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Comparison between sepsis-induced coagulopathy and sepsis-associated coagulopathy criteria in identifying sepsis-associated disseminated intravascular coagulation

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World Journal of Emergency Medicine 2024年第3期15卷 190-196页

作者： Huixin Zhao yiming dong Sijia Wang Jiayuan Shen Zhenju Song Mingming Xue Mian Shao Department of Emergency Medicine Zhongshan HospitalFudan UniversityShanghai 200032China

BACKGROUND:Disseminated intravascular coagulation(DIC)is associated with increased mortality in sepsis patients.In this study,we aimed to assess the clinical ability of sepsis-induced coagulopathy(SIC)and sepsis-associated coagulopathy(SAC)criteria in identifying overt-DIC and preDIC status in sepsis patients.METHODS:Data from 419 sepsis patients were retrospectively collected from July 2018 to December 2022.The performances of the SIC and SAC were assessed to identify overt-DIC on days 1,3,7,or 14.The SIC status or SIC score on day 1,the SAC status or SAC score on day 1,and the sum of the SIC or SAC scores on days 1 and 3 were compared in terms of their ability to identify pre-DIC.The SIC or SAC status on day 1 was evaluated as a pre-DIC indicator for anticoagulant initiation.RESULTS:On day 1,the incidences of coagulopathy according to overt-DIC,SIC and SAC criteria were 11.7%,22.0%and 31.5%,respectively.The specificity of SIC for identifying overt-DIC was significantly higher than that of the SAC criteria from day 1 to day 14(P3 had a significantly higher sensitivity(72.00%)and area under the curve(AUC)(0.69)in identifying pre-DIC than did the SIC or SAC status(sensitivity:SIC status 44.00%,SAC status 52.00%;AUC:SIC status 0.62,SAC status 0.61).The sum of the SIC scores on days 1 and 3 had a higher AUC value for identifying the pre-DIC state than that of SAC(0.79 vs.0.69,P<0.001).Favorable effects of anticoagulant therapy were observed in SIC(adjusted hazard ratio[HR]=0.216,95%confidence interval[95%CI]:0.060–0.783,P=0.018)and SAC(adjusted HR=0.146,95%CI:0.041–0.513,P=0.003).CONCLUSION:The SIC and SAC seem to be valuable for predicting overt-DIC.The sum of SIC scores on days 1 and 3 has the potential to help identify pre-DIC.

关键词： Sepsis Disseminated intravascular coagulation Sepsis-induced coagulopathy Sepsis-associated coagulopathy

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基于数据挖掘技术的税务风险检测方法评述

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Engineering 2024年第3期34卷 43-59页

作者： Qinghua Zheng yiming Xu Huixiang Liu Bin Shi Jiaxiang Wang Bo dong School of Computer Science and Technology Xi’an Jiaotong UniversityXi’an 710049China Shaanxi Provincial Key Laboratory of Big Data Knowledge Engineering Xi’an Jiaotong UniversityXi’an 710049China School of Distance Education Xi’an Jiaotong UniversityXi’an 710049China

Tax risk behavior causes serious loss of fiscal revenue,damages the country’s public infrastructure,and disturbs the market economic order of fair competition.In recent years,tax risk detection,driven by information technology such as data mining and artificial intelligence,has received extensive attention.To promote the high-quality development of tax risk detection methods,this paper provides the first comprehensive overview and summary of existing tax risk detection methods worldwide.More specifi-cally,it first discusses the causes and negative impacts of tax risk behaviors,along with the development of tax risk detection.It then focuses on data-mining-based tax risk detection methods utilized around the world.Based on the different principles employed by the algorithms,existing risk detection methods can be divided into two categories:relationship-based and non-relationship-based.A total of 14 risk detection methods are identified,and each method is thoroughly explored and analyzed.Finally,four major technical bottlenecks of current data-driven tax risk detection methods are analyzed and discussed,including the difficulty of integrating and using fiscal and tax fragmented knowledge,unexplainable risk detection results,the high cost of risk detection algorithms,and the reliance of existing algorithms on labeled information.After investigating these issues,it is concluded that knowledge-guided and datadriven big data knowledge engineering will be the development trend in the field of tax risk in the future;that is,the gradual transition of tax risk detection from informatization to intelligence is the future development direction.

关键词： Tax risk detection Data mining Knowledge guide Informatization Intellectualization

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Plant genomic resources at National Genomics Data Center:assisting in data-driven breeding applications

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aBIOTECH 2024年第1期5卷 94-106页

作者： dongmei Tian Tianyi Xu Hailong Kang Hong Luo Yanqing Wang Meili Chen Rujiao Li Lina Ma Zhonghuang Wang Lili Hao Bixia Tang dong Zou Jingfa Xiao Wenming Zhao yiming Bao Zhang Zhang Shuhui Song National Genomics Data Center Beijing Institute of GenomicsChinese Academy of Sciences&China National Center for BioinformationBeijing 100101China CAS Key Laboratory of Genome Sciences and Information Beijing Institute of GenomicsChinese Academy of Sciences&China National Center for BioinformationBeijing 100101China University of Chinese Academy of Sciences Beijing 100049China

Genomic data serve as an invaluable resource for unraveling the intricacies of the higher plant systems,including the constituent elements within and among species.Through various efforts in genomic data archiving,integrative analysis and value-added curation,the National Genomics Data Center(NGDC),which is a part of the China National Center for Bioinformation(CNCB),has successfully established and currently maintains a vast amount of database resources.This dedicated initiative of the NGDC facilitates a data-rich ecosystem that greatly strengthens and supports genomic research efforts.Here,we present a comprehensive overview of central repositories dedicated to archiving,presenting,and sharing plant omics data,introduce knowledgebases focused on variants or gene-based functional insights,highlight species-specific multiple omics database resources,and briefly review the online application tools.We intend that this review can be used as a guide map for plant researchers wishing to select effective data resources from the NGDC for their specific areas of study.

关键词： Plant-omics data Data repositories Data integration Knowledgebase Plant genomics

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DNA storage: research landscape and future prospects

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National Science Review 2020年第6期7卷 1092-1107页

作者： yiming dong Fajia Sun Zhi Ping Qi Ouyang Long Qian Center for Quantitative Biology and Peking-Tsinghua Center for Life Sciences Peking University Academician Workstation of BGI Synthetic Genomics BGI-Shenzhen The State Key Laboratory for Artificial Microstructures and Mesoscopic Physics School of Physics Peking University

The global demand for data storage is currently outpacing the world’s storage capabilities. DNA, the carrier of natural genetic information, offers a stable, resource-and energy-efficient and sustainable data storage solution. In this review, we summarize the fundamental theory, research history, and technical challenges of DNA storage. From a quantitative perspective, we evaluate the prospect of DNA, and organic polymers in general, as a novel class of data storage medium.

关键词： DNA storage information compilation sequencing

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Recent advances in chemical protein synthesis:method developments and biological applications

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Science China Chemistry 2024年第4期67卷 1060-1096页

作者： Suwei dong Ji-Shen Zheng yiming Li Huan Wang Gong Chen Yongxiang Chen Gemin Fang Jun Guo Chunmao He Honggang Hu Xuechen Li Yanmei Li Zigang Li Man Pan Shan Tang Changlin Tian Ping Wang Bian Wu Chuanliu Wu Junfeng Zhao Lei Liu State Key Laboratory of Natural and Biomimetic Drugs and School of Pharmaceutical SciencesPeking UniversityBeijing 100191China Division of Life Sciences and Medicine University of Science and Technology of ChinaHefei 230027China School of Food and Biological Engineering Engineering Research Center of Bio-processMinistry of EducationHefei University of TechnologyHefei 230009China School of Chemistry and Chemical Engineering Nanjing UniversityNanjing 210023China State Key Laboratory of Elemento-Organic Chemistry Nankai UniversityTianjin 300071China Department of Chemistry Tsinghua UniversityBeijing 100084China Institute of Health Sciences Anhui UniversityHefei 230601China College of Chemistry Central China Normal UniversityWuhan 430079China School of Chemistry and Chemical Engineering South China University of TechnologyGuangzhou 510640China School of Medicine or Institute of Translational Medicine Shanghai UniversityShanghai 200444China Department of Chemistry The University of Hong KongHong Kong 999077China Shenzhen Graduate School Peking UniversityShenzhen 518055China School of Chemistry and Chemical Engineering Shanghai Jiao Tong UniversityShanghai 200240China School of Life Sciences University of Science and Technology of ChinaHefei 230026China Department of Chemical Biology Shanghai Jiao Tong UniversityShanghai 200240China Institute of Microbiology Chinese Academy of SciencesBeijing 100101China Department of Chemistry Xiamen UniversityXiamen 361005China School of Pharmaceutical Science Guangzhou Medical UniversityGuangzhou 511436China

The central dogma of modern biology underscores the pivotal roles proteins play in diverse biological processes,the study of which necessitates advanced methods to produce proteins with precision and versatility.Chemical protein synthesis,a powerful approach utilizing chemical reactions for the de novo construction of structurally accurate proteins,has emerged as a transformative tool for studying proteins and generating protein derivatives/mimics inaccessible by natural biological machinery,including post-translationally modified proteins,proteins comprised of unnatural amino acids,as well as mirror-image proteins.This review summarizes recent strides in synthetic method developments for chemical protein synthesis,including innovative techniques in solid-phase peptide synthesis,the challenges presented by difficult sequences in either synthesis or folding and the exploration of novel ligation reactions using both chemical and enzymatic methods.Furthermore,the review also delves into newly developed protocols for site-selective protein modifications and the generation of stapled or macrocyclized peptides/miniproteins,highlighting the power of chemical methods to make structurally diverse proteins.Recent applications of synthetic proteins in investigating post-translational modifications(phosphorylation,lipidation,glycosylation,ubiquitination,etc.),mirror-image biological processes and drug development are further discussed.Together,these topics provide a comprehensive overview of the current landscape of chemical protein synthesis.

关键词： chemical protein synthesis solid-phase peptide synthesis ligation reactions post-translational modifications mirror-image proteins peptide drugs

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超高温陶瓷复合材料研究进展

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无机材料学报 2024年第6期39卷 571-590页

作者：张幸红王义铭程源董顺胡平哈尔滨工业大学航天学院复合材料与结构研究所哈尔滨150001

随着高速飞行器朝着更宽空域、更长时间和更高速度的方向发展,对飞行器的鼻锥、前缘和发动机燃烧室等关键结构的热防护性能提出了更加严苛的要求,发展在极端环境下使用的高性能热防护材料是当前的研究重点。超高温陶瓷复合材料具有优异... 详细信息

随着高速飞行器朝着更宽空域、更长时间和更高速度的方向发展,对飞行器的鼻锥、前缘和发动机燃烧室等关键结构的热防护性能提出了更加严苛的要求,发展在极端环境下使用的高性能热防护材料是当前的研究重点。超高温陶瓷复合材料具有优异的抗氧化烧蚀性能,是一类极具应用潜力的非烧蚀型热防护材料。然而,本征脆性问题限制了超高温陶瓷复合材料的工程化应用,需通过组分结构调控对其进行强韧化。同时,飞行器有效载荷提升也对超高温陶瓷复合材料提出了轻量化的要求。本文系统概述了超高温陶瓷复合材料近年来取得的主要研究进展,包括压力烧结、泥浆浸渍、前驱体浸渍裂解、反应熔渗、化学气相渗透/沉积与“固-液”组合工艺等制备方法,颗粒、晶须、软相物质、短切纤维和连续纤维等强韧化方法及其机制,抗氧化烧蚀性能与机理,以及轻量化设计等。讨论了超高温陶瓷复合材料组分、微结构和性能之间的关系,并指出了超高温陶瓷复合材料目前存在的挑战以及未来的发展趋势。

关键词：超高温陶瓷复合材料强韧化抗氧化烧蚀轻量化综述

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Magnetocardiograph as a noninvasive and radiation-free diagnostic device for myocardial infarction:a systematic review and meta-analysis

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Emergency and Critical Care Medicine 2023年第2期3卷 70-77页

作者： Yansong Xu Xiaole Han Mingyue Guo Ruochuan Li yiming dong Jiaxin Fan Xiaofei Yin Fei Xie Jiaojiao Pang Yuguo Chen Department of Emergency Medicine Qilu Hospital of Shandong UniversityJinanShandongChina Shandong Key Laboratory for Magnetic Field-free Medicine and Functional Imaging Institute of Magnetic Field-free Medicine and Functional ImagingShandong UniversityJinanShandongChina Shandong Provincial Clinical Research Center for Emergency and Critical Care Medicine Institute of Emergency and Critical Care Medicine of Shandong UniversityChest Pain CenterQilu Hospital of Shandong UniversityJinanShandongChina NMPA Key Laboratory for Clinical Research and Evaluation of Innovative Drug Qilu Hospital of Shandong UniversityJinanShandongChina The National Medical Science and Technology Industry-Education Integration Innovation Platform Qilu Hospital of Shandong UniversityJinanShandongChina Key Laboratory of Ultra-Weak Magnetic Field Measurement Technology Ministry of EducationSchool of Instrumentation and Optoelectronic EngineeringBeihang UniversityBeijingChina

Background:This study aimed to evaluate the diagnostic accuracy of magnetocardiograph,a relatively new noninvasive device,in patients with myocardial infarction(MI).Methods:To identify studies assessing the diagnostic accuracy of magnetocardiography for MI,we searched four databases on November 7,2022,the Cochrane Central Register of Controlled Trials,MEDLINE,EMBASE,and Web of Science,plus ClinicalTrials.gov.Three reviewers screened the studies independently and emailed the authors for more precise data when necessary.The Quality Assessment of Diagnostic Accuracy Studies 2 tool was used to evaluate the quality of the included studies.STATA(version 17;Stata Corporation,College Station,TX,USA)was used for meta-analysis of 22 contingency table data.Results:A total of 6 articles were included in this study.The diagnostic parameters of all included studies were summarized as follows:the pooled sensitivity was 0.91(95%confidence intervals[95%CIs]:0.81–0.96;I 2=88.54);specificity was 0.83(95%CI:0.75–0.89;I 2=83);positive likelihood ratio was 5.3(95%CI:3.5–8.2);negative likelihood ratio was 0.1(95%CI:0.04–0.24);and diagnostic odds ratio was 51(95%CI:16–161).The area under the curve for the receiver operating characteristic curve was 0.92(95%CI:0.89–0.94).After metaregression analysis,we found that the number of channels and the way of environmental magnetic noise elimination were heterogeneous sources.Conclusion:In summary,our meta-analysis shows that magnetocardiography holds a high accuracy in diagnosing MI and takes the advantages of noninvasive,radiation-free,and noncontact.However,further high-quality studies to confirm its usefulness in diagnosing MI are warranted.

关键词： Diagnosis Magnetocardiograph Meta-analysis Myocardial infarction Systematic review

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森林生态效益补偿优先级机制研究及应用——基于碳汇总量与变化量视角

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生态学报 2024年第5期44卷 1892-1903页

作者：董一鸣孙博文徐琳瑜北京师范大学环境学院北京100875

森林生态效益补偿制度对于提高森林建设者积极性、促进森林生态效益提升具有重要意义。然而,我国森林生态效益补偿实践中依然存在仅以森林面积为补偿依据导致激励错位的问题。基于此,结合国家“双碳”目标,提出一种基于碳汇总量与变化... 详细信息

森林生态效益补偿制度对于提高森林建设者积极性、促进森林生态效益提升具有重要意义。然而,我国森林生态效益补偿实践中依然存在仅以森林面积为补偿依据导致激励错位的问题。基于此,结合国家“双碳”目标,提出一种基于碳汇总量与变化量双向视角的综合森林生态效益补偿优先级机制,选取我国重要生态功能区秦巴山区为案例,分别从森林碳汇总量与变化量视角量化各区县生态补偿优先级,并构建二者结合的综合优先级模型,以促进在生态补偿实践中的资金分配公平性与激励性。研究发现,(1)在研究期内大多区县森林碳汇总量增长,但存在个别区县森林碳汇功能降低的现象,具体原因存在差异;(2)碳汇总量优先级与碳汇变化量优先级清单存在差异。总量优先级高的区县,变化量优先级较低,因此,生态补偿应综合考虑各区县森林碳汇在两个维度的表现;(3)综合优先级排名结果呈现“高值-中值-低值”的不同区间特征,该补偿机制在综合优先级高值区激励区县扩建森林、新增森林碳汇,在中值区激励区县保育森林,在低值区鼓励区县结合森林现状从扩建与保育两个方向提升森林碳汇功能。以森林碳汇保育与增汇成果为导向,有效探索碳汇功能在生态补偿中的实践价值,为我国区域森林生态效益补偿实践的公平性与科学性提供研究基础。

关键词：森林碳汇秦巴山区生态补偿优先级

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甲外锚腱骨缝合治疗新鲜腱性锤状指

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中华手外科杂志 2024年第1期40卷 70-72页

作者：陆一鸣王斌戚仁竞董辉张乃臣江苏省苏北人民医院手外科扬州225000 扬州大学临床医学院扬州225000 大连医科大学大连116044

目的探讨甲外锚腱骨缝合治疗新鲜腱性锤状指的临床疗效。方法我院自2020年1月至2022年10月采用甲外锚腱骨缝合法治疗新鲜腱性锤状指患者22例,开放性损伤15例,闭合性损伤7例。均为单指手术。结果术后22例患者均获得随访,时间12~24个月,平... 详细信息

目的探讨甲外锚腱骨缝合治疗新鲜腱性锤状指的临床疗效。方法我院自2020年1月至2022年10月采用甲外锚腱骨缝合法治疗新鲜腱性锤状指患者22例,开放性损伤15例,闭合性损伤7例。均为单指手术。结果术后22例患者均获得随访,时间12~24个月,平均18.3个月。所有创口均Ⅰ期愈合,无并发症发生。根据Crawford锤状指疗效评价标准:优8例,良12例,可1例,差1例。根据中华医学会上肢部分功能评定试用标准:优7例,良14例,可1例。根据Miller标准评价伸肌腱功能:优7例,良13例,中1例,差1例。结论甲外锚腱骨缝合治疗新鲜腱性锤状指损伤,具有固定牢靠、活动好、并发症少、费用低等优点。

关键词：腱损伤治疗结果锤状指甲外锚腱骨缝合

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基于图像分割技术的皮革面积检测算法

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中国皮革 2024年第7期53卷 19-24页

作者：董钰颖杨一铭西安航空职业技术学院航空维修工程学院陕西西安710089

为解决目前皮革绷板干燥工序中皮革有效面积难以用传统方法检测的问题,本文提出了一种皮革轮廓分割方法,并设计皮革面积检测算法。首先,本文通过搭建试验平台模拟绷展状态下的羊革,利用单目相机获得羊革原图像,经过降噪、二值化完成图... 详细信息

为解决目前皮革绷板干燥工序中皮革有效面积难以用传统方法检测的问题,本文提出了一种皮革轮廓分割方法,并设计皮革面积检测算法。首先,本文通过搭建试验平台模拟绷展状态下的羊革,利用单目相机获得羊革原图像,经过降噪、二值化完成图像的预处理。然后,利用腐蚀、膨胀处理实现对羊革轮廓与绷板夹的分割。最终,识别分割后羊革轮廓,进行羊革有效面积计算。试验结果表明,本算法可有效分割绷展状态下的羊革与绷板夹,得到羊革有效面积,基本满足自动化皮革绷板机的工艺需求。本算法不仅可进一步提高皮革得革率,增加制革企业经济效益,也为智能化皮革绷板机的设计提供了技术基础。

关键词：面积检测图像分割皮革绷板机轮廓曲线

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