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Activin A receptor type 1C single nucleotide polymorphisms associated with esophageal squamous cell carcinoma risk in Chinese population

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World Journal of Gastrointestinal Oncology 2025年第1期17卷 39-51页

作者： Si-Yun Lin Hou Huang Jin-Jie Yu Feng Su Tian Jiang Shao-Yuan Zhang Lu Lv Tao Long Hui-Wen Pan jun-Qing Qi Qiang Zhou Wei-Feng Tang Guo-Wen Ding Li-Ming Wang Li-Jie Tan jun yin Department of Thoracic Surgery Zhongshan Hospital Affiliated to Fudan UniversityShanghai 200032China Shanghai Key Laboratory of Clinical Geriatric Medicine Huadong Hospital Affiliated to Fudan UniversityShanghai 200040China Department of Cardiothoracic Surgery The Affiliated People's Hospital of Jiangsu UniversityZhenjiang 212002Jiangsu ProvinceChina Department of Thoracic Surgery Sichuan Cancer Hospital&InstituteChengdu 610042Sichuan ProvinceChina Department of Cardiothoracic Surgery Nanjing Drum Tower HospitalThe Affiliated Hospital of Nanjing University Medical SchoolNanjing 210000Jiangsu ProvinceChina Department of Respiratory and Critical Care Medicine Shanghai Xuhui Central HospitalShanghai 200032China

BACKGROUND Transforming growth factor-β(TGF-β)superfamily plays an important role in tumor progression and *** A receptor type 1C(ACVR1C)is a TGF-βtype I receptor that is involved in tumorigenesis through binding to dif-ferent *** To evaluate the correlation between single nucleotide polymorphisms(SNPs)of ACVR1C and susceptibility to esophageal squamous cell carcinoma(ESCC)in Chinese Han *** In this hospital-based cohort study,1043 ESCC patients and 1143 healthy controls were *** SNPs(rs4664229,rs4556933,rs77886248,rs77263459,rs6734630)of ACVR1C were assessed by the ligation detection reaction ***-Weinberg equilibrium test,genetic model analysis,stratified analysis,linkage disequi-librium test,and haplotype analysis were *** Participants carrying ACVR1C rs4556933 GA mutant had significantly decreased risk of ESCC,and those with rs77886248 TA mutant were related with higher risk,especially in older male *** the haplotype analysis,ACVR1C Trs4664229Ars4556933Trs77886248Crs77263459Ars6734630 increased risk of ESCC,while Trs4664229Grs4556933Trs77886248Crs77263459Ars6734630 was associated with lower susceptibility to *** ACVR1C rs4556933 and rs77886248 SNPs were associated with the susceptibility to ESCC,which could provide a potential target for early diagnosis and treatment of ESCC in Chinese Han population.

关键词： Activin A receptor type 1C Single nucleotide polymorphisms Esophageal squamous cell carcinoma Genetic susceptibility Hospital-based cohort study

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Extension of covariant derivative(Ⅰ): From component form to objective form

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Acta Mechanica Sinica 2015年第1期31卷 79-87页

作者： Ya-jun yin Department of Engineering Mechanics School of AerospaceTsinghua University

This paper extends the covariant derivative un der curved coordinate systems in 3D Euclid space. Based on the axiom of the covariant form invariability, the classical covariant derivative that can only act on components is ex tended to the generalized covariant derivative that can act on any geometric quantity including base vectors, vectors and tensors. Under the axiom, the algebra structure of the gen eralized covariant derivative is proved to be covariant dif ferential ring. Based on the powerful operation capabilities and simple analytical properties of the generalized covariant derivative, the tensor analysis in curved coordinate systems is simplified to a large extent.

关键词： Tensor analysis Classical covariant derivatives Generalized covariant derivatives The axiom of the covari-ant form invariability Covariant differential ring

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Extension of covariant derivative(Ⅲ): From classical gradient to shape gradient

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Acta Mechanica Sinica 2015年第1期31卷 96-103页

作者： Ya-jun yin Department of Engineering Mechanics School of Aerospace Tsinghua University

This paper further extends the generalized covari ant derivative from the first covariant derivative to the sec ond one on curved surfaces. Through the linear transforma tion between the first generalized covariant derivative and the second one, the second covariant differential transformation group is set up. Under this transformation group, the sec ond class of differential invariants and integral invariants on curved surfaces is made clear. Besides, the symmetric struc ture of the tensor analysis on curved surfaces are revealed.

关键词： Tensor analysis on curved surfaces The sec-ond generalized covariant derivative The second covariantdifferential transformation group The second class of dif-ferential and integral invariants

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Extension of covariant derivative(Ⅱ): From flat space to curved space

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Acta Mechanica Sinica 2015年第1期31卷 88-95页

作者： Ya-jun yin Department of Engineering Mechanics School of Aerospace Tsinghua University

This paper extends the classical covariant deriva tive to the generalized covariant derivative on curved sur faces. The basement for the extension is similar to the pre vious paper, i.e., the axiom of the covariant form invariabil ity. Based on the generalized covariant derivative, a covari ant differential transformation group with orthogonal duality is set up. Through such orthogonal duality, tensor analy sis on curved surfaces is simplified intensively. Under the covariant differential transformation group, the differential invariabilities and integral invariabilities are constructed on curved surfaces.

关键词： Tensor analysis on curved surfaces Classicalcovariant derivative and generalized covariant derivative Axiom of the covariant form invariability Covariant differ-ential transformation group Differential invariabilities andintegral invariabilities

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A generalized presentation of multi-caloric effects based on exterior derivative theory and its applications

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Communications in Theoretical Physics 2024年第8期76卷 156-163页

作者： jun yin School of Materials Science and Engineering Nankai UniversityTianjin 300350China School of Mechanical Engineering and Automation Fuzhou UniversityFuzhou 350108China

The emerging concept of multi-caloric effects, introduced in 2010, entails the application of multiple interplay fields to a thermodynamic system. While multi-caloric effects are the main focus of experimental endeavors, theoretical considerations fall short of providing a thorough understanding. This paper introduces a comprehensive presentation on multi-caloric effects,employing the method and theory of exterior derivative formations. It addresses every aspect of thermodynamic systems, showcasing its applicability to multi-caloric materials(both singlephase and multi-phase materials), and its adaptability to different scenarios(either in single or multiple force fields). The formulation of Maxwell relationships, characterized by their generality and universality, enables a clear prediction in entropy and temperature, facilitating a distinct identification between independent and interdependent contributions from multi-caloric effects. These insights hold significant importance in designing and developing specialized thermodynamic materials, optimizing functional performances and exploring innovative mechanisms.

关键词： multicaloric effects Maxwell relations isothermal entropy adiabatic temperature

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The role of lipids in fermentative propionate production from the co-fermentation of lipid and food waste

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Frontiers of Environmental Science & Engineering 2023年第7期17卷 107-118页

作者： Niyou Xu Ting Chen jun yin School of Environmental Science and Engineering Zhejiang Gongshang UniversityHangzhou 310012China Zhejiang Provincial Key Laboratory of Solid Waste Treatment and Recycling Hangzhou 310012China

Food waste(FW)is a promising renewable low-cost biomass substrate for enhancing the economic feasibility of fermentative propionate *** lipids,a common component of food waste,can be used as a carbon source to enhance the production of volatile fatty acids(VFAs)during co-fermentation,few studies have evaluated the potential for directional propionate production from the co-fermentation of lipids and *** this study,co-fermentation experiments were conducted using different combinations of lipids and FW for VFA *** contributions of lipids and FW to propionate production,hydrolysis of substrates,and microbial composition *** were *** results revealed that lipids shifted the fermentation type of FW from butyric to propionic acid *** on the estimated propionate production kinetic parameters,the maximum propionate productivity increased significantly with an increase in lipid content,reaching 6.23 g propionate/(L·d)at a lipid content of 50%.Propionate-producing bacteria Prevotella,Veillonella,and norank f Propionibacteriaceae were enriched in the presence of lipids,and the succinate pathway was identified as a prominent fermentation route for propionate ***,the Kyoto Encyclopedia of Genes and Genomes functional annotation revealed that the expression of functional genes associated with amino acid metabolism was enhanced by the presence of ***,these findings will contribute to gaining a better understanding of targeted propionate production from FW.

关键词： Acidogenic fermentation Microbial community Volatile fatty acid Propionate Foodwaste Lipid

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Industry news:the additive manufacturing of nerve conduits for the treatment of peripheral nerve injury

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Bio-Design and Manufacturing 2022年第1期5卷 6-8页

作者： ying Han jun yin The State Key Laboratory of Fluid Power and MechatronicSystems School of Mechanical EngineeringZhejiangUniversityHangzhou 310028China Key Laboratory of 3D Printing Process and Equipmentof Zhejiang Province School of Mechanical EngineeringZhejiang UniversityHangzhou 310028China

Peripheral nerve injury and nerve conduit manufacturing The global nerve injury repair and regeneration market is expected to reach$9.7 billion by 2025,a compound annual growth rate of 9.1%between 2020 and 2025[1].One component alone,peripheral nerve injury(PNI),encompasses 5 million new cases worldwide every year[2].Although nerve autograft is considered the gold standard for PNI repair,this process sufers because of a short supply of autologous nerves as well as potential harm caused to the *** recent decades,as a promising alternative to autografts。

关键词： injury nerves additive

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Mapping determinants of rural poverty in Guangxi–a less developed region of China

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Journal of Mountain Science 2020年第7期17卷 1749-1762页

作者： ZHAO yin-jun LU Yuan Key Laboratory of Environment Change and Resources Use in Beibu Gulf Ministry of EducationNanning Normal UniversityNanning530001China School of Geography and Planning Nanning Normal UniversityNanning530001China

Rapid urbanization in China has led to an increasing imbalance in regional *** Guangxi Zhuang Autonomous Region,a less developed border region with unique cultural diversity,has a relatively large population(4.52 million people in 2015)under the poverty line,according to the national standard of *** has launched a national campaign to reduce poverty using a wide range of new development policies and large-scale ***,there have been few studies on the determinants of poverty at the county level across a *** paper aims to explore the spatial and social differences related to poverty among 109 counties by considering the spatial heterogeneity of poverty *** statistical models revealed that slope(Slp),GDP per capita(GDPP),the ethnic minority population ratio(EMPR),medical and technical personnel of healthcare institutions(MTP)and illiteracy rate(IR)significantly affect the patterns of the poverty rate,with a high adjusted R2(0.67),while the poverty rate affects GDPP,IR,MTP and EMPR;i.e.,the effects are ***,the IR is significantly affected by the provision of schools and transportation *** these determinants,social factors may be *** spatial patterns of these relationships demonstrate remarkable variation across the province and between minor and major *** quantitative evidence is enhanced by indepth interviews with selected *** results are expected to be useful for the anti-poverty project in Guangxi.

关键词： Determinants Ordinary least squares regression Geographically weighted regression Poverty Spatial distribution Guangxi

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A Study of International Arbitrators' Substantive Ethical Obligations and Chinese Strategies

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学术界 2018年第12期 260-271页

作者： yin jun Law School&Institute of International Law Wuhan University Wuhan Hubei 430072

The increased complexity and scales of international arbitration cases require a larger roster of righteous and experienced international arbitrators. The difficulty to define ethics or ethical obligation in the area of international arbitration has caused increased discussion and confusion. As a result,the tendency towards codification of ethical obligations would provide a more precise and practical mean to regulate arbitrators' behavior. The legal sources of ethical obligations of international arbitrators contain international conventions,national laws,arbitral institutions' rules as well as institutional codes of ethics. The main substantive ethical obligations include disclosing,investigating,conducting the arbitration in accordance with the arbitration agreement,maintaining confidentiality,being competent and diligent. Chinese authorities and foreign-related arbitral institutions should enhance the codification and uniformity of the international arbitrators' ethical obligations. The relevant strategies for revising the Arbitration Lawand arbitrators' ethical codes,unifying the foreign-related arbitration institution ethical rules and joining the harmonious progress of international arbitration should be considered correspondingly.

关键词： international arbitration arbitrator ethical obligation codification

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Two-Dimensional Cathode Materials for Aqueous Rechargeable Zinc-Ion Batteries

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Chinese Journal of Chemistry 2022年第8期40卷 973-988页

作者： Yurou Wang jun yin Jian Zhu School of Materials Science and Engineering Nankai UniversityTianjin 300350China

Rechargeable aqueous zinc-ion batteries(ZIBs)featuring low cost,superior performance,and environmental benignity have attracted dramatic atten-tion as a promising alternative energy storage system to lithium-ion ***,the development of ZIBs is still hindered by the limited selection of cathode materials due to the large solvation sheath and charge density of Zn^(2+).Two-dimensional(2D)materials have attracted extraor-dinary attention owing to the unique layered structure bonded by weak van der Waals'forces,which makes them promising host materials for Zn^(2+)intercalation/*** this review,the synthesis and properties of 2D materials for cathodes in ZIBs are ***,various re-ports on 2D materials as ZIBs cathodes are *** key strategies to elicit improved Zn2+storage abilities:defect engineering,hetero-structure engineering,and interlayer engineering,are ***,this review ends with perspectives relating to the challenges and opportu-nities of 2D materials-based ZIBs.

关键词： Two-dimensional materials Zinc-ion batteries Electrochemistry Nanostructures Energy conversion

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