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Pharmacological targeting cGAs/s.iNG/NF-κB axis by tryptanthrin induces microglia polarization toward M2 phenotype and promotes functional recovery in a mouse model of s.inal cord injury

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Neural Regeneration Research 2025年第11期20卷 3287-3301页

作者： Ziwei Fan Mengxian Jia Jian Zhou Zhoule Zhu Yumin Wu Xiaowu Lin yiming Qian Jiashu Lian Xin Hua Jianhong Dong Zheyu Fang Yuqing Liu sibing Chen Xiumin Xue Juanqing Yue Minyu Zhu Ying Wang Zhihui Huang Honglin Teng Department of Orthopedics(s.ine surgery) the First Affiliated Hospital of Wenzhou Medical UniversityWenzhouZhejiang ProvinceChina school of Pharmacy Hangzhou Normal UniversityHangzhouZhejiang ProvinceChina Department of Neurology The First Affiliated Hospital of Wenzhou Medical UniversityWenzhouZhejiang ProvinceChina Department of Pathology Affiliated Hangzhou First People’s HospitalSchool of MedicineWestlake UniversityHangzhouZhejiang ProvinceChina Department of Clinical Research Center Affiliated Hangzhou First People’s HospitalSchool of MedicineWestlake UniversityHangzhouZhejiang ProvinceChina

The M1/M2 phenotypic s.ift of microglia after s.inal cord injury plays an important role in the regulation of neuroinflammation during the secondary injury phase of s.inal cord *** of s.ifting microglia polarization from M1(neurotoxic and proinflammatory type)to M2(neuroprotective and anti-inflammatory type)after s.inal cord injury appears to be *** possesses an anti-inflammatory biological ***,its roles and the underlying molecular mechanisms.in s.inal cord injury remain *** this study,we found that tryptanthrin inhibited microglia-derived inflammation by promoting polarization to the M2 phenotype in *** promoted M2 polarization through inactivating the cGAs/s.iNG/NF-κB ***,we found that targeting the cGAs/s.iNG/NF-κB pathway with tryptanthrin s.ifted microglia from the M1 to M2 phenotype after s.inal cord injury,inhibited neuronal loss,and promoted tissue repair and functional recovery in a mouse model of s.inal cord ***,using a conditional co-culture system,we found that microglia treated with tryptanthrin suppressed endoplas.ic reticulum stress-related neuronal *** together,these results suggest that by targeting the cGAs/s.iNG/NF-κB axis,tryptanthrin attenuates microglia-derived neuroinflammation and promotes functional recovery after s.inal cord injury through s.ifting microglia polarization to the M2 phenotype.

关键词： cGAs/s.iNG functional recovery microglia neuroinflammation neuroprotection nuclear factor-κB polarization s.inal cord injury tryptanthrin

Analysis of energy release rate for composite delaminated cylindrical shells subjected to axial compres.ion

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Acta Mechanica sinica 2006年第6期22卷 537-546页

作者： Jinhua Yang yiming Fu Department of Engineering Mechanics Hunan University Changsha 410082 China

in this paper, the postbuckling governing equations and the analytical expres.ion of the energy release rates associated with delamination growth in a compres.ion-loaded cylindrical shell are derived by using the variational principle of moving boundary and the Griffith fracture criterion. The finite difference method is used to generate the postbuckling solutions of the delaminated cylindrical shells, and with these solutions, the values of the energy release rates are determined. in simulational examples, the effects of a wide range of parameters, such as delamination sizes and depths, boundary conditions, geometrical parameters, material properties and laminate stacking sequences on the energy release rates of axisymmetrical laminated cylindrical shells are intensively discussed.

关键词： Composite cylindrical shell Delamination Griffith criterion Energy release rates Finite difference method

A hexahedron element formulation with a new multi-resolution analysis

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s.ience China(Physics,Mechanics & Astronomy) 2015年第1期58卷 65-74页

作者： XiA yiming CHEN shaoLin Civil Engineering Department Nanjing University of Aeronautics and Astronautics

A multiresolution hexahedron element is presented with a new multiresolution analysis(MRA)*** MRA framework is formulated out of a mutually nes.ing displacement subspace sequence,whose basis functions are constructed of scaling and s.ifting on element domain of a basic node shape *** basic node shape function is constructed from s.ifting to other seven quadrants around a specific node of a basic isoparametric element in one quadrant and joining the corresponding node shape functions of eight elements at the specific *** MRA endows the proposed element with the resolution level(RL)to adjust structural analysis *** a result,the traditional 8-node hexahedron element is a monoresolution one and also a special case of the proposed *** mes.ing for the monoresolution finite element model is based on the empiricism while the RL adjus.ing for the multiresolution is laid on the solid mathematical *** simplicity and clarity of shape function construction with the Kronecker delta property and the rational MRA enable the proposed element method to be more rational,easier and efficient in its.implementation than the conventional mono-resolution solid element method or other MRA *** multiresolution hexahedron element method is more adapted to dealing with the accurate computation of structural problems.

关键词： hexahedron element multiresolution analysis (MRA) resolution level (RL) basic node shape function mutually nes.ing displacement subspace sequence scaling and s.ifting

New results on the robust stability analysis of neural networks with discrete and distributed time delays

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Journal of systems Engineering and Electronics 2008年第3期19卷 592-597页

作者： su Weiwei Chen yiming Coll. of s.ience Yanshan Univ. Qinhuangdao 066004 P. R. China

Delay-dependent robust stability of cellular neural networks with time-varying discrete and distributed time-varying delays.is considered. Based on Lyapunov stability theory and the linear matrix inequality （LMis） technique, delay-dependent stability criteria are derived in terms of LMis avoiding bounding certain cross terms, which often leads to conservatism. The effectiveness of the proposed stability criteria and the improvement over the exis.ing results are illustrated in the numerical examples.

关键词： neural networks delay-dependent robust stability Lyapunov stability theory linear matrix inequality(LMi) distributed delay norm-bounded uncertainties.

Analysis of nonlinear vibration for symmetric angle-ply laminated viscoelas.ic plates with damage

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Acta Mechanica sinica 2005年第5期21卷 459-466页

作者： Yufang Zheng yiming Fu Department ofEngineering Mechanics Hunan University Changsha410082 China

The behavior of nonlinear vibration for symmetric angle-ply laminated plates.including the material viscoelas.icity and damage evolution is.inves.igated. By employing the von Karman＇s nonlinear theory, strain energy equivalence principle and Boltzmann superposition principle, a set of governing equations of nonlinear integro-differential type are derived. By applying the finite difference method, Newmark method and iterative procedure, the governing equations are solved. The effects of loading amplitudes, exciting frequencies and different ply orientations on the critical time to failure initiation and nonlinear vibration amplitudes of the structures are discussed. Numerical results are presented for the different parameters and compared with the available data.

关键词： Viscoelas.icity . Damage evolution. Laminated plates . structure's failure initiation

stochas.ic partial differential equations with gradient driven by space-time fractional noises

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Frontiers of Mathematics.in China 2021年第2期16卷 479-497页

作者： yiming JiANG Xu YANG school of Mathematical s.iences and LPMC Nankai UniversityTianjin 300071China school of Mathematics and information s.ience North Minzu UniversityYinchuan 750021China

We establish a class of stochas.ic partial differential equations (sPDEs) driven by space-time fractional noises, where we suppose that the drfit term contains a gradient and satis.ies certain non-Lipschitz condition.... 详细信息

关键词： stochas.ic partial differential equation(sPDE) fractional noise uniqueness strong solution Hölder continuity

spectrum of the Operator Corresponding to the M/M/1 Queueing Model with Vacations and Multiple Phases of Operation and Application

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Acta Mathematica sinica,English series 2020年第10期36卷 1183-1202页

作者： Nurehemaiti yiming Geni GUPUR College of Mathematics and systems s.ience Xinjiang UniversityUrumqi 830046P.R.China

We describe the point spectrum of the operator which corresponds to the M/M/1 queueing model with vacations and multiple phases of *** by using this result we prove that the essential growth bound of the C0-semigroup generated by the operator is 0,the C0-semigroup is not compact,not eventually compact,even not ***,we verify that it is.impos.ible that the time-dependent solution of the M/M/1 queueing model with vacations and multiple phases of operation exponentially converges to its steady-state *** addition,we obtain the spectral radius and essential spectral radius of the ***,we discuss other spectrum of the operator and obtain a set which belongs to the union of its continuous spectrum and residual spectrum.

关键词： M/M/1 queueing model with vacations and multiple phases of operation time-dependent solution C0-semigroup point spectrum spectrum

Azimuth space-variant properties of BisAR with nonequal velocities

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Journal of systems Engineering and Electronics 2008年第5期19卷 919-922页

作者： Yang Yonghong Pi yiming school of Electronic Engineering Univ. of Electronic Science and Technology of China Chengdu 610054 P. R. China

Bistatic sAR possesses characteris.ic of the azimuth space-variant when the velocities of trans.itter and receiver are not equal. The geometric model of BisAR with the parallel trajectories and the nonequal platform velocities.is presented. Analyzing the motion relations.ip of trans.itter and receiver, the formula of azimuth spacevariant is derived in time domain. Via Taylor polynomial expansions, the azimuth space-variant is factorized by four terms： zero-order, first-order, second-order, and third-order term. And, their impacts on impulse response are illuminated. some characteris.ics about azimuth space-variant of airborne BisAR case are exhibited by simulation experiments, and these simulated results are coincident with the formulae of azimuth space-variant.

关键词： bistatic sAR range migration azimuth space-variant imaging formation algorithm.

Composition and Construction of High-and Low-Energy Ooid shoals and Their Relations.ips with Environmental Changes: A Case study from the Cambrian Zhangxia Formation in the Ordos Basin, North China

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Journal of Earth s.ience 2023年第1期34卷 156-172页

作者： Zhen Wang yiming Gong state Key Laboratory of Biogeology and Environmental Geology School of Earth SciencesChina University of GeosciencesWuhan430074China

On the basis of systematic study of sedimentary facies, microfacies and geochemistry of measured strata sections and wells, the ooid shoals of the Cambrian Miaolingian Zhangxia Formation in the southern Ordos Basin are composed of both high-and low-energy ooid shoals. The characteris.ics of the high-energy shoals are sparry cementation, with moderate to well sorting, large grain size, high ooid content and low micrite, weak micritization, and well-preserved internal textures of the ooids. Macroscopically, the high-energy ooid shoals display a thick-bedded aggradational stacking pattern in upward coarsening and thickening sequences. The low-energy ooid shoals are mainly made up of micritic cementation, with moderate to poor sorting, relatively small grain size, lower ooid content and higher micrite, strong micritization, and poorly-preserved internal textures of the ooids. Macroscopically, the low-energy ooid shoals show a thin-bedded, interbedded stacking pattern in upward fining and thinning sequences. The sedimentological evidence and carbon isotope data show that the differences of internal fabric and sedimentary evolution of both high-and low-energy ooid shoals are closely related to the sea-level change.

关键词： Cambrian sedimentary model North China ooid shoals Ordos Basin Zhangxia Formation