检索结果-南通市图书馆

Neural stem cell-derived exosomes promote mitochondrial biogenesis and restore abnormal protein distribution in a mouse model of Alzheimer's disease

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2024年第7期19卷 1593-1601页

作者： Bo Li Yujie chen Yan Zhou Xuanran Feng Guojun Gu Shuang Han Nianhao cheng Yawen Sun yiming Zhang Jiahui cheng Qi Zhang Wei Zhang Jianhui Liu Department of Radiology Renji HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghaiChina Morphology and Spatial Multi-Omics Technology Platform Shanghai Institute of Nutrition and HealthChinese Academy of SciencesShanghaiChina Department of Anesthesiology Tongji HospitalSchool of MedicineTongji UniversityShanghaiChina Department of Blood Transfusion Huashan HospitalFudan UniversityShanghaiChina

Mitochondrial dysfunction is a hallmark of Alzheimer’s disease.We previously showed that neural stem cell-derived extracellular vesicles improved mitochondrial function in the cortex of AP P/PS1 mice.Because Alzheimer’s disease affects the entire brain,further research is needed to elucidate alterations in mitochondrial metabolism in the brain as a whole.Here,we investigated the expression of several important mitochondrial biogenesis-related cytokines in multiple brain regions after treatment with neural stem cell-derived exosomes and used a combination of whole brain clearing,immunostaining,and lightsheet imaging to clarify their spatial distribution.Additionally,to clarify whether the sirtuin 1(SIRT1)-related pathway plays a regulatory role in neural stem cell-de rived exosomes interfering with mitochondrial functional changes,we generated a novel nervous system-SIRT1 conditional knoc kout AP P/PS1mouse model.Our findings demonstrate that neural stem cell-de rived exosomes significantly increase SIRT1 levels,enhance the production of mitochondrial biogenesis-related fa ctors,and inhibit astrocyte activation,but do not suppress amyloid-βproduction.Thus,neural stem cell-derived exosomes may be a useful therapeutic strategy for Alzheimer’s disease that activates the SIRT1-PGC1αsignaling pathway and increases NRF1 and COXIV synthesis to improve mitochondrial biogenesis.In addition,we showed that the spatial distribution of mitochondrial biogenesis-related factors is disrupted in Alzheimer’s disease,and that neural stem cell-derived exosome treatment can reverse this effect,indicating that neural stem cell-derived exosomes promote mitochondrial biogenesis.

关键词： Alzheimer’s disease mitochondrial biogenesis neural stem cell-derived exosome SIRT1-PGC1α regional brain distribution whole brain clearing and imaging

Human-Robot Collaboration Framework Based on Impedance Control in Robotic Assembly

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Engineering 2023年第11期30卷 83-92页

作者： Xingwei Zhao yiming chen Lu Qian Bo Tao Han Ding State Key Laboratory of Digital Manufacturing Equipment and Technology School of Mechanical Science and EngineeringHuazhong University of Science and TechnologyWuhan 430074China

Human–robot(HR)collaboration(HRC)is an emerging research field because of the complementary advantages of humans and robots.An HRC framework for robotic assembly based on impedance control is proposed in this paper.In the HRC framework,the human is the decision maker,the robot acts as the executor,while the assembly environment provides constraints.The robot is the main executor to perform the assembly action,which has the position control,drag and drop,positive impedance control,and negative impedance control modes.To reveal the characteristics of the HRC framework,the switch condition map of different control modes and the stability analysis of the HR coupled system are discussed.In the end,HRC assembly experiments are conducted,where the HRC assembly task can be accomplished when the assembling tolerance is 0.08 mm or with the interference fit.Experiments show that the HRC assembly has the complementary advantages of humans and robots and is efficient in finishing complex assembly tasks.

关键词： Human-robot collaboration Impedance control Robotic assembly

Evolutionary Game Analysis of the Production Decisions of Automakers in the Chinese Automobile Industry:A Tripartite Model of Government,Automakers,and Consumers

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Journal of Systems Science and Systems Engineering 2023年第6期32卷 708-728页

作者： Jinhuan Tang Qiong Wu yiming chen Yuran Jin Kun Wang School of Economics and Management Shenyang Aerospace UniversityShenyang110136China School of Business Administration University of Science and Technology LiaoningAnshan114051China

Based on the evolutionary game approach,this paper analyzes how the automaker makes rational production decisions under the influence of the government and consumers.A tripartite evolutionary game model of“government-automaker-consumer”is established to explore the interactions under the condition of bounded rationality.The study shows that:1)The increase of credit price and credit ratio will promote the diffusion of new energy vehicles(NEVs).2)The cost premium of NEVs and the shrinking market will slow the spread of NEVs to some extent but will not prevent NEVs from becoming a trend in the automobile industry.However,the cost premium of fuel vehicles(FVs)will accelerate the development of the NEV industry.3)Government subsidies can promote the development of NEV industry to some extent,but they are not always effective.The government can simultaneously implement subsidies for automakers and consumers in the early stages,and choose to implement the subsidy only for consumers in the medium term.Additionally,there is no need to implement the subsidy policy at a later stage.

关键词： Dual-credit policy new energy vehicles tripartite evolutionary game government subsidy

Denitration of Nitroarenes Under Ambient Physiological Conditions Catalyzed by Graphdiyne-Supported Palladium

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

CCS Chemistry 2024年第3期6卷 641-651页

作者： Endong Zhang Yanyan chen Fengting Lv Zicheng Zuo Feng He Yongjun Li yiming Huang Yuliang Li Shu Wang Beijing National Laboratory for Molecular Sciences Key Laboratory of Organic SolidsInstitute of ChemistryChinese Academy of SciencesBeijing 100190 College of Chemistry University of Chinese Academy of SciencesBeijing 100049

The direct cleavage of C–NO_(2)bonds for reductive denitration of nitroarenes remains a challenging transformation in synthetic organic chemistry.Herein,we report a biocompatible palladium-deposited graphdiyne nanocatalyst(Pd@GDY/DSPE-PEG)that can catalyze reductive denitration of nitroarenes under ambient physiological conditions.Mechanistic studies support this transformation via the oxidative addition of nitroarenes with Pd(0)and subsequent ligand exchange to form arylpalladium hydride.This one-step reductive denitration via Pd@GDY/DSPE-PEG successfully facilitates the repair of the nitrated proteins arising from endogenic ONOO−and restores their physiological function,including blocking the apoptosis pathway in living cells.Moreover,Pd@GDY/DSPE-PEG was further successfully applied for catalytic denitration to reduce the level of 3-nitrotyrosine residues of proteins located in the mouse brain hippocampus in vivo.This study provides an ideal strategy for designing highly active enzymatic mimicking synthetic catalysts for the regulation of the nitrated protein level and the detoxification of nitrative damage of living cells and tissues.

关键词： 3-nitrotyrosine artificial nanaocatalysts reductive denitration palladium-deposited graphdiyne repairing nitrated protein

Id2 epigenetically controls CD8^(+)T-cell exhaustion by disrupting the assembly of the Tcf3-LSD1 complex

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Cellular & Molecular Immunology 2024年第3期21卷 292-308页

作者： yiming Li Mingwei Han Haolin Wei Wan Huang Zhinan chen Tianjiao Zhang Meirui Qian Lin Jing Gang Nan Xiuxuan Sun Shuhui Dai Kun Wang Jianli Jiang Ping Zhu Liang chen Department of Cell Biology of National Translational Science Center for Molecular Medicine and Department of Clinical Immunology of Xijing Hospital Fourth Military Medical UniversityXi’anShaanxi 710032China State Key Laboratory of New Targets Discovery and Drug Development for Major Diseases GanzhouJiangxi341000Xi’anShaanxi 710032China School of Medicine Shanghai UniversityShanghai 200444China

CD8^(+)T-cell exhaustion is a state of dysfunction that promotes tumor progression and is marked by the generation of Slamf6^(+)progenitor exhausted(Tex^(prog))and Tim-^(3+)terminally exhausted(Tex^(term))subpopulations.Inhibitor of DNA binding protein 2(Id2)has been shown to play important roles in T-cell development and CD8^(+)T-cell immunity.However,the role of Id2 in CD8^(+)T-cell exhaustion is unclear.Here,we found that Id2 transcriptionally and epigenetically regulates the generation of Texprog cells and their conversion to Texterm cells.Genetic deletion of Id2 dampens CD8^(+)T-cell-mediated immune responses and the maintenance of stem-like CD8^(+)T-cell subpopulations,suppresses PD-1 blockade and increases tumor susceptibility.Mechanistically,through its HLH domain,Id2 binds and disrupts the assembly of the Tcf3-Tal1 transcriptional regulatory complex,and thus modulates chromatin accessibility at the Slamf6 promoter by preventing the interaction of Tcf3 with the histone lysine demethylase LSD1.Therefore,Id2 increases the abundance of the permissive H3K4me2 mark on the Tcf3-occupied E-boxes in the Slamf6 promoter,modulates chromatin accessibility at the Slamf6 promoter and epigenetically regulates the generation of Slamf6+Texprog cells.An LSD1 inhibitor GSK2879552 can rescue the Id2 knockout phenotype in tumor-bearing mice.Inhibition of LSD1 increases the abundance of Slamf6^(+)Tim-3^(−)Tex^(prog) cells in tumors and the expression level of Tcf1 in Id2-deleted CD8+T cells.This study demonstrates that Id2-mediated transcriptional and epigenetic modification drives hierarchical CD8^(+)T-cell exhaustion,and the mechanistic insights gained may have implications for therapeutic intervention with tumor immune evasion.

关键词： Id2 T-cell exhaustion Epigenetic modification Immune evasion

Restoring After Central Nervous System Injuries:Neural Mechanisms and Translational Applications of Motor Recovery

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neuroscience Bulletin 2022年第12期38卷 1569-1587页

作者： Zhengrun Gao Zhen Pang yiming chen Gaowei Lei Shuai Zhu Guotao Li Yundong Shen Wendong Xu Department of Hand Surgery Huashan HospitalFudan UniversityShanghai 200040China The National Clinical Research Center for Aging and Medicine Fudan UniversityShanghai 200040China Department of Hand and Upper Extremity Surgery Jing’an District Central HospitalFudan UniversityShanghai 200040China Institutes of Brain Science Fudan UniversityShanghai 200040China State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science Fudan UniversityShanghai 200040China Institute of Automation State Key Laboratory of Management and Control for Complex SystemsChinese Academy of SciencesBeijing 100190China Co-innovation Center of Neuroregeneration Nantong UniversityNantong 226000China Research Unit of Synergistic Reconstruction of Upper and Lower Limbs after Brain Injury Chinese Academy of Medical SciencesShanghai 200400China

Central nervous system(CNS)injuries,including stroke,traumatic brain injury,and spinal cord injury,are leading causes of long-term disability.It is estimated that more than half of the survivors of severe unilateral injury are unable to use the denervated limb.Previous studies have focused on neuroprotective interventions in the affected hemisphere to limit brain lesions and neurorepair measures to promote recovery.However,the ability to increase plasticity in the injured brain is restricted and difficult to improve.Therefore,over several decades,researchers have been prompted to enhance the compensation by the unaffected hemisphere.Animal experiments have revealed that regrowth of ipsilateral descending fibers from the unaffected hemisphere to denervated motor neurons plays a significant role in the restoration of motor function.In addition,several clinical treatments have been designed to restore ipsilateral motor control,including brain stimulation,nerve transfer surgery,and brain–computer interface systems.Here,we comprehensively review the neural mechanisms as well as translational applications of ipsilateral motor control upon rehabilitation after CNS injuries.

关键词： Stroke Traumatic brain injury Spinal cord injury Brain-computer interface system Neuroplasticity Ipsilateral motor control Axon regrowth

Three-step learning strategy for designing 15Cr ferritic steels with enhanced strength and plasticity at elevated temperature

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Materials Science & Technology 2023年第33期164卷 79-94页

作者： Xiaobing Hu yiming chen Jianlin Lu chen Xing Jiajun Zhao Qingfeng Wu Yuhao Jia Junjie Li Zhijun Wang Jincheng Wang State Key Laboratory of Solidification Processing Northwestern Polytechnical UniversityXi'an 710072China

15Cr ferrite steels are urgently required in advanced Ultra-supercritical power plants but meet design challenges in balancing excellent strength and plasticity at high temperatures.We developed a three-step learning strategy based on mutually driven machine learning and purposeful experiments to complete this multi-objective task.Compared with traditional adaptive learning and local-interpolation learning,this step-by-step modular manner provides good transparency and interpretability of the information flow,which is ensured by identifying essential factors from an exquisitely prepared composition-microstructure dataset,and learning valuable knowledge about the composition-property relationship.The requirement of only two groups of experiments indicates the low cost and high efficiency of the strategy.Performing the strategy,we found that Ti is another key element affecting the Laves phase besides Mo and W,and their effects on ultimate tensile strength(UTS)and elongation were also uncovered.Importantly,several low-cost steels free of Co were successfully designed,and the best steel exhibited 156%,31%,and 62%higher UTS and elongation at 650°C than the typical 9Cr,15Cr,and 20Cr steels,respectively.Based on the advantages and success of the strategy in terms of alloy improvement,we believe the strategy suits other multi-objective design tasks in more materials systems.

关键词： 15Cr ferrite steels Machine learning Multi-objective design Strength and plasticity trade-off

Plant genomic resources at National Genomics Data Center:assisting in data-driven breeding applications

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

aBIOTECH 2024年第1期5卷 94-106页

作者： Dongmei Tian Tianyi Xu Hailong Kang Hong Luo Yanqing Wang Meili chen Rujiao Li Lina Ma Zhonghuang Wang Lili Hao Bixia Tang Dong Zou Jingfa Xiao Wenming Zhao yiming Bao Zhang Zhang Shuhui Song National Genomics Data Center Beijing Institute of GenomicsChinese Academy of Sciences&China National Center for BioinformationBeijing 100101China CAS Key Laboratory of Genome Sciences and Information Beijing Institute of GenomicsChinese Academy of Sciences&China National Center for BioinformationBeijing 100101China University of Chinese Academy of Sciences Beijing 100049China

Genomic data serve as an invaluable resource for unraveling the intricacies of the higher plant systems,including the constituent elements within and among species.Through various efforts in genomic data archiving,integrative analysis and value-added curation,the National Genomics Data Center(NGDC),which is a part of the China National Center for Bioinformation(CNCB),has successfully established and currently maintains a vast amount of database resources.This dedicated initiative of the NGDC facilitates a data-rich ecosystem that greatly strengthens and supports genomic research efforts.Here,we present a comprehensive overview of central repositories dedicated to archiving,presenting,and sharing plant omics data,introduce knowledgebases focused on variants or gene-based functional insights,highlight species-specific multiple omics database resources,and briefly review the online application tools.We intend that this review can be used as a guide map for plant researchers wishing to select effective data resources from the NGDC for their specific areas of study.

关键词： Plant-omics data Data repositories Data integration Knowledgebase Plant genomics

Characterization of natural fiber from manau rattan(Calamus manan)as a potential reinforcement for polymer-based composites

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Bioresources and Bioproducts 2022年第3期7卷 190-200页

作者： Linhu Ding Xiaoshuai Han Lihua Cao yiming chen Zhe Ling Jingquan Han Shuijian He Shaohua Jiang Jiangsu Co-Innovation Center of Efficient Processing and Utilization of Forest Resources International Innovation Center for Forest Chemicals and MaterialsCollege of Materials Science and EngineeringNanjing Forestry UniversityNanjing 210037China Jiangsu Co-Innovation Center of Efficient Processing and Utilization of Forest Resources College of Chemical EngineeringNanjing Forestry UniversityNanjing 210037China

Researches on novel natural fibers in polymer-based composites will help promote the invention of novel reinforcement and expand their possible applications.Herein,in this study,novel cellulosic fibers were extracted from the stem of manau rattan(Calamus manan)by mechanical separation.The chemical,thermal,mechanical and morphological properties of manau rattan fibers were comprehensively analyzed and studied by Fourier transform infrared spectroscopy(FT-IR),X-ray photoelectron spectroscopy(XPS),X-ray diffraction(XRD)analysis,thermogravimetric analysis(TGA),single fiber tensile test and scanning electron microscopy(SEM).Component analysis re-sults showed that the cellulose,hemicellulose and lignin contents of C.manan fibers were 42wt%,20wt%,and 27wt%,respectively.The surface of the rattan fiber was hydrophilic according to the oxygen/carbon ratio of 0.49.The C.manan has a crystalline index of 48.28%,inducing a max-imum degradation temperature of 332.8°C.This reveals that it can be used as a reinforcement for thermoplastic composites whose operating temperature is below 300°C.The average ten-sile strength can reach(273.28±52.88)MPa,which is beneficial to improve the mechanical properties of rattan fiber reinforced composites.The SEM images displayed the rough surface of the fiber,which helped to enhance the interfacial adhesion between the fibers and matrices in composites.These results indicate the great potential of C.manan fibers as the reinforcement in polymer-based composites.

关键词： Cellulose Manau rattan(Calamus manan) Mechanical properties Natural fiber Thermal analysis