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Identification and validation of a new prognostic signature based on cancer-associated fibroblast-driven genes in breast cancer

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World Journal of Clinical Cases 2024年第4期12卷 700-720页

作者： Zi-Zheng Wu Yuan-Jun Wei Tong Li Jie Zheng yin-feng Liu Meng Han Diagnosis and Treatment Center The First Hospital of QinhuangdaoQinhuangdao 066000Hebei ProvinceChina Department of General Surgery Hebei Medical UniversityShijiazhuang 050000Hebei ProvinceChina Breast Disease Diagnosis and Treatment Center The First Hospital of QinhuangdaoHebei Medical UniversityQinhuangdao 066000Hebei ProvinceChina Breast Disease Diagnosis and Treatment Center Chengde Medical CollegeChengde 067000Hebei ProvinceChina

BACKGROUND Breast cancer(BC),a leading malignant disease,affects women all over the *** associated fibroblasts(CAFs)stimulate epithelial-mesenchymal transition,and induce chemoresistance and *** To establish a CAFs-associated prognostic signature to improve BC patient out-come *** We retrieved the transcript profile and clinical data of 1072 BC samples from The Cancer Genome Atlas(TCGA)databases,and 3661 BC samples from the The Gene Expression *** and immune cell infiltrations were quantified using CIBERSORT ***-associated gene identification was done by weighted gene co-expression network analysis.A CAF risk signature was established via univariate,least absolute shrinkage and selection operator regression,and mul-tivariate Cox regression *** receiver operating characteristic(ROC)and Kaplan-Meier curves were employed to evaluate the predictability of the ***,a nomogram was developed with the risk score and patient clinical *** Spearman's correlations analysis,the relationship between CAF risk score and gene set enrichment scores were *** samples were collected to validate gene expression by quantitative real-time polymerase chain reaction(qRT-PCR).RESULTS Employing an 8-gene(IL18,MYD88,GLIPR1,TNN,BHLHE41,DNAJB5,FKBP14,and XG)signature,we attemp-ted to estimate BC patient *** on our analysis,high-risk patients exhibited worse outcomes than low-risk *** analysis revealed the risk score as an independent indicator of BC patient *** analysis exhibited satisfactory nomogram *** area under the curve showed 0.805 at 3 years,and 0.801 at 5 years in the TCGA *** also demonstrated that a reduced CAF risk score was strongly associated with enhanced chemotherapeutic *** risk score was significantly correlated with most hallmark gene ***,the prognostic signature were further validated by qRT-

关键词： Breast cancer Prognosis Gene signature The Cancer Genome Atlas The Gene Expression Omnibus

Protective Effects of Danmu Extract Syrup on Acute Lung Injury Induced by Lipopolysaccharide in Mice through Endothelial Barrier Repair

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Chinese Journal of Integrative Medicine 2024年第3期30卷 243-250页

作者： XU Han XU Si-cong LI Li-yan WU Yu-huang TAN yin-feng CHEN Long LIU Pei LIANG Chang-fu HE Xiao-ning LI Yong-hui Hainan Provincial Key Lab of Research&Development on Tropic Herbs Hainan Medical UniversityHaikou571199China Department of Stomatology the Second Affiliated Hospital of Hainan Medical UniversityHaikou571199China

Objective:To investigate the effects of Danmu Extract Syrup(DMS) on lipopolysaccharide(LPS)-induced acute lung injury(ALI) in mice and explore the ***:Seventy-two male Balb/C mice were randomly divided into 6 groups according to a random number table(n=12),including control(normal saline),LPS(5 mg/kg),LPS+DMS 2.5 mL/kg,LPS+DMS 5 mL/kg,LPS+DMS 10 mL/kg,and LPS+Dexamethasone(DXM,5 mg/kg) *** pretreatment with DMS and DXM,the ALI mice model was induced by LPS,and the bronchoalveolar lavage fluid(BALF) were collected to determine protein concentration,cell counts and inflammatory *** lung tissues of mice were stained with hematoxylin-eosin,and the wet/dry weight ratio(W/D) of lung tissue was *** levels of tumor necrosis factor-α(TNF-α),interleukin(IL)-6 and IL-1βin BALF of mice were detected by enzyme linked immunosorbent *** expression levels of Claudin-5,vascular endothelial(VE)-cadherin,vascular endothelial growth factor(VEGF),phospho-protein kinase B(p-Akt) and Akt were detected by Western blot ***:DMS pre-treatment significantly ameliorated lung histopathological *** with the LPS group,the W/D ratio and protein contents in BALF were obviously reduced after DMS pretreatment(P<0.05 or P<0.01).The number of cells in BALF and myeloperoxidase(MPO) activity decreased significantly after DMS pretreatment(P<0.05 or P<0.01).DMS pre-treatment decreased the levels of TNF-α,IL-6 and IL-1β(P<0.01).Meanwhile,DMS activated the phosphoinositide 3-kinase/protein kinase B(PI3K/Akt) pathway and reversed the expressions of Claudin-5,VE-cadherin and VEGF(P<0.01).Conclusions:DMS attenuated LPS-induced ALI in mice through repairing endothelial *** might be a potential therapeutic drug for LPS-induced lung injury.

关键词： Danmu Extract Syrup acute lung injury inflammatory factors vascular endothelial growth factor phosphoinositide 3-kinase/protein kinase B Chinese medicine Nauclea officinalis

Profound loss of microbial necromass carbon in permafrost thaw-subsidence in the central Tibetan Plateau

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Advances in Climate Change Research 2024年第4期15卷 647-657页

作者： Wen-Ting ZHOU Quan-Lian LI Shi-Chang KANG Xiao-Dong WU Tian MA Xiao-Bo WU Xin XIONG Tanuj SHUKLA Maheswar RUPAKHETI Dipesh RUPAKHETI Da-He QIN Xiu-feng yin Cryosphere Research Station on the Qinghai-Tibet Plateau State Key Laboratory of Cryospheric ScienceNorthwest Institute of Eco-Environment and ResourcesChinese Academy of SciencesLanzhou 730000China Key Laboratory of Cryospheric Science and Frozen Soil Engineering Norhwest Instiute of Eco-Evironment and ResourcesChinese Academy of Scienes Lanzhou 730000China University of Chinese Academy of Sciences Beijing 100049China State Key Laboratory of Herbage Improvement and Grassland Agro-ecosystems and College of Pastoral Agriculture Science and TechnologyLanzhou UniversityLanzhou730020China Lushan Botanical Garden Chinese Academy of SciencesJiujiang 332900China Research Institute for Sustainability-Helmholtz Centre Potsdam Potsdam 14467Germany Jiangsu Key Laboratory of Atmospheric Environment Monitoring and Pollution Control Collaborative Innovation Center of Atmospheric Environment and Equipment TechnologySchool of Environmental Science and EngineeringNanjing University of Information Science and TechnologyNanjing 210044China

Climate warming is causing rapid permafrost degradation,including thaw-induced subsidence,potentially resulting in heightened carbon ***,our understanding of the levels and variations of carbon components in permafrost,particularly during the degradation process,remains *** uncertainties arising from this process lead to inaccurate assessments of the climate effects during permafrost *** vast expanses of permafrost in the Tibetan Plateau,there is limited research available on SOC components,particularly in the central Tibetan *** remarkable variations in hydrothermal conditions across different areas of the Tibetan Plateau,the existing limited studies make it challenging to assess the overall SOC components in the permafrost across the Tibetan Plateau and simulate their future *** this study,we examined the properties of soil organic carbon(SOC)and microbial necromass carbon(MicrobialNC)in a representative permafrost thaw-subsidence area at the southern edge of continuous permafrost in the central Tibetan *** results indicate that prior to the thaw-subsidence,the permafrost had a SOC content of 72.68±18.53 mg g^(-1),with MicrobialNC accounting for 49.6%.The thaw-subsidence of permafrost led to a 56.4%reduction in SOC,with MicrobialNC accounting for 70.0%of the lost *** constitutes the primary component of permafrost SOC,and it is the main component that is lost during thaw-subsidence *** in MicrobialNC are primarily correlated with factors pH,plant input,and microbial *** present study holds crucial implications for both the ecological and biogeochemical processes associated with carbon release from permafrost,and it furnishes essential data necessary for modeling the global response of permafrost to climate *** on this study and previous research,permafrost thawing in the Tibetan Plateau causes substantial loss of ***,there's remarkable heterogeneit

关键词： Tibetan Plateau Thaw-subsidence Soil organic carbon Microbial necromass carbon Amino sugars

Ailanthone ameliorates pulmonary fibrosis by suppressing JUN-dependent MEOX1 activation

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Acta Pharmaceutica Sinica B 2024年第8期14卷 3543-3560页

作者： Lixin Zhao Yuguang Zhu Hua Tao Xiying Chen feng yin yingyi Zhang Jianfeng Qin Yongyin Huang Bikun Cai Yonghao Lin Jiaxiang Wu Yu Zhang Lu Liang Ao Shen Xi-Yong Yu The Fifth Affiliated Hospital Guangzhou Municipal and Guangdong Provincial Key Laboratory of Molecular Target and Clinical PharmacologyNMPA&State Key LaboratorySchool of Pharmaceutical SciencesGuangzhou Medical UniversityGuangzhou 511436China

Pulmonary fibrosis poses a significant health threat with very limited therapeutic options *** this study,we reported the enhanced expression of mesenchymal homobox 1(MEOX1)in pulmonary fibrosis patients,especially in their fibroblasts and endothelial cells,and confirmed MEOX1 as a central orchestrator in the activation of profibrotic *** high-throughput screening,we identified Ailanthone(AIL)from a natural compound library as the first small molecule capable of directly targeting and suppressing *** demonstrated the ability to inhibit both the activation of fibroblasts and endothelial-to-mesenchymal transition of endothelial cells when challenged by transforming growth factor-b1(TGF-b1).In an animal model of bleomycin-induced pulmonary fibrosis,AIL effectively mitigated the fibrotic process and restored respiratory ***,AIL acted as a suppressor of MEOX1 by disrupting the interaction between the transcription factor JUN and the promoter of MEOX1,thereby inhibiting MEOX1 expression and *** summary,our findings pinpointed MEOX1 as a cell-specific and clinically translatable target in ***,we demonstrated the potent anti-fibrotic effect of AIL in pulmonary fibrosis,specifically through the suppression of JUN-dependent MEOX1 activation.

关键词： Ailanthone MEOX1 Pulmonary fibrosis JUN TGF-b1 High-throughput screening Natural product

Network pharmacology combined with molecular docking revealed the potential targets of Coridius chinensis in prostate cancer treatment

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World Journal of Clinical Cases 2024年第27期12卷 6094-6104页

作者： Mei Zhang Jing Ma feng-yin Zeng Xiao-Hui Hou School of Preclinical Medicine Zunyi Medical UniversityZunyi 563000Guizhou ProvinceChina

BACKGROUND Prostate cancer(PCa)has high morbidity and mortality rates in elderly *** a history of thousands of years,traditional Chinese medicine derived from insects could be an important source for developing cancer-targeted drugs to prevent tumorigenesis,enhance therapeutic effects,and reduce the risk of recurrence and *** studies have shown that Coridius chinensis(Cc)has anticancer *** To elucidate the mechanism of action of Cc against PCa via network pharma-cology and molecular *** Potential targets for Cc and PCa were predicted using ChemDraw 19.0 software,the PharmMapper database and the GeneCards ***,the STRING database was used to construct the protein–protein interaction *** Ontology(GO),Kyoto Encyclopedia of Genes and Genomes(KEGG)enrichment and molecular docking analyses were subsequently conducted to identify the key targets,active ingredients and pathways *** GO and KEGG analyses indicated that the PI3K-Akt signalling pathway was the critical pathway(P value<1.0×10-8).Multiple targeting ingredients that can affect multiple pathways in PCa have been identified in *** active compounds(asponguanosines A,asponguanine B,asponguanine C,aspong-pyrazine A,N-acetyldopamine,aspongadenine B and aspongpyrazine B)were selected for molecular docking with 9 potential targets,and the results revealed that aspongpyrazine A and asponguanosine A are the main components by which Cc affects PCa(affinity<-5 kcal/mol,hydrogen bonding),but more studies are *** We used network pharmacology to predict the bioactive components and important targets of Cc for the treatment of PCa,supporting the development of Cc as a natural anticancer agent.

关键词： Coridius chinensis Molecular docking Network pharmacology Prostate cancer Traditional Chinese medicine

Effect of interlayer bonded bilayer graphene on friction

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Chinese Physics B 2024年第8期33卷 389-395页

作者：李耀隆田振国尹海峰张任良 Hebei Key Laboratory of Mechanical Reliability for Heavy Equipment and Large Structures Yanshan UniversityQinhuangdao 066004China School of Civil Engineering and Mechanics Yanshan UniversityQinhuangdao 066004China

We study the friction properties of interlayer bonded bilayer graphene by simulating the movement of a slider on the surface of bilayer graphene using molecular *** results show that the presence of the interlayer covalent bonds due to the local sp^(3) hybridization of carbon atoms in the bilayer graphene seriously reduces the frictional coefficient of the bilayer graphene surface to 30%,depending on the coverage of interlayer sp^(3) bonds and normal *** a certain coverage of interlayer sp3bonds,when the normal load of the slider reaches a certain value,the surface of this interlayer bonded bilayer graphene will lose the friction reduction effect on the *** findings provide guidance for the regulation and manipulation of the frictional properties of bilayer graphene surfaces through interlayer covalent bonds,which may be useful for applications of friction related graphene based nanodevices.

关键词： nanoscale friction molecular dynamic simulation bilayer graphene interlayer covalent bond

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数据规制政策差异与服务业价值链关联

国际贸易问题 2024年第2期 17-33页

作者：党修宇殷凤上海大学经济学院

本文基于ECIPE-DTE提供的数据规制政策信息构建了数据规制政策差异指数,并利用2000—2018年54个经济体19个细分服务行业的增加值数据,检验了数据规制政策差异对服务业价值链关联的影响。基准分析结果表明,数据规制政策差异对服务业价值... 详细信息

本文基于ECIPE-DTE提供的数据规制政策信息构建了数据规制政策差异指数,并利用2000—2018年54个经济体19个细分服务行业的增加值数据,检验了数据规制政策差异对服务业价值链关联的影响。基准分析结果表明,数据规制政策差异对服务业价值链关联存在显著的负向影响,该结论在一系列稳健性检验后依然成立。异质性分析结果表明,与跨境数据规制政策差异不同,国内数据规制政策差异对服务业价值链关联的抑制作用存在时滞性且抑制作用相对较弱。此外,数据规制政策差异对数字密集型服务行业以及南—南经济体的服务业价值链关联的抑制作用也更加显著。扩展性分析结果表明,贸易成本和生产率是数据规制政策差异影响服务业价值链关联的重要渠道;经济体通过缔结数据跨境流动类规则以及合作包容类规则有助于削弱数据规制政策差异对服务业价值链关联的负向影响。

关键词：数据规制政策差异贸易成本生产率服务业价值链关联

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RTA中数字贸易规则与服务业价值链关联

财经研究 2024年第6期50卷 93-107页

作者：党修宇殷凤上海大学经济学院

文章基于协定文本覆盖、法律约束力及具体条款深化形式三个方面重构数字贸易规则指标评价体系,结合2000—2018年65个经济体19个细分服务行业数据,检验了数字贸易规则深度对服务业价值链关联的影响。结果表明,数字贸易规则深度的提升能... 详细信息

文章基于协定文本覆盖、法律约束力及具体条款深化形式三个方面重构数字贸易规则指标评价体系,结合2000—2018年65个经济体19个细分服务行业数据,检验了数字贸易规则深度对服务业价值链关联的影响。结果表明,数字贸易规则深度的提升能显著促进服务业价值链关联,该结论在一系列稳健性检验后仍成立；机制检验显示,数字贸易规则深度通过对制度距离相近的经济体产生规制融合效应、降低交易成本以及提高生产率成为提高经济体间服务业价值链关联的重要驱动力。文章还从国别、行业、条款、价值链四个视角检验了数字贸易规则深度对服务业价值链关联的异质性影响,并进一步以中国为视角检验了数字贸易规则深度对中外服务业价值链关联的影响。因此,中国需根据不同经济体和条款构建差异化的数字贸易规则谈判策略,通过缔结更高标准的数字贸易规则增强中国与贸易伙伴的价值链韧性。

关键词：数字贸易规则深度服务业价值链关联规制融合交易成本生产率

中小学课后服务质量评价体系构建:意蕴、依据与维度

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教育理论与实践 2024年第14期44卷 12-16页

作者：晋银峰洛阳师范学院教育科学学院河南洛阳471934

要实现中小学课后服务长远发展,必须研制切实可行的质量评价体系,以评价提升课后服务质量。中小学课后服务质量评价体系构建应满足多元利益诉求、促进多方协商共识、体现学生身心发展特点,其构建应顺应教育行政机构的政策需求,体现利益... 详细信息

要实现中小学课后服务长远发展,必须研制切实可行的质量评价体系,以评价提升课后服务质量。中小学课后服务质量评价体系构建应满足多元利益诉求、促进多方协商共识、体现学生身心发展特点,其构建应顺应教育行政机构的政策需求,体现利益相关者理论和CIPP评价理论模型的理论阐释,奠基于学校教育高效运行的实践需求。在课后服务质量评价体系构建过程中,可以从四个维度共同发力:科学的服务目标是构建方向,充足的教育资源投入是构建保障,完善的服务过程是构建依托,客观的服务评价是构建要求。

关键词：中小学课后服务质量评价体系服务目标教育资源服务过程服务评价