovaccines,which have gained considerable interest recently for their strong anti-tumor immune *** can prompt the immune system to generate antibodies and activate various immune cells,leading to a response against tumor tissues and reducing the negative effects and recurrence risks of traditional chemotherapy and *** enhance the flexibility and targeting of vaccines,nanovaccines utilize nanotechnology to encapsulate or carry antigens at the nanoscale level,enabling more controlled and precise drug delivery to enhance immune *** nanovaccines function by encapsulating tumor-specific antigens or tumor-associated antigens within *** small size of these nanomaterials allows for precise targeting of T cells,dendritic cells,or cancer cells,thereby eliciting a more potent anti-tumor *** this paper,we focus on the classification of carriers for cancer nanovaccines,the roles of different target cells,and clinically tested cancer nanovaccines,discussing strategies for effectively inducing cytotoxic T lymphocytes responses and optimizing antigen presentation,while also looking ahead to the translational challenges of moving from animal experiments to clinical trials.

关键词： Cancer nanovaccines Immunotherapy Nanobiotechnology Immune targets Signaling pathway

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A cellulose-based lithium-ion battery separator with regulated ionic transport and high thermal stability for extreme environments

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Nano Research 2025年第1期18卷 315-322页

作者： Kun-peng Yang Song Xie Zi-Meng Han Hao-Cheng Liu Chong-Han yin Wen-Bin Sun Zhang-Chi Ling Huai-Bin Yang De-Han Li Qing-fang Guan Shu-Hong Yu Department of Chemistry New Cornerstone Science LaboratoryInstitute of Biomimetic Materials&ChemistryAnhui Engineering Laboratory of Biomimetic MaterialsDivision of Nanomaterials&ChemistryHefei National Research Center for Physical Sciences at the MicroscaleUniversity of Science and Technology of ChinaHefei 230026China Institute of Innovative Materials Department of Materials Science and EngineeringDepartment of ChemistrySouthern University of Science and TechnologyShenzhen 518055China

Separators play a critical role in lithium-ion ***,the restrictions of thermal stability and inferior electrical performance in commercial polyolefin separators significantly limit their applications under harsh ***,we report a cellulose-assisted self-assembly strategy to construct a cellulose-based separator massively and *** an ultrahigh ionic conductivity in electrolytes of 3.7 mS·cm^(-1) and the ability to regulate ion transport,the obtained separator is a promising alternative for high-performance lithium-ion *** addition,integrated with high thermal stability,the cellulose-based separator endows batteries with high safety at high temperatures,greatly expanding the application scenarios of energy storage devices in extreme environments.

关键词： lithium-ion batteries bio-inspired materials battery separators cellulose nanofiber ultrahigh ionic conductivity high safety

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Reduced mesencephalic astrocyte-derived neurotrophic factor expression by mutant androgen receptor contributes to neurodegeneration in a model of spinal and bulbar muscular atrophy pathology

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Neural Regeneration Research 2025年第9期20卷 2655-2666页

作者： Yiyang Qin Wenzhen Zhu Tingting Guo Yiran Zhang Tingting Xing peng yin Shihua Li Xiao-Jiang Li Su Yang Guangdong Key Laboratory of Non-human Primate Research Key Laboratory of CNS Regeneration(Ministry of Education)Guangdong–HongKong–Macao Institute of CNS RegenerationJinan UniversityGuangzhouGuangdong ProvinceChina

Spinal and bulbar muscular atrophy is a neurodegenerative disease caused by extended CAG trinucleotide repeats in the androgen receptor gene,which encodes a ligand-dependent transcription facto *** mutant androgen receptor protein,characterized by polyglutamine expansion,is prone to misfolding and forms aggregates in both the nucleus and cytoplasm in the brain in spinal and bulbar muscular atrophy *** aggregates alter protein-protein interactions and compromise transcriptional *** this study,we reported that in both cultured N2a cells and mouse brain,mutant androgen receptor with polyglutamine expansion causes reduced expression of mesencephalic astrocyte-de rived neurotrophic *** n of mesencephalic astrocyte-derived neurotrophic factor amelio rated the neurotoxicity of mutant androgen receptor through the inhibition of mutant androgen receptor *** down endogenous mesencephalic astrocyte-derived neurotrophic factor in the mouse brain exacerbated neuronal damage and mutant androgen receptor *** findings suggest that inhibition of mesencephalic astrocyte-derived neurotrophic factor expression by mutant androgen receptor is a potential mechanism underlying neurodegeneration in spinal and bulbar muscular atrophy.

关键词： androgen receptor mesencephalic astrocyte-derived neurotrophic factor mouse model neurodegeneration neuronal loss neurotrophic factor polyglutamine disease protein misfolding spinal and bulbar muscular atrophy transcription factor

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Inhibition of the NLRP3 inflammasome attenuates spiral ganglion neuron degeneration in aminoglycoside-induced hearing loss

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Neural Regeneration Research 2025年第10期20卷 3025-3039页

作者： Jia fang Zhuangzhuang Li pengjun Wang Xiaoxu Zhang Song Mao yini Li Dongzhen Yu Xiaoyan Li Yazhi Xing Haibo Shi Shankai yin Department of Otolaryngology Head and Neck Surgery Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of MedicineOtolaryngology Institute of Shanghai Jiao Tong UniversityShanghai Key Laboratory of Sleep Disordered BreathingShanghaiChina Department of Otorhinolaryngology-Head and Neck Surgery Shanghai Children’s HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghaiChina

Aminoglycosides are a widely used class of antibacterials renowned for their effectiveness and broad antimicrobial ***,their use leads to irreversible hearing damage by causing apoptosis of hair cells as their direct *** addition,the hearing damage caused by aminoglycosides involves damage of spiral ganglion neurons upon *** investigate the mechanisms underlying spiral ganglion neuron degeneration induced by aminoglycosides,we used a C57BL/6J mouse model treated with *** found that the mice exhibited auditory deficits following the acute loss of outer hair *** ganglion neurons displayed hallmarks of pyroptosis and exhibited progressive degeneration over *** profiling of these neurons showed significant upregulation of genes associated with inflammation and immune response,particularly those related to the NLRP3 *** of the canonical pyroptotic pathway in spiral ganglion neurons was observed,accompanied by infiltration of macrophages and the release of proinflammatory *** intervention targeting NLRP3 using Mcc950 and genetic intervention using NLRP3 knockout ameliorated spiral ganglion neuron degeneration in the injury *** findings suggest that NLRP3 inflammasome-mediated pyroptosis plays a role in aminoglycoside-induced spiral ganglion neuron *** of this pathway may offer a potential therapeutic strategy for treating sensorineural hearing loss by reducing spiral ganglion neuron degeneration.

关键词： degeneration hearing loss macrophages Mcc950 neuroinflammation NLRP3 inflammasome ototoxicity pyroptosis sensorineural hearing loss spiral ganglion neuron

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Protein-based functional hydrogel improves cutaneous nerve repair and diabetic wound healing

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Nano Research 2025年第1期18卷 586-596页

作者： Hanzhi Lu Mingrui Cui Yi Wang Xinran Du Xinyi Zhou Yuhan fang Xiaoyan Gao ying peng Jianyong Zhu Guang Yang Fulun Li Department of Dermatology Yueyang Hospital of Integrated Traditional Chinese and Western MedicineShanghai University of Traditional Chinese MedicineShanghai 200437China Shanghai Engineering Research Center of Nano-Biomaterials and Regenerative Medicine College of Biological Science and Medical EngineeringDonghua UniversityShanghai 201620China Clinical Laboratory Medicine Center Yueyang Hospital of Integrated Traditional Chinese and Western MedicineShanghai University of Traditional Chinese MedicineShanghai 200437China

Cutaneous nerve regeneration in diabetic wounds remains a challenge for current clinical ***,a natural protein-based functional hydrogel is developed using keratin as the sole matrix,and protocatechuic aldehyde(PA)and zinc ions as the building blocks through dual-dynamic crosslinking reactions of thiol-aldehyde addition and catecholzinc ions *** unique structural design endows the hydrogel with excellent injectability,skin adhesion,self-healing and antibacterial ability,and *** addition,this hydrogel acts as a drug carrier for the loading and sustained release of phellopterin(PP),a natural compound extracted from traditional Chinese medicine Angelica *** findings demonstrate that the PP-loaded hydrogel promotes cutaneous nerve regeneration,angiogenesis and tissue remodeling in the full-thickness wounds in both db/db and streptozotocin-induced C57BL/6 diabetic mice,notably by the synergistic effect of zinc ions and PP,showing a great potential in diabetic wound therapy.

关键词： functional hydrogel cutaneous nerve regeneration dynamic crosslinking diabetic wounds

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Tracking controller design for air handling units with uncertainties

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Building Simulation 2023年第4期16卷 547-556页

作者： fang Shang Yongshuai Ji Wei peng Jingdong Duan Yikai yin Shandong Key Laboratory of Intelligent Buildings Technology School of Information and Electrical EngineeringShandong Jianzhu UniversityJinan 250101China QingDao iESLab Electronic Co. LTD.Jinan 250101China

As an important component of the heating,ventilating and air conditioning(HVAC)systems,air handling units(AHUs)are responsible for regulating indoor temperature and *** this paper,a multivariable nonlinear dynamic model of the AHUs with unknown strength of the humidity source is considered,and an improved backstepping controller is proposed to realize the tracking objective of the indoor temperature,relative humidity and carbon dioxide ***,the original system is represented in simplified state space form,and then the state transformation is introduced with a gain to overcome the difficulty caused by the unknown strength of the humidity ***,the improved backstepping controller is designed in a step-by-step ***,the stability of the closed-loop system is analyzed in ***,we consider the case that the AHUs work in summer of Jinan,China,as an *** simulation results show the effectiveness of the ***,the performance of the improved backstepping controller are compared with that of the decoupled sliding mode and PID controllers.

关键词： air handling units tracking control uncertain parameters backstepping

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Gut-brain axis as a bridge in obesity and depression:Mechanistic exploration and therapeutic prospects

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World Journal of Psychiatry 2025年第1期15卷 12-20页

作者： Rui-ying fang Xiao-Rui Pan Xin-Xing Zeng Zheng-Zheng Li Bo-Fan Chen Hai-Min Zeng Jie peng The Second Clinical Medical College The Second Affiliated HospitalJiangxi Medical CollegeNanchang UniversityNanchang 330006Jiangxi ProvinceChina

A recent study by Wang et al,published in the World Journal of Psychiatry,provided preventative and therapeutic strategies for the comorbidity of obesity and *** gut-brain axis,which acts as a two-way communication system between the gastrointestinal tract and the central nervous system,plays a pivotal role in the pathogenesis of these *** suggests that metabolic byproducts,such as short-chain fatty acids,lipopolysaccharide and bile acids,which are generated by the gut microbiota,along with neurotransmitters and inflammatory mediators within the gut-brain axis,modulate the host's metabolic processes,neuronal regulation,and immune responses through diverse *** interaction between obesity and depression via the gut-brain axis involves disruptions in the gut microbiota balance,inflammatory immune responses,and alterations in the neuroendocrine *** the gut-brain axis,for example,through a ketogenic diet,the use of probiotics,and the supplementation of antioxidants,offers new remedial approaches for obesity and *** research that explores the mechanisms of the gut-brain axis is needed to provide more evidence for clinical treatment.

关键词： Gut-brain axis Obesity Depression Gut microbiota Mechanism

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APPLICATION OF INTEGER CODING ACCELERATING GENETIC ALGORITHM IN RECTANGULAR CUTTING STOCK PROBLEM

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Chinese Journal of Mechanical Engineering 2006年第3期19卷 335-339页

作者： fang Hui yin Guofu LI Haiqing peng Biyou School of Manufacturing Science and Technology Sichuan University Chengdu 610065 China

An improved genetic algorithm and its application to resolve cutting stock problem arc presented. It is common to apply simple genetic algorithm （SGA） to cutting stock problem, but the huge amount of computing of SGA is a serious problem in practical application. Accelerating genetic algorithm （AGA） based on integer coding and AGA＇s detailed steps are developed to reduce the amount of computation, and a new kind of rectangular parts blank layout algorithm is designed for rectangular cutting stock problem. SGA is adopted to produce individuals within given evolution process, and the variation interval of these individuals is taken as initial domain of the next optimization process, thus shrinks searching range intensively and accelerates the evaluation process of SGA. To enhance the diversity of population and to avoid the algorithm stagnates at local optimization result, fixed number of individuals are produced randomly and replace the same number of parents in every evaluation process. According to the computational experiment, it is observed that this improved GA converges much sooner than SGA, and is able to get the balance of good result and high efficiency in the process of optimization for rectangular cutting stock problem.

关键词： Accelerating genetic algorithm Efficiency of optimization Cutting stock problem

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Transient Mould Friction Based on the Wavelet Theory

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Journal of Iron and Steel Research International 2015年第9期22卷 785-794页

作者： Yong MA Cheng peng Wei GUI fang-yin WANG School of Materials Science and Engineering Hefei University of Technology

The mould friction is an important parameter reflecting the initial shell and mould lubrication *** research of mould friction is very important to the optimization and developing of continuous *** measured mould friction under hydraulic oscillation mode was researched with wavelet analysis to reveal its time-frequency ***,the mould friction signals under different production conditions were monitored and the mould friction was ***,mother wavelet function was selected from three wavelet functions which were chosen preliminary according to the characteristics of mould friction and wavelet *** wavelet transformation,mould friction signal was projected onto the wavelet domain,and the time-frequency characteristics of mould friction under different production conditions were obtained and *** friction under different production conditions such as different oscillation mode,casting speed fluctuation,increasing and decreasing stage of casting speed and breakout occurrence was reported in detail in the wavelet time-frequency *** characteristics of mould friction were reflected well through wavelet transformation which proved that wavelet analysis had a good feasibility for mould friction study and can further reveal the nature of mould friction.

关键词： mould friction hydraulic oscillator time-frequency wavelet transform coefficient wavelet

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