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Pharmacological targeting cGAS/STING/NF-κB axis by tryptanthrin induces microglia polarization toward M2 phenotype and promotes functional recovery in a mouse model of spinal cord injury

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Neural Regeneration Research 2025年第11期20卷 3287-3301页

作者： Ziwei Fan Mengxian Jia Jian Zhou Zhoule Zhu Yumin Wu Xiaowu Lin yiming qian.jiashu lian Xin Hua Jianhong Dong Zheyu Fang Yuqing Liu Sibing Chen Xiumin Xue Juanqing Yue Minyu Zhu Ying Wang Zhihui Huang Honglin Teng Department of Orthopedics(Spine Surgery) the First Affiliated Hospital of Wenzhou Medical UniversityWenzhouZhejiang ProvinceChina School of Pharmacy Hangzhou Normal UniversityHangzhouZhejiang ProvinceChina Department of Neurology The First Affiliated Hospital of Wenzhou Medical UniversityWenzhouZhejiang ProvinceChina Department of Pathology Affiliated Hangzhou First People’s HospitalSchool of MedicineWestlake UniversityHangzhouZhejiang ProvinceChina Department of Clinical Research Center Affiliated Hangzhou First People’s HospitalSchool of MedicineWestlake UniversityHangzhouZhejiang ProvinceChina

The M1/M2 phenotypic shift of microglia after spinal cord injury plays an important role in the regulation of neuroinflammation during the secondary injury phase of spinal cord *** of shifting microglia polarization from M1(neurotoxic and proinflammatory type)to M2(neuroprotective and anti-inflammatory type)after spinal cord injury appears to be *** possesses an anti-inflammatory biological ***,its roles and the underlying molecular mechanisms in spinal cord injury remain *** this study,we found that tryptanthrin inhibited microglia-derived inflammation by promoting polarization to the M2 phenotype in *** promoted M2 polarization through inactivating the cGAS/STING/NF-κB ***,we found that targeting the cGAS/STING/NF-κB pathway with tryptanthrin shifted microglia from the M1 to M2 phenotype after spinal cord injury,inhibited neuronal loss,and promoted tissue repair and functional recovery in a mouse model of spinal cord ***,using a conditional co-culture system,we found that microglia treated with tryptanthrin suppressed endoplasmic reticulum stress-related neuronal *** together,these results suggest that by targeting the cGAS/STING/NF-κB axis,tryptanthrin attenuates microglia-derived neuroinflammation and promotes functional recovery after spinal cord injury through shifting microglia polarization to the M2 phenotype.

关键词： cGAS/STING functional recovery microglia neuroinflammation neuroprotection nuclear factor-κB polarization spinal cord injury tryptanthrin

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功能性石墨烯/聚乙烯醇复合薄膜的制备与性能

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林业工程学报 2018年第2期3卷 109-115页

作者：王希李影连海兰陈一鸣郭露汪倩徐长妍南京林业大学材料科学与工程学院南京210037

可生物降解、具有良好水溶性、优异成膜性及黏结力的聚乙烯醇在包装领域具有极大的应用潜力,但其较低拉伸强度和阻隔性能严重影响应用效果。笔者以自制氧化石墨烯为加强相,以维生素C为绿色还原剂,制备了石墨烯/聚乙烯醇复合薄膜,重点研... 详细信息

可生物降解、具有良好水溶性、优异成膜性及黏结力的聚乙烯醇在包装领域具有极大的应用潜力,但其较低拉伸强度和阻隔性能严重影响应用效果。笔者以自制氧化石墨烯为加强相,以维生素C为绿色还原剂,制备了石墨烯/聚乙烯醇复合薄膜,重点研究了石墨烯的含量对复合薄膜性能的影响。结果表明,石墨烯的引入不仅可明显改善聚乙烯醇基复合薄膜的拉伸强度和阻水阻氧性能,而且还可赋予其导电性能。但是石墨烯的用量存在一个阈值:当石墨烯质量分数从1%逐步增加到5%时,复合薄膜的拉伸强度、对水的接触角和导电率均逐渐增加,吸水率和氧气透过系数均逐渐降低;但当石墨烯质量分数超过5%时,上述效果将不复存在,故将质量分数5%定为石墨烯/聚乙烯醇复合薄膜中石墨烯用量的阈值。

关键词：聚乙烯醇还原氧化石墨烯复合薄膜阻隔性能拉伸性能导电性能

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阿多拉扶正霖降低飞行员高微核率的临床研究

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中华航空航天医学杂志 1997年第4期8卷 238-239页

作者：刘倩秦莲安一明叶素榕陈水弟魏国志中国人民解放军第476医院

阿多拉扶正霖降低飞行员高微核率的临床研究刘倩秦莲安一明叶素榕陈水弟魏国志关键词（ＫＥＹＷＯＲＤＳ）微核率（Ｍｉｃｒｏｎｕｃｌｅｕｓｆｒｅｑｕｅｎｃｙ）辐射损伤（Ｒａｄｉａｔｉｏｎｉｎｊｕｒｉｅｓ）中国图书资料分类法分... 详细信息

阿多拉扶正霖降低飞行员高微核率的临床研究刘倩秦莲安一明叶素榕陈水弟魏国志关键词（ＫＥＹＷＯＲＤＳ）微核率（Ｍｉｃｒｏｎｕｃｌｅｕｓｆｒｅｑｕｅｎｃｙ）辐射损伤（Ｒａｄｉａｔｉｏｎｉｎｊｕｒｉｅｓ）中国图书资料分类法分类号Ｒ８５２．７培养人体外周血淋巴...

关键词：微核率辐射损伤飞行员阿多拉扶正霖

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益气健脾针法修复急性胃肠损伤肠道屏障的临床研究

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中国中医急症 2021年第12期30卷 2119-2122页

作者：连佳明钱义明李璟钱风华陈嘉琪陈晓桐丁纯蕾上海中医药大学附属岳阳中西医结合医院上海200437

目的观察益气健脾针法修复急性胃肠损伤肠道屏障的临床疗效。方法70例脓毒症急性胃肠损伤患者随机分为治疗组与对照组各35例。对照组予西医常规治疗,治疗组在对照组治疗的基础上加用益气健脾针法治疗。两组疗程均为7 d。观察并比较两组... 详细信息

目的观察益气健脾针法修复急性胃肠损伤肠道屏障的临床疗效。方法70例脓毒症急性胃肠损伤患者随机分为治疗组与对照组各35例。对照组予西医常规治疗,治疗组在对照组治疗的基础上加用益气健脾针法治疗。两组疗程均为7 d。观察并比较两组患者治疗前与治疗第7天后的急性生理与慢性健康(APACHEⅡ)评分、器官功能衰竭评价(SOFA)评分、AGI分级、危重病腹胀中医辨证评分、腹内压、肠鸣音、肠脂肪酸结合蛋白、D-乳酸、二胺氧化酶情况。结果治疗后两组患者胃肠道症状改善,腹腔压减少,肠鸣音增加,APACHEⅡ评分、AGI分级、危重病腹胀中医辨证评分降低,治疗组改善程度均优于对照组(P<0.05);治疗组SOFA评分、肠脂肪酸结合蛋白、D-乳酸、二胺氧化酶数值下降(P<0.05)。结论益气健脾针法治疗脓毒症急性胃肠损伤可以改善患者的胃肠道功能和症状,降低肠道的通透性,减轻肠道缺血状态,其机制可能与修复患者肠黏膜屏障损伤相关。

关键词：脓毒症急性胃肠损伤针刺益气健脾肠道屏障

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基于脑肠肽探讨针刺治疗急性胃肠损伤的作用机制

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实用临床医药杂志 2021年第18期25卷 120-123页

作者：陈嘉琪钱义明钱风华李璟连佳明陈晓桐林柏柏丁纯蕾上海中医药大学附属岳阳中西医结合医院重症医学科上海200080 上海中医药大学附属岳阳中西医结合医院针灸科上海200080

急性胃肠损伤在ICU病房发病率逐年升高,急性胃肠损伤对脓毒症的预后和治疗都有影响。目前急性胃肠损伤的西医治疗多采取胃肠道减压、抗感染、应用有益菌等基础对症治疗,而中医治疗急性胃肠损伤则具有安全、副作用小等独特优势。研究发... 详细信息

急性胃肠损伤在ICU病房发病率逐年升高,急性胃肠损伤对脓毒症的预后和治疗都有影响。目前急性胃肠损伤的西医治疗多采取胃肠道减压、抗感染、应用有益菌等基础对症治疗,而中医治疗急性胃肠损伤则具有安全、副作用小等独特优势。研究发现针刺可以通过调节脑肠肽的分泌来控制炎症,修复肠黏膜,调节胃肠动力,从而达到改善胃肠道功能的目的。本研究基于脑肠肽探讨针刺治疗急性胃肠损伤的作用机制。

关键词：针刺脑肠肽急性胃肠损伤机制脓毒症

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从“痰饮”论治脓毒症毛细血管渗漏综合征

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陕西中医 2021年第2期42卷 222-224,238页

作者：林柏柏沈梦雯钱义明赵雷连佳明陈嘉琪孙旗褚梦瑶钱风华上海中医药大学上海200080 上海中医药大学附属岳阳中西医结合医院上海200437

脓毒症是急诊及ICU常见的急危重症之一,容易并发毛细血管渗漏综合征(CLS),累及全身多脏器,出现以全身进行性水肿、低血压,低蛋白血症、低氧血症、少尿等为主要临床表现的一种综合征。然现代医学在其治疗上仍无特异性手段,大都是对症支... 详细信息

脓毒症是急诊及ICU常见的急危重症之一,容易并发毛细血管渗漏综合征(CLS),累及全身多脏器,出现以全身进行性水肿、低血压,低蛋白血症、低氧血症、少尿等为主要临床表现的一种综合征。然现代医学在其治疗上仍无特异性手段,大都是对症支持的综合治疗,并且在液体管理、改善毛细血管通透性、呼吸机机械通气、连续性肾脏替代疗法、调节免疫抑制等疗效方面参差不齐。随着中医药研究水平的不断提高,在治疗脓毒症方面中医药发挥了其独特的优势,本文通过温习中医大量文献,以“痰饮”为切入点,从“虚、饮、瘀”三个证候要素,并且结合现代药理研究角度系统阐述脓毒症并发毛细血管渗漏综合征的病因病机及治疗方法,希冀为临床治疗该病提供新的思路及方向。

关键词：脓毒症毛细血管渗漏综合征痰饮病因病机辨证施治温药活血化瘀

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CEPC Technical Design Report

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Radiation Detection Technology and Methods 2024年第1期8卷 I0003-I0016,1-1091页

作者： Waleed Abdallah Tiago Carlos Adorno de Freitas Konstantin Afanaciev Shakeel Ahmad Ijaz Ahmed Xiaocong Ai Abid Aleem Wolfgang Altmannshofer Fabio Alves Weiming An Rui An Daniele Paolo Anderle Stefan Antusch Yasuo Arai Andrej Arbuzov Abdesslam Arhrib Mustafa Ashry Sha Bai Yu Bai Yang Bai Vipul Bairathi Csaba Balazs Philip Bambade Yong Ban Tripamo Bandyopadhyay Shou-Shan Bao Desmond P.Barber Ayse Bat Varvara Batozskaya Subash Chandra Behera Alexander Belyaev Michele Bertucci Xiao-Jun Bi Yuanjie Bi Tianjian Bian Fabrizio Bianchi Thomas Biekotter Michela Biglietti Shalva Bilanishvili Deng Binglin Denis Bodrov Anton Bogomyagkov Serge Bondarenko Stewart Boogert Maarten Boonekamp Marcello Borri Angelo Bosotti Vincent Boudry Mohammed Boukidi Igor Boyko Ivanka Bozovic Giuseppe Bozzi Jean-Claude Brient Anastasiia Budzinskaya Masroor Bukhari Vladimir Bytev Giacomo Cacciapaglia Hua Cai Wenyong Cai Wujun Cai Yijian Cai Yizhou Cai Yuchen Cai Haiying Cai Huacheng Cai Lorenzo Calibbi Junsong Cang Guofu Cao Jianshe Cao Antoine Chance Xuejun Chang Yue Chang Zhe Chang Xinyuan Chang Wei Chao Auttakit Chatrabhuti Yimin Che Yuzhi Che Bin Chen Danping Chen Fuqing Chen Fusan Chen Gang Chen Guoming Chen Hua-Xing Chen Huirun Chen Jinhui Chen Ji-Yuan Chen Kai Chen Mali Chen Mingjun Chen Mingshui Chen Ning Chen Shanhong Chen Shanzhen Chen Shao-Long Chen Shaomin Chen Shiqiang Chen Tianlu Chen Wei Chen Xiang Chen Xiaoyu Chen Xin Chen Xun Chen Xurong Chen Ye Chen Ying Chen Yukai Chen Zelin Chen Zilin Chen Gang Chen Boping Chen Chunhui Chen Hok Chuen Cheng Huajie Cheng Shan Cheng Tongguang Cheng Yunlong Chi Pietro Chimenti Wen Han Chiu Guk Cho Ming-Chung Chu Xiaotong Chu Ziliang Chu Guglielmo Coloretti Andreas Crivellin Hanhua Cui Xiaohao Cui Zhaoyuan Cui Brunella D'Anzi Ling-Yun Dai Xinchen Dai Xuwen Dai Antonio De Maria Nicola De Filippis Christophe De La Taille Francesca De Mori Chiara De Sio Elisa Del Core Shuangxue Deng Wei-Tian Deng Zhi Deng Ziyan Deng Bhupal Dev Tang Dewen Biagio Di Micco Ran Ding Siqin Dingl Yadong Ding Haiyi Dong Jianin AGH University of Science and Technology Faculty of Physics and Applied Computer ScienceKrakow Anhui University HefeiAnhui Applied Physics Department Federal Urdu University of ArtsScience and TechnologyIslamabad Banaras Hindu University Institute of ScienceVaranasi Bandirma Onyedi Eylul University Bandirma Beihang University Beijing Beijing Computational Science Research Center Beijing Beijing Conveyi LTD Beijing Beijing Glass Research Institute Co. LtdBeijing Beijing Institute of Technology Beijing Beijing Normal University Beijing Brown University ProvidenceRI Budker Institute of Nuclear Physics Novosibirsk Cadi Ayyad University Laboratory of Fundamental and Applied PhysicsPolydisciplinary FacultyMarrakech Cairo University Giza Center for Theory and Computation National Tsing Hua UniversityHsinchu Central China Normal University WuhanHubei Central South University ChangshaHunan Centro de Fisica Teorica de Particulas Universidade Tecnica de LisboaLisboa Chengdu KaitengSifang Digital Radio&TV Equipment Co. LtdChengduSichuan China academy of engineering physics MianyangSichuan China building materials academy Beijing China Center of Advanced Science and Technology Beijing China Institute of Atomic Energy Beijing China Jiliang University HangzhouZhejiang China Nuclear Instrument CO. LTDBeijing China University of Geosciences Beijing China University of Geosciences WuhanHubei China University of Mining and Technology XuzhouJiangsu China West Normal University NanchongSichuan Chongqing University Department of PhysicsChongqing Chulalongkorn University Bangkok City University of Hong Kong Department of PhysicsHong Kong Cockcroft Institute Daresbury Cornell University IthacaNY CPPM(AMU/IPhU&CNRS/INP) Marseille Dalian Minzu University DalianLiaoning Dalian University of Technology Department of PhysicsDalian Deutsches Elektronen-Synchrotron DESY Hamburg Dzhelepov Laboratory of Nuclear Problems of Joint Institute for Nuclear Research(DLNP JINR) Dubna East China University Of Science And Technol

The Circular Electron Positron Collider(CEPC)is a large scientific project initiated and hosted by China,fostered through extensive collaboration with international *** complex comprises four accelerators:a 30 GeV Linac,a 1.1 GeV Damping Ring,a Booster capable of achieving energies up to 180 GeV,and a Collider operating at varying energy modes(Z,W,H,and tt).The Linac and Damping Ring are situated on the surface,while the subterranean Booster and Collider are housed in a 100 km circumference underground tunnel,strategically accommodating future expansion with provisions for a potential Super Proton Proton Collider(SPPC).The CEPC primarily serves as a Higgs *** its baseline design with synchrotron radiation(SR)power of 30 MW per beam,it can achieve a luminosity of 5×10^(34)cm^(-2)s^(-1)per interaction point(IP),resulting in an integrated luminosity of 13 ab^(-1)for two IPs over a decade,producing 2.6 million Higgs *** the SR power to 50 MW per beam expands the CEPC's capability to generate 4.3 million Higgs bosons,facilitating precise measurements of Higgs coupling at sub-percent levels,exceeding the precision expected from the HL-LHC by an order of *** Technical Design Report(TDR)follows the Preliminary Conceptual Design Report(Pre-CDR,2015)and the Conceptual Design Report(CDR,2018),comprehensively detailing the machine's layout,performance metrics,physical design and analysis,technical systems design,R&D and prototyping efforts,and associated civil engineering ***,it includes a cost estimate and a preliminary construction timeline,establishing a framework for forthcoming engineering design phase and site selection *** is anticipated to begin around 2027-2028,pending government approval,with an estimated duration of 8 *** commencement of experiments and data collection could potentially be initiated in the mid-2030s.

关键词： initiated exceeding precise

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