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Chinese Annals of Mathematics,Series B 2022年第5期43卷 643-658页

作者： Liting YOU huijuan SONG Jingxue yin School of Mathematical Sciences South China Normal UniversityGuangzhou 510631China School of Mathematics and Statistics Jiangxi Normal UniversityNanchang 330022China

In this paper,the authors study the multiplicity of solutions to the weighted p-Laplacian with isolated singularity and diffusion suppressed by convection-div(|x|^(α)|■u|^(p-2)■u)+λ^(1)/|x|β|■u|^(p-2)■u·x=|x|^(γ)g(|x|)in B{0}subject to nonlinear Robin boundary value condition|x|^(α)|■u|^(p-2)■u·n=A-ρu on■B,whereλ>0,B■RN(N≥2)is the unit ball centered at the origin,α>0,p>1,β∈R,γ>-N,g∈C(0,1])with g(0)>0,A∈R,ρ>0 and n is the unit outward *** same problem with diffusion promoted by convection,namely λ≤0,has already been discussed by the last two authors(Song-yin(2012)),where the existence,nonexistence and classification of singularities for solutions are *** different from[Song,*** yin,J.X.,Removable isolated singularities of solutions to the weighted p-Laplacian with singular convection,***.,35,2012,1089-1100],in the present caseλ>0,namely the diffusion is suppressed by the convection,non-singular solutions are not only existent but also may be infinite which vary according only to the values of solutions at the isolated singular *** the same time,the singular solutions may exist only if the diffusion dominates the convection.

关键词： Weighted p-Laplacian Multiplicity of solutions Isolated singularities Convection

Resistance to the Strawberry Neopestalotiopsis Crown Rot of Collections from National Germplasm Repository for Strawberry in JAAS

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Resistance to the Strawberry Neopestalotiopsis Crown Rot of ...

补骨脂的质量特征解析及其在减毒工艺中的应用

中国植物病理学会2024年学术年会

作者： WU Ejiao YANG huijuan PANG Fuhua ZHAO Mizhen QIAO Yushan Institute of Pomology Jiangsu Academy of Agricultural Sciences/Jiangsu Key Laboratory for Horticultural Crop Genetic Improvement College of Horticulture Nanjing Agricultural University

In recent years strawberry crown rot caused by Neopestalotiopsis *** occurred in many places in China,leading to an increasing economic *** order to understand the resistance level of strawberry germplasm resources,321 cultivated varieties selected from the demonstration bases and National Germplasm Repository for Strawberry in Jiangsu Academy of Agricultural Sciences were determined for resistance to Neopestalotiopsis crown rot by a detached leaf assay through pathogen plugs and conidia suspension *** lesion growth rate was calculated by the AUDPC(Area Under the Disease Progress Curve) and the number of conidia production was collected by the hemocytometer under optical electron microscopy for five *** results showed that strawberry germplasm resources from different geographical sources was different,strawberry cultivars from Japanese such as ' Benihoppe''Kaorino' generally exhibit higher resistance,whereas cultivars from European and American such as' Sweet Charlie' 'Mara des Bois' tend to display lower *** total AUDPC was ranging from0.00 to 5.73 and 0.00 to 5.78,with the average of 1.10 and 1.19 for the pathogen plugs and conidia suspension inoculation,*** average conidia production was 20.87,with the highest number of 172.25 for 'Mara des Bois',and lowest number of 0.08 for 'jiuxiang'.The immunity(I),high resistance(HR),resistance(R),moderate resistance(MR),susceptibility(S),and high susceptibility(HS) was account for 0.01%,27.10%,11.46%,26.79%,6.23% and26.79%,*** results provide a scientific basis for selection of resistance varieties in practical production and breeding disease-resistant strawberry cultivars in the future.

关键词： Neopestalotiopsis crown rot resistance area under the disease progress curve conidia production

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中草药 2024年第8期55卷 2784-2791页

作者：张潇予王丹妮柴欣于卉娟崔英王跃飞天津中医药大学中医药研究院现代中药创制全国重点实验室组分中药国家重点实验室天津市中药化学与分析重点实验室天津301617 现代中医药海河实验室天津301617

补骨脂Psoraleae Fructus为临床常用中药,是补益类中成药或方剂中的重要组成药味。近年来,补骨脂的肝毒性对其临床用药安全构成威胁,阻碍了含补骨脂方剂的中药新药开发,限制了补骨脂及其中成药的临床应用。通过对补骨脂的化学成分及药... 详细信息

补骨脂Psoraleae Fructus为临床常用中药,是补益类中成药或方剂中的重要组成药味。近年来,补骨脂的肝毒性对其临床用药安全构成威胁,阻碍了含补骨脂方剂的中药新药开发,限制了补骨脂及其中成药的临床应用。通过对补骨脂的化学成分及药理活性,果皮和种子中的化学成分分布特征,在生长、贮藏、加工炮制过程中补骨脂香豆素类成分转化特征,香豆素类成分体内代谢转化特征及潜在的肝毒性成分等质量特征及其在补骨脂减毒工艺中的应用分析,为补骨脂及含补骨脂中成药的提取工艺、质量标准研究提供参考。

关键词：补骨脂药理活性肝毒性减毒工艺补骨脂素异补骨脂素补骨脂苷异补骨脂苷

ST段抬高型心肌梗死患者术后近远期死亡风险因素及与慢性闭塞病变的关系

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岭南心血管病杂志 2023年第1期29卷 1-5页

作者：尹慧娟李娜李小娜李颖佳运城市中心医院心血管内三科山西运城044000

目的探讨急性ST段抬高型心肌梗死(ST-segment elevation myocardial infarction,STEMI)患者术后近远期死亡危险因素及与慢性完全闭塞(chronic total occlusion,CTO)病变的关系。方法本研究回顾性纳入2017年1月至2020年6月于运城市中心... 详细信息

目的探讨急性ST段抬高型心肌梗死(ST-segment elevation myocardial infarction,STEMI)患者术后近远期死亡危险因素及与慢性完全闭塞(chronic total occlusion,CTO)病变的关系。方法本研究回顾性纳入2017年1月至2020年6月于运城市中心医院行急诊经皮冠状动脉介入(percutaneous coronary intervention,PCI)治疗的STEMI患者共357例的临床资料,根据冠状造影结果是否存在CTO分为CTO组和非CTO组。分析两组患者一般资料、超声心动图指标、实验室检查指标及预后资料,采用Logistic回归模型评价STEMI患者术后近远期死亡独立危险因素。结果CTO组和非CTO组患者的心肌梗死病史比例、接受冠状动脉旁路移植术(coronary artery bypass grafting,CABG)治疗比例、左心室射血分数(left ventricular ejection fraction,LVEF)、左心室舒张末期内径(left ventricular end-diastolic diameter,LVEDD)比较,差异有统计学意义(P<0.05)。CTO组患者住院期间全因病死率、心源性病死率、心力衰竭发生率及总主要不良心血管事件(major adverse cardiovascular event,MACE)发生率均显著高于非CTO组,差异有统计学意义(P<0.05);CTO组患者术后1年全因病死率、心源性病死率、心力衰竭发生率、再次血运重建率及总MACE发生率均显著高于非CTO组,差异有统计学意义(P<0.05)。多因素分析结果显示,高龄、低LVEF及近4周内吸烟是STEMI患者住院期间死亡独立危险因素(P<0.05);合并CTO、高龄、心力衰竭病史及低LVEF是STEMI患者术后1年死亡独立危险因素(P<0.05)。结论STEMI患者预后与多种因素有关,包括年龄、低LVEF、近4周内吸烟情况、是否合并CTO或心力衰竭病史,其中合并CTO者术后1年内死亡风险往往较高。

关键词：心肌梗死慢性闭塞病变住院随访死亡

Successful rescue of disseminated Nocardia infection with multiple abscesses in a patient with membranous nephropathy after cardiopulmonary resuscitation:A three-year follow-up

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Journal of Biomedical Research 2024年第2期38卷 189-194,I0019,I0020页

作者： Yili Xu Hanyang Qian Wen Qian Li Dong Weiying Liu Yan Zhu Yaning Mei Yi Xu Ling Wang Yi Xia Xu Qi Huanping Mei Xueqiang Xu huijuan Mao Changying Xing Ningning Wang Department of Nephrology the First Affiliated Hospital of Nanjing Medical UniversityJiangsu Province HospitalNanjingJiangsu 210029China Department of Nephrology Nanjing Tongren HospitalNanjingJiangsu 211102China Department of Image the First Affiliated Hospital of Nanjing Medical UniversityJiangsu Province HospitalNanjingJiangsu 210029China Department of Infectious Disease the First Affiliated Hospital of Nanjing Medical UniversityJiangsu Province HospitalNanjingJiangsu 210029China Department of Nephrology the Second Hospital of NanjingNanjingJiangsu 210029China Department of Microorganism the First Affiliated Hospital of Nanjing Medical UniversityJiangsu Province HospitalNanjingJiangsu 210029China Department of Hematology the First Affiliated Hospital of Nanjing Medical UniversityJiangsu Province HospitalNanjingJiangsu 210029China Department of Rheumatology and Immunology the First Affiliated Hospital of Nanjing Medical UniversityJiangsu Province HospitalNanjingJiangsu 210029China

Nocardiosis manifests as an opportunistic infection,primarily affecting individuals who are immunocompromised and susceptible to the *** present a case study of one patient with nephrotic syndrome and membranous nephropathy,who underwent treatment with prednisone and cyclosporine in *** early 2017,the patient was diagnosed with a"fungal infection"and discontinued the use of *** one month of anti-infection therapy,a cranial magnetic resonance imaging scan showed multiple abscesses in the right temporal *** diagnosis of nocardiosis was confirmed based on the presence of metastatic abscess masses,multiple lung and brain lesions,and a positive culture of Nocardia in the *** changed the anti-infection therapy to a combination of trimethoprim-sulfamethoxazole(TMP-SMX),minocycline,and ***,the patient experienced a sudden cardiac arrest and subsequently recovered after cardiopulmonary *** the five-month follow-up period following the discharge,the patient displayed an enhanced nutritional status and stable renal *** focal infection ultimately resolved during the subsequent three ***-infection caused by Nocardia should be considered in immunocompromised patients,and TMP-SMX is the preferred initial therapy;however,because of the high mortality rate,a long-term combination therapy with imipenem,cefotaxime,amikacin,and TMP-SMX is suggested.

关键词： Nocardia infection glomerulonephritis membranous nephrology cardiopulmonary resuscitation

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卵巢黏液性癌的诊治进展

中国癌症杂志 2024年第1期34卷 90-96页

作者：李桐杨慧娟复旦大学附属肿瘤医院胸外科复旦大学遗传工程国家重点实验室复旦大学胸部肿瘤研究所复旦大学上海医学院肿瘤学系上海200032 复旦大学附属肿瘤医院妇瘤科复旦大学上海医学院肿瘤学系上海200032

卵巢黏液性癌(mucinous ovarian cancer,MOC)是卵巢上皮性癌的一种罕见病理学类型,临床上治疗多参考卵巢浆液性癌(serous ovarian cancer,SOC)的相关指南,但由于MOC的临床病理学特征和分子生物学特征与SOC显著不同,因此诊断和治疗均需... 详细信息

卵巢黏液性癌(mucinous ovarian cancer,MOC)是卵巢上皮性癌的一种罕见病理学类型,临床上治疗多参考卵巢浆液性癌(serous ovarian cancer,SOC)的相关指南,但由于MOC的临床病理学特征和分子生物学特征与SOC显著不同,因此诊断和治疗均需仔细鉴别。手术联合辅助化疗为目前治疗MOC的标准方案,但由于其患病率低,临床试验难以开展,循证医学证据缺乏,术中阑尾切除指征、术后辅助化疗方案的选择等均缺乏共识。此外,还需进一步转化靶向治疗和免疫治疗的临床前研究,以利于MOC的精准诊断及个体化治疗。

关键词：卵巢癌卵巢黏液性癌诊治进展

内部控制视角下政府环境监管与企业绿色技术创新——市场化水平的调节作用

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科技进步与对策 2024年第19期41卷 100-108页

作者：赵莉王慧娟中国矿业大学经济管理学院江苏徐州221116

“双碳”背景下,工业企业如何平衡环境保护与经济发展的关系成为亟待解决的问题。以2012—2019年中国120个城市工业企业为研究对象,选取内部控制、市场化水平作为中介变量与调节变量,探讨政府环境监管对企业绿色技术创新的影响,并通过... 详细信息

“双碳”背景下,工业企业如何平衡环境保护与经济发展的关系成为亟待解决的问题。以2012—2019年中国120个城市工业企业为研究对象,选取内部控制、市场化水平作为中介变量与调节变量,探讨政府环境监管对企业绿色技术创新的影响,并通过构建回归模型进行分析,结果表明:①政府环境监管对企业绿色技术创新具有正向影响;②企业内部控制在政府环境监管对绿色技术创新的影响过程中发挥部分中介作用;③市场化水平负向调节政府环境监管与绿色技术创新的关系。结论可为政府加强环境监管,从而进一步改善市场环境提供重要参考。

关键词：政府环境监管绿色技术创新内部控制市场化水平

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朱正与初版《鲁迅传略》

鲁迅研究月刊 2024年第4期 73-81页

作者：林会娟魏建山东师范大学文学院 250014

朱正初版《鲁迅传略》是1949年后出版的首部鲁迅传记,学术价值高却鲜有专论。本文对朱正初版《鲁迅传略》写作、出版的动机、时间等基本问题正本清源,纠正目前学界以讹传讹的错误信息,并从“青年”视角考察朱正初版《鲁迅传略》的特定... 详细信息

朱正初版《鲁迅传略》是1949年后出版的首部鲁迅传记,学术价值高却鲜有专论。本文对朱正初版《鲁迅传略》写作、出版的动机、时间等基本问题正本清源,纠正目前学界以讹传讹的错误信息,并从“青年”视角考察朱正初版《鲁迅传略》的特定语境以及与作者作为“革命青年”的历史关联,揭示此书经历了怎样的历史选择。并探究其以《斯大林传略》为范本的写作实践以及存在的问题,通过“重返”历史现场返观该书出版前后及文本,可以获得诸多学术的和历史的启示。

关键词：朱正《鲁迅传略》革命青年《斯大林传略》

Immune-tumor interaction dictates spatially directed evolution of esophageal squamous cell carcinoma

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National Science Review 2024年第5期11卷 170-185页

作者： Yong Zhou Shanlan Mo Heyang Cui Ruifang Sun Weimin Zhang Xiaofei Zhuang Enwei Xu Hongyi Li Yikun Cheng Yongsheng Meng Meilin Liu Ting Yan huijuan Liu Ling Zhang Bin Yang Yanfeng Xi Shubin Wang Xiaolong Cheng Shuai Cheng Li Zhihua Liu Qimin Zhan Zheng Hu Yongping Cui Cancer Institute Department of Pathology Peking University Shenzhen Hospital Shenzhen Peking University-the Hong Kong University of Science and Technology(PKU-HKUST) Medical Center Institute of Cancer ResearchShenzhen Bay Laboratory Key Laboratory of Cellular Physiology of the Ministry of Education Department of Pathology Shanxi Medical University City University of Hong Kong Shenzhen Research Institute CAS Key Laboratory of Quantitative Engineering Biology Shenzhen Institute of Synthetic BiologyShenzhen Institute of Advanced TechnologyChinese Academy of Sciences Department of Surgery Faculty of Medicine The Chinese University of Hong Kong Department of Tumor Biobank Shanxi Province Cancer HospitalShanxi Hospital Affiliated to Cancer HospitalChinese Academy of Medical SciencesCancer Hospital Affiliated to Shanxi Medical University Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education/Beijing) Laboratory of Molecular Oncology Peking University Cancer Hospital & Institute Research Unit of Molecular Cancer Research Chinese Academy of Medical Sciences Department of Thoracic Surgery Shanxi Province Cancer HospitalShanxi Hospital Affiliated to Cancer HospitalChinese Academy of Medical SciencesCancer Hospital Affiliated to Shanxi Medical University Department of Pathology Shanxi Province Cancer HospitalShanxi Hospital Affiliated to Cancer HospitalChinese Academy of Medical SciencesCancer Hospital Affiliated to Shanxi Medical University College of Letters & Science University of California Berkeley State Key Laboratory of Molecular Oncology National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College

Esophageal squamous cell carcinoma（ESCC） is a poor-prognostic cancer type with extensive intra-and inter-patient heterogeneity in both genomic variations and tumor microenvironment（TME）. However, the patterns and drivers of spatial genomic and microenvironmental heterogeneity of ESCC remain largely unknown. Here, we generated a spatial multi-omic atlas by whole-exome, transcriptome, and methylome sequencing of 507 tumor samples from 103 patients. We identified a novel tumor suppressor PREX2,accounting for 22% of ESCCs with frequent somatic mutations or hyper-methylation, which promoted migration and invasion of ESCC cells in vitro. Analysis of the TME and quantification of subclonal expansion indicated that ESCCs undergo spatially directed evolution, where subclones mostly originated from the tumor center but had a biased clonal expansion to the upper direction of the ***, we found upper regions of ESCCs often underwent stronger immunoediting with increased selective fitness, suggesting more stringent immune selection. In addition, distinct TMEs were associated with variable genomic and clinical outcomes. Among them, hot TME was associated with high immune evasion and subclonal heterogeneity. We also found that immunoediting, instead of CD8+T cell abundance, acts as an independent prognostic factor of ESCCs. Importantly, we found significant heterogeneity in previously considered potential therapeutic targets, as well as BRCAness characteristics in a subset of patients, emphasizing the importance of focusing on heterogeneity in ESCC targeted ***, these findings provide novel insights into the mechanisms of the spatial evolution of ESCC and inform precision therapeutic strategies.

关键词： squamous cell carcinoma heterogeneity multi-omics evolution tumor microenvironment

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阿尔茨海默病实验室诊断技术的研究进展

国际生物医学工程杂志 2020年第5期43卷 412-417,424页

作者：车伯琛阴慧娟吴金鹏李迎新中国医学科学院生物医学工程研究所天津300192

阿尔茨海默病(AD)是失智型神经退行性疾病,在老龄人口中发病率呈上升趋势,且预后不良,因此AD的早期诊断技术亟待提升。从神经心理评估、神经影像技术和生物标志物检测等分类诊断领域入手,具体介绍了简易智能状态量表、蒙特利尔认知评估... 详细信息

阿尔茨海默病(AD)是失智型神经退行性疾病,在老龄人口中发病率呈上升趋势,且预后不良,因此AD的早期诊断技术亟待提升。从神经心理评估、神经影像技术和生物标志物检测等分类诊断领域入手,具体介绍了简易智能状态量表、蒙特利尔认知评估量表、记忆与执行功能筛查量表、结构性MRI、功能性MRI、正电子发射计算机断层显像、基于MRI的人工智能分析以及β淀粉样蛋白(Aβ)、同型半胱氨酸、S100B蛋白、Aβ42、tau蛋白、尿液AD相关神经丝蛋白(AD7c-NTP)和视网膜Aβ斑含量测定等检测技术的临床应用特点,阐述了各自局限性,总结了技术的发展趋势。AD早期诊断体系的构建,需区分不同痴呆类型,并基于多模态诊断技术综合运用,方能提高筛查效率。

关键词：阿尔茨海默病诊断技术早期诊断