检索结果-南通市图书馆

Cyclosporin A protects Balb/c mice from liver damage induced by superantigen SEB and D-GaIN

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 1999年第3期5卷 209-212页

作者： yin, t tong, SQ Xie, YC Lu, DY Shanghai Second Med Univ Fac Med Lab Sci Ruijin Hosp Shanghai 200025 Peoples R China Shanghai Second Med Univ Dept Microbiol Shanghai 200025 Peoples R China Shanghai Second Med Univ Dept Internal Med Ruijin Hosp Shanghai 200025 Peoples R China

AIM to investigate the pathogenic effect ofSEB and D-GalN on liver and the protection ofcyclosporin A, the relationship between hepaticapoptosis and necrosis and the possiblemechanism of acute hepatic *** After staphylococcal enterotoxin B(SEB ) mixed with D--galactosamine (D-GaiN )were injected intraperitoneally into Balb/c miceand those previously treated with cyclosporin A,blood samples were collected and livers wereisolated at 2, 6, 12 and 24 h. Patterns othepatocellular death were studiedmorphologically and biochemically, circulatingcytokines (tNF-a, IFN--y ) and mice mortalitywithin 24h was ***’LtS the SEB could induce the typicalapoptotic changes of hepatocytes, the D-GaiNcould induce hepatocytes apoptosis anddegeneration at the same time, and the micehaving received the SEB + D-GaiN injectionsdeveloped apoptosis at 2 and 6 h, but after 12 hhepatocytes were characterized by severein jury, whereas all the examinations in thecyclosporin A treated mice were *** Hepatic cell apoptosis might berelated to necrosis, and massive hepatocyteapoptosis is likely the initiating step of acutehepatic necrosis in mice. the effects induced bySEB and D--GaiN on hepatocytes might bemediated by t cells, and could be prevented bycyclosporin A.

关键词： SEB CSA Cyclosporin A protects Balb/c mice from liver damage induced by superantigen SEB and D-GaIN

targeting EGFR and sonic hedgehog pathways for locally advanced eyelid and periocular carcinomas

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Clinical Cases 2014年第9期2卷 432-438页

作者： Vivian t yin Helen Merritt Bita Esmaeli Orbital Oncology and Ophthalmic Plastic Surgery Program Department of Plastic Surgery The University of Texas MD Anderson Cancer Center Department of Ophthalmology and Visual Science The University of Texas Medical School

For patients with metastatic or locally advanced eyelid and periocular carcinoma not amenable to surgical excision, targeted therapies have shown efficacy with better tolerability compared to cytotoxic chemotherapy. Overexpression of epithelial growth factor receptor was found in squamous cell carcinomas. Vismodegib targets the mutation in the hedgehog pathway identified in basal cell carcinoma and basal cell nevus syndrome. targeted therapies provide a novel and potentially effective treatment alternative for patients with eyelid carcinoma not amendable for surgery, including those with metastatic, locally advanced disease, advanced age, and significant comorbidities. High cost, need for long-term treatment, and toxicity are relative limitations.

关键词： Vismodegib Periocular basal cell carcinoma Sonic hedgehog Epithelial growth factor receptor inhibition Periocular squamous cell carcinoma

StRUCtURE IMPROVEMENt AND tEMPERAtURE FIELD SIMULAtION OF PREPARING NANOPOWDER BY EVAPORAtION-CONDENSAtION MEtHOD

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Acta Metallurgica Sinica(English Letters) 2008年第3期21卷 178-182页

作者： J.S. Bao Y. yin t.G. Liu Z.Y. Yang School of Mechanical and Electrical Engineering China University of Mining and Technology Xuzhou221116 China

A new apparatus, with a segregable conical water cooling condenser, which is heated by an electric arc using the evaporation-condensation method to prepare carbon-coated nanopowder, has been developed by the authors. Numerical simulation of the temperature field is done by the ANSYS software, and temperature in the reaction vessel is measured with the help of an experiment, to verify the simulation result. Influence of the temperature field in the reaction vessel, on the process of preparing nanopowder is then discussed simply. It is shown that the segregable conical water cooling condenser and carbon-coated surface process can be used to prepare steady carbon-coated metal nanopowder, at a lower cost and higher yield rate than the traditional structure. Simulation of the temperature field in the apparatus shows that the arc heating method can form a temperature field in the apparatus, which is quite favorable for nanopowder formation. Experiments show that the rational parameters using this apparatus, with the arc heating method to prepare carbon-coated nanopowder are electricity 60-100 A and arc length 5-8 mm.

关键词： Evaporation-condensation method Electric arc heating temperature field Condenser structure

Lower Silurian Graptolites from tungtzu

在线全文

学校读者我要写书评

暂无评论

地质学报 1945年 211-219+338页

作者： t.H.yin and A.t.Mu (Geological Survey of China)

with 1 plate the graptolite faunas listed below were collected in 1944 by *** and the senior author from the so-called Chiutienya shale of Chiutienya,Hanchiatien,and *** and Hanchiatien lie within the

关键词： ACI Lower Silurian Graptolites from tungtzu

ACUtE MONOCYtIC LEUKEMIA CASE REPORt WItH AUtOPSY FINDINGS

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

中华医学杂志(英文版) 1934年第11期48卷 1113-1125+1181页

作者： JULIA MORGAN yin-t'ANG HSU Departments of Medicine and Pathology Cheeloo University Hospital and School of MedicineTsinanShantungChina

*** is made of a case of acute monocytic leukemia in aChinese *** age of the patient,course of the disease,and the bloodfindings correspond,in the main,with those reported by others in *** in this case are the positive blood culture,thegross hematuria,the exceptionally high monocyte percentage in theperipheral blood with absence of polymorphonuclear neutrophiles,andulceration of the caecum found at *** autopsy showed an extremely generalized infiltration ofmonocytes throughout the organs.

关键词：

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第2期20卷 366-377页

作者： Samuel Abokyi Dennis Yan-yin tse School of Optometry The Hong Kong Polytechnic UniversityKowloonHong Kong Special Administrative RegionChina Research Center for SHARP Vision The Hong Kong Polytechnic UniversityKowloonHong Kong Special Administrative RegionChina Center for Eye and Vision Research Sha TinHong Kong Special Administrative RegionChina

Retinal aging has been recognized as a significant risk factor for various retinal disorders,including diabetic retinopathy,age-related macular degeneration,and glaucoma,following a growing understanding of the molecular underpinnings of their *** comprehensive review explores the mechanisms of retinal aging and investigates potential neuroprotective approaches,focusing on the activation of transcription factor *** meta-analyses have demonstrated promising outcomes of transcription factor EB-targeted strategies,such as exercise,calorie restriction,rapamycin,and metformin,in patients and animal models of these common retinal *** review critically assesses the role of transcription factor EB in retinal biology during aging,its neuroprotective effects,and its therapeutic potential for retinal *** impact of transcription factor EB on retinal aging is cell-specific,influencing metabolic reprogramming and energy homeostasis in retinal neurons through the regulation of mitochondrial quality control and nutrient-sensing *** vascular endothelial cells,transcription factor EB controls important processes,including endothelial cell proliferation,endothelial tube formation,and nitric oxide levels,thereby influencing the inner blood-retinal barrier,angiogenesis,and retinal ***,transcription factor EB affects vascular smooth muscle cells,inhibiting vascular calcification and *** retinal pigment epithelial cells,transcription factor EB modulates functions such as autophagy,lysosomal dynamics,and clearance of the aging pigment lipofuscin,thereby promoting photoreceptor survival and regulating vascular endothelial growth factor A expression involved in *** cell-specific functions of transcription factor EB significantly impact retinal aging mechanisms encompassing proteostasis,neuronal synapse plasticity,energy metabolism,microvasculature,and inflammation,ultimately offering pro

关键词： age-related macular degeneration anti-aging interventions autophagy calorie restriction diabetic retinopathy exercise glaucoma neuromodulation phagocytosis photoreceptor outer segment degradation retinal aging transcription factor EB

Investigating Müller glia reprogramming in mice: a retrospective of the last decade, and a look to the future

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第4期20卷 946-959页

作者： Zhiyuan yin Jiahui Kang Xuan Cheng Hui Gao Shujia Huo Haiwei Xu Key Lab of Visual Damage and Regeneration&Restoration of Chongqing Southwest Eye HospitalSouthwest HospitalThird Military Medical University(Army Medical University)ChongqingChina

Müller glia,as prominent glial cells within the retina,plays a significant role in maintaining retinal homeostasis in both healthy and diseased *** lower vertebrates like zebrafish,these cells assume responsibility for spontaneous retinal regeneration,wherein endogenous Müller glia undergo proliferation,transform into Müller glia-derived progenitor cells,and subsequently regenerate the entire retina with restored ***,Müller glia in the mouse and human retina exhibit limited neural reprogramming.Müller glia reprogramming is thus a promising strategy for treating neurodegenerative ocular disorders.Müller glia reprogramming in mice has been accomplished with remarkable success,through various *** in molecular,genetic,epigenetic,morphological,and physiological evaluations have made it easier to document and investigate the Müller glia programming process in ***,there remain issues that hinder improving reprogramming efficiency and ***,understanding the reprogramming mechanism is crucial toward exploring factors that will improve Müller glia reprogramming efficiency,and for developing novel Müller glia reprogramming *** review describes recent progress in relatively successful Müller glia reprogramming *** also provides a basis for developing new Müller glia reprogramming strategies in mice,including epigenetic remodeling,metabolic modulation,immune regulation,chemical small-molecules regulation,extracellular matrix remodeling,and cell-cell fusion,to achieve Müller glia reprogramming in mice.

关键词： cell fusion chemical small-molecules epigenetic extracellular matrix immune metabolic mice Müller glia neurodegenerative diseases reprogramming retina regeneration

Neuronal regulated cell death in aging-related neurodegenerative diseases:key pathways and therapeutic potentials

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第8期20卷 2245-2263页

作者： Run Song Shiyi yin Jiannan Wu Junqiang Yan Department of Neurology The First Affiliated HospitalCollege of Clinical Medicine of Henan University of Science and TechnologyLuoyangHenan ProvinceChina Neuromolecular Biology Laboratory The First Affiliated HospitalCollege of Clinical Medicine of Henan University of Science and TechnologyLuoyangHenan ProvinceChina

Regulated cell death(such as apoptosis,necroptosis,pyroptosis,autophagy,cuproptosis,ferroptosis,disulfidptosis)involves complex signaling pathways and molecular effectors,and has been proven to be an important regulatory mechanism for regulating neuronal aging and ***,excessive activation of regulated cell death may lead to the progression of aging-related *** review summarizes recent advances in the understanding of seven forms of regulated cell death in age-related ***,the newly identified ferroptosis and cuproptosis have been implicated in the risk of cognitive impairment and neurodegenerative *** forms of cell death exacerbate disease progression by promoting inflammation,oxidative stress,and pathological protein *** review also provides an overview of key signaling pathways and crosstalk mechanisms among these regulated cell death forms,with a focus on ferroptosis,cuproptosis,and *** instance,FDX1 directly induces cuproptosis by regulating copper ion valency and dihydrolipoamide S-acetyltransferase aggregation,while copper mediates glutathione peroxidase 4 degradation,enhancing ferroptosis ***,inhibiting the Xc-transport system to prevent ferroptosis can increase disulfide formation and shift the NADP^(+)/NADPH ratio,transitioning ferroptosis to *** insights help to uncover the potential connections among these novel regulated cell death forms and differentiate them from traditional regulated cell death *** conclusion,identifying key targets and their crosstalk points among various regulated cell death pathways may aid in developing specific biomarkers to reverse the aging clock and treat age-related neurodegenerative conditions.

关键词： apoptosis autophagy cuproptosis disulfidptosis ferroptosis necroptosis neurodegenerative disease neurological aging diseases PANoptosis pyroptosis

Unleashing the Potential of Electroactive Hybrid Biomaterials and Self‑Powered Systems for Bone therapeutics

在线全文

学校读者我要写书评

暂无评论

Nano-Micro Letters 2025年第2期17卷 463-497页

作者： Shichang Liu Farid Manshaii Jinmiao Chen Xinfei Wang Shaolei Wang Junyi yin Ming Yang Xuxu Chen Xinhua yin Yunlei Zhou Honghui Hospital Xi’an Jiaotong UniversityXi’an 710018People’s Republic of China Department of Bioengineering Henry Samueli School of Engineering and Applied ScienceUniversity of California Los AngelesLos Angeles 90095USA Hangzhou Institute of technology Xidian UniversityHangzhou 311231People’s Republic of China

the incidence of large bone defects caused by traumatic injury is increasing worldwide,and the tissue regeneration process requires a long recovery time due to limited self-healing *** bioelectrical phenomena have been well recognized as critical biophysical factors in bone remodeling and *** by bioelectricity,electrical stimulation has been widely considered an external intervention to induce the osteogenic lineage of cells and enhance the synthesis of the extracellular matrix,thereby accelerating bone *** ongoing advances in biomaterials and energy-harvesting techniques,electroactive biomaterials and self-powered systems have been considered biomimetic approaches to ensure functional recovery by recapitulating the natural electrophysiological microenvironment of healthy bone *** this review,we first introduce the role of bioelectricity and the endogenous electric field in bone tissue and summarize different techniques to electrically stimulate cells and ***,we highlight the latest progress in exploring electroactive hybrid biomaterials as well as self-powered systems such as triboelectric and piezoelectric-based nanogenerators and photovoltaic cell-based devices and their implementation in bone tissue ***,we emphasize the significance of simulating the target tissue’s electrophysiological microenvironment and propose the opportunities and challenges faced by electroactive hybrid biomaterials and self-powered bioelectronics for bone repair strategies.

关键词： Electroactive biomaterials Self-powered bioelectronics Bone regeneration Bone tissue