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Enhancing m^(6)A modification in the motor cortex facilitates corticospinal tract remodeling after spinal cord injury

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Neural Regeneration Research 2025年第6期20卷 1749-1763页

作者： Tian Qin Yuxin Jin yiming Qin Feifei Yuan Hongbin Lu Jianzhong Hu Yong Cao Chengjun Li Department of Spine Surgery and Orthopedics Xiangya HospitalCentral South UniversityChangshaHunan ProvinceChina Key Laboratory of Organ Injury Aging and Regenerative Medicine of Hunan ProvinceChangshaHunan ProvinceChina National Clinical Research Center for Geriatric Disorders Xiangya HospitalCentral South UniversityChangshaHunan ProvinceChina Department of Sports Medicine Xiangya HospitalCentral South UniversityChangshaHunan ProvinceChina

Spinal cord injury typically causes corticospinal tract disruption. Although the disrupted corticospinal tract can self-regenerate to a certain degree, the underlying mechanism of this process is still unclear. N6-methyladenosine(m^(6)A) modifications are the most common form of epigenetic regulation at the RNA level and play an essential role in biological processes. However, whether m^(6)A modifications participate in corticospinal tract regeneration after spinal cord injury remains unknown. We found that expression of methyltransferase 14 protein(METTL14) in the locomotor cortex was high after spinal cord injury and accompanied by elevated m^(6)A levels. Knockdown of Mettl14 in the locomotor cortex was not favorable for corticospinal tract regeneration and neurological recovery after spinal cord injury. Through bioinformatics analysis and methylated RNA immunoprecipitation-quantitative polymerase chain reaction, we found that METTL14 regulated Trib2 expression in an m^(6)A-regulated manner, thereby activating the mitogen-activated protein kinase pathway and promoting corticospinal tract regeneration. Finally, we administered syringin, a stabilizer of METTL14, using molecular docking. Results confirmed that syringin can promote corticospinal tract regeneration and facilitate neurological recovery by stabilizing METTL14. Findings from this study reveal that m^(6)A modification is involved in the regulation of corticospinal tract regeneration after spinal cord injury.

关键词： corticospinal tract remodeling epigenetic regulations locomotor cortex m^(6)A modification methyltransferase 14 protein(METTL14) mitogen-activated protein kinase neural regeneration spinal cord injury syringin TRIB2

Recombinant chitinase-3-like protein 1 alleviates learning and memory impairments via M2 microglia polarization in postoperative cognitive dysfunction mice

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Neural Regeneration Research 2025年第9期20卷 2727-2736页

作者： Yujia Liu Xue Han Yan Su yiming Zhou Minhui Xu Jiyan Xu Zhengliang Ma Xiaoping Gu Tianjiao Xia Department of Anesthesiology Nanjing Drum Tower HospitalAffiliated Hospital of Medical SchoolNanjing UniversityNanjingJiangsu ProvinceChina Medical School Nanjing UniversityNanjingJiangsu ProvinceChina Jiangsu Key Laboratory of Molecular Medicine Nanjing UniversityNanjingJiangsu ProvinceChina State Key Laboratory of Pharmaceutical Biotechnology Nanjing UniversityNanjingJiangsu ProvinceChina Department of Anesthesiology Zhongshan HospitalFudan UniversityShanghaiChina

Postoperative cognitive dysfunction is a seve re complication of the central nervous system that occurs after anesthesia and surgery,and has received attention for its high incidence and effect on the quality of life of *** date,there are no viable treatment options for postoperative cognitive *** identification of postoperative cognitive dysfunction hub genes could provide new research directions and therapeutic targets for future *** identify the signaling mechanisms contributing to postoperative cognitive dysfunction,we first conducted Gene Ontology and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analyses of the Gene Expression Omnibus GSE95426 dataset,which consists of mRNAs and long non-coding RNAs differentially expressed in mouse hippocampus3 days after tibial *** dataset was enriched in genes associated with the biological process"regulation of immune cells,"of which Chill was identified as a hub ***,we investigated the contribution of chitinase-3-like protein 1 protein expression changes to postoperative cognitive dysfunction in the mouse model of tibial fractu re *** were intraperitoneally injected with vehicle or recombinant chitinase-3-like protein 124 hours post-surgery,and the injection groups were compared with untreated control mice for learning and memory capacities using the Y-maze and fear conditioning *** addition,protein expression levels of proinflammatory factors(interleukin-1βand inducible nitric oxide synthase),M2-type macrophage markers(CD206 and arginase-1),and cognition-related proteins(brain-derived neurotropic factor and phosphorylated NMDA receptor subunit NR2B)were measured in hippocampus by western *** with recombinant chitinase-3-like protein 1 prevented surgery-induced cognitive impairment,downregulated interleukin-1βand nducible nitric oxide synthase expression,and upregulated CD206,arginase-1,pNR2B,and brain-derived neurotropic factor expr

关键词： Chil1 hippocampus learning and memory M2 microglia neuroinflammation postoperative cognitive dysfunction(POCD) recombinant CHI3L1

Pharmacological targeting cGAS/STING/NF-κB axis by tryptanthrin induces microglia polarization toward M2 phenotype and promotes functional recovery in a mouse model of spinal cord injury

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Neural Regeneration Research 2025年第11期20卷 3287-3301页

作者： Ziwei Fan Mengxian Jia Jian Zhou Zhoule Zhu Yumin Wu Xiaowu Lin yiming Qian Jiashu Lian Xin Hua Jianhong Dong Zheyu Fang Yuqing Liu Sibing Chen Xiumin Xue Juanqing Yue Minyu Zhu Ying Wang Zhihui Huang Honglin Teng Department of Orthopedics(Spine Surgery) the First Affiliated Hospital of Wenzhou Medical UniversityWenzhouZhejiang ProvinceChina School of Pharmacy Hangzhou Normal UniversityHangzhouZhejiang ProvinceChina Department of Neurology The First Affiliated Hospital of Wenzhou Medical UniversityWenzhouZhejiang ProvinceChina Department of Pathology Affiliated Hangzhou First People’s HospitalSchool of MedicineWestlake UniversityHangzhouZhejiang ProvinceChina Department of Clinical Research Center Affiliated Hangzhou First People’s HospitalSchool of MedicineWestlake UniversityHangzhouZhejiang ProvinceChina

The M1/M2 phenotypic shift of microglia after spinal cord injury plays an important role in the regulation of neuroinflammation during the secondary injury phase of spinal cord *** of shifting microglia polarization from M1(neurotoxic and proinflammatory type)to M2(neuroprotective and anti-inflammatory type)after spinal cord injury appears to be *** possesses an anti-inflammatory biological ***,its roles and the underlying molecular mechanisms in spinal cord injury remain *** this study,we found that tryptanthrin inhibited microglia-derived inflammation by promoting polarization to the M2 phenotype in *** promoted M2 polarization through inactivating the cGAS/STING/NF-κB ***,we found that targeting the cGAS/STING/NF-κB pathway with tryptanthrin shifted microglia from the M1 to M2 phenotype after spinal cord injury,inhibited neuronal loss,and promoted tissue repair and functional recovery in a mouse model of spinal cord ***,using a conditional co-culture system,we found that microglia treated with tryptanthrin suppressed endoplasmic reticulum stress-related neuronal *** together,these results suggest that by targeting the cGAS/STING/NF-κB axis,tryptanthrin attenuates microglia-derived neuroinflammation and promotes functional recovery after spinal cord injury through shifting microglia polarization to the M2 phenotype.

关键词： cGAS/STING functional recovery microglia neuroinflammation neuroprotection nuclear factor-κB polarization spinal cord injury tryptanthrin

基于RIME-IAOA的混合模型短期光伏功率预测

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三峡大学学报（自然科学版） 2025年第1期47卷 81-88页

作者：王仁明魏逸明席磊三峡大学电气与新能源学院湖北宜昌443002

光伏发电在如今的新能源发展中逐渐成为重点,其中光伏功率预测成为研究的主要方向.为了提升光伏功率预测的精度和效率,提出了RIME-VMD-IAOA-LSTM模型.该模型通过霜冰优化算法(RIME)优化变分模态分解(VMD)的参数来提升分解效率;引入余弦... 详细信息

光伏发电在如今的新能源发展中逐渐成为重点,其中光伏功率预测成为研究的主要方向.为了提升光伏功率预测的精度和效率,提出了RIME-VMD-IAOA-LSTM模型.该模型通过霜冰优化算法(RIME)优化变分模态分解(VMD)的参数来提升分解效率;引入余弦控制因子的动态边界策略来控制算数优化算法(AOA)数值的增长速率从而提升算法的精度和稳定性;利用自适应T分布变异策略来改进AOA的局部搜索能力和全局开发能力,更好地避免局部最优解.两种智能优化算法的加入使得整体模型的预测效率和速度都有很大提升,实验结果表明组合模型RIMEVMD-IAOA-LSTM相比于其他预测模型有较高的光伏功率预测精度.

关键词：霜冰优化算法变分模态分解算术优化算法余弦控制因子策略自适应T分布策略短期光伏功率预测

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High-performance and multifunctional organic photovoltaic devices

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2024年第10期25卷 841-853页

作者： yiming WANG Lijian ZUO State Key Laboratory of Silicon Materials Department of Polymer Science and EngineeringZhejiang UniversityHangzhou 310027China Zhejiang University-Hangzhou Global Scientific and Technological Innovation Center Hangzhou 310014China

Organic photovoltaic devices(OPVs)are emerging as a promising renewable energy source for the *** unique advantages,such as semitransparency,light weight,superior flexibility,and low cost,enable a wide range of ***,compared to silicon-based photovoltaics,OPVs still face challenges for further improving their ***,there is a need to explore their potential of multi-functionality for practical application in various *** review summarizes the recent achievements in optimizing device performance and enhancing power-conversion efficiency,particularly via tuning the intermolecular interaction to reduce the electron-vibration coupling and non-radiative charge recombination(denoted as the“dilution effect”).Moreover,the representative development of ultra-thin Ag transparent electrode-based OPVs with multi-functional capabilities(such as semitransparency,flexibility,stretchability,and better aesthetics)has also been ***,this review aims to provide a broad landscape on the recent development of OPV and to unlock the full potential of OPVs.

关键词： Organic photovoltaic Multi-component Semitransparent Flexibility

Universal FRFT-based algorithm for parameter estimation of chirp signals

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Journal of Systems Engineering and Electronics 2012年第4期23卷 495-501页

作者： Rong Chen yiming Wang School of Electronics and Information Engineering Soochow UniversitySuzhou 215006P.R.China National Laboratory of Information Control Technology for Communication System Jiaxing 314001P.R.China

The realization of the parameter estimation of chirp signals using the fractional Fourier transform （FRFT） is based on the assumption that the sampling duration of practical observed signals would be equal to the time duration of chirp signals contained in the former. However, in many actual circumstances, this assumption seems unreasonable. On the basis of analyzing the practical signal form, this paper derives the estimation error of the existing parameter estimation method and then proposes a novel and universal parameter estimation algorithm. Furthermore, the proposed algorithm is developed which allows the estimation of the practical observed Gaussian windowed chirp signal. Simulation results show that the new algorithm works well.

关键词： fractional Fourier transform (FRFT) chirp signal,parameter estimation observation window.

Phase noise filtering and phase unwrapping method based on unscented Kalman filter

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Journal of Systems Engineering and Electronics 2011年第3期22卷 365-372页

作者： Xianming Xie yiming Pi School of Electronic Engineering University of Electronic Science and Technology of ChinaChengdu 611731P.R.China

This paper presents a new phase unwrapping algorithm based on the unscented Kalman filter（UKF） for synthetic aperture radar（SAR） *** method is the result of combining an UKF with path-following strategy and an omni-directional local phase slope *** technique performs simultaneously noise filtering and phase unwrapping along the high-quality region to the low-quality region,which is also able to avoid going directly through the noisy *** addition,phase slope is estimated directly from the sample frequency spectrum of the complex interferogram,by which the underestimation of phase slope is *** and real data processing results validate the effectiveness of the proposed method,and show a significant improvement with respect to the extended Kalman filtering（EKF） algorithm and some conventional phase unwrapping algorithms in some situations.

关键词： phase unwrapping unscented Kalman filter(UKF) path-following strategy.

A hexahedron element formulation with a new multi-resolution analysis

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Science China(Physics,Mechanics & Astronomy) 2015年第1期58卷 65-74页

作者： XIA yiming CHEN ShaoLin Civil Engineering Department Nanjing University of Aeronautics and Astronautics

A multiresolution hexahedron element is presented with a new multiresolution analysis(MRA)*** MRA framework is formulated out of a mutually nesting displacement subspace sequence,whose basis functions are constructed of scaling and shifting on element domain of a basic node shape *** basic node shape function is constructed from shifting to other seven quadrants around a specific node of a basic isoparametric element in one quadrant and joining the corresponding node shape functions of eight elements at the specific *** MRA endows the proposed element with the resolution level(RL)to adjust structural analysis *** a result,the traditional 8-node hexahedron element is a monoresolution one and also a special case of the proposed *** meshing for the monoresolution finite element model is based on the empiricism while the RL adjusting for the multiresolution is laid on the solid mathematical *** simplicity and clarity of shape function construction with the Kronecker delta property and the rational MRA enable the proposed element method to be more rational,easier and efficient in its implementation than the conventional mono-resolution solid element method or other MRA *** multiresolution hexahedron element method is more adapted to dealing with the accurate computation of structural problems.

关键词： hexahedron element multiresolution analysis (MRA) resolution level (RL) basic node shape function mutually nesting displacement subspace sequence scaling and shifting

Analysis of energy release rate for composite delaminated cylindrical shells subjected to axial compression

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Acta Mechanica Sinica 2006年第6期22卷 537-546页

作者： Jinhua Yang yiming Fu Department of Engineering Mechanics Hunan University Changsha 410082 China

In this paper, the postbuckling governing equations and the analytical expression of the energy release rates associated with delamination growth in a compression-loaded cylindrical shell are derived by using the variational principle of moving boundary and the Griffith fracture criterion. The finite difference method is used to generate the postbuckling solutions of the delaminated cylindrical shells, and with these solutions, the values of the energy release rates are determined. In simulational examples, the effects of a wide range of parameters, such as delamination sizes and depths, boundary conditions, geometrical parameters, material properties and laminate stacking sequences on the energy release rates of axisymmetrical laminated cylindrical shells are intensively discussed.

关键词： Composite cylindrical shell Delamination Griffith criterion Energy release rates Finite difference method