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Circadian rhythm dysfunction and psychopathology in the offspring of parents with bipolar disorder:a highrisk study in the Chinese population

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General Psychiatry 2024年第3期37卷 388-400页

作者： Binbin Lei Hongliang Feng Lulu Yang Jing Wang Jie Chen Weidong Song Chao Jiang Kun Zhang Qunfeng Wang Jessie Chi Ching Tsang Ngan yin chan Yaping Liu Joey W.Y.chan Jiyang Pan Bin Zhang Tao Li Kathleen Ries Merikangas Jihui Zhang Yun Kwok Wing Guangdong Cardiovascular Institute Guangdong Provincial People's HospitalGuangdong Academy of Medical SciencesGuangzhouGuangdongChina Guangdong Mental Health Center Guangdong Provincial People's Hospital(Guangdong Academy of Medical Sciences)Southern Medical UniversityGuangzhouGuangdongChina Li Chiu Kong Family Sleep Assessment Unit Department of PsychiatryFaculty of MedicineThe Chinese University of Hong KongHong KongChina Center for Sleep and Circadian Medicine The Affiliated Brain Hospital of Guangzhou Medical UniversityGuangzhouGuangdongChina Department of Psychiatry Faculty of MedicineThe Chinese University of Hong KongNew TerritoriesHong KongChina Key Laboratory of Neurogenetics and channelopathies of Guangdong Province and the Ministry of Education of China Guangzhou Medical UniversityGuangzhouGuangdongChina Shenzhen Nanshan Center for Chronic Diseases Control(Shenzhen Nanshan Mental Health Center) ShenzhenChina Department of Clinical Psychology Shenzhen Fuyong People's HospitalShenzhenChina Department of Mental Illness Prevention and Treatment Shenzhen Longgang Center for Chronic Diseases ControlShenzhenChina Department of Neurology Zhongnan Hospital of Wuhan UniversityWuhanHubeiChina Sleep Medical Center The First Affiliated Hospital of Jinan UniversityGuangzhouGuangdongChina Department of Psychiatry Nanfang HospitalSouthern Medical UniversityGuangdong-Hong Kong-Macao Greater Bay Area Center for Brain Science and Brain-Inspired IntelligenceGuangzhouGuangdongChina Department of Neurobiology Affiliated Mental Health Center&Hangzhou Seventh People's HospitalZhejiang University School of MedicineHangzhouZhejiangChina Genetic Epidemiology Research Branch Intramural Research ProgramNational Institute of Mental HealthBethesdaMarylandUSA

Background Understanding the evolution of circadian rhythm dysfunction and psychopathology in the high-risk population has important implications for the prevention of bipolar ***,some of the previous studies on the emergence of psychopathologies and circadian dysfunction among high-risk populations were inconsistent and *** To examine the prevalence rates of sleep and circadian dysfunctions,mental disorders and their symptoms in the offspring of parents with(O-BD)and without bipolar disorder(O-control).Methods The study included 191 O-BD and 202 O-control subjects aged 6-21 years from the Greater Bay Area,*** diagnoses and symptoms of sleep/circadian rhythm and mental disorders were assessed by the Diagnostic Interview for Sleep Patterns and Disorders,and the Schedule for Affective Disorders and Schizophrenia for School-Age Children-Present and Lifetime Version,*** estimating equations and shared frailty proportional hazards models of survival analysis were applied to compare the outcomes in the *** Adjusting for age,sex and region of recruitment,there was a significantly higher risk of delayed sleep phase symptoms(9.55%vs 2.58%,adjusted OR:4.04)in O-BD than in O-control.O-BD had a nearly fivefold higher risk of mood disorders(11.70%vs 3.47%,adjusted OR:4.68)and social anxiety(6.28%vs 1.49%,adjusted OR:4.70),a fourfold higher risk of depressive disorders(11.17%vs 3.47%,adjusted OR:3.99)and a threefold higher risk of mood symptoms(20.74%vs 10.40%,adjusted OR:2.59)than *** analysis revealed that O-BD children(aged under 12 years)had a nearly 2-fold higher risk of any mental and behavioural symptoms than O-control,while there was a nearly 4-fold higher risk of delayed sleep phase symptoms,a 7.5-fold higher risk of social anxiety and a 3-fold higher risk of mood symptoms in O-BD adolescents(aged 12 years and over).Conclusions There was an increase in delayed sleep phase symptoms in O-BD

关键词： prevention dysfunction bipolar

Ovarian-adnexal reporting and data system ultrasound evaluation and pathological characteristics of ovarian collision tumor

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World Journal of Clinical Cases 2024年第22期12卷 4932-4939页

作者： chan yin Yong Wang Zhi-Hui Fei Li-Hong Sun Wei-Ai Zhou Heng Li Department of Ultrasound Hunan University of Arts and Sciences Affiliated Changde Maternal and Child Health HospitalChangde 415000Hunan ProvinceChina Department of Ultrasound People's Hospital of Shimen CountyChangde 415300Hunan ProvinceChina Department of Ultrasound Medicine The Maternal and Child Health Hospital of ChangdeChangde 415000Hunan ProvinceChina Department of Psychology The Maternal and Child Health Hospital of ChangdeChangde 415000Hunan ProvinceChina Department of Gynaecology Hunan University of Arts and Sciences Affiliated Changde Maternal and Child Health HospitalChangde 415000Hunan ProvinceChina Department of Ultrasound The First People's Hospital of ChangdeChangde 415000Hunan ProvinceChina

BACKGROUND Collision tumor are neoplasms,including two histologically distinct tumors that coexist in the same mass without histological *** incidence of collision tumor is low and is rare *** To investigate ultrasound images and application of ovarian-adnexal reporting and data system(O-RADS)to evaluate the risk and pathological characteristics of ovarian collision *** This study retrospectively analyzed 17 cases of ovarian collision tumor diagnosed pathologically from January 2020 to December *** clinical features,ultrasound images and histopathological features were collected and *** O-RADS score was used for *** O-RADS score was determined by two senior doctors in the gynecological ultrasound *** with O-RADS score of 1-3 were classified as benign tumors,and lesions with O-RADS score of 4 or 5 were classified as malignant *** There were 17 collision tumors detected in 16 of 6274 patients who underwent gynecological *** average age of 17 women with ovarian collision tumor was 36.7 years(range 20-68 years),in whom,one occurred bilaterally and the rest occurred *** average tumor diameter was 10 cm,of which three were 2-5 cm,11 were 5-10 cm,and three were>10 ***(29.4%)tumors with O-RADS score 3 were endometriotic cysts with fibroma/serous cystadenoma,and unilocular or multilocular cysts contained a small number of parenchymal ***(64.7%)tumors had an O-RADS score of 4,including two in category 4A,six in category 4B,and three in category 4C;all of which were multilocular cystic tumors with solid components or multiple papillary ***(5.9%)tumor had an O-RADS score of *** case was a solid mass,and a small amount of pelvic effusion was detected under *** pathology was high-grade serous cystic cancer combined with cystic mature *** were nine(52.9%)tumors with elevated serum carbohydrate antigen(CA)125 and two(11.8%)with

关键词： Ovarian collision tumor Ovarian-adnexal reporting and data system Epithelial tumor Serous cystadenoma Ultrasound images

Performance in the Fundamentals of Laparoscopic Surgery: Does it reflect global rating scales in the Objective Structured Assessment of Technical Skills in porcine laparoscopic surgery?

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Asian Journal of Urology 2024年第3期11卷 443-449页

作者： Ho Yee Tiong Wei Zheng So Jeremy Yuen-Chun Teoh Shuji Isotani Gang Zhu Teng Aik Ong Eddie Shu-yin chan Peggy Sau-Kwan Chu Kittinut Kijvikai Ming Liu Bannakji Lojanapiwat Michael Wong Anthony Chi-Fai Ng Yong Loo Lin School of Medicine Department of SurgeryNational University of SingaporeSingapore S.H.Ho Urology Centre Department of SurgeryThe Chinese University of Hong KongHong KongChina Department of Urology Juntendo University Graduate School of MedicineTokyoJapan Department of Urology National University HospitalSingapore Department of Urology Beijing United Family HospitalBeijingChina Department of Surgery University of Malaya Specialist CentreKuala LumpurMalaysia Division of Urology Department of SurgeryTuen Mun HospitalHong Kong Department of Urology Ramathibodi HospitalMahidol UniversitySalayaThailand Department of Urology Beijing HospitalBeijingChina Department of Urology Chiangmai Ram HospitalChiang MaiThailand International Urology Fertility&Gynaecology CentreSingapore

Objective:To correlate the utility of the Fundamentals of Laparoscopic Surgery(FLS)manual skills program with the Objective Structured Assessment of Technical Skills(OSATS)global rating scale in evaluating operative ***:The Asian Urological Surgery Training and Educational Group(AUSTEG)Laparoscopic Upper Tract Surgery Course implemented and validated the FLS program for its usage in laparoscopic surgical ***’basic laparoscopic skills were assessed using three different training models(peg transfer,precision cutting,and intra-corporeal suturing).They also performed live porcine laparoscopic surgery at the same *** surgery skills were assessed by blinded faculty using the OSATS rating ***:From March 2016 to March 2019,a total of 81 certified urologists participated in the course,with a median of 5 years of post-residency *** differences in task time did not reach statistical significance,those with more surgical experience were visibly faster at completing the peg transfer and intra-corporeal suturing FLS ***,they took longer to complete the precision cutting task than participants with less *** OSATS scores correlated weakly with all three FLS tasks(peg transfer time:r=0.331,r^(2)=0.110;precision cutting time:r=0.240,r^(2)=0.058;suturing with intracorporeal knot time:r=0.451,r^(2)=0.203).Conclusion:FLS task parameters did not correlate strongly with OSATS globing rating scale *** FLS task models demonstrated strong validity,it is important to assimilate the inconsistencies when benchmarking technical proficiency against real-life operative competence,as evaluated by FLS and OSATS,respectively.

关键词： TheFundamentalsof Laparoscopic Surgery The Objective Structured Assessment of Technical Skills Laparoscopic training Surgical education Surgical training Urological laparoscopic surgery

Transcriptional dysregulation in neurodegenerative diseases:who tipped the balance of yin Yang 1 in the brain?

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Neural Regeneration Research 2019年第7期14卷 1148-1151页

作者： Zhefan Stephen Chen Ho yin Edwin chan School of Life Sciences Faculty of ScienceThe Chinese University of Hong Kong Gerald Choa Neuroscience Centre The Chinese University of Hong Kong

yin Yang 1(YY1) is a multi-functional transcription factor that regulates gene expression in a range of cell types,including *** controls neuronal differentiation,as well as neuronal specification and migration during the development of the mammalian nervous ***,YY1 also mediates the transcription of genes that are required for neuronal *** impairment of the transcriptional function of YY1 causes neuronal *** review summarizes recent research findings that unveil the dysfunction of YY1 in multiple neurodegenerative *** expression of disease proteins perturbs the function of YY1 via distinct molecular mechanisms,including recruitment to protein aggregates,protein degradation and aberrant nuclear/cytoplasmic *** the pathogenic roles of YY1 will further broaden our knowledge of the disease mechanisms in distinct neurodegenerative disorders.

关键词： Alzheimer’s disease amyotrophic lateral sclerosis neurodegeneration protein aggregates recruitment protein degradation subcellular localization transcriptional regulation yin Yang 1

融合热点与长短期兴趣的图神经网络课程推荐模型

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计算机科学与探索 2024年第6期18卷 1600-1612页

作者：刘源董永权陈成贾瑞印婵江苏师范大学计算机科学与技术学院江苏徐州221116 徐州市云计算工程技术研究中心江苏徐州221116 江苏省教育信息化工程技术研究中心江苏徐州221116

近年来大规模在线开放课程(MOOCs)平台为用户提供了海量的学习资源,亟需一种有效的个性化课程推荐方法帮助用户解决信息过载问题。现有的课程推荐方法忽略了课程间的时序性且无法较好地捕获课程间的长距离依赖关系,同时面临用户学习兴... 详细信息

近年来大规模在线开放课程(MOOCs)平台为用户提供了海量的学习资源,亟需一种有效的个性化课程推荐方法帮助用户解决信息过载问题。现有的课程推荐方法忽略了课程间的时序性且无法较好地捕获课程间的长距离依赖关系,同时面临用户学习兴趣表示和冷启动两个关键问题。基于此,提出一种融合热点与长短期兴趣的图神经网络课程推荐模型(GHLS4CR)。该模型设计无环时序图和无环快捷图两种会话图构建方法来缓解现有方法存在的时序信息丢失和不善于捕获长距离依赖的问题;将用户长短期兴趣进行图级表示,并与热门课程信息进行融合实现个性化推荐,同时缓解冷启动问题。通过在学堂在线(XuetangX)公开数据集MOOCCourse上的大量实验表明,GHLS4CR在个性化课程推荐领域优于FISSA和LESSR等主流推荐模型。与次好的LESSR模型相比,Recall@5提高了13.28%,MRR@5提高了15.50%。

关键词：课程推荐基于会话的推荐图神经网络长短期兴趣冷启动

护理专业教师信息化教学能力调查分析——以广西地区为例

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教育教学论坛 2024年第27期 25-28页

作者：凌银婵广西医科大学护理学院广西南宁530021

通过调查分析广西护理专业教师信息化教学能力现状并分析其影响因素,选取广西6所医学院校共96名护理专业专职教师作为研究对象,采用护理教师信息化教学能力调查表进行调查。结果显示,广西护理专业教师信息化教学能力得分为(120.44±14.... 详细信息

通过调查分析广西护理专业教师信息化教学能力现状并分析其影响因素,选取广西6所医学院校共96名护理专业专职教师作为研究对象,采用护理教师信息化教学能力调查表进行调查。结果显示,广西护理专业教师信息化教学能力得分为(120.44±14.87)分。其中,认识维度得分23.55±3.73,基础与技能维度得分36.25±5.27,应用与实践维度得分53.09±7.94,研究与创新维度得分7.86±3.53,性别、年龄、培训经历与信息化教学能力水平相关。由此得出,广西护理专业教师信息化能力水平处于中等水平,各子能力水平发展不均衡,需结合各方面因素进行改革以提升教师的信息化教学水平。

关键词：信息化教学能力护理教师

Effects of SARS-CoV-2 infection on incidence and treatment strategies of hepatocellular carcinoma in people with chronic liver disease

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World Journal of Hepatology 2024年第2期16卷 211-228页

作者： Lung-Yi Mak Matthew Shing Hin Chung Xue Li Francisco Tsz Tsun Lai Eric Yuk Fai Wan Celine Sze Ling Chui Franco Wing Tak Cheng Esther Wai yin chan Ching Lung Cheung Ivan Chi Ho Au Xi Xiong Wai-Kay Seto Man-Fung Yuen Carlos King Ho Wong Ian Chi Kei Wong Department of Medicine The University of Hong KongHong KongChina State Key Laboratory of Liver Research The University of Hong KongHong KongChina Department of Pharmacology and Pharmacy The University of Hong KongHong KongChina Laboratory of Data Discovery for Health(D24H) Hong Kong Science and Technology ParkHong KongChina Department of Family Medicine and Primary Care The University of Hong KongHong KongChina School of Nursing The University of Hong KongHong KongChina School of Public Health The University of Hong KongHong KongChina Research Department of Practice and Policy University College LondonLondon WC1E 6BTUnited Kingdom Aston School of Pharmacy Aston UniversityBirmingham B47ETUnited Kingdom

BACKGROUND Chronic liver disease(CLD)was associated with adverse clinical outcomes among people with severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)*** To determine the effects of SARS-CoV-2 infection on the incidence and treatment strategy of hepatocellular carcinoma(HCC)among patients with *** A retrospective,territory-wide cohort of CLD patients was identified from an electronic health database in Hong *** with confirmed SARS-CoV-2 infection[coronavirus disease 2019(COVID-19)+CLD]between January 1,2020 and October 25,2022 were identified and matched 1:1 by propensity-score with those without(COVID-19-CLD).Each patient was followed up until death,outcome event,or November 15,*** outcome was incidence of *** outcomes included all-cause mortality,adverse hepatic outcomes,and different treatment strategies to HCC(curative,non-curative treatment,and palliative care).Analyses were further stratified by acute(within 20 d)and post-acute(21 d or beyond)phases of SARS-CoV-2 *** rate ratios(IRRs)were estimated by Poisson regression *** Of 193589 CLD patients(>95%non-cirrhotic)in the cohort,55163 patients with COVID-19+CLD and 55163 patients with COVID-19-CLD were included after 1:1 propensity-score *** 249-d median follow-up,COVID-19+CLD was not associated with increased risk of incident HCC(IRR:1.19,95%CI:0.99-1.42,P=0.06),but higher risks of receiving palliative care for HCC(IRR:1.60,95%CI:1.46-1.75,P<0.001),compared to *** both acute and post-acute phases of infection,COVID-19+CLD were associated with increased risks of allcause mortality(acute:IRR:7.06,95%CI:5.78-8.63,P<0.001;post-acute:IRR:1.24,95%CI:1.14-1.36,P<0.001)and adverse hepatic outcomes(acute:IRR:1.98,95%CI:1.79-2.18,P<0.001;post-acute:IRR:1.24,95%CI:1.13-1.35,P<0.001),compared to *** Although CLD patients with SARS-CoV-2 infection were not associated with increased risk of HCC,they

关键词： SARS-CoV-2 infection Chronic liver disease Long COVID Post-COVID-19 syndrome Cirrhosis Hepatocellular carcinoma

The Strategies of Pathogen-Oriented Therapy on Circumventing Antimicrobial Resistance

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Research 2020年第1期2020卷 238-269页

作者： Zifang Shang Siew yin chan Qing Song Peng Li Wei Huang Frontiers Science Center for Flexible Electronics(FSCFE) Xi’an Institute of Flexible Electronics(IFE)&Xi’an Institute of Biomedical Materials and Engineering(IBME)Northwestern Polytechnical University(NPU)Xi’an 710072China Key Laboratory for Organic Electronics and Information Displays(KLOEID)and Institute of Advanced Materials(IAM) Nanjing University of Posts and Telecommunications(NUPT)Nanjing 210023China Key Laboratory of Flexible Electronics(KLOFE)&Institute of Advanced Materials(IAM) Jiangsu National Synergetic Innovation Center for Advanced Materials(SICAM)Nanjing Tech University(NanjingTech)Nanjing 211816China

The emerging antimicrobial resistance(AMR)poses serious threats to the global public *** antibiotics have been eclipsed in combating with drug-resistant ***,the developing and deploying of novel antimicrobial drugs have trudged,as few new antibiotics are being developed over time and even fewer of them can hit the *** therapeutic strategies to resolve the AMR crisis are urgently ***-oriented therapy(POT)springs up as a promising approach in circumventing antibiotic *** tactic underling POT is applying antibacterial compounds or materials directly to infected regions to treat specific bacteria species or strains with goals of improving the drug efficacy and reducing nontargeting and the development of drug *** review exemplifies recent trends in the development of POTs for circumventing AMR,including the adoption of antibiotic-antibiotic conjugates,antimicrobial peptides,therapeutic monoclonal antibodies,nanotechnologies,CRISPR-Cas systems,and microbiota *** these alternative approaches alone or in combination shows promising advantages for addressing the growing clinical embarrassment of antibiotics in fighting drug-resistant bacteria.

关键词： drugs fighting alone

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温控食物配送机器人的设计研究

移动信息 2024年第9期46卷 338-340页

作者：罗豪邓嫄媛尹婵罗杰周耕多成都大学成都610106

基于人工智能等新一代信息技术的发展,配送机器人成为餐饮行业的重要设备之一.针对传统配送机器人存在的温度不易控制等问题,文中提出一种依托工业互联网技术、人工智能技术的温控食物配送机器人,通过应用了温度传感器及湿度传感器的送... 详细信息

基于人工智能等新一代信息技术的发展,配送机器人成为餐饮行业的重要设备之一.针对传统配送机器人存在的温度不易控制等问题,文中提出一种依托工业互联网技术、人工智能技术的温控食物配送机器人,通过应用了温度传感器及湿度传感器的送餐箱实现对配送食物的温度和湿度的精准控制,提高配送机器人的保温性能.仿真试验证明,该温控食物配送机器人不仅实现了食物的自动配送,提高了配送效率和准确性,还能结合食物温度变化规律等自动实现保温保湿,防止配送食物降温过快,确保食物在送餐箱内的新鲜度,具有良好的应用前景.

关键词：配送机器人温控食物人工智能技术