检索结果-南通市图书馆

Building a sequence map of the pig pan-genome from multiple de novo assemblies and Hi-C data

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Science China(Life Sciences) 2020年第5期63卷 750-763页

作者： x.aomeng Tian Ran Li Weiwei fu Yan Li x.hong wang Ming Li Duo Du Qianzi Tang Yudong Cai yiming Long Yue Zhao Mingzhou Li Yu Jiang Key Laboratory of Animal Genetics Breeding and Reproduction of Shaanxi ProvinceCollege of Animal Science and TechnologyNorthwest A&F UniversityYangling 712100China Institute of Animal Genetics and Breeding College of Animal Science and TechnologySichuan Agricultural UniversityChengdu 611130China

Pigs were domesticated independently in the Near East and China,indicating that a single reference genome from one individual is unable to represent the full spectrum of divergent sequences in pigs ***,12 de novo pig assemblies from Eurasia were compared in this study to identify the missing sequences from the reference *** a result,72.5 Mb of nonredundant sequences(~3% of the genome)were found to be absent from the reference genome(Sscrofa11.1)and were defined as *** the pan-sequences,9.0 Mb were dominant in Chinese pigs,in contrast with their low frequency in European *** sequence dominant in Chinese pigs contained the complete genic region of the tazarotene-induced gene 3(TIG3)gene which is involved in fatty acid *** flanking sequences and Hi-C based methods,27.7% of the sequences could be anchored to the reference *** supplementation of these sequences could contribute to the accurate interpretation of the 3D chromatin structure.A web-based pan-genome database was further provided to serve as a primary resource for ex.loration of genetic diversity and promote pig breeding and biomedical research.

关键词： pan-genome pig reference genome 3D chromatin structure presence-absence variation

Analysis and performance test on dynamic seed corn threshing and conveying process with variable diameter and spacing

在线全文

学校读者我要写书评

暂无评论

International Journal of Agricultural and Biological Engineering 2023年第2期16卷 259-266页

作者： Fei Dai yiming Zhao Yuanx.ang Liu Ruijie Shi Shanglong x.n Qiufeng fu Wuyun Zhao College of Mechanical and Electrical Engineering Gansu Agricultural UniversityLanzhou 730070China Jiuquan OK Seed Machinery Co. Ltd.Jiuquan 735000GansuChina

In order to further reduce the damage rate in threshing seed corn,a seed corn threshing testbed with variable diameter and spacing that can realize dynamic adjustment of parameters,such as feed quantity,rotating speed of the threshing device,threshing spacing of the threshing units,was designed in this *** software of finite element analysis ANSYS Workbench was applied to do modal analysis on the threshing ax.s designed for variable diameter and spacing of seed *** first 8 orders of natural frequencies were distributed in 201.12-1640.20 Hz,with corresponding vibration amplitude in 5.86-27.04 mm,showing reasonable structural design of the threshing ax.s,which could realize effective seed corn threshing and *** element method was applied to do simulation analysis on the seed corn threshing and conveying process with variable diameter and *** the condition of different feed quantity,different rotating speed of the thresher,the moving speed of corn clusters and contact force among clusters were measured through simulation,and the working characteristics of the threshing testbed for low-damage and dynamic threshing and conveying of seed corn with variable diameter and spacing were *** performance test results of the testbed of seed corn with variable diameter and spacing showed that,when the rotating speed of the threshing ax.s was 190-290 r/min,feed quantity was 1.80-3.80 kg/s,the damage rate of seed corn was 0.32%-0.63%,threshing rate was 99.20%-99.82%,and content impurity rate was 4.23%-5.86%,the mass of threshed corn grains first increased and then decreased along the ax.al *** test verification process was in line with the simulation results;thus,the test results could satisfy the requirements in design and actual operation.

关键词： seed corn threshing device with variable diameter and spacing threshing and conveying process performance test

The nodulation and nyctinastic leaf movement is orchestrated by clock gene LHY in Medicago truncatula

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Integrative Plant Biology 2020年第12期62卷 1880-1894页

作者： yiming Kong Lu Han x.u Liu Hongfeng wang Lizhu Wen x.aolin Yu x.aodong x. Fanjiang Kong Chunx.ang fu Kirankumar S.Mysore Jiangqi Wen Chuanen Zhou The Key Laboratory of Plant Development and Environmental Adaptation Biology Ministry of EducationSchool of Life ScienceShandong UniversityQingdao 266237China School of Life Sciences Guangzhou UniversityGuangzhou 510006China Key Laboratory of Plant Stress Biology School of Life SciencesHenan UniversityKaifeng 475001China Shandong Provincial Key Laboratory of Energy Genetics Key Laboratory of BiofuelsQingdao Institute of Bioenergy and Bioprocess TechnologyChinese Academy of SciencesQingdao 266101China Noble Research Institute LLCArdmoreOklahomaUSA

As sessile organisms,plants perceive,respond,and adapt to the environmental changes for optimal growth and *** plant growth and fitness are enhanced by circadian clocks through coordination of numerous biological *** legume species,nitrogen-fix.ng root nodules were developed as the plant organs specialized for symbiotic transfer of ni-trogen between microsymbiont and ***,we report that the endogenous circadian rhythm in nodules is regulated by MtLHY in legume species Medicago *** of function of MtLHY leads to a reduction in the number of nodules formed,resulting in a diminished ability to assimilate *** operation of the 24-h rhythm in shoot is further influenced by the availability of nitrogen produced by the nodules,leading to the irregulated nyctinastic leaf movement and reduced biomass in mtlhy *** data shed new light on the roles of MtLHY in the orchestration of circadian oscillator in nodules and shoots,which provides a mechanistic link between nodulation,nitrogen assimilation,and clock function.

关键词： nodulation movement nodules

Environmental Information Governance Reform in the Era of Big Data--From Information Disclosure to Public Service

在线全文

学校读者我要写书评

暂无评论

Meteorological and Environmental Research 2017年第5期8卷 1-5,18页

作者： fu yiming Beijing Institute of Big Data Research Beijing 100000China

The development of environmental information governance includes three phases: providing for oneself,information disclosure,and public service. And then China is in the transition and transformation of environmental information disclosure to the environmental information public service. The core of the transformation is public participation,in the whole procedure of environmental information supply decision making,production,and quality supervision and evaluation,etc. The target path of the environmental information governance reform includes five parts: improvement of public satisfaction,optimizing information disclosure,information quality control,integration of information resources,and multiple supply.

关键词： Environmental information Governance reform Information disclosure Public service Big data

Load-forecasting method for IES based on LSTM and dynamic similar days with multi-features

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Global Energy Interconnection 2023年第3期6卷 285-296页

作者： Fan Sun Yaojia Huo Lei fu Huilan Liu x. wang yiming Ma State Grid Ningx.a Electric Power Technical Research Institute Yinchuan 750002P.R.China College of Electronic Information Engineering Hebei UniversityBaoding 071002P.R.China State Key Laboratory of Alternate Electrical Power System with Renewable Energy Sources North China Electric Power UniversityBaoding 071003P.R.China

To fully ex.loit the rich characteristic variation laws of an integrated energy system(IES)and further improve the short-term load-forecasting accuracy,a load-forecasting method is proposed for an IES based on LSTM and dynamic similar days with *** ex.ansion was performed to construct a comprehensive load day covering the load and meteorological information with coarse and fine time granularity,far and near time *** Gaussian mix.ure model(GMM)was used to divide the scene of the comprehensive load day,and gray correlation analysis was used to match the scene with the coarse time granularity characteristics of the day to be *** typical days with the highest correlation with the day to be predicted in the scene were selected to construct a“dynamic similar day”by *** key features of adjacent days and dynamic similar days were used to forecast multi-loads with fine time granularity using *** the static features as input and the selection method of similar days based on non-ex.ended single features,the effectiveness of the proposed prediction method was verified.

关键词： Integrated energy system Load forecast Long short-term memory Dynamic similar days Gaussian mix.ure model

Tauroursodeox.cholic acid(TUDCA)improves intestinal barrier function associated with TGR5-MLCK pathway and the alteration of serum metabolites and gut bacteria in weaned piglets

在线全文

学校读者我要写书评

暂无评论

Journal of Animal Science and Biotechnology 2022年第6期13卷 1917-1931页

作者： Min Song Fenglin Zhang yiming fu x.n Yi Shengchun Feng Zhichang Liu Dun Deng Qiang Yang Miao Yu Canjun Zhu x.aotong Zhu Lina wang Ping Gao Gang Shu x.anyong Ma Qingyan Jiang Songbo wang Guangdong Provincial Key Laboratory of Animal Nutrition Control ALLT ECH-SCAU Animal Nutrition Control Research Allianceand National Engineering Research Center for Breeding Swine IndustryCollege of Animal ScienceSouth China Agricultural UniversityGuangzhou 510642P.R.China Institute of Animal Science Guangdong Academy of Agricultural SciencesState Key Laboratory of Livestock and Poultry BreedingKey Laboratory of Animal Nutrition and Feed Science in South ChinaMinistry of Agriculture and Rural AffairsGuangdong Key Laboratory of Animal Breeding and NutritionGuangdong Engineering Technology Research Center of Animal Meat Quality and Safety Control and EvaluationGuangzhou 510640P.R.China Maoming Branch Guangdong Laboratory for Lingnan Modern Agricultural Science and TechnologyMaoming 525000P.R.China

Background:Tauroursodeox.cholic acid(TUDCA),a hydrophilic bile acid,is the main medicinal component of bear bile and is commonly used to treat a variety of hepatobiliary ***,TUDCA has been shown to modulate the intestinal barrier function and alleviate DSS-induced colitis in ***,the effect of TUDCA on the intestinal barrier of weaned piglets remains largely ***:The weaned piglets and porcine IPEC-J2 intestinal epithelial cells were used to investigate the effects of TUDCA on intestinal barrier function in weaned piglets and ex.lore the possible underlying *** vivo,72 healthy weaned piglets were randomly allocated into 2 groups according to their gender and body weight,and piglets were fed the basal diet with 0(control,CON)and 200 mg/kg TUDCA for 30 d,*** female and three male piglets reflecting the average bodyweight were slaughtered in each group and samples were *** vitro,IPEC-J2 cells were subjected to 100μmol/L TUDCA to ex.lore the possible underlying ***:Our results demonstrated that dietary TUDCA supplementation significantly reduced the diarrhea incidence of weaned piglets,possibly attributing to the TUDCA-enhanced intestinal barrier function and *** addition,TUDCA supplementation altered serum metabolites and the relative abundance of certain gut bacteria,which might contribute to the improved intestinal barrier ***,the in-vitro results showed that TUDCA improved the ***-induced epithelial barrier impairment of IPEC-J2 cells and increased Takeda G-coupled protein receptor 5(TGR5)protein ***,knockdown of TGR5 and inhibition of myosin light chain kinase(MLCK)pathway abolished the TUDCA-improved epithelial barrier impairment in ***-treated IPEC-J2 cells,indicating the involvement of TGR5-MLCK in this ***:These findings showed that TUDCA improved intestinal barrier function associated with TGR5-MLCK pathway and the al

关键词： Gut bacteria Intestinal barrier function Serum metabolites Tauroursodeox.cholic acid(TUDCA) TGR5-MLCK pathway Weaned piglets

Development of a new hydrophobic magnetic biochar for removing oil spills on the water surface

在线全文

学校读者我要写书评

暂无评论

Biochar 2022年第1期4卷 177-193页

作者： x.aojun Sun Hongrui fu Mutai Bao Wei Liu Chengyi Luo Yang Li yiming Li Jinren Lu Frontiers Science Center for Deep Ocean Multispheres and Earth System and Key Laboratory of Marine Chemistry Theory and TechnologyMinistry of EducationOcean University of ChinaQingdao 266100China College of Chemistry and Chemical Engineering Ocean University of ChinaQingdao 266100China China Petrochemical Corporation(Sinopec Group) Beijing 100728China

More technologies are urgently needed for combined use to effectively eliminate the effect of oil spills,an environmental problem of widespread *** these technologies,sorption methods are available to remove residual oil and prevent the further spread on the water *** this study,biochars,prepared from different feed-stock materials and pyrolysis temperatures,were screened and further modified to improve their application in the water *** cornstalk biochar(CSBC),corncob biochar(CCBC),Sophora sawdust biochar(SSBC),and rice husk biochar(RHBC),the CSBC had ex.ellent oil sorption capacity,especially prepared at 350℃(CSBC350),which has a complete and full pore ***,magnetic and silane agent modifications of CSBC350(OMBC)were performed to enhance the properties of the magnetic field controllability and hydrophobicity to increase oil *** OMBC ex.ibited satisfactory oil sorption capacities to crude oil,diesel oil,and engine oil in the water-oil system of 8.77 g g^(−1),4.01 g g^(−1),and 4.44 g g^(−1),*** sorption process of CSBC350 and OMBC complied with the pseudo-second-order kinetics(R^(2)>0.97)and the Langmuir isotherm models(R^(2)>0.80)based on the highest regression *** sorption mechanisms are dominated by hydrophobic forces,pore intercepts,and hydrogenbond *** biochar adsorbent can availably cooperate with other physical methods to eliminate oil contaminants,which can be an outstanding fuel source for producing heat.

关键词： Oil spill Cornstalk biochar Hydrophobic magnetic biochar Oil sorption

LIM domain proteins Pinch1/2 regulate chondrogenesis and bone mass in mice

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Bone Research 2020年第4期8卷 416-428页

作者： yiming Lei x.ekun fu Pengyu Li Six.ong Lin Qinnan Yan Yumei Lai x.n Liu Yishu wang x.aochun Bai Chuanju Liu Di Chen x.enong Zou x. Cao Huiling Cao Guozhi x.ao Guangdong Provincial Key Laboratory of Cell Microenvironment and Disease Research Shenzhen Key Laboratory of Cell Microenvironmentand School of MedicineSouthern University of Science and TechnologyShenzhen 518055China Department of Spine Surgery Orthopedic Research InstituteThe First Affiliated Hospital of Sun Yat-sen UniversityGuangdong Provincial Key Laboratory of Orthopedics and TraumatologyGuangzhou 510080China Department of Orthopedic Surgery Rush University Medical CenterChicagoIL 60612USA Department of Cell Biology School of Basic Medical SciencesSouthern Medical UniversityGuangzhou 510515China Department of Orthopedic Surgery New York University School of MedicineNew YorkNY 10003USA Department of Cell Biology New York University School of MedicineNew YorkNY 10016USA Research Center for Human Tissues and Organs Degeneration Shenzhen Institutes of Advanced TechnologyChinese Academy of SciencesShenzhen 518055China Department of Orthopedic Surgery The Johns Hopkins UniversityBaltimoreMD 21205USA

The LIM domain-containing proteins Pinch1/2 regulate integrin activation and cell–ex.racellular matrix.interaction and ***,we report that deleting Pinch1 in limb mesenchymal stem cells(MSCs)and Pinch2 globally(double knockout;dKO)in mice causes severe chondrodysplasia,while single mutant mice do not display marked *** deletion decreases chondrocyte proliferation,accelerates cell differentiation and disrupts column *** loss drastically reduces Smad2/3 protein ex.ression in proliferative zone(PZ)chondrocytes and increases Runx. and Col10a1 ex.ression in both PZ and hypertrophic zone(HZ)*** loss increases sclerostin and Rankl ex.ression in HZ chondrocytes,reduces bone formation,and increases bone resorption,leading to low bone *** vitro studies revealed that Pinch1 and Smad2/3 colocalize in the nuclei of *** its C-terminal region,Pinch1 interacts with Smad2/3 *** loss increases Smad2/3 ubiquitination and degradation in primary bone marrow stromal cells(BMSCs).Pinch loss reduces TGF-β-induced Smad2/3 phosphorylation and nuclear localization in primary ***,compared to those from single mutant mice,BMSCs from dKO mice ex.ress dramatically lower protein levels ofβ-catenin and Yap1/Taz and display reduced osteogenic but increased adipogenic differentiation ***,ablating Pinch1 in chondrocytes and Pinch2 globally causes severe osteopenia with subtle limb ***,our findings demonstrate critical roles for Pinch1/2 and a functional redundancy of both factors in the control of chondrogenesis and bone mass through distinct mechanisms.

关键词： Smad2/3 globally mass

Inhibition of fibroblast activation protein ameliorates cartilage matrix.degradation and osteoarthritis progression

在线全文

学校读者我要写书评

暂无评论

Bone Research 2023年第1期11卷 136-147页

作者： Aoyuan Fan Genbin Wu Jianfang wang Laiya Lu Jingyi wang Hanjing Wei Yux. Sun Yanhua x. Chunyang Mo x.aoying Zhang Zhiying Pang Zhangyi Pan yiming wang Liangyu Lu Guojian fu Mengqiu Ma Qiaoling Zhu Dandan Cao Jiachen Qin Feng Yin Rui Yue Department of Joint Surgery Shanghai East HospitalTongji University School of MedicineShanghai200092China Department of Orthopedic Surgery Shanghai General HospitalShanghai Jiao Tong University School of MedicineShanghai200240China Institute for Regenerative Medicine Shanghai East HospitalFrontier Science Center for Stem Cell ResearchShanghai Key Laboratory of Signaling and Disease ResearchSchool of Life Sciences and TechnologyTongji UniversityShanghai200092China Department of Cardiology Shanghai Tenth People’s HospitalTongji University School of MedicineShanghai200072China Shanghai Institute of Stem Cell Research and Clinical Translation Shanghai200120China Shanghai Clinical Research Center for Aging and Medicine Shanghai200040China

Fibroblast activation protein(Fap)is a serine protease that degrades denatured type I collagen,α2-antiplasmin and *** is highly ex.ressed in bone marrow stromal cells and functions as an osteogenic suppressor and can be inhibited by the bone growth factor Osteolectin(Oln).Fap is also ex.ressed in synovial fibroblasts and positively correlated with the severity of rheumatoid arthritis(RA).However,whether Fap plays a critical role in osteoarthritis(OA)remains poorly ***,we found that Fap is significantly elevated in osteoarthritic synovium,while the genetic deletion or pharmacological inhibition of Fap significantly ameliorated posttraumatic OA in ***,we found that Fap degrades denatured type II collagen(Col II)and Mmp13-cleaved native Col ***-articular injection of r Fap significantly accelerated Col II degradation and OA *** contrast,Oln is ex.ressed in the superficial layer of articular cartilage and is significantly downregulated in *** deletion of Oln significantly ex.cerbated OA progression,which was partially rescued by Fap deletion or ***-articular injection of r Oln significantly ameliorated OA *** together,these findings identify Fap as a critical pathogenic factor in OA that could be targeted by both synthetic and endogenous inhibitors to ameliorate articular cartilage degradation.

关键词： cartilage superficial inhibited