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Tracking the in vivo spatio-temporal patterns of neovascularization via NIR-II fluorescence imaging

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Nano Research 2020年第11期13卷 3123-3129页

作者： Mo Chen Sijia Feng yimeng yang Yunxia Li Jian Zhang Shiyi Chen Jun Chen Institute of Sports Medicine of Fudan University Department of Orthopaedic Sports MedicineHuashan HospitalFudan UniversityShanghai200041China

The in vivo spatio-temporal patterns of neovascularization are still poorly understood because it is limited to multi-scale techniques from the cellular level to living animal level.Owing to deep tissue-penetration and zero autofluorescence background,the second near-infrared(NIR-II,1,000–1,700 nm)fluorescence imaging recently shows promise in breaking through this dilemma by dynamically tracking the pathophysiological process of neovascularization in vivo.Here,NIR-II fluorescence imaging was recruited for monitoring blood vessels in order to visualize the vascular injury and quantitively assess neovascularization in mouse models of acute skeleton muscle contusion and hindlimb ischemia.The temporal analysis of real-time NIR-II fluorescence intensity demonstrated that the blood flow perfusion of ischemia area was able to rapidly restore to 96%of pre-ischemic state within one week.Moreover,the spatial analysis revealed that the lower and outer quadrants of ischemia area in the mouse model of hindlimb ischemia always had relatively high blood flow perfusion compared with other quadrants during three weeks post-ischemia,and even exceeded pre-ischemic quantity at 21 days post-ischemia.In conclusion,this in vivo imaging technique has significant potential utility for studying the spatio-temporal patterns of neovascularization in vivo.

关键词： bioimaging second near-infrared(NIR-II)fluorescence nanoprobes spatio-temporal neovascularization

控股股东股权质押、内部控制与企业ESG表现

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安徽商贸职业技术学院学报 2024年第2期23卷 39-46页

作者：杨永杰杨薏蒙甘肃政法大学商学院兰州730070

选取2013—2022年上市公司为样本,通过构建有调节的中介模型对控股股东股权质押与企业ESG表现之间的关系进行实证检验。研究发现:控股股东股权质押会抑制企业的ESG表现,且这一结论在经过遗漏变量、反向因果关系和样本选择偏误的检验后... 详细信息

选取2013—2022年上市公司为样本,通过构建有调节的中介模型对控股股东股权质押与企业ESG表现之间的关系进行实证检验。研究发现:控股股东股权质押会抑制企业的ESG表现,且这一结论在经过遗漏变量、反向因果关系和样本选择偏误的检验后仍然稳健;在非国有企业以及股权集中度较高的企业中控股股东股权质押对企业ESG表现的抑制作用更为显著;控股股东股权质押通过拉低企业内部控制质量降低企业ESG表现,融资约束负向调节内部控制的中介作用。

关键词：控股股东股权质押企业ESG表现内部控制融资约束有调节的中介

In vivo and in situ real-time fluorescence imaging of peripheral nerves in the NIR-II window

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Nano Research 2019年第12期12卷 3059-3068页

作者： Zhujun Feng yimeng yang Jian Zhang Kan Wang Yunxia Li Heng Xu Zhen Wang Ewelina Biskup Shixian Dong Xing yang Yuefeng Hao Jun Chen Yan Wo Department of Anatomy and Physiology School of MedicineShanghai Jiao Tong UniversityShanghai 200025China Sports Medicine Institute ofFudan University Department of Orthopedic Sports MedicineHuashan HospitalFudan UniversityShanghaiChina Department of Instrument Science and Engineering School of Electronic Information and Electrical EngineeringShanghai Jiao long UniversityShanghai Engineering Research Center for Intelligent diagnosis and treatment instrumentKey Laboratory of Thin Film and Microfabrication(Ministry of Education)Shanghai 200240China Department of Plastic Surgery Ninth People's HospitalShanghai Jiao Tong University School of MedicineShanghai 200025China Department cf physical education Fudan UniversityShanghai 200040China Department of Internal Medicine University Hospital of BaselPetersgraben 44051 BaselSwitzerland Department of orthopedics Affiliated Suzhou Hospital of Nanjing Medical UniversitySuzhou 215500China

The peripheral nervous system(PNS)is essential for performing and maintaining various motor and sensory functions.Abnormalities can lead to a series of peripheral neurological conditions,such as paraesthesia,pain,or spasms,which are debilitating and lowering the quality of life.Thecurrent guidelines for diagnosis rely predominantly on clinical symptoms resulting from PNS dysfunction,which occur already at an advancedstage.There are currently no effective methods that visually reflect the extent of peripheral neuropathy.In our study,we present a novel in vivoand in situ real-time imaging of peripheral nerves based on the second near-infrared window(NIR-II)fluoresce nee.In NIR-II system,lead sulfidequa ntum dots(PbS Qds)with NIR-II fluoresce nee specifically bound to motor neuro rvspecific protein agrin,acting as image con trast.In micemodel,peripheral nerves were visible as soon as after 2 h post injection.We provide evidenee for the efficacy of this approach,which allows todirectly dem on strate peripheral nerves,their structure,and pote ntial damagesites and degree.Furthermore,our products were of goodbiocompatibility,while the n eural fluoresce nee signal was solid,bright and stable for 4 h in vivo.Thus,overall,our results suggest that NIR-II isan effective new method for direct imaging of peripheral nerves in vivo,opening new horizons on early,improved and more precise,targeteddiag no sis.A resulti ng more rapid installatio n of perso nalized therapy facilitates a better prognosis of clinical peripheral neuropathy.

关键词： peripheral nerve the second near-infrared window(NIR-II) fluorescent imaging Agrin@PbS Qds biocompatibility

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高职全程式职业生涯规划教育实施途径研究

邯郸职业技术学院学报 2024年第1期37卷 43-45页

作者：郭丽平王振广杨轶萌邯郸职业技术学院河北邯郸056005

大学生就业形势越来越严峻。高职院校通过课程教学、主题班会、个体咨询、生涯讲座、生涯工作坊等方式,从入学到毕业,对学生开展全程式职业生涯规划教育增强学生生涯规划意识,促使学生在校期间有目的地针对职业目标开展学习和训练,提高... 详细信息

大学生就业形势越来越严峻。高职院校通过课程教学、主题班会、个体咨询、生涯讲座、生涯工作坊等方式,从入学到毕业,对学生开展全程式职业生涯规划教育增强学生生涯规划意识,促使学生在校期间有目的地针对职业目标开展学习和训练,提高学生求职技能,有效提高学生就业信心和就业能力。

关键词：高职全程式职业生涯规划实施途径

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山西省腐烂茎线虫群体的形态和遗传分析

植物病理学报 2024年第2期54卷 304-317页

作者：杨艺萌丰叶青董海龙赵增旗王建明徐玉梅山西农业大学植物保护学院山西太谷030801 新西兰土地环境研究所新西兰奥克兰1142

本研究对分离自山西省马铃薯、甘薯和薯蓣块茎中的腐烂茎线虫8个群体进行形态特征观察和数值测量,对形态数据进行SPSS差异显著性和PCA分析;采用通用引物对其ITS rDNA进行PCR扩增与序列测定,利用Geneious Prime 2019.2.3和DNAMAN 9.0软... 详细信息

本研究对分离自山西省马铃薯、甘薯和薯蓣块茎中的腐烂茎线虫8个群体进行形态特征观察和数值测量,对形态数据进行SPSS差异显著性和PCA分析;采用通用引物对其ITS rDNA进行PCR扩增与序列测定,利用Geneious Prime 2019.2.3和DNAMAN 9.0软件计算相似距离和序列比对,Arlequin 3.5软件中的AMOVA模块分析分子变异方差,MrBayes 3.2.7构建贝叶斯系统发育树,并用PopART 4.8.4软件构建TCS单倍型网络图。结果表明,腐烂茎线虫群体YH277、YH279、tg38、XF01、CZ15、TY15、tg49属于A型,寄主有甘薯、马铃薯和薯蓣;为害马铃薯群体PX04属于C型。PX04和其余7个群体在形态上存在明显差异,尾部稍尖;PCA分析显示PX04与其他7个群体可以明显区分开。选用薯类作物为寄主的腐烂茎线虫77条ITS序列构建TCS单倍型网络图,结果显示共享单倍型2个和独享单倍型26个。其中H1单倍型是共享率最高的,推测其可能为祖先单倍型;26个独享单倍型中马铃薯群体独享数目最多,其群体单倍型和核苷酸多样性最丰富,单倍型多样性指数Hd值为0.841,群体间核苷酸多样性指数Pi值为0.00502。AMOVA分析表明,山西省腐烂茎线虫遗传差异主要来源于种群间,腐烂茎线虫A型与C型之间存在较大的遗传分化。

关键词：腐烂茎线虫遗传多样性系统发育树单倍型

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整体观视角下代谢紊乱相关慢性病防治

中华中医药杂志 2024年第2期39卷 631-635页

作者：杨依萌薛惠中张华张文征蔡秉洋郑晓艳蔡阳平姜碧瑶陈宇肖永华北京中医药大学第一临床医学院北京100029 北京中医药大学东直门医院肾病内分泌Ⅱ科北京100700 北京中医药大学东直门医院国际部健康管理中心北京100007 北京中医药大学东直门医院通州院区临床营养科北京101100

代谢紊乱相关慢性病发病率逐年升高,成为我国重大公共卫生问题。文章基于整体观,从人体“整体-局部”联动以及时间、空间的动态发展角度,重新思考代谢紊乱相关慢性病发生发展过程,提出“单组分代谢异常-代谢综合征-代谢紊乱相关慢性病... 详细信息

代谢紊乱相关慢性病发病率逐年升高,成为我国重大公共卫生问题。文章基于整体观,从人体“整体-局部”联动以及时间、空间的动态发展角度,重新思考代谢紊乱相关慢性病发生发展过程,提出“单组分代谢异常-代谢综合征-代谢紊乱相关慢性病”的疾病顺序发展链条。并针对代谢紊乱早期筛查缺失等临床问题,探讨代谢紊乱相关慢性病的早期防治策略。提出如将红外热成像等新型检测技术与智慧医学相结合的方法,构建代谢紊乱早期筛查新工具,为我国的慢性病防治提供有益的思路和启发。

关键词：中医学整体观代谢紊乱慢性病早期防治策略

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连山县茶产业SWOT分析及发展策略研究

中国茶叶 2024年第2期46卷 50-55页

作者：杨益萌韦惠娟韦月旺李安生黄维黄玉旺刘少群孙彬妹郑鹏华南农业大学园艺学院广东广州510642 连山壮族自治县农业农村局果茶服务中心广东清远513200

茶产业是连山壮族瑶族自治县的重要产业之一。文章运用SWOT分析法,发现连山县茶产业具有产业历史悠久、自然环境优越、品种资源丰富、市场广阔且有战略支撑等优势和机遇,但也面临生产技术落后、生产规模不足、品牌知名度较低等劣势和挑... 详细信息

茶产业是连山壮族瑶族自治县的重要产业之一。文章运用SWOT分析法,发现连山县茶产业具有产业历史悠久、自然环境优越、品种资源丰富、市场广阔且有战略支撑等优势和机遇,但也面临生产技术落后、生产规模不足、品牌知名度较低等劣势和挑战,在此基础上,尝试从S-O、W-O、S-T、W-T 4个方向提出相应的策略,以为连山县茶产业高质量发展提供建议。

关键词：连山县茶产业 SWOT分析产业发展策略建议

Pore-pressure and stress-coupled creep behavior in deep coal:Insights from real-time NMR analysis

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International Journal of Mining Science and Technology 2024年第1期34卷 77-90页

作者： Wenhao Jia Hongwei Zhou Senlin Xie yimeng Wang Xinfeng Hu Lei Zhang School of Mechanics and Civil Engineering China University of Mining and Technology-BeijingBeijing 100083China School of Energy and Mining Engineering China University of Mining and Technology-BeijingBeijing 100083China State Key Laboratory of Coal Resources and Safe Mining China University of Mining and Technology-BeijingBeijing 100083China College of Safety and Emergency Management Engineering Taiyuan University of TechnologyTaiyuan 030024China

Understanding the variations in microscopic pore-fracture structures(MPFS) during coal creep under pore pressure and stress coupling is crucial for coal mining and effective gas treatment. In this manuscript, a triaxial creep test on deep coal at various pore pressures using a test system that combines in-situ mechanical loading with real-time nuclear magnetic resonance(NMR) detection was conducted.Full-scale quantitative characterization, online real-time detection, and visualization of MPFS during coal creep influenced by pore pressure and stress coupling were performed using NMR and NMR imaging(NMRI) techniques. The results revealed that seepage pores and microfractures(SPM) undergo the most significant changes during coal creep, with creep failure gradually expanding from dense primary pore fractures. Pore pressure presence promotes MPFS development primarily by inhibiting SPM compression and encouraging adsorption pores(AP) to evolve into SPM. Coal enters the accelerated creep stage earlier at lower stress levels, resulting in more pronounced creep deformation. The connection between the micro and macro values was established, demonstrating that increased porosity at different pore pressures leads to a negative exponential decay of the viscosity coefficient. The Newton dashpot in the ideal viscoplastic body and the Burgers model was improved using NMR experimental results, and a creep model that considers pore pressure and stress coupling using variable-order fractional operators was developed. The model’s reasonableness was confirmed using creep experimental data. The damagestate adjustment factors ω and β were identified through a parameter sensitivity analysis to characterize the effect of pore pressure and stress coupling on the creep damage characteristics(size and degree of difficulty) of coal.

关键词： Real-time monitoring Pore pressure-stress coupling Microscopic pore-fracture structure Variable-order fractional creep model Deep coal

Scanning transmission electron microscopy and atom probe tomography analysis of non-stoichiometry long-period-stacking-ordered structures in Mg-Ni-Y/Sm alloys

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Journal of Magnesium and Alloys 2024年第3期12卷 954-965页

作者： yimeng Chen Manuel Legrée Jean-Louis Bobet Alexander Kvit CAMECA Instruments Inc MadisonWI 53711USA ICMCB Universitéde BordeauxPessacCEDEX 33608France NIAC&Materials Science Department University of WisconsinMadisonWI 53706USA

The long-period-stacking-ordered(LPSO)structure affects the mechanical,corrosion and hydrolysis properties of Mg alloys.The current work employs high angle annular dark field-scanning transmission electron microscopy(HAADF-STEM)and atom probe tomography(APT)to investigate the structural and local chemical information of LPSO phases formed in Mg-Ni-Y/Sm ternary alloys after extended isothermal annealing.Depending on the alloying elements and their concentrations,Mg-Ni-Y/Sm develops a two-phase LPSO+α-Mg structure in which the LPSO phase contains defects,hybrid LPSO structure,and Mg insertions.HAADF-STEM and APT indicate non-stoichiometric LPSO with incomplete Ni_(6)(Y/Sm)_(8) clusters.In addition,the APT quantitatively determines the local composition of LPSO and confirms the presence of Ni within the Mg bonding layers.These results provide insight into a better understanding of the structure and hydrolysis properties of LPSO-Mg alloys.

关键词： Magnesium alloys Long-range ordering Atom probe tomography(APT) STEM HAADF Hydrolysis properties.