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Controlled patterning of upconversion nanocrystals through capillary force

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Journal of Rare Earths 2020年第5期38卷 546-551页

作者： yiming wu Jiahui Xu Xiaogang Liu Department of Chemistry National University of SingaporeU7543Singapore The N.1 Institute for Health National University of Singapore117456Singapore

Lanthanide-doped upconversion nanoparticles(UCNPs)can absorb near-infrared photons and convert them into visible and ultraviolet *** nanomaterials possess extraordinary optical performance and hold potential as active platforms for a variety of technological *** ability to fabricate highly ordered nanoparticle-based photonic elements over a large area is of fundamental significance for luminescence *** all the efforts made,however,large-area spatial patterning of UCNPs into ordered arrays with high controllability remains a *** this study,we report a highthroughput strategy to pattern optical nanomaterials through the use of polymer microspheres and templated assembly of *** technique utilizes capillary force to drive hybrid clusters into the physical template,resulting in large-area,spatially ordered arrays of *** findings reported in this work may promote the development of novel nonlinear optical devices,such as solid-state laser arrays,high-density optical storage,and anti-counterfeiting labels.

关键词： Upconversion nanoparticles Self-assembly Patterning Rare earths

Genetic architecture, epigenetic influence and environment exposure in the pathogenesis of Autism

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Science China(Life Sciences) 2015年第10期58卷 958-967页

作者： YU Li wu yiming wu Bai-Lin Children's Hospital of Fudan University Institutes of Biomedical Science Shanghai Medical College of Fudan University Claritas Genomics Boston Children's Hospital Harvard Medical School

Autism spectrum disorder(ASD) is a spectral neurodevelopment disorder affecting approximately 1% of the population. ASD is characterized by impairments in reciprocal social interaction, communication deficits and restricted patterns of behavior. Multiple factors, including genetic/genomic, epigenetic/epigenomic and environmental, are thought to be necessary for autism development. Recent reviews have provided further insight into the genetic/genomic basis of ASD. It has long been suspected that epigenetic mechanisms, including DNA methylation, chromatin structures and long non-coding RNAs may play important roles in the pathology of ASD. In addition to genetic/genomic alterations and epigenetic/epigenomic influences, environmental exposures have been widely accepted as an important role in autism etiology, among which immune dysregulation and gastrointestinal microbiota are two prominent ones.

关键词： autism spectrum disorder genetic architecture genomie disorder gene mutation copy number variants single nucleotide variants genetic pathways epigenetic influence DNA methylation chromatin remodeling long non-coding RNAs environment exposure immune dysregulation gastrointestinal microbiota

Return just your search:privacy-preserving homoglyph search for arbitrary languages

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Frontiers of Computer Science 2022年第2期16卷 140-151页

作者： Bowen ZHAO Shaohua TANG Ximeng LIU yiming wu School of Computer Science and Engineering South China University of TechnologyGuangzhou 510006China Zheng Zhiming Lab Peng Cheng LaboratoryShenzhen 518055China College of Mathematics and Computer Science Fuzhou UniversityFuzhou 350108China

Searchable encryption is an effective way to ensure the security and availability of encrypted outsourced cloud *** existing solutions,the keyword exact search solution is relatively inflexible,while the fuzzy keyword search solution either has a high index overhead or suffers from the ***,no existing fuzzy keyword search solution considers the homoglyph search on encrypted *** this paper,we propose an efficient privacy-preserving homoglyph search scheme supporting arbitrary languages(POSA,in short).We enhance the performance of the fuzzy keyword search in three ***,we formulate the similarity of homoglyph and propose a privacy-preserving homoglyph ***,we put forward an index build mechanism without the false-positive,which reduces the storage overhead of the index and is suitable for arbitrary ***,POSA returns just the user’s search,i.e.,all returned documents contain the search keyword or its *** theoretical analysis and experimental evaluations on real-world datasets demonstrate the effectiveness and efficiency of POSA.

关键词： searchable encryption cloud storage fuzzy search privacy preservation arbitrary languages

Trajectory planning-based control of underactuated wheeled inverted pendulum robots

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Science China(Information Sciences) 2019年第5期62卷 23-25页

作者： Dingkun LIANG Ning SUN yiming wu Yongchun FANG Institute of Robotics and Automatic Information Systems (IRAIS) Tianjin Key Laboratory of Intelligent Robotics (tj KLIR) Nankai University

Dear editor,In modern industries, underactuated mechanical systems play an important role in various fields [1–6]. The wheeled inverted pendulum robot(WIPR) is a special type of non-linear and underactuated systems w... 详细信息

关键词： Trajectory planning-based control of underactuated wheeled inverted pendulum robots Figure

Nanovaccines for cancer immunotherapy:Current knowledge and future perspectives

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Chinese Chemical Letters 2023年第8期34卷 57-68页

作者： yiming wu Zhe Zhang Yuquan Wei Zhiyong Qian Xiawei Wei Laboratory of Aging Research and Cancer Drug Target State Key Laboratory of Biotherapy and Cancer CenterNational Clinical Research Center for GeriatricsWest China HospitalSichuan UniversityChengdu 610041China

Cancer immunotherapy harnesses the immune system to attack tumors and has received extensive attention in recent *** vaccines as an important branch of immunotherapy are designed for delivering tumor antigens to antigen-presenting cells(APCs)to stimulate a strong immune response to against tumors,representing a potentially therapeutic and prophylactic effect with the long-term anticancer ***,the disappointing outcomes of their clinical use might be attributed to dilemma in antigen selection,immunogenicity,lymph nodes(LNs)targeting ability,lysosomal escape ability,immune evasion,***,aiming to overcome these barriers,has been utilized in cancer vaccine development for *** preclinical and clinical studies demonstrate positive results in nanomaterials-based cancer vaccines with considerable improvement in the vaccine *** this review,we systematically introduced the characteristics of nanovaccines and highlighted the different types of nanomaterials used for cancer vaccine *** addition,the opportunities and challenges of the emerging nanotechnology-based cancer vaccines were discussed.

关键词： Cancer immunotherapy Cancer vaccines Nanoparticles Antitumor immune response Clinical transformation

The phototherapy toward corneal neovascularization elimination:An efficient,selective and safe strategy

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Chinese Chemical Letters 2021年第1期32卷 99-101页

作者： Jingwen Yu Chengchao Chu yiming wu Gang Liu Wei Li Eye Institute of Xiamen University Fujian Provincial Key Laboratory of Ophthalmology and Visual ScienceSchool of MedicineXiamen UniversityXiamen 361102China State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics&Center for Molecular Imaging and Translational Medicine School of Public HealthXiamen UniversityXiamen 361102China

Corneal neovascularization(CNV) can induce severe visual impairment and even *** treatments have limited efficacy and some undesirable side ***(FT) is a modern medical technique in CNV treatment and worth further *** has various advantages and nanoparticle-mediated drug delive ry also contributes to CNV *** combined with functional nanoparticles featuring photoacoustic imaging contrast properties can accomplish accurate and safe inhibition of CNV,thus is promising in clinical application.

关键词： Corneal neovascularization Phototherapy Nanotechnology R-nano ICG Photoacoustic imaging

Productivity in the Southern Ocean Antarctic Zone during the Northern Hemisphere Glaciation(NHG)and its link to atmospheric pCO_(2)

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Science China Earth Sciences 2024年第7期67卷 2242-2252页

作者： yiming wu Jingteng GUO Xiangyu ZHAO Wenshen XIAO Heng LIU Zhifang XIONG Tiegang LI Key Laboratory of Marine Geology and Metallogeny First Institute of OceanographyMinistry of Natural ResourcesQingdao 266061China Laboratory for Marine Geology Laoshan LaboratoryQingdao 266237China School of Oceanography Shanghai Jiao Tong UniversityShanghai 200030China Key Laboratoryof Polar Ecosystem and Climate Change Shanghai Jiao Tong UniversityMinistry of EducationShanghai 200030China State Key Laboratory of Marine Geology Tongji UniversityShanghai 200092China

A decrease in atmospheric CO_(2)partial pressure(pCO_(2))is considered an important prerequisite for the onset and intensification of Northern Hemisphere Glaciation(NHG).However,how the ocean sequestered missing CO_(2)during the NHG is still *** in surface productivity and deep ventilation in the Southern Ocean(SO)have been proposed to explain the variations in atmospheric pCO_(2)over the last eight glacial cycles,but it is unclear whether these mechanisms contributed to the decrease in atmospheric pCO_(2)during the *** titanium-normalized contents and mass accumulation rates of biogenic opal and total organic carbon from the International Ocean Discovery Program(IODP)Expedition 374 Site U1524A,we reconstruct the productivity in the Ross Sea,Antarctica,from 3.3 Ma to 2.4 *** productivity records exhibit a long-term decreasing trend and several distinct phased evolutionary ***,the local productivity fluctuated dramatically during 3.3-3.0 Ma,decreased gradually during 3.0-2.6 Ma,and remained relatively constant during 2.6-2.4 *** comparing productivity with its potential influences,we infer that the phased and long-term evolutions of productivity were mainly controlled by changes in deep ocean *** ice expansion might have decreased productivity during 3.3-3.0 Ma by light *** in eolian dust input have little effect on *** analysis revealed no coupling linkage between productivity and atmospheric pCO_(2),indicating that the productivity in the SO Antarctic Zone(AZ)was not the main factor controlling the atmospheric CO_(2)decrease during the *** improve our understanding of the role of SO processes in the NHG,further studies should focus on the potential influences of deep ocean ventilation on atmospheric pCO_(2)in the AZ,and similar studies should also be extended to the sea area in the Subantarctic Zone.

关键词： Ross Sea Biogenic opal Total organic carbon Deep ocean ventilation Sea ice Ocean carbon cycle

Geology and Geochemistry of the Yangtizishan-Moshishan Metamorphosed Sedimentary Anatase Deposit in Zhenglan Qi,Inner Mongolia:Discovery of a New Genetic Type of Titanium Deposit

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Acta Geologica Sinica(English Edition) 2011年第6期85卷 1419-1433页

作者： ZHAO yiming LI Daxin wu Liangshi CHEN Wenming FENG Chengyou WANG Peihua GAO Xuedong Institute of Mineral Resources Chinese Academy of Geological Sciences Beij＇ing 100037 China

Anatase and its allomorphic mineral rutile have the most prominent economic significance among titanium mineral resources and constitute one of the badly needed mineral resources currently in China. The Yantizishan-Moshishan anatase deposit was formerly referred to as an iron deposit. Based on recent investigation and exploration the authors believe that it is actually a large metamorphosed sedimentary anatase-dominated deposit belonging to a new genetic type. Ore bodies occur in stratoid and lenticular forms in Mesoproterozoic （1751 Ma） schist, metasandstone （metasiltstone）, and amphibolite. Rich ores have perthitic structure comprising chiefly interbedded quartz perthite （with disseminated anatase and rutile） and anatase perthite. Ore minerals are mainly anatase and subordinately rutile and ilmenite （±hematite）, while nonmetallic minerals are chiefly quartz with a certain amount of anthophyllite and biotite （±garnet）. The grain sizes of anatase, ruffle and ilmenite are 0.01-0.1 mm. Rich ores contain 3.14% to 15.46% TiO2. averaging 6.91%, while the low-grade ores have TiO2 content about 1.2%to 2.97%, averaging 1.76%. The ores have relatively high TFe and V contents. Trace elements in anatase and rutile such as Nb and Cr were analyzed by the electron microprobe. According to their relatively low Nb and Cr contents, source anatase and rutile must have come from meta-mafic rocks. Trace elements of the associated ilmenite show relatively high MnO and low MgO contents, just in contrast to those of ilmenite in V-Ti-magnetite ores of magmatic origin. The protoliths of amphibolite wall rocks should be basalt and picrite-basalt. Pertochemical data suggest that the tectonic setting of these rocks belongs to an island arc or a transitional belt between the island arc and oceanic ridge. Silicon isotope study shows that δ30Si values of different anatase ores, quartzite, and schist in this deposit are 0.1‰ to -0.9‰, similar to those of marine hydrothermal exhalative sedimentary

关键词： geology geochemistry anatase deposit new type Yangtizishan-Moshishan Inner Mongolia

Developing a one-step triplet-repeat primed PCR assay for diagnosingmyotonic dystrophy

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Journal of Genetics and Genomics 2018年第10期45卷 549-552页

作者： Xiaoping Lan Na Li Hongling Wan Lintong Luo yiming wu Sanxiang Li Yu An Bai-Lin wu Children's Hospital of Fudan University Shanghai 201102China Institute of Biomedical Sciences and Department of Pathology Shanghai Medical College of Fudan UniversityShanghai 200032China College of Bioengineering and Technology Tianshui Normal UniversityTianshui 741001China Molecular Diagnostic Laboratory Children's Hospital of Shanghai Jiao Tong UniversityShanghai 200040China College of Life Science and Technology Longdong UniversityQingyang 745000China MOE Key Laboratory of Contemporary Anthropology Fudan UniversityShanghai 200433China Boston Children's Hospital and Harvard Medical School BostonMA 02115USA

Myotonic dystrophy type 1 (DM1),or Steiner’s disease,is an autosomal dominant disorder caused by the expansion of unstable trinucleotide repeats (CTG) in the 3’ untranslated region of the myotonic dystrophy protein kinase gene (DMPK) (Brook et al.,1992;Mahadevan et al.,1992).The number of CTG repeats observed in normal individuals is in a range of 5-34,while the individuals with 35-49 CTG repeats are usually asymptomatic but at risk of

关键词： PCR TP CTG Developing a one-step triplet-repeat primed PCR assay for diagnosing myotonic dystrophy