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Effect of plateletcrit and methylenetetrahydrofolate reductase(MTHFR)C677T genotypes on folic acid efficacy in stroke prevention

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Signal Transduction and Targeted Therapy 2024年第6期9卷 2694-2701页

作者： Yuncong Shi Zhengzhipeng Zhang Binyan wang Yu wang Xiangyi Kong Yong Sun Aimin Li yimin Cui Yan Zhang Jianping Li Yong Huo Hui Huang Cardiovascular Department The Eighth Affiliated HospitalJoint Laboratory of Guangdong-Hong Kong-Macao Universities for Nutritional Metabolism and Precise Prevention and Control of Major Chronic DiseasesSun Yat-sen UniversityShenzhenChina Shenzhen Evergreen Medical Institute ShenzhenChina Shenzhen Tailored Medical Laboratory ShenzhenChina Department of Cardiology Beijing Anzhen HospitalCapital Medical UniversityBeijingChina Department of Neurosurgery The First Affiliated Hospital of Kangda College of Nanjing Medical UniversityLianyungangChina Institute of Clinical Pharmacology Peking University First HospitalBeijingChina Department of Cardiology Peking University First HospitalBeijingChina

Previous studies have shown that low platelet count combined with high plasma total homocysteine(tHcy)increased stroke risk and can be lowered by 73% with folic ***,the combined role of other platelet activation parameters and the methylenetetrahydrofolate reductase(MTHFR)C677T genotypes on stroke risk and folic acid treatment benefit remain to be *** study aimed to investigate if platelet activation parameters and MTHFR genotypes jointly impact folic acid treatment efficacy in first stroke *** were derived from the China Stroke Primary Prevention *** study includes a total of 11,185 adult hypertensive patients with relevant platelet activation parameters and MTHFR genotype *** simultaneously considering both platelet activation parameters(plateletcrit,platelet count,mean platelet volume,platelet distribution width)and MTHFR genotypes,patients with both low plateletcrit(Q1)and the TT genotype had the highest stroke incidence rate(5.6%)in the enalapril *** subgroup significantly benefited from folic acid treatment,with a 66% reduction in first stroke(HR:0.34;95%CI:0.14-0.82;p=0.016).Consistently,the subgroup with low plateletcrit(Q1)and the CC/CT genotype also benefited from folic acid treatment(HR:0.40;95%CI:0.23-0.70;p=0.001).In Chinese hypertensive adults,low plateletcrit can identify those who may greatly benefit from folic acid treatment,in particular,those with the TT genotype,a subpopulation known to have the highest stroke risk.

关键词： prevention treatment MTHFR

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Extreme Enrichment of Tellurium in Deep-Sea Sediments

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Acta Geologica Sinica(English Edition) 2005年第4期79卷 547-551页

作者： LI Yanhe wang yimin SONG Hebin YUE Guoliang Laboratory of Isotope Geology Ministry of Land and Resources Beijing 100037 Institute of Mineral Resources Chinese Academy of Geological Sciences Beijing 100037 National Geoanalysis Center Beijing 100037

Tellurium is a sort of scattered rare element on the earth. Its concentration is very low in earth＇s crust, only 1.0 ng/g. However, it has extremely high abundance in Co-rich crusts, marine polymetallic nodules, deep-sea sediments and aerolites. To find out the origin of tellurium enrichment in deep-sea sediments, we analyzed and compared tellurium concentrations and helium isotope compositions in the magnetic parts and those in the bulk parts of deep-sea sediments. The result indicates that the helium content, 3He/4He ratio and tellurium concentration are obviously higher in the magnetic parts than those in the bulk parts. The 3He abundance varies synchronously with the tellurium concentration. 3He and Te have a distinct positive correlation with each other. It is the first time that the paper brings forward that the extreme enrichment of tellurium in deep-sea sediments, like helium isotope anomalies, probably results from the input of interplanetary dust particles （IDPs）. Similarly, the extreme enrichment of tellurium in marine polymetallic nodules and Co-rich crusts is possibly related to IDPs.

关键词： deep-sea sediments extreme enrichment of tellurium helium isotope interplanetary dust particles

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Sudden cardiac arrest in a patient with epilepsy induced by chronic inflammation on the cerebral surface

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Neural Regeneration Research 2012年第6期7卷 470-474页

作者： Yuxi Liu Weicheng Hao Xiaoming Yang yimin wang Yu Su Institutes of Epilepsy Shanxi Medical University Taiyuan 030001 Shanxi Province China

The present study analyzed a patient with epilepsy due to chronic inflammation on the cerebral surface underwent sudden cardiac arrest. Paradoxical brain discharge, which occurred prior to epileptic seizures, induced a sudden cardiac arrest. However, when the focal brain pressure was relieved, cardiac arrest disappeared. A 27-year-old male patient underwent pre-surgical ram monitoring for 160 hours. During monitoring, secondary tonic-clonic seizures occurred five times. A burst of paradoxical brain discharges occurred at 2-19 seconds （mean 8 seconds） prior to epileptic seizures. After 2-3 seconds, sudden cardiac arrest occurred and lasted for 12-22 seconds （average 16 seconds）. The heart rate subsequently returned to a normal rate. Results revealed arachnoid pachymenia and adhesions, as well as mucus on the focal cerebral surface, combined with poor circulation and increased pressure, lntracranial electrodes were placed using surgical methods. Following removal of the arachnoid adhesions and mucus on the local cerebral surface, paradoxical brain discharge and epileptic seizures occurred three times, but sudden cardiac arrest was not recorded during 150-hour monitoring. Post-surgical histological examination indicated meningitis. Experimental findings suggested that paradoxical brain discharge led to cardiac arrest instead of epileptic seizures; the insult was associated with chronic inflammation on the cerebral surface, which subsequently led to hypertension and poor blood circulation in focal cerebral areas.

关键词： chronic inflammation epilepsy sudden cardiac arrest sudden death video-electroencephalogram

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A Large-Scale Online Survey on Clinical Severity and Associated Risk Factors for SARS-CoV-2 Omicron Infection — China, April–May 2023

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China CDC weekly 2024年第15期6卷 305-311,I0001-I0004页

作者： Yanxia Sun Yuping Duan Jie Qian yimin Qu Ye wang Guohui Fan Qiangru Huang Zhongjie Li Weizhong Yang Luzhao Feng State Key Laboratory of Respiratory Health and Multimorbidity Key Laboratory of Pathogen Infection Prevention and ControlMinistry of EducationSchool of Population Medicine and Public HealthChinese Academy of Medical Science&Peking Union Medical CollegeBeijingChina

What is already known about this topic?Individuals who initially contract severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)lack significant mixed ***,it is crucial to monitor the clinical characteristics and associated factors of these individuals in order to inform *** is added by this report?The common symptoms reported were fever,cough,and sore *** and receiving four vaccination doses within a 6-month period were found to be associated with a shorter duration of virus shedding,decreased hospitalization rate,and reduced risk of *** aged 60 years and older,as well as those with underlying medical conditions,had a higher risk of developing *** are the implication for public health practices?Online surveys conducted through social media platforms have the potential to complement disease surveillance and data collection *** terms of vaccination prioritization,it is recommended to prioritize older individuals and those with underlying diseases.

关键词： doses Online initially

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Degradation of iopamidol in the permanganate/sulfite process:Evolution of iodine species and effect on the subsequent formation of disinfection by-products

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Journal of Environmental Sciences 2024年第1期135卷 345-352页

作者： yimin Lin Hongyu Dong Yating Zhu Gongming Zhou Junlian Qiao Xiaohong Guan State Key Laboratory of Pollution Control and Resources Reuse College of Environmental Science and EngineeringTongji UniversityShanghai 200092China Department of Environmental Science School of Ecological and Environmental SciencesEast China Normal UniversityShanghai 200241China

Permanganate/sulfite(Mn(VII)/S(IV))process is a promising pre-oxidation technology for sequestering the emerging organic contaminants in drinking water treatment ***(IPM),a representative of iodinated X-ray contrast media,has been widely detected in water sources and has the risk of forming iodinated disinfection byproducts(I-DBPs)in water treatment *** this study,we investigated the evolution of iodine species during the IPM degradation by the Mn(VII)/S(IV)process and its effect on the subsequent formation of I-DBPs during chlorination at pH 7.0 and *** could be effectively degraded in the Mn(VII)/S(IV)process at environmentally relevant pH(pH 7.0 and 8.0).The results of quenching and competitive oxidation kinetic experiments revealed that SO^(·-)_(4)was the major reactive oxidizing species contributing to the degradation of IPM whereas the contributions of HO·and reactive manganese species were negligible in the Mn(VII)/S(IV)process.I–and IO–3were generated while no HOI was detected during the degradation of IPM in the Mn(VII)/S(IV)*** effects of IPM oxidation by Mn(VII)/S(IV)on the subsequent formation of chlorinated disinfection by-products(Cl-DBPs)during chlorination were related to the category of *** pre-oxidation of IPM by Mn(VII)/S(IV)resulted in the generation of I-DBPs during the disinfection process although no I-DBPs were detected if no pre-oxidation was *** finding of this study suggested that attention should be paid to the toxicity of DBPs when water containing iodinated organic contaminants is treated by Mn(VII)/S(IV)process or other pre-oxidation technologies.

关键词： Permanganate/sulfite Iopamidol Sulfate radical Iodinated disinfection byproducts Pre-oxidation

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某126 kV GIS运行中产生振动异响的分析和解决方案

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高压电器 2023年第7期59卷 200-206页

作者：王益民上海西电高压开关有限公司上海201700

随着GIS在中国电网中的普遍应用,变电站现场出现了较多的GIS振动异响现象。振动异响现象往往由装配不良、局部放电等原因所引起。此外,还有一种振动异响会随着GIS不同的运行状态而时强时弱地变化。文中对出现这种振动异响的某126 kV GI... 详细信息

随着GIS在中国电网中的普遍应用,变电站现场出现了较多的GIS振动异响现象。振动异响现象往往由装配不良、局部放电等原因所引起。此外,还有一种振动异响会随着GIS不同的运行状态而时强时弱地变化。文中对出现这种振动异响的某126 kV GIS进行了壳体振动频率、加速度的现场测量,计算了母线壳体和母线导体的固有频率,对产生原因进行了分析,并提出了简便易行的解决方案。

关键词： GIS 振动异响固有频率共振解决方案

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Polymeric ionic liquid—assisted polymerization for soluble polyaniline nanofibers

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Frontiers of Chemical Science and Engineering 2021年第1期15卷 118-126页

作者： Jie Liu Jiahao Shen Jingjing wang Yuan Liang Routeng Wu Wenwen Zhang Delin Shi Saixiang Shi Yanping wang yimin wang Yumin Xia Key Laboratory of High Performance Fibers&Products(Ministry of Education) State Key Laboratory for Modification of Chemical Fibers and Polymer MaterialsCollege of ScienceCollege of Materials Science and EngineeringDonghua UniversityShanghai 201620China Hunan Changsha Aiwanting Home Texitle Products Co.Ltd Changsha 410600China

To enhance the solubility of polyanilines(PANI),polymeric ionic liquid(PIL)was introduced into the polymerization synthesis of PANI with various *** structure and properties of the modified PANIs were characterized by 1H NMR,Fourier transform infrared spectroscopy,thermogravimetric analysis,ultraviolet-visible spectrum,*** was found that the obtained PANIs doped with PILs were soluble in various organic solvents such as N,N-dimethyl formamide and *** with the pure PANI,the PANIs doped by PILs showed remarkable solubility and their chemical structure and conductivity kept integrated.

关键词： polyaniline polymeric ionic liquid doping solubility

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Elegant Reminders

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China Weekly 2024年第9期 56-59页

作者： Song yimin wang Zhiwei 不详

A testament to his political achievements,Han Qi's stone stele embodies literary and artistic *** in his personal study,the monument has evolved into an inspiring sanctuary for future generations of literati Thesecond... 详细信息

关键词： significance. literary political

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Music Interesting Chimes

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China Weekly 2024年第7期 53-55页

作者： Song yimin wang Zhiwei 不详

A set of bronze chimes from more than 2,400 years ago reveals new aspects of ancient Chinese music,unexpectedly retuning our understanding of global music history.

关键词： tuning bronze Music

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Paleoenvironmental implications of high-density records in Co-rich seamount crusts from the Pacific Ocean

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Science China Earth Sciences 2008年第10期51卷 1460-1469页

作者： wang XiaoHong ZHOU LiPing wang yimin ZHANG XueHua LIU XiaoMing FAN XingTao LIU KeXin ZHOU JianXiong Ministry of Education Key Laboratory for Earth Surface Processes Department of GeographyPeking UniversityBeijing 100871China National Research Center for Geoanalysis Beijing 100037China Guangzhou Marine Geological Survey Guangzhou 510760China The Key Laboratory of Continental Dynamics Northwest UniversityXi’an 710069China The Key Laboratory of Heavy Ion Physics Ministry of EducationPeking UniversityBeijing 100871China Institute of Mineral Resources Chinese Academy of Geological SciencesBeijing 100037China

Co-rich seamount crusts have been shown to possess great potential for providing information on paleoceanographic and paleoclimatic changes. High resolution data are essential to decipher and correctly understand such high-density records. With the development of modern microprobe techniques, detailed sampling of crusts can be performed and it is possible to retrieve detailed information about envi- ronmental changes recorded in the seamount crusts. We report here geochemical results of more than 40 elements (including all rare earth elements) of four Co-rich seamount crust samples, which were collected from seamounts in the central and western Pacific Ocean. These data were obtained with two micro-probe techniques: Electron Probe Micro Analyzer and Laser Ablation Inductively Coupled Plasma Mass Spectrometry. The chronological framework of the seamount crust samples was determined using the cos- mogenic 10Be and the Co-chronometer. Records of elemental composition, P, and Al/(Fe + Mn) and Y/Ho ratios across the sections of the four samples are used to identify paleoceanographic and paleoclimatic events over the past ~30 Ma. These data show that: (1) Al/(Fe + Mn) in the western Pacific seamount crust is a useful proxy for the assessment of changes of source materials related to the variability of the Asian monsoon; (2) P and Y/Ho can be used as proxies to infer biogenic episodes. Finally we discuss the methodology related to dating and micro-probe analysis used in crust study.

关键词： Co-rich seamount crust micro-probe chronology geochemical record paleo-oceanic environment

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