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The efficacy and safety of pramipexole ER versus IR in Chinese patients with Parkinson’s disease: a randomized, double-blind, double-dummy, parallel-group study

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Translational Neurodegeneration 2014年第1期3卷 80-88页

作者： Ying Wang Shenggang Sun Suiqiang Zhu Chunfeng liu yiming liu Qing Di Huifang Shang Yan Ren Changhong Lu Mark Forrest Gordon Nolwenn Juhel Shengdi Chen for the Pramipexole ER Study Team Ruijin Hospital affiliated to Shanghai Jiao Tong University School of Medicine ShanghaiChina Union Hospital affiliated to Tongji Medical College of Huazhong University of Science and Technology WuhanChina Tongji Hospital affiliated to Tongji Medical College of Huazhong University of Science and Technology WuhanChina The Second Affiliated Hospital of Soochow University SuzhouChina Qilu Hospital affiliated to Shandong University JinanChina Nanjing Brain Hospital NanjingChina West China Hospital affiliated to Sichuan University ChengduChina First Affiliated Hospital of China Medical University ShenyangChina Boehringer Ingelheim International Trading(Shanghai)Co LtdShanghaiChina Boehringer Ingelheim Pharmaceuticals IncRidgefieldCTUSA Boehringer Ingelheim France S.A.S ReimsFrance Department of Neurology Ruijin Hospital affiliated to Shanghai Jiaotong University School of MedicineShanghaiChina 不详

Objective:To evaluate the non-inferiority of pramipexole extended-release(ER)versus immediate-release(IR)in Chinese patients with Parkinson’s disease(PD)in a double-blind,randomized,parallel-group ***:Subjects were Chinese patients with idiopathic PD with diagnosis≥2 years prior to trial,age≥30 years old at diagnosis,and Modified Hoehn and Yahr score 2-4 during‘on’-*** received treatment with pramipexole ER(n=234)or IR(n=239).Non-inferiority was based on the primary endpoint,the change from baseline to end of maintenance(week 18)in the UPDRS(Parts II+III)total ***:For the primary endpoint,the adjusted mean changes(standard error)of UPDRS Parts II+III at week 18 were−13.81(0.655)and−13.05(0.643)for ER and IR formulations,respectively,using ANCOVA adjusted for treatment and centre(fixed effect)and baseline(covariate).The adjusted mean between group difference was 0.8 for the 2-sided 95%CI(−1.047,2.566).Since the lower limit of the 2-sided 95%CI(−1.047)for treatment difference was higher than the non-inferiority margin of−4,non-inferiority between pramipexole ER and IR was *** incidence of adverse events(AEs)was 68.8%in the ER arm and 73.6%in the IR arm with few severe AEs(ER:2.1%;IR:3.8%).Conclusion:Based on the UPDRS II+III score,pramipexole ER was non-inferior to pramipexole *** safety profiles of pramipexole ER and IR were *** results were based on comparable mean daily doses and durations of treatment for both formulations.

关键词： Parkinson’s disease Pramipexole ER Pramipexole IR Non-inferiority Unified Parkinson’s Disease Rating Scale(UPDRS) Safety

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Forest fire monitoring, detection and decision making systems by wireless sensor network

Forest fire monitoring, detection and decision making system...

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第30届中国控制与决策会议

作者： YongMin liu yiming liu HongLei Xu Kok Lay Teo School of Computer and Information Engineering Central South University of Forestry and Technology Department of Mathematics and Statistics School of Science Curtin University

Wireless Sensor Networks（WSNs） can be used for many applications, such as industrial automatic control, remote environmental monitoring and target tracking. The similar system is promising applications in forest fires can make a real-time monitoring and detection. Wireless sensor network consists of numerous small nodes in most situations, which small nodes are deployed in remote and inaccessible hostile environments or over large geographical areas. The large number of small nodes sense environmental changes and report them to cluster head node over network architect, which the deployment and maintenance should be easy and scalable. A new approach for forest fire monitoring and detection was present in this paper, which it is by using data aggregation in wireless sensor network. The proposed approach can provide faster and efficiently reaction to forest fires while consuming economically WSN’s energy, which has been validated and evaluated in extensive simulation experiments.

关键词： Forest fire wireless sensor network data aggregation decision making

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A Study on Remediation Technologies for Cadmium Contamination in Greenhouse Vegetable Fields

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Agricultural Biotechnology 2021年第1期10卷 59-64页

作者： Xueping SHI Huiwei ZHAO yiming liu Wei liu Chenghai ZHENG Chuan LU Lifang ZHAI National Semi-arid Agriculture Engineering and Technology Research Center Shijiazhuang 050051China College of Chemistry and Environmental Science Hebei UniversityBaoding 071002China

Based on the literature and experimental results, three kinds of amendments, namely, rice biochar, hydroxyapatite and potassium dihydrogen phosphate(KH2PO4), and deeper ploughing were selected to evaluate the field application effect of soil amendments and agronomic measures on the remediation of Cd contamination in greenhouses. Cd-contaminated greenhouse screening was conducted from 2015 to 2017. In September 2017, comparative tests of eight treatments were performed in September 2017, and a selective test was performed in September 2018. The results of the screening of contaminated areas indicated that the distributions of over-standard sites and Cd content were significantly different. Greenhouse No. 4, in which the highest over-standard rate was 83.33% and the average content of Cd in soil was 0.535 mg/kg, was used as a comparative test experimental site for eight treatments. Greenhouse No. 1 was selected as the optimum test greenhouse for selective testing, with three plots having average Cd concentrations of 0.530, 0.568 and 0.792 mg/kg. The 8 months following comparative treatment showed that the content of available Cd following the treatment of rice biochar+hydroxyapatite+deeper ploughing(treatment T6) was reduced by 32.55% and 24.96% compared with the CK(the control) and 2 months following treatment, respectively. The content of available Cd using rice biochar+KH2PO4+deeper ploughing(treatment T7) treatment decreased by 47.88% and 31.00% compared with the CK and 2 months following treatment. The selective test results showed that in rice biochar+hydroxyapatite+deeper ploughing: the total Cd content of decreased from 0.489 to 0.372 mg/kg(23.86% lower), compared with the CK, and the mean content of available Cd decreased by 10.71% after 8 months, which was the lowest available Cd measured(0.133 mg/kg). In addition, the bean plant Cd content, bioconcentration factor(BCF) and translocation coefficient(TF) decreased by 15.86%, 23.68% and 25.77%, respectively. R

关键词： Facility vegetable fields Cd Contaminant remediation Technical study

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基于多区块链结构的综合能源系统调度构架

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电力系统自动化 2021年第23期45卷 12-20页

作者：黄伟左欣雅刘弋铭华北电力大学电气与电子工程学院北京市102206 国网内蒙古东部电力有限公司呼伦贝尔供电公司内蒙古自治区呼伦贝尔市021100

综合能源系统(IES)调度中存在难以维护供能主体隐私、难以辨别数据真伪、安全性和可靠性低等问题。文中利用分散式调度方法和区块链中分布式数据存储、智能合约、共识机制、多链扩容和加密技术,提出了包括迭代链、终值链以及数据层、网... 详细信息

综合能源系统(IES)调度中存在难以维护供能主体隐私、难以辨别数据真伪、安全性和可靠性低等问题。文中利用分散式调度方法和区块链中分布式数据存储、智能合约、共识机制、多链扩容和加密技术,提出了包括迭代链、终值链以及数据层、网络层、合约层、共识层、应用层的IES调度构架。该构架以数据层为基础,采用无向联通结构建立主体间的通信网络;在合约层封装基于拉格朗日乘子法的分散式调度模型;在共识层,针对分散式调度的数据一致性,迭代链和终值链分别应用一致性协议算法和拜占庭容错共识机制。算例验证结果表明,所提IES调度构架基于少量通信数据可有效运行,能够防止主体背叛、削弱服务器宕机的影响,提高了IES调度的隐私性、安全性和可靠性。

关键词：综合能源系统分散式调度区块链多链扩容一致性协议拜占庭容错共识机制

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Research on the Sustainable Development of Agriculture

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Asian Agricultural Research 2019年第7期11卷 19-23页

作者： yiming liu Xinyu WANG Chuan LU Zhimin WEI Wei LU National Engineering Research Center of Semi-arid Agriculture Shijiazhuang 050000 China Institute of Millet Crops Hebei Academy of Agriculture and Forestry Sciences Shijiazhuang 050035 China Cereal Crops Research Laboratory of Hebei Province Shijiazhuang 050035 China National Foxtail Millet Improvement Center Shijiazhuang 050035 China

Based on the background of sustainable development of agriculture, its concepts and characteristics were analyzed, and the present situation of research on the sustainable development of agriculture at home and abroad was studied. Furthermore, some measures to promote the sustainable development of agriculture in China were proposed.

关键词： Modern agriculture Sustainable development

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高寒地区典型办公建筑南向组合式外窗热工设计优化

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清华大学学报（自然科学版） 2023年第11期63卷 1878-1886页

作者：刘依明许沛琪刘念雄清华大学建筑学院北京100084

为提升西藏高寒地区办公建筑的节能效果与室内使用品质,针对日喀则市某典型办公楼进行分析。借助DesignBuilder软件,对采用9种不同形式南向外窗设计的建筑案例进行建筑负荷、主要房间操作温度及热舒适的全年逐时模拟。该研究分析了各案... 详细信息

为提升西藏高寒地区办公建筑的节能效果与室内使用品质,针对日喀则市某典型办公楼进行分析。借助DesignBuilder软件,对采用9种不同形式南向外窗设计的建筑案例进行建筑负荷、主要房间操作温度及热舒适的全年逐时模拟。该研究分析了各案例的性能差异,结果表明:断热桥铝合金6 mm单玻幕墙、 6 mm透明+12 mm空气+6 mm透明的中空双层窗以及保温窗帘构成的组合式外窗,能够显著降低办公楼全年负荷,并提升主要房间的室内热舒适,可作为西藏高寒地区办公建筑南向外窗设计的优先选择。

关键词：高寒地区组合式外窗太阳得热系数建筑负荷逐时操作温度热舒适

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Analysis of Summertime Typical Pollution in Pearl River Delta Region——Numerical Simulation of Meteorological Field

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Meteorological and Environmental Research 2014年第4期5卷 9-18页

作者： Zhang Xiaochen liu yiming Deng Xuejiao Chen Pakwai Feng Yerong Fan Qi Department of Atmospheric Science School of Environmental Science and EngineeringSun Yat-Sen University Guangzhou Institute of Tropical Marine Meteorology China Meteorological Administration The Hong Kong Observatory Guangdong Key Laboratory of Regional Numerical Forecast

Based on meteorological field and air quality observation data, air pollution process over Pearl River Delta （PRD） in August of 2012 was analyzed. There were five notable pollution processes in this month, in which four pollution processes were related to typhoon. By using meso-scale meteorological model WRF, meteorological characteristics of two pollution processes induced by tropical cyclone were contrasted and analyzed. Results showed that O9 and PMTo concentrations significantly increased in PRD region during Typhoon Haikui period （7 -8 August）, and other pollutant concentrations were also high. However, 03 and PM10 concentrations did not significantly increase during Typhoon Kai-Tak period （16 -17 August）. This kind of concentration difference between two processes was related to typhoon pathway, wind direction and velocity, atmospheric boundary layer height, vertical transport and horizontal divergence field.

关键词： PRD region Pollution characteristics Tropical cyclone WRF model China

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基于长短期记忆神经网络的船体及螺旋桨性能退化评估

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中国造船 2023年第4期64卷 207-218页

作者：刘易明刘伊凡王旭沃金金宁波大学海运学院宁波315832 中电科(宁波)海洋电子研究院宁波315000

采用线性插值和时空插值构建包含气象、航行性能和机舱信息的船舶综合数据库,经统计分析筛选出9个输入变量,基于长短期记忆神经网络建立航速预测模型,获得由预测航速与实测值的残差描述的船体及螺旋桨性能退化的特征参数,建立以航速残... 详细信息

采用线性插值和时空插值构建包含气象、航行性能和机舱信息的船舶综合数据库,经统计分析筛选出9个输入变量,基于长短期记忆神经网络建立航速预测模型,获得由预测航速与实测值的残差描述的船体及螺旋桨性能退化的特征参数,建立以航速残差的时间序列为路径的船体及螺旋桨性能退化评估方法。基于某30万吨散货船一年的航行数据进行性能退化评估,航速预测结果的均方误差为0.01,目标船的性能退化路径具有时间相关性和单调变化的趋势。

关键词：健康管理船体和螺旋桨性能退化长短期记忆神经网络

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个人数据主体收益权的理论迷思与制度选择

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学习与实践 2024年第8期 21-31页

作者：袁康刘羿鸣武汉大学法学院湖北武汉430072 武汉大学国家网络安全学院湖北武汉430072

是否应以法定形式明确个人数据主体收益权,当前在理论界存在较大分歧。个人数据在数据价值链中的价值倍增,主要得益于数据处理者而非个人的投入,其体量上的规模性和分布上的碎片化决定了向个人分配收益存在经济性缺失,即设置个人数据主... 详细信息

是否应以法定形式明确个人数据主体收益权,当前在理论界存在较大分歧。个人数据在数据价值链中的价值倍增,主要得益于数据处理者而非个人的投入,其体量上的规模性和分布上的碎片化决定了向个人分配收益存在经济性缺失,即设置个人数据主体收益权缺乏正当性和合理性基础。立法应对个人数据主体收益权采取“原则否定,约定例外”的态度,在个人数据价值的初次分配中放弃个人的法定收益权,但允许其以约定方式取得经济利益。同时,在保障个人数据主体在先权益的前提下,探索数据服务税、数据基金等集体利益实现机制,以体现个人在数据价值分配中的应有地位。

关键词：个人数据主体收益权成本-收益分析在先权益

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Homogeneous permeation and oriented crystallization in nanostructured mesopores for efficient and stable printable mesoscopic perovskite solar cells

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Science China Chemistry 2024年第11期67卷 3688-3696页

作者： Guodong Zhang Yanjie Cheng Tingting Niu Ziwei Zheng Zongwei Li Junwei Xiang Qiaojiao Gao Minghao Xia Lijuan Guo yiming liu Mengru Zhang Yiran Tao Xueqin Ran Mingjie Li Guichuan Xing Yingdong Xia Lingfeng Chao Anyi Mei Hongwei Han Yonghua Chen Key Laboratory of Flexible Electronics(KLoFE)and Institute of Advanced Materials(IAM) School of Flexible Electronics(Future Technologies)Nanjing Tech UniversityNanjing 211816China Michael Grätzel Center for Mesoscopic Solar Cells Wuhan National Laboratory for OptoelectronicsKey Laboratory of Materials Chemistry for Energy Conversion and Storage of Ministry of EducationHuazhong University of Science and TechnologyWuhan 430074China Department of Physics The Chinese University of Hong KongNew TerritoriesHong Kong SAR 999077China Department of Applied Physics The Hong Kong Polytechnic UniversityKowloon 999077China Shenzhen Research Institute The Hong Kong Polytechnic UniversityShenzhen 518057China Joint Key Laboratory of the Ministry of Education Institute of Applied Physics and Materials EngineeringUniversity of MacaoAvenida da UniversidadeTaipa 999078China

The low-cost and scalable printable mesoporous perovskite solar cells(p-MPSCs) face significant challenges in regulating perovskite crystal growth due to their nanoscale mesoporous scaffold structure, which limits the improvement of device power conversion efficiency(PCE). In particular, the most commonly used solvents, N,N-dimethylformamide(DMF) and dimethyl sulfoxide(DMSO), have a single chemical interaction with the precursor components and high volatility, which is insufficient to self-regulate the perovskite crystallization process, leading to explosive nucleation and limited growth within mesoporous scaffolds. Here, we report a mixed solvent system composed of methylamine formaldehyde(MAFa)-based ionic liquid and acetonitrile(ACN) with the strong C=O–Pb coordination and N–H···I hydrogen bonding with perovskite components. We found that the mixed solvent system is beneficial for the precursor solution to homogeneously penetrate into the mesoporous scaffold,and the strong C=O–Pb coordination and N–H···I hydrogen bonding interaction can promote the oriented growth of perovskite crystals. This synergistic effect increased the PCE of the p-MPSCs from 17.50% to 19.21%, which is one of the highest records for p-MPSC in recent years. Additionally, the devices exhibit positive environmental stability, retaining over 90% of the original PCE after 1,200 h of aging under AM 1.5 illumination conditions at 55 ℃ and 55% humidity.

关键词： printable mesoscopic perovskite solar cells ionic liquid crytallization control hight efficiency and stability

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