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Fatigue Behaviors of a Ni-free ZrCuFeAlAg Bulk Metallic Glass in Simulated Body Fluid

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Journal of Materials Science & Technology 2014年第6期30卷 622-626页

作者： yimei wang Yan Liu Lin Liu School of Materials Science and Engineering State Key Lab for Materials Processing and Die & Mould Technology Huazhong University of Science and Technology

Fatigue behaviors of a biocompatible Ni-free Zr60.14Cu22.31Fe4.85Al9.7Ag3 Zr-based bulk metallic glass （BMG） have been studied under three-point-bending test in a simulated body fluid （SBF） at 37 ℃ and compared with those in air at room temperature （RT）. The BMG shows a high fatigue limit of approximately 366 MPa in SBF, which was slightly lower than that in air （400 MPa）. The fatigue cracks tended to initiate from the defects such as cast-pores, inclusions and corners of the samples and propagate in a similar path in SBF and in air. Three distinct regions, i.e. a crack-initiation region, a stable crack-growth region and an unstable fast-fracture region were clearly observed on the fatigue-fractured surface. Although pitting occurred at the defects where crack initiated, it does not affect significantly the fatigue life of the BMG, because the lifetime in the present BMG is mainly determined by crack propagation. The high corrosion-fatigue limit of the studied BMG results from its excellent corrosion resistance in SBF and intrinsically good toughness.

关键词： Ni-free Zr-based bulk metallic glass Corrosion fatigue Simulated body fluid

[Correlation and predictive value analysis of systemic inflammation grade and plaque stability in patients with carotid artery stenosis]

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Zhonghua yi xue za zhi 2025年第7期105卷 537-543页

作者： Q H wang C Tang J Cai Y M wang L Zheng B Zhao L Z Fan Q Ni Z S Liang T Qiao Department of Vascular Surgery Nanjing Drum Tower Hospital Affiliated Hospital of Medical School Nanjing University Nanjing 210008 China. Department of Vascular Surgery Nanjing Drum Tower Hospital Clinical College of Nanjing University of Traditional Chinese Medicine Chinacal College of Nanjing University of Traditional Chinese Medicine Nanjing 210008 China. Department of Geriatrics Nanjing Drum Tower Hospital Affiliated Hospital of Medical School Nanjing University Nanjing 210008 China.

To analyze the correlation between the systemic inflammation score (SIG) and plaque stability in patients with carotid artery stenosis, and to evaluate the predictive value. The clinical data of 149 patients with carotid artery stenosis who were hospitalized in Drum Tower Hospital, the Affiliated Hospital of Nanjing University Medical School from January 2019 to October 2023 were retrospectively analyzed, including 124 males and 25 females, aged (68.2±8.9) years. According to the results of pathological analysis of specimens after carotid endarterectomy, the patients were divided into plaque stable group (=70) and plaque vulnerable group (=79). After preoperative blood biochemical indexes were collected and neutrophil-lymphocyte ratio and modified glasgow prognostic score(mGPS) were calculated, the SIG was calculated together. The multivariate logistic regression model was used to analyze the correlative factors of plaque stability in patients with carotid artery stenosis, and the receiver operating characteristic (ROC) curve was used to analyze the predictive value of SIG for plaque stability in patients with carotid artery stenosis. The proportion of patients with a history of diabetes in the plaque vulnerable group [36.7% (29/79) vs 20.0% (14/70)] and IL-6 [0.43 (0.31, 0.64) vs 0.34 (0.17, 0.44) ng/L] were higher than those in the plaque stabilization group(both <0.05). The mGPS score and SIG score of the plaque vulnerable group were higher than those of the plaque stabilization group (both <0.05). The results of the multivariate logistic regression model showed that diabetes history (=2.82, 95%: 1.23-6.48), high interleukin-6 (IL-6) level (=1.16, 95%: 1.01-1.33), and high SIG scores [with SIG=0 as the reference, (SIG=1)=1.76,95%:1.21-2.41; (SIG=2)=2.21,95%:1.51-3.01; (SIG=3)=4.47,95%:2.42-6.52; (SIG=4)=3.19,95%:2.01-4.36] were risk factors for plaque instability in patients with carotid artery stenosis. The results of ROC curve analysis showed that when the S

关键词：颈动脉狭窄动脉粥样硬化系统性炎症评分斑块稳定性

Enhanced hepatotoxicity induced by repeated exposure to polychlorinated biphenyls and 2,3,7,8-tetrachlorodibenzo-p-dioxin in combination in male rats

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Journal of Environmental Sciences 2011年第1期23卷 119-124页

作者： yimei wang Chunfeng Lu Zhiguo Sheng Gang Liu Ze Fu Benzhan Zhu Shuangqing Peng Evaluation and Research Center for Toxicology Institute of Disease Control and Prevention Academy of Military Medical Sciences Beijing 100071 China State Key Laboratory of Environmental Chemistry and Ecotoxicology Research Center for Eco-Environmental Sciences Chinese Academy of Sciences Beijing 100085 China Department of Pharmacology Basic Medical College Jiamusi University Jiamusi 154007 China

2,3,7,8-Tetrachlorodibenzo-p-dioxin （TCDD） and polychlorinated biphenyls （PCBs） are among persistent polyhalogenated aromatic hydrocarbons that exist as complex mixtures in the environment worldwide. The present study was attempted to investigate the hepatotoxicity following repeated exposure to TCDD and PCBs in combination in male rats, and to reveal the involvement of potential mechanisms. Male Sprague-Dawley rats were exposed to TCDD （10 Ixg/kg） and Aroclor 1254 （10 mg/kg, a representative mixture of PCBs） alone or in combination by intragastric administration. After 12-day exposure, all treatments produced significant hepatotoxicity as characterized by changes of plasma biochemistry and histopathological changes. These effects were more prominent in the combined group. Furthermore, all treatments induced hepatic cytochrome P450 1A1 （CYP1A1） expression, and the maximal level of CYP1A1 expression was observed in the combined group, as in the case of the most severe hepatotoxicity evoked by the combined exposure. These findings indicated that the hepatotoxicity induced by TCDD and Aroclor 1254 might be ascribed to the high expression of hepatic CYP1A1. The present study demonstrates the enhanced hepatotoxicity after exposure to TCDD and PCBs in combination in rats.

关键词： 2,3,7,8-tetrachlorodibenzo-p-dioxin polychlorinated biphenyls combined exposure hepatotoxicity

T-2 toxin induces developmental toxicity and apoptosis in zebrafish embryos

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Journal of Environmental Sciences 2014年第4期26卷 917-925页

作者： Guogang Yuan yimei wang Xiaoyan Yuan Tingfen Zhang Jun Zhao Liuyu Huang Shuangqing Peng Evaluation and Research Center for Toxicology Institute of Disease Control and Prevention Academy of Military Medical Sciences

T-2 toxin is one of the most important trichothecene mycotoxins occurring in various agriculture products. The developmental toxicity of T-2 toxin and the exact mechanism of action at early life stages are not understood precisely. Zebrafish embryos were exposed to different concentrations of the toxin at 4-6 hours post fertilization （hpf） stage of development, and were observed for different developmental toxic effects at 24, 48, 72, and 144 hpf. Exposure to 0.20 Ixmol/L or higher concentrations of T-2 toxin significantly increased the mortality and malformation rate such as tail deformities, cardiovascular defects and behavioral changes in early developmental stages of zebrafish. T-2 toxin exposure resulted in significant increases in reactive oxygen species （ROS） production and cell apoptosis, mainly in the tall areas, as revealed by Acridine Orange staining at 24 hpf. In addition, T-2 toxin-induced severe tail deformities could be attenuated by co-exposure to reduced glutathione （GSH）. T-2 toxin and GSH co-exposure induced a significant decrease of ROS production in the embryos. The overall results demonstrate that T-2 toxin is able to produce oxidative stress and induce apoptosis, which are involved in the developmental toxicity of T-2 toxin in zebrafish embryos.

关键词： T-2 toxin developmental toxicity apoptosis zebrafish embryo oxidative stress

Alkoxy-Functionalized Bithiophene/thiazoles: Versatile Building Blocks for High-Performance Organic and Polymeric Semiconductors

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Accounts of Materials Research 2023年第3期4卷 237-250页

作者： Kun Yang Zhicai Chen yimei wang Xugang Guo Department of Materials Science and Engineering Southern University of Science and Technology(SUSTech)ShenzhenGuangdong 518055China State Key Laboratory of Chemo/Biosensing and Chemometrics College of Chemistry and Chemical EngineeringHunan UniversityChangshaHunan 410082China

CONSPECTUS:Organic electronics has experienced substantial advances in the past decade,driven by the development of high-performance organic semiconductors(OSCs)in combination with device *** the pursuit of new aromatic building blocks has been a central topic in OSC innovation,the installation of novel side chains is also of significance for accessing high-performance solution-processable OSCs due to their great impact on(macro)molecular conformation/configuration,energy levels,intra/intermolecular interaction,and packing motifs,as well as film morphology of the *** to tuning the length,branching point,anchoring position,and terminal group of alkyl side chains,alkoxy functionalization can afford multifaceted advantages by modulating the properties of bothπ-conjugated main chains and side chain *** instance,the oxygen atom in alkoxy chains not only greatly decreases the steric hindrance between adjacent aromatic rings due to its reduced van der Waal radius(∼1.4Å)versus that of a CH_(2) moiety(∼2.0Å)but also induces intramolecular noncovalent interaction for improving backbone coplanarity and charge transport *** highly electron-donating alkoxy chains can also greatly facilitate the intramolecular charge transfer(ICT),and hence the resulting semiconductors can yield absorption beyond the infrared region,which is essential for full coverage of solar absorption in photovoltaic ***,the high polarity of oligo(ethylene glycol)-type alkoxy side chains can improve the miscibility of the OSCs with molecular dopants and ions,thus enabling them as a key part of the OSCs for emerging applications such as organic thermoelectrics and organic electrochemical *** this Account,we summarize our pioneering and systematic efforts on the rational design,synthesis,and applications of novel alkoxy-functionalized head-to-head(HH)-linked bithiophene/thiazole-based building blocks and related organic/polymeric s

关键词： properties chains hence

中医“肺肠合治”法联合双歧杆菌活菌胶囊在重症肺炎合并胃肠功能障碍患者中的应用效果

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检验医学与临床 2025年第1期22卷 76-80页

作者：王忆梅张宇成朱怡栋张高峰江苏省常熟市中医院重症医学科江苏苏州215516

目的分析中医“肺肠合治”法联合双歧杆菌活菌胶囊在重症肺炎合并胃肠功能障碍患者中的应用效果。方法回顾性分析2019年6月至2023年6月该院重症监护室(ICU)收治的153例重症肺炎合并胃肠功能障碍患者的临床资料,根据不同治疗方案分为... 详细信息

目的分析中医“肺肠合治”法联合双歧杆菌活菌胶囊在重症肺炎合并胃肠功能障碍患者中的应用效果。方法回顾性分析2019年6月至2023年6月该院重症监护室(ICU)收治的153例重症肺炎合并胃肠功能障碍患者的临床资料,根据不同治疗方案分为研究组(77例)和对照组(76例)。所有患者均接受基础治疗,对照组采用双歧杆菌活菌胶囊治疗,研究组在对照组基础上联合中医“肺肠合治”法治疗。比较两组基线资料、相关评分[急性生理学与慢性健康评价Ⅱ(APACHEⅡ)评分、序贯性脏器衰竭评价(SOFA)评分、胃肠功能衰竭(GIF)评分、临床肺部感染量表(CPIS)评分]、胃肠功能指标[胃泌素(GAS)、胃动素(MTL)、D-乳酸、二胺氧化酶(DAO)]、炎症指标[降钙素原(PCT)、C反应蛋白(CRP)]、病死率。结果研究组ICU停留、机械通气时间明显短于对照组,治疗后两组氧合指数(PaO_(2)/FiO)均高于治疗前,且研究组均高于对照组,差异均有统计学意义(P0.05)。结论在双歧杆菌活菌胶囊基础上联合中医“肺肠合治”法能有效缩短患者ICU停留、机械通气时间,改善PaO_(2)/FiO,恢复胃肠功能,降低炎症指标水平。

关键词：肺肠合治双歧杆菌活菌胶囊重症肺炎胃肠功能障碍机械通气

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Revisiting the Bithiophene Imide-Based Polymer Donors: Molecular Aggregation and Orientation Control Enabling New Polymer Donors for High-Performance All-Polymer Solar Cells

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Chinese Journal of Chemistry 2022年第24期40卷 2900-2908,I0002页

作者： Jie Yang Bin Liu Jin-Woo Lee yimei wang Huiliang Sun Zhicai Chen Qingqing Bai Bumjoon J.Kim Yan Jiang Li Niu Xugang Guo Department of Materials Science and Engineering Southern University of Science and Technology(SUSTech)No.1088Xueyuan RoadShenzhenGuangdong518055 China Center for Advanced Analytical Science School of Chemistry and Chemical EngineeringGuangzhou UniversityGuangzhouGuangdong510006 China Energy Materials and Optoelectronics Unit Songshan Lake Materials LaboratoryDongguanGuangdong523808 China Department of Chemical and Biomolecular Engineering Korea Advanced Institute of Science and Technology(KAIST)Daejeon34141 Republic of Korea

Bithiophene imide (BTI)-based polymers have been promising photovoltaic materials due to their high mobility and tunable energy levels. However, BTI polymers have rarely been revisited since organic solar cells (OSCs) entered the era of non-fullerene electron acceptors (NFEA) likely owing to their incompatibility with NFEAs. Herein, fine-tuning the aggregation and orientation of BTI-based donor-π-acceptor (D-π-A) polymer donors was achieved by incorporating the linear n-octyl group into thiophene π-bridge. The resulting polymer donor G15 shows excellent compatibility with NFEA L15 (polymer acceptor). The G15-based all-polymer OSCs achieve high power conversion efficiency of 15.17%. This is significantly higher than that (< 5%) of its analogue with isomerized branched alkyl chains and also among the highest values for all-polymer OSCs. The results highlight that well-tailored BTI polymer donors are attractive photovoltaic materials for further exploration in non-fullerene organic solar cells.

关键词： Bithiophene imide Molecular orientation Isomerization Polymer donors All-polymer solar cells

逝去的时代,或记忆的持存——论《你好,安娜》与《公开的情书》

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扬子江文学评论 2021年第6期 100-106页

作者：王一梅南京师范大学文学院

2019年8月,作家蒋韵出版了小说新作《你好,安娜》①,这部回溯一代人青春,追忆往事的长篇小说在探问晦涩的时代与揭示秘密的原罪的同时,着重凸显了善与爱、真与美这些高蹈之物的价值与意义,而其间关乎罪与罚、忏悔与救赎、人性与道德的发... 详细信息

2019年8月,作家蒋韵出版了小说新作《你好,安娜》①,这部回溯一代人青春,追忆往事的长篇小说在探问晦涩的时代与揭示秘密的原罪的同时,着重凸显了善与爱、真与美这些高蹈之物的价值与意义,而其间关乎罪与罚、忏悔与救赎、人性与道德的发微,又为小说带来了正典式的厚重感与哲理式的深沉感。

关键词：正典忏悔与救赎善与爱罪与罚蒋韵安娜人性与道德厚重感

独立第三方学科评价服务的方法与实践——以北京大学图书馆支持药学国际评估的评价分析为例

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图书情报工作 2020年第16期64卷 29-35页

作者：王怡玫刘秀文北京大学图书馆北京100871

[目的/意义]大陆地区多家高校自2002年起陆续开展的自主学科国际评估工作旨在通过国际视角对本校的学科目标定位、人才培养体系、科学研究实力、国际影响力等进行全方位的综合审视。图书馆作为高校信息服务的重要阵地,在评估学科发展态... 详细信息

[目的/意义]大陆地区多家高校自2002年起陆续开展的自主学科国际评估工作旨在通过国际视角对本校的学科目标定位、人才培养体系、科学研究实力、国际影响力等进行全方位的综合审视。图书馆作为高校信息服务的重要阵地,在评估学科发展态势方面发挥着积极作用。对图书馆作为第三方在该领域开展工作的方法和实践进行总结有着重要的借鉴意义。[方法/过程]在充分了解学科国际评估特点的基础上,构建以用户需求为导向、以文献计量方法为手段的独立第三方学科评价分析报告体系,以有效支撑高校自主开展国际评估。以北京大学药学国际评估第三方评价分析报告为例,详细介绍对标机构筛选、基础数据获得、评价指标布局等重点工作,为学科国际评估工作提供精准的参考支持。[结果/结论]北京大学图书馆为国际评估撰写的第三方评价分析报告,客观分析了参评机构、参评学科的科研布局、发展趋势与影响力,并与国际对标高校进行对比,显示参评高校在国际同行间的竞争力。今后,图书馆应充分发挥信息服务优势,拓展服务对象,以第三方视角提供客观、合理、科学的分析报告以辅助各类评价工作。

关键词：国际评估文献计量分析科研评价用户导向