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Chinese Journal of Chemical Engineering 2024年第1期65卷 276-285页

作者： yin wu Yan Sun Department of Biochemical Engineering School of Chemical Engineering and Technology and Key Laboratory of Systems Bioengineering and Frontiers Science Center for Synthetic Biology(Ministry of Education)Tianjin UniversityTianjin 300350China

Biocatalysis in organic solvents(OSs)has numerous important applications,but native enzymes in OSs often exhibit limited catalytic ***,we proposed a computation-aided surface charge engineering strategy to improve the catalytic performance of haloalkane dehalogenase DhaA in OSs based on the energetic analysis of substrate binding to the DhaA *** variants with enhanced OS resistance were obtained by replacing negative charged residues on the surface with positive charged residue(Arg).Particularly,a four-substitution variant E16R/E93R/E121R/E257R exhibited the best catalytic performance(five-fold improvement in OS resistance and seven-fold half-life increase in 40%(vol)dimethylsulfoxide).As a result,the overall catalytic performance of the variant could be at least 26 times higher than the wild-type *** spectroscopy and molecular dynamics simulation studies revealed that the residue substitution mainly enhanced OS resistance from four aspects:(a)improved the overall structural stability,(b)increased the hydrophobicity of the local microenvironment around the catalytic triad,(c)enriched the hydrophobic substrate around the enzyme molecule,and(d)lowered the contact frequency between OS molecules and the catalytic *** findings validate that computationaided surface charge engineering is an effective and ingenious rational strategy for tailoring enzyme performance in OSs.

关键词： Surface charge engineering Organic solvent resistance Molecular dynamics simulation Haloalkane dehalogenase

Periodic Solutions of Singular Second Order Equations at Resonance

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Acta Mathematica Sinica,English Series 2015年第10期31卷 1599-1610页

作者： yin yin wu Ding Bian QIAN School of Mathematical Sciences Soochow University Department of Fondamental Courses Wuxi Institute of Technology

In this paper, we study the existence of positive periodic solutions for singular second order equations x＂＋ n2/4＋h（x） = p（t）, where h has a singularity at the origin and n is a positive integer. We give an explicit condition to ensure the existence of positive periodic solutions when h is an unbounded perturbation at infinity by using qualitative analysis and topological dezree theory.

关键词： Second order equations singularity periodic solutions resonance unbounded perturba-tions

Extent, reasons and consequences of off-labeled and unlicensed drug prescription in hospitalized children: a narrative review

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World Journal of Pediatrics 2021年第4期17卷 341-354页

作者： Wasim Shuib Xin-yin wu Fang Xiao Xiangya School of Public Health Central South UniversityChangsha410078China

Background Off-label and unlicensed prescriptions pose a severe safety concern among the pediatric *** aimed to summarize the up-to-date evidence on the extent,reasons,and consequences of off-label and unlicensed drugs in hospitalized pediatric *** We systematically searched PubMed,EMBASE,SCOPUS,Web of Science and Google Scholar between 1990 and 2020 in which the last search was conducted on 12 February *** included studies with the following inclusion criteria:(1)observational studies in design;(2)target population was hospitalized pediatric patients whether admitted in the intensive care unit or in the general ward;(3)study reporting the prevalence of off-label,unlicensed prescriptions or both;and(4)published in *** A total of 47 studies were eligible for *** proportion of off-label and unlicensed prescriptions ranged from 7.4%to 99.5%and 0.1%to 74.4%,*** most frequent category of off-label prescriptions was prescription outside the age range,with the most commonly reported reason for off-label prescriptions being the lack of information specifically for pediatrics on the drug information *** consequences of off-label and unlicensed prescriptions ranged from minor and bearable skin reactions to debilitating renal failure,risking *** Off-label and unlicensed prescriptions are extensive and require progressively meditative ***,the pediatric population is currently a“therapeutic orphan”.Unless adequate pediatric clinical trials and licensed drugs become available,off-label and unlicensed drug prescription should not entirely be banned but rather promoted in an organized manner.

关键词： Licensed medicines Off-label prescribing Pediatrics Unlicensed prescribing

Structural Adjustment Approaches and Policy Design of the Chinese Economy： A Comparison Between New and Old Structural Economics

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Fudan Journal of the Humanities and Social Sciences 2017年第4期10卷 431-454页

作者： yin wu School of Economics Southwestern University of Finance and Economics Liulin Campus No.555 Liutai Avenue Wenjiang District Chengdu 611130 China

The structural adjustment of China＇s economy requires the support of economic theories dedicated to structural issues. But new structural economics （NSE） is significantly different from old structural economics （OSE） in terms of development strategies and policies. They expound on the paths of industrial structure improvement and steady economic growth for developing countries from two different perspectives, comparative advantage and first-mover advantage, which result in a toss-up. From the clashing theories and observations of the true state of Chinese economy, we can see that the core features of China＇s current economic structure are a cumulative result of the insufficient ＂complementary＂ and ＂inducing＂ roles of government investment, which requires the introduction of certain investment models to design an effective structural adjustment plan. From the perspective of investment priority, scope （public service or production）, motives, capacity and decision-making and multi-sectoral coordination, this paper analyzes the key connections between NSE and OSE and strives to design an appropriate and accurate investment plan from the perspective of stability, flexibility and under- pinning in the hope of resolving the issues facing the structural adjustment of the Chinese economy. The first step is to identify investment priorities and enable the market to play the decisive role and the government the guiding role. The second step is to identify crucial nodes and adapt investments to trends of the new industrial revolution. The third step is to focus on the resolution of livelihood issues to steer China out of the low-income trap and clear of the middle-income trap. Not only do investment variables have to become an instrument to continuously improve Chi- na＇s factor endowment structure, but also investment as a mechanism underpinning development has to be adopted throughout the entire duration of the process of reform to fulfill the goal of structural adjustment pur

关键词： Structural adjustment of China' economy ~ New structuraleconomics Old structural economics - Investment model

Eclogites and their country gneisses: studies on inclusions in the accessory minerals of country gneisses

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Chinese Science Bulletin 1998年第1期43卷 65-68页

作者： Jingbo Liu yin wu Lianjie Guo Chinese Acad Sci Inst Geol Beijing 100029 Peoples R China

The mineral inclusions in accessory minerals of the country gneisses have been studied in order to interpret relation between eclogites and their country gneissic rocks. Omphacite inclusions have been identified in titanite and zircon, which indicates that the present mineral assemblages of country gneisses are the last retrograded assemblages and eclogites and their country gneissic rocks probably have a same metamorphic history.

关键词： eclogite inclusion omphacite.

Meeting the Demands of Socialist Core Values and Leading the People's Spiritual Needs

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学术界 2015年第10期 264-269页

作者： wu yin Yang Wei School of Marxism Beijing Jiaotong University Beijing 100044

The spiritual needs are uniquely human,which are the conditions of human existence and *** the process of socialist modernization construction in our country,the social economy develops rapidly and the material basis compacts *** people' s development is far *** socialist core values can lead people' s spiritual needs to be healthy and *** can also build the civic spiritual support system for social development,as well as help people establish the values and faiths that adapt to the socialist construction in our country.

关键词：社会主义现代化价值观社会主义建设人类生存物质基础社会经济支持系统社会发展

Determining factors in potential evapotranspiration changes over China in the period 1971-2008

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Chinese Science Bulletin 2010年第29期55卷 3329-3337页

作者： yin YunHe wu ShaoHong DAI ErFu Institute of Geographic Sciences and Natural Resources Research Chinese Academy of Sciences Beijing 100101 China

Potential evapotranspiration(ETo) is important to hydrological cycling and the global energy *** on a modified FAO56-Penman-Monteith model,ETo was simulated for 603 meteorological stations across China in the period *** distribution and temporal change of ETo were characterized,and the determining factors in ETo were revealed by sensitivity *** show obvious regional differences in annual average ETo and its determining *** general,annual average ETo decreased in the period 1971-2008,but increased since the *** speed and sunshine duration were determining factors in the annual ETo trend,with smaller contributions from relative humidity and *** wind speed was the determining factor in decreasing annual ETo in northern temperate regions and the Tibetan *** spatial extent of wind speed influence contracted to northwest China in summer,and expanded to the whole country in *** sunshine duration was the determining factor in decreasing annual ETo in subtropical and tropical regions,especially in summer,with a larger spatial influence mainly to the southeast of the farming-pastoral *** change has distinct impacts on earth surface ecosystems and environment depending on different determining factors.

关键词：潜在蒸散量中国农牧交错地区空间分布敏感性分析决定性能源平衡电子交易

Destruction of Spiral Wave Using External Electric Field Modulated by Logistic Map

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Communications in Theoretical Physics 2007年第4期47卷 675-678页

作者： MA Jun CHEN Yong JIN wu-yin Department of Physics Lanzhou University of Technology Lanzhou 730050 China Institute of Theoretical Physics Lanzhou University Lanzhou 730000 China School of Mechanical and Electronical Engineering Lanzhou University of Technology Lanzhou 730050 China

Evolution of spiral wave generated from the excitable media within the Barkley model is investigated. The external gradient electric field modulated by the logistic map is imposed on the media （along x- and y-axis）. Drift and break up of spiral wave are observed when the amplitude of the electric field is modulated by the chaotic signal from the logistic map, and the whole system could become homogeneous finally and the relevant results are compared when the gradient electric field is modulated by the Lorenz or Rossler chaotic signal.

关键词： spiral wave Barkley model logistic map

Effect of temperature on the passivation behavior of steel rebar

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International Journal of Minerals,Metallurgy and Materials 2014年第5期21卷 455-461页

作者： Shan-meng Chen Bei Cao yin-shun wu Ke Ma School of Materials Science and Engineering University of Science and Technology Beijing

Steel rebar normally forms an oxide or rusty skin before it is embedded into concrete and the passivation properties of this skin will be heavily influenced by temperature. To study the effect of temperature on the passivation properties of steel rebar under different surface conditions, we conducted scanning electron microscopy （SEM） observations and electrochemical measurements, such as measurements of the free corrosion potential and polarization curves of HPB235 steel rebar. These measurements identified three kinds of surfaces： polished, oxide skin, and rusty skin. Our results show that the passivation properties of all the surface types decrease with the increase of temperature. Temperature has the greatest effect on the rusty-skin rebar and least effect on the polished steel rebar, because of cracks and crevices on the mill scale on the steel rebar＇s surface. The rusty-skin rebar exhibits the highest corrosion rate because crevice corrosion can accelerate the corrosion of the steel rehar, particularly at high temperature. The results also indicate that the threshold temperatures of passivation for the oxide-skin rebar and the rusty-skin rebar are 37℃and 20℃, respectively.

关键词： steel rebar steel corrosion passivation temperature

Quantum Discord and Entanglement in Heisenberg XXZ Spin Chain after Quenches

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Chinese Physics Letters 2012年第6期29卷 31-34页

作者： REN Jie wu yin-Zhong ZHU Shi-Qun Department of Physics and Jiangsu Laboratory of Advanced Functional Material Changshu Institute of TechnologyChangshu 215500 School of Physical Science and Technology Soochow UniversitySuzhouJiangsu 215006

Using the adaptive time-dependent density-matrix renormalization group method,the dynamics of entanglement and quantum discord of an one-dimensional spin-1/2 XXZ chain is studied when anisotropic interaction quenches are applied at different *** dynamics of the quantum discord and pairwise entanglement between the nearest qubits shows that the entanglement and quantum discord will first oscillate and then approach to a constant *** quantum discord can be used to predict the quantum phase transition,while the entanglement cannot.

关键词： value quantum Heisenberg