检索结果-南通市图书馆

Whole-genome sequencing identifies novel genes for autism in Chinese trios

Science China Life Sciences 2024年

作者： Suhua Chang Jia Jia Liu yilu zhao Tao Pang Xiangyu Zheng Zhirui Song Anyi Zhang Xuping Gao Lingxue Luo Yanqing Guo Jing Liu Li Yang Lin Lu Peking University Sixth Hospital Peking University Institute of Mental HealthNHC Key Laboratory of Mental Health (Peking University)National Clinical Research Center for Mental Disorders (Peking University Sixth Hospital) Chinese Academy of Medical Sciences Research Unit (No.2018RU006) Peking University School of Nursing Peking University Wuhan Biobank National Institute on Drug Dependence Peking University

Autism spectrum disorder (ASD) is a neurodevelopmental disorder with high genetic heritability but *** understanding its genetics requires whole-genome sequencing (WGS),but the ASD studies utilizing WGS data in Chinese population are *** this study,we present a WGS study for 334 individuals,including 112 ASD patients and their non-ASD *** identified 146 de novo variants in coding regions in 85 cases and 60 inherited variants in coding *** integrating these variants with an association model,we identified 33 potential risk genes (P<0.001) enriched in neuron and regulation related biological *** the well-known ASD genes (SCN2A,NF1,SHANK3,CHD8 etc.),several high confidence genes were highlighted by a series of functional analyses,including CTNND1,DGKZ,LRP1,DDN,ZNF483,NR4A2,SMAD6,INTS1,and MRPL12,with more supported evidence from GO enrichment,expression and network *** also integrated RNA-seq data to analyze the effect of the variants on the gene expression and found 12 genes in the individuals with the related variants had relatively biased *** further presented the clinical phenotypes of the proband carrying the risk genes in both our samples and Caucasian samples to show the effect of the risk genes on *** variants in noncoding regions,a total of 74 de novo variants and 30 inherited variants were predicted as pathogenic with high confidence,which were mapped to specific genes or regulatory *** number of de novo variants found in patient was significantly associated with the parents’ages at the birth of the child,and gender with *** also identified small de novo structural variants in ASD *** results in this study provided important evidence for understanding the genetic mechanism of ASD.

关键词：

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

云南省净初级生产力时空变化及其影响因素分析

引用

遥感信息 2024年第1期39卷 93-103页

作者：郑洁茹温兴平王俊霖赵一璐曹毅昆明理工大学国土资源工程学院昆明650093 云南省矿产资源预测评价工程实验室昆明650093

净初级生产力(net primary production,NPP)是衡量生态系统碳循环的重要指标。文章基于MOD17A3HGF数据和气象数据,利用Theil-Sen Median趋势分析、重心模型和相关性分析等方法对云南省2011—2020年NPP时空变化特征和影响因素进行研究,... 详细信息

净初级生产力(net primary production,NPP)是衡量生态系统碳循环的重要指标。文章基于MOD17A3HGF数据和气象数据,利用Theil-Sen Median趋势分析、重心模型和相关性分析等方法对云南省2011—2020年NPP时空变化特征和影响因素进行研究,并定量区分人类活动和气候变化对植被的影响。结果表明:2011—2020年云南省NPP在空间上呈自西向东、自南向北逐渐下降的分布特征,平均值为1025.22 gC·m^(-2)·a^(-1);高波动区主要分布在迪庆藏族自治州和怒江傈僳族自治州;NPP与气温显著相关区域主要分布在滇东地区,与降水显著相关区域主要分布在滇中和滇东北地区;影响研究区植被恢复的因子顺序为:气候变化>气候变化与人类活动共同作用>人类活动;影响研究区植被退化的因子顺序为:人类活动>气候变化与人类活动共同作用>气候变化。

关键词： NPP 重心模型时空变化影响因素人类活动云南省

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Off-stoichiometry-guided design of high-strength chemically complex intermetallic-based alloys with outstanding ductility

引用

Journal of Materials Science & Technology 2023年第29期160卷 28-33页

作者： Bo Xiao Jixun Zhang Shaofei Liu yilu zhao Lianyong Xu C.T.Liu Tao Yang Department of Materials Science and Engineering Mechanical Behavior Division of Shenyang National Laboratory for Materials ScienceCity University of Hong KongHong KongChina Center for Advanced Nuclear Safety and Sustainable Development City University of Hong KongHong KongChina Hong Kong Institute for Advanced Study City University of Hong KongHong KongChina School of Materials Science and Engineering Harbin Institute of Technology(Shenzhen)Shenzhen 518055China School of Materials Science and Engineering Tianjin UniversityTianjin 300350China

*** The lasting drive for improved energy efficiency in power gen-eration encourages the innovative design of advanced structural materials with superb mechanical properties[1-6].Among these materials,ordered intermetallic alloys[7-9],as a unique class of metallic materials,have drawn increasing concern from both the scientific and industrial communities due to their intriguing high-temperature properties,strong chemical binding,and low atomic mobility[10,11].However,in light of the insufficient number of slip systems and/or intrinsically weak grain boundary(GB),they are usually brittle at ambient temperature,severely hindering their practical use in engineering systems[12].Previous studies reported that the change in alloy stoichiometry has a significant beneficial effect on the ductility of intermetallic *** instance,Liu et al.

关键词： intermetallic ductility alloys

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

用于稠油热采井的耐温凝胶堵剂研制与评价——以春光油田为例

引用

石油地质与工程 2024年第1期38卷 113-116页

作者：赵长喜程红晓耿超徐丽娜王晓东赵一潞中国石化河南油田分公司石油工程技术研究院河南南阳473132

针对河南春光油田稠油热采水平井水窜严重的问题,通过耐高温凝胶堵剂配方研究及性能评价,配套双封定位封堵工艺,实现了水平井不同水窜位置的有效封堵。所研制的耐高温凝胶堵剂,具有耐温耐盐性能好和封堵强度高的特点,耐盐1.00×10^(5)mg... 详细信息

针对河南春光油田稠油热采水平井水窜严重的问题,通过耐高温凝胶堵剂配方研究及性能评价,配套双封定位封堵工艺,实现了水平井不同水窜位置的有效封堵。所研制的耐高温凝胶堵剂,具有耐温耐盐性能好和封堵强度高的特点,耐盐1.00×10^(5)mg/L,耐温达到350℃,高温60 h后突破真空度仍保持在0.065 MPa以上,现场实施后有效延缓了稠油水平井水窜速度,改善了稠油热采水平井开发效果。

关键词：稠油热采水平井水窜凝胶堵剂

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Simultaneously improving mechanical properties and oxidation resistance of Ti-bearing high-entropy superalloys at intermediate temperature via silicon addition

引用

Journal of Materials Science & Technology 2023年第26期157卷 30-41页

作者： Shaofei Liu Weicheng Xiao Bo Xiao Jiang Ju Yinghao Zhou yilu zhao Zengbao Jiao Junhua Luan Qian Li Jinxiong Hou Ji-jung Kai Tao Yang Department of Mechanical Engineering City University of Hong KongHong Kong 999077China Center for Advanced Nuclear Safety and Sustainable Development City University of Hong KongHong Kong 999077China Department of Materials Science and Engineering City University of Hong KongHong Kong 999077China School of Materials Science and Engineering Harbin Institute of TechnologyShenzhen 518055China Department of Mechanical Engineering The Hong Kong Polytechnic UniversityHong Kong 999077China Hong Kong Institute for Advanced Study City University of Hong KongHong Kong 999077China

Ti-bearing high-entropy superalloys(HESAs)often suffer from severe intergranular embrittlement and terrible oxidation degradation at intermediate *** we showcase that minor Si addition can effectively mitigate the intergranular embrittlement and improve the oxidation resistance of the a(Ni_(2)Co_(2)FeCr)_(92) Ti_(4)Al_(4) HESA at 700℃ *** analysis revealed that the intergranu-lar G phase induced by 2 at%Si addition can effectively suppress the inward diffusion of oxygen along grain boundaries at 700℃,thus enhancing the tensile ductility of the alloy from∼8.3%to∼13.4%.Be-sides,the 2 at%Si addition facilitated the formation of a continuous Al_(2)O_(3) layer during oxidation,con-tributing to a remarkable reduction in the growth rate of the oxide scale to a quarter of the Si-free *** results demonstrate that Si can be a favorable alloying element to design advanced HESAs with syn-ergistically improved thermal-mechanical performance.

关键词： High-entropy superalloy Mechanical property Oxidation behavior Intermediate temperature Silicon addition

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Development of the high-strength ductile ferritic alloys via regulating the intragranular and grain boundary precipitation of G-phase

引用

Journal of Materials Science & Technology 2023年第5期136卷 180-199页

作者： Mujin Yang Chao Huang Jiajia Han Haichen Wu yilu zhao Tao Yang Shenbao Jin Chenglei Wang Zhou Li Ruiying Shu Cuiping Wang Huanming Lu Gang Sha Xingjun Liu School of Materials Science and Engineering Harbin Institute of TechnologyShenzhen 518055China Department of Mechanical and Energy Engineering Southern University of Science and TechnologyShenzhen 518055China College of Materials and Fujian Provincial Key Laboratory of Materials Genome Xiamen UniversityXiamen 361005China Test Center Ningbo Institute of Materials Technology and EngineeringChinese Academy of SciencesNingbo 315201China Department of Materials Science and Engineering City University of Hong KongHong KongChina Department of Materials Science and Engineering Nanjing University of Science and TechnologyNanjing 210094China State Key Laboratory of Advanced Welding and Joining Harbin Institute of TechnologyShenzhen 150001China Institute of Materials Genome and Big Data Harbin Institute of TechnologyShenzhen 518055China

A typical G-phase strengthened ferritic model alloy(1Ti:Fe-20Cr-3Ni-1Ti-3Si,wt.%)has been carefully studied using both advanced experimental(EBSD,TEM and APT)and theoretical(DFT)*** the classic“solid solution and aging”process,the superfine(Fe,Ni)_(2)TiSi-L2_(1)particles densely precipitate within the ferritic grain and subsequently transform into the(Ni,Fe)_(16)Ti_(6)Si_(7)-G *** the meanwhile,the elemental segregation at grain boundaries and the resulting precipitation of a large amount of the(Ni,Fe)_(16)Ti_(6)Si_(7)-G phase are also *** nanoscale microstructural evolutions result in a remarkable increase in hardness(100-300 HV)and severe *** the“cold rolling and aging”process is used,the brittle fracture is effectively suppressed without loss of nano-precipitation strengthening *** yield strength of 1700 MPa with 4%elongation at break is *** key improvement in mechanical properties is mainly attributed to the pre-cold rolling process which effectively avoids the dense precipitation of the G-phase at the grain *** findings could shed light on the further exploration of the precipitation site via optimal processing strategies.

关键词： G-phase Precipitation strengthening Grain boundary segregation Nano-precipitates

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Automatic modeling algorithm of stochastic error for inertial sensors

引用

Control Theory and Technology 2024年第1期22卷 81-91页

作者： Luodi zhao Long zhao School of Automation Science and Electrical Engineering Beihang UniversityBeijing100191China Digital Navigation Center Beihang UniversityBeijing100191China Science and Technology on Aircraft Control Laboratory Beihang UniversityBeijing100191China

This paper proposes an automatic algorithm to determine the properties of stochastic processes and their parameters for inertial error. The proposed approach is based on a recently developed method called the generalized method of wavelet moments (GMWM), whose estimator was proven to be consistent and asymptotically normally distributed. This algorithm is suitable mainly (but not only) for the combination of several stochastic processes, where the model identification and parameter estimation are quite difficult for the traditional methods, such as the Allan variance and the power spectral density analysis. This algorithm further explores the complete stochastic error models and the candidate model ranking criterion to realize automatic model identification and determination. The best model is selected by making the trade-off between the model accuracy and the model complexity. The validation of this approach is verified by practical examples of model selection for MEMS-IMUs (micro-electro-mechanical system inertial measurement units) in varying dynamic conditions.

关键词： GMWM Stochastic process Inertial sensor Sensor calibration Error model Allan variance

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Meeting the challenges of invasive alien species

引用

National Science Review 2024年第3期11卷 296-298页

作者： Weijie zhao NSR news

The Xinjiang Uygur Autonomous Region of China is famous for its tomato production. Abundant sunshine, large day–night temperature difference and the abundant irrigation by snowmelt from the Tianshan Mountains produce...

关键词：

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Ling-Ling Chen: RNA has its own features;don't study it as a protein

引用

National Science Review 2024年第2期11卷 301-305页

作者： Weijie zhao NSR

Non-coding RNA(ncRNA) has been a very active research area over the past 30 years. From small nc RNA – the discovery of RNA interference won the lead researchers the Nobel Prize, to long ncRNA(lncRNA), which has attracted much attention in recent years, various nc RNAs participate in all kinds of biological processes and show a variety of biomedical application prospects.

关键词： RNA

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

One dimensional CeO_(2) nanorods/poly(ethylene oxide) solid composite electrolyte for all-solid-state lithium-ion batteries

引用

Journal of Rare Earths 2024年第3期42卷 570-577,I0005页

作者： Yudi Guo Erqing zhao Xiaofang zhao Shuailei Liu School of Chemistry and Materials Engineering Xinxiang UniversityXinxiang453003China School of Chemistry and Chemical Engineering Henan Institute of Science and TechnologyXinxiang453003China

The research of poly(ethylene oxide)(PEO)-based solid composite electrolyte with high ionic conductivity and excellent interfacial stability is the key to the development of all-solid-state lithium-ion batteries(ASSLIBs). Herein, uniform nanorod structured CeO_(2) fillers were controllably synthesized by electrospinning, which were subsequently filled into PEO polymer to prepare CeO_(2)/PEO solid composite electrolyte. The addition of CeO_(2) nanorods can reduce both the glass transition temperature and the melting point of PEO polymer, and also interact with PEO and lithium bis(trifluoromethanesulphonyl)imide(LITFSI) by Lewis acid—base reaction. Therefore, the solid composite electrolyte exhibits a high ionic conductivity of 4.52 × 10^(-4)S/cm, a wide electrochemical stability window of about 4.8 V, and a good interfacial stability with Li at 55℃. Moreover, the LiFePO_4/Li ASSLIB divulges the discharging specific capacity of 165, 162, 156 and 146 mA,h/g at 0.2, 0.5, 1 and 2 C, respectively, and achieves the capacity retention of 90.3% after 150 cycles at 0.5 C. Consequently, one dimensional CeO_(2) nanorods can be considered as an alternative filler for polymeric solid electrolyte.

关键词： Poly(ethylene oxide) Solid composite electrolyte CeO_(2)nanorods Ionic conductivity Rare earths

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：