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Artificial“honeycomb-honey”decorated with non-noble plasmonic nanoparticles for superior solar capture and thermal energy storage

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Nano Research 2022年第9期15卷 8065-8075页

作者： Haolei Wang Xianglei liu Qingyang Luo Haichen Yao Qiao Xu Yang Tian Jianguo Wang yimin Xuan School of Energy and Power Engineering Nanjing University of Aeronautics and AstronauticsNanjing 210016China Key Laboratory of Thermal Management and Energy Utilization of Aviation Vehicles Ministry of Industry and Information TechnologyNanjing 210016China

Phase change materials(PCMs)are popular solutions to tackle the unbalance of thermal energy supply and demand,but suffer from low thermal conductivity and leakage problems.Inspired by how honeybees store honey,we propose artificial“honeycombhoney”for excellent solar and thermal energy storage capacity based on TiN nanoparticles decorated porous AlN skeletonsPCMs composites.The thermal conductivity of composites achieves 21.58 W/(m·K)at AlN loading of 20 vol.%,superior to the state-of-the-art ceramic-based composites.The charging/discharging time is reduced to about half of pure PCMs with shapestability and thermal reliability well maintained over 500 melting/freezing cycles.The underlying mechanism can be attributed to the combination of single-crystal AlN whiskers with few crystal defects and reduced phonon scattering,as well as vertically arranged three-dimantional(3D)heat conduction channels.A rapid and efficient solar thermal storage is also demonstrated with solar thermal storage efficiency achieving a high value of 92.9%without employing additional spectrum selective coatings.This is benefited from high thermal conductivity and full-spectrum solar absorptance of up to 95%induced by plasmonic resonances of TiN nanoparticles.In addition,by embedding LiNO3-NaCl eutectics,the phase change enthalpy of composites reaches as high as 208 kJ/kg,making high energy storage density and fast energy storage rate compatible.This work offers new routes to achieve rapid,efficient,stable,and compact solar capture and thermal energy storage.

关键词： thermal energy storage shape-stability honeycomb thermal conductivity solar thermal conversion

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灰毡毛忍冬花器官发育相关LmSOC1基因克隆及表达分析

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中南林业科技大学学报 2024年第5期44卷 181-190页

作者：龙丽君马英姿曾慧杰李昌珠张岗刘思思李依民湖南省林业科学院经济林研究所湖南长沙410004 中南林业科技大学生命科学与技术学院湖南长沙410004 陕西中医药大学陕西省中医药管理局“秦药”研发重点实验室陕西西安712046 陕西中医药大学省部共建特色秦药资源研究开发国家重点实验室(培育)陕西咸阳712083

【目的】克隆灰毡毛忍冬MADS-box家族基因SOC1(SUPPRESSOR OF OVEREXPRESSION OF CO1),对其进行生物信息学和表达模式分析,为探究灰毡毛忍冬花冠不开放机制奠定理论基础。【方法】基于花蕾型灰毡毛忍冬转录组数据,筛选到开花调控基因LmS... 详细信息

【目的】克隆灰毡毛忍冬MADS-box家族基因SOC1(SUPPRESSOR OF OVEREXPRESSION OF CO1),对其进行生物信息学和表达模式分析,为探究灰毡毛忍冬花冠不开放机制奠定理论基础。【方法】基于花蕾型灰毡毛忍冬转录组数据,筛选到开花调控基因LmSOC1的Unigene序列并克隆全长cDNA序列,通过生物信息学分析和实时荧光定量PCR技术分析编码蛋白特性和不同品种中LmSOC1基因的表达特异性,最后将LmSOC1基因插入到原核表达质粒载体pTOPO-D1中,并在表达宿主BL21(DE3)中进行蛋白表达。【结果】LmSOC1基因包含645bp的ORF区,LmSOC1蛋白不含信号肽、无跨膜区,为稳定的亲水性蛋白。系统进化树分析表明,LmSOC1蛋白与黄花蒿、榴莲、可可等的SOC1蛋白亲缘关系更近。实时荧光定量PCR分析表明,在2个花蕾型灰毡毛忍冬品种的花蕾和叶片中均检测到LmSOC1基因的表达,而叶片中表达量明显高于花蕾。同时,在早期花蕾中LmSOC1基因的表达量高于晚期花蕾,在‘金翠蕾’品种中这一表达差异极显著(P<0.01)。最后成功在大肠杆菌BL21(DE3)中表达出重组蛋白。【结论】通过对LmSOC1基因的克隆和表达分析发现,该基因可能在灰毡毛忍冬花器官发育过程中发挥重要作用,为进一步研究该基因在植物花发育中的生物学功能奠定了基础。

关键词：灰毡毛忍冬 MADS-box LmSOC1 基因克隆表达分析原核表达

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Identification of differentially expressed genes and signaling pathways in neutrophils during sepsis-induced immunosuppression via bioinformatics analysis

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Chinese Medical Journal 2022年第17期135卷 2131-2133页

作者： Yongxin Zheng Zhihui Zhang Yongbo Huang Jinping Wang Ling Sang Yonghao Xu Xiaoqing liu yimin Li Department of Pulmonary and Critical Care Medicine State Key Laboratory of Respiratory DiseasesGuangzhou Institute of Respiratory HealthThe First Affiliated Hospital of Guangzhou Medical UniversityGuangzhouGuangdong 510000China Department of Cardiovascular Medicine The First Affiliated Hospital of Guangzhou Medical UniversityGuangzhouGuangdong 510000China

To the Editor:Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to infection.Sepsis deeply perturbs immune homeostasis,and impairs innate and adaptive immunity by directly altering ... 详细信息

关键词： homeostasis immunity analysis

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Interface engineering of FeCo LDH@NiCoP nanowire heterostructures for highly efficient and stable overall water splitting

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Chinese Chemical Letters 2022年第8期33卷 4003-4007页

作者： Yong Jiang Yurong Li yimin Jiang Xiaorui liu Wei Shen Ming Li Rongxing He College of Chemistry and Chemical Engineering Southwest UniversityChongqing 400715China

Developing efficient and inexpensive OER electrocatalysts is a challenge for overall water splitting.Herein,the heterostructured Fe Co LDH@NiCoP/NF nanowire arrays with high performance were rationally designed and prepared using an interface engineering strategy.Benefitting from the special heterostructure between Fe Co LDH and Ni Co P,the as-synthesized Fe Co LDH@Ni Co P/NF electrocatalyst exhibits outstanding OER performance with an exceptionally low overpotential of 206 mV to achieve 20 mA/cm^(2)current density in an alkaline electrolyte.Importantly,a cell constructed using the FeCo LDH@NiCoP/NF electrocatalyst as cathode and anode just needs a voltage of 1.48 V at 10 mA/cm^(2),and shows excellent stability over 80 h.Experimental and theoretical results verified that the introduction of Ni Co P efficiently regulates the electronic structure of Fe Co LDH,which tremendously boosts the conductivity and intrinsic catalytic activity of FeCo LDH@NiCoP/NF electrocatalyst.The present work provides guidance for the preparation of other efficient and cheap electrocatalytic materials.

关键词： OER Heterostructure Interface engineering Water-splitting DFT

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Association between sleep duration and incidence of type 2 diabetes in China: the REACTION study

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Chinese Medical Journal 2022年第10期135卷 1242-1248页

作者： Hongzhou liu Gang Chen Junping Wen Anping Wang yimin Mu Jingtao Dou Weijun Gu Li Zang Saichun Zhang Zhaohui Lyu Department of Endocrinology The First Medical CenterChinese PLA General HospitalBeijing 100853China Department of Endocrinology Fujian Provincial HospitalKey Laboratory of EndocrinologyFujian Medical UniversityFuzhouFujian 350001China

Backgrounds: Inadequate sleep duration is associated with a higher risk of type 2 diabetes and the relationship is nonlinear. We aim to assess the curve relationship between night sleep duration and the incidence of type 2 diabetes in China.Methods: A cohort of 11,539 participants from the REACTION study without diabetes at baseline (2011) were followed until 2014 for the development of type 2 diabetes. The average number of hours of sleep per night was grouped. Incidence rates and odds ratios (ORs) were calculated for the development of diabetes in each sleep duration category.Results: Compared to people who sleep for 7 to 8 h/night, people with longer sleep duration (≥9 h/night) had a greater risk of type 2 diabetes (OR: 1.27;95% CI: 1.01-1.61), while shorter sleep (<6 h/night) had no significant difference in risk of type 2 diabetes. When the dataset was stratified based on selected covariates, the association between type 2 diabetes and long sleep duration became more evident among individuals <65 years of age, male, body mass index <24 kg/m2 or with hypertension or hyperlipidemia, no interaction effects were observed. Furthermore, compared to people persistently sleeping 7 to 9 h/night, those who persistently slept ≥9 h/night had a higher risk of type 2 diabetes. The optimal sleep duration was 6.3 to 7.5 h/night.Conclusions: Short or long sleep duration was associated with a higher risk of type 2 diabetes. Persistently long sleep duration increased the risk.

关键词： Sleep duration Type 2 diabetes Prevalence Risk

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衣物消毒剂引起的颗粒状角化不全四例

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中国麻风皮肤病杂志 2024年第7期40卷 480-483页

作者：夏曼琪邵蕾周欣梁毅敏陈紫妍黄琼霄田歆刘玉梅广州医科大学皮肤病研究所广东广州510000 广州市皮肤病医院皮肤科广东广州510000 广东省泗安医院皮肤科广东东莞523001

颗粒状角化不全较罕见,临床易误诊。本文报道衣物消毒剂引起的颗粒状角化不全4例,3例患者停止接触消毒剂、全身使用润肤剂后皮损消退,1例患者口服糖皮质激素后皮损明显改善。因此对于皮损表现为对称性红斑伴反复脱屑、呈羊皮纸样外观的... 详细信息

颗粒状角化不全较罕见,临床易误诊。本文报道衣物消毒剂引起的颗粒状角化不全4例,3例患者停止接触消毒剂、全身使用润肤剂后皮损消退,1例患者口服糖皮质激素后皮损明显改善。因此对于皮损表现为对称性红斑伴反复脱屑、呈羊皮纸样外观的患者,皮肤科医生应提高颗粒状角化不全的诊治意识,详细询问消毒剂接触史,指导患者及时停止接触消毒剂并使用润肤剂,必要时可考虑短期系统应用糖皮质激素。

关键词：颗粒状角化不全消毒剂

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Targeting integrin pathways:mechanisms and advances in therapy

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Signal Transduction and Targeted Therapy 2023年第2期8卷 381-422页

作者： Xiaocong Pang Xu He Zhiwei Qiu Hanxu Zhang Ran Xie Zhiyan liu Yanlun Gu Nan Zhao Qian Xiang yimin Cui Department of Pharmacy Peking University First HospitalXishiku StreetXicheng District100034BeijingChina Institute of Clinical Pharmacology Peking University First HospitalXueyuan Road 38Haidian District100191BeijingChina

Integrins are considered the main cell-adhesion transmembrane receptors that play multifaceted roles as extracellular matrix(ECM)-cytoskeletal linkers and transducers in biochemical and mechanical signals between cells and their environment in a wide range of states in health and diseases.Integrin functions are dependable on a delicate balance between active and inactive status via multiple mechanisms,including protein-protein interactions,conformational changes,and trafficking.Due to their exposure on the cell surface and sensitivity to the molecular blockade,integrins have been investigated as pharmacological targets for nearly 40 years,but given the complexity of integrins and sometimes opposite characteristics,targeting integrin therapeutics has been a challenge.To date,only seven drugs targeting integrins have been successfully marketed,including abciximab,eptifibatide,tirofiban,natalizumab,vedolizumab,lifitegrast,and carotegrast.Currently,there are approximately 90 kinds of integrin-based therapeutic drugs or imaging agents in clinical studies,including small molecules,antibodies,synthetic mimic peptides,antibody-drug conjugates(ADCs),chimeric antigen receptor(CAR)T-cell therapy,imaging agents,etc.A serious lesson from past integrin drug discovery and research efforts is that successes rely on both a deep understanding of integrin-regulatory mechanisms and unmet clinical needs.Herein,we provide a systematic and complete review of all integrin family members and integrin-mediated downstream signal transduction to highlight ongoing efforts to develop new therapies/diagnoses from bench to clinic.In addition,we further discuss the trend of drug development,how to improve the success rate of clinical trials targeting integrin therapies,and the key points for clinical research,basic research,and translational research.

关键词： drugs mechanisms inactive

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冠心病合并糖尿病患者药物素养自评量表的编制及信效度检验

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中华护理杂志 2024年第9期59卷 1065-1072页

作者：刘海婷王咏梅郑贝贝蔡丽丽叶林斌吴佳芸宁丽李益民陈为霞杭州市第一人民医院心内科杭州市310006 杭州市第一人民医院内分泌科杭州市310006 杭州市第一人民医院护理部杭州市310006 海宁市中医院院部

目的编制冠心病合并糖尿病患者药物素养自评量表并检验其信效度。方法在药物素养概念模型指导下,通过文献分析、质性访谈、专家函询法编制量表初稿。便利选取2022年11月—2023年4月浙江省某三级甲等综合医院421例冠心病合并糖尿病患者... 详细信息

目的编制冠心病合并糖尿病患者药物素养自评量表并检验其信效度。方法在药物素养概念模型指导下,通过文献分析、质性访谈、专家函询法编制量表初稿。便利选取2022年11月—2023年4月浙江省某三级甲等综合医院421例冠心病合并糖尿病患者进行调查,检验量表信效度。结果冠心病合并糖尿病患者药物素养自评量表包括获取、理解、交流、评价、计算5个维度,共23个条目。量表总的Cronbach’sα系数为0.911,重测信度为0.948,量表水平内容效度指数为0.997,量表各维度及总分与校标量表的相关系数为0.485~0.926。探索性因子分析提取5个公因子,累计方差贡献率为73.753%;验证性因子分析显示量表因子结构稳定。结论该量表具有良好的信效度,可作为冠心病合并糖尿病患者自评药物素养水平的有效评估工具。

关键词：冠心病糖尿病药物素养量表信度效度护理

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NOD样受体蛋白3(NLRP3)炎性小体在肝细胞癌发生发展中的作用

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临床肝胆病杂志 2024年第2期40卷 397-401页

作者：余学海陈本栋刘伊敏马勇新张旭升周红才马海燕宁夏医科大学总医院小儿外科银川750000 宁夏医科大学总医院肝胆外科银川750000 宁夏医科大学银川750000

近年来,关于NOD样受体蛋白3(NLRP3)炎性小体在肿瘤中的研究已成为热点话题,尤其是在黑色素瘤、结直肠癌、肺癌、乳腺癌等肿瘤中,越来越多的证据表明炎症在促进肿瘤的发生发展、血管生成和肿瘤侵袭中具有重要的作用。肝细胞癌(HCC)是原... 详细信息

近年来,关于NOD样受体蛋白3(NLRP3)炎性小体在肿瘤中的研究已成为热点话题,尤其是在黑色素瘤、结直肠癌、肺癌、乳腺癌等肿瘤中,越来越多的证据表明炎症在促进肿瘤的发生发展、血管生成和肿瘤侵袭中具有重要的作用。肝细胞癌(HCC)是原发性肝癌中最常见的类型,而关于NLRP3炎性小体在HCC发生发展中的作用仍争议不断。因此,本文就NLRP3炎性小体在HCC进展过程中的潜在影响以及在抗癌治疗中的作用机制作一综述,认为NLRP3炎性小体可以作为HCC患者的有效治疗靶点。

关键词：癌,肝细胞 NLR家族,热蛋白结构域包含蛋白3 细胞焦亡

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CAS FGOALS-f3-L Model Datasets for CMIP6 Historical Atmospheric Model Intercomparison Project Simulation

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Advances in Atmospheric Sciences 2019年第8期36卷 771-778页

作者： Bian HE Qing BAO Xiaocong WANG Linjiong ZHOU Xiaofei WU yimin liu Guoxiong WU Kangjun CHEN Sicheng HE Wenting HU Jiandong LI Jinxiao LI Guokui NIAN Lei WANG Jing YANG Minghua ZHANG Xiaoqi ZHANG State Key Laboratory of Numerical Modeling for Atmospheric Sciences and Geophysical Fluid Dynamics Institute of Atmospheric PhysicsChinese Academy of SciencesBeijing 100029China Chinese Academy of Sciences Center for Excellence in Tibetan Plateau Earth Sciences Beijing 100101China University of Chinese Academy of Sciences Beijing 100049China Geophysical Fluid Dynamics Laboratory PrincetonNJ 08540-6649USA School of Atmospheric Sciences/Plateau Atmosphere and Environment Key Laboratory of Sichuan Province Chengdu University of Information TechnologyChengdu 610225China State Key Laboratory of Earth Surface Processes and Resource Ecology/Academy of Disaster Reduction and Emergency Management Ministry of Civil Affairs and Ministry of Education Faculty of Geographical ScienceBeijing Normal UniversityBeijing 100875China School of Atmospheric Sciences Nanjing University of Information Science and TechnologyNanjing 210044China

The outputs of the Chinese Academy of Sciences(CAS) Flexible Global Ocean–Atmosphere–Land System(FGOALS-f3-L) model for the baseline experiment of the Atmospheric Model Intercomparison Project simulation in the Diagnostic,Evaluation and Characterization of Klima common experiments of phase 6 of the Coupled Model Intercomparison Project(CMIP6) are described in this paper. The CAS FGOALS-f3-L model, experiment settings, and outputs are all given. In total,there are three ensemble experiments over the period 1979–2014, which are performed with different initial states. The model outputs contain a total of 37 variables and include the required three-hourly mean, six-hourly transient, daily and monthly mean datasets. The baseline performances of the model are validated at different time scales. The preliminary evaluation suggests that the CAS FGOALS-f3-L model can capture the basic patterns of atmospheric circulation and precipitation well, including the propagation of the Madden–Julian Oscillation, activities of tropical cyclones, and the characterization of extreme precipitation. These datasets contribute to the benchmark of current model behaviors for the desired continuity of CMIP.

关键词： CMIP6 AMIP FGOALS-f3-L MJO tropical cyclone extreme precipitation

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