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International Journal of Minerals,Metallurgy and Materials 2025年第2期32卷 488-497页

作者： yiling li Xiaoyao Yu Yingjie Zhou Yao lin Ying Wu Key Laboratory of the Ministry of Education for Advanced Catalysis Materials College of Chemistry and Materials ScienceZhejiang Normal UniversityJinhua 321004China

BiVO_(4)porous spheres modified by ZnO were designed and synthesized using a facile two-step *** resulting ZnO/BiVO_(4)composite catalysts have shown remarkable efficiency as piezoelectric catalysts for degrading Rhodamine B(RhB)unde mechanical vibrations,they exhibit superior activity compared to pure *** 40wt%ZnO/BiVO_(4)heterojunction composite displayed the highest activity,along with good stability and *** enhanced piezoelectric catalytic activity can be attributed to the form ation of an I-scheme heterojunction structure,which can effectively inhibit the electron-hole ***,hole(h+)and superoxide radical(·O_(2)^(-))are proved to be the primary active ***,ZnO/BiVO_(4)stands as an efficient and stable piezoelectric catalyst with broad potential application in the field of environmental water pollution treatment.

关键词： piezoelectric catalytic heterojunction dye degradation ultrasonic vibration

A new method to solve the Reynolds equation including mass-conserving cavitation by physics informed neural networks(PINNs)with both soft and hard constraints

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Friction 2024年第6期12卷 1165-1175页

作者： Yinhu XI Jinhui DENG yiling li School of Mechanical Engineering Anhui University of Science and TechnologyHuainan 232001China Ericsson AB Datalinjen 3Linköping 58330Sweden

In this work,a new method to solve the Reynolds equation including mass-conserving cavitation by using the physics informed neural networks(PINNs)is *** complementarity relationship between the pressure and the void fraction is *** are several difficulties in problem solving,and the solutions are ***,the difficulty for considering the pressure inequality constraint by PINNs is solved by transferring it into one equality constraint without introducing *** the void fraction inequality constraint is considered by using the hard constraint with the max-min ***,to avoid the fluctuation of the boundary value problems,the hard constraint method is also utilized to apply the boundary pressure values and the corresponding functions are ***,for avoiding the trivial solution the limitation for the mean value of the void fraction is *** results are validated against existing data,and both the incompressible and compressible lubricant are *** agreement can be found for both the domain and domain boundaries.

关键词： Reynolds equation mass-conserving cavitation physics informed neural networks hard constraints trivial solution

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单肺通气致肺损伤的机制及保护策略研究进展

陕西医学杂志 2025年第1期54卷 138-141页

作者：王贝姜力李依玲孟杰武汉科技大学附属孝感医院湖北孝感432000 武汉科技大学医学部医学院湖北武汉430065 武汉大学附属同仁医院普外科湖北武汉430060

单肺通气(OLV)是临床常见的一种通气技术,能够有效隔离患侧肺,实现对非手术侧肺通气的目的。目前,OLV广泛应用于各类大型手术中,有效提高了手术的有效性与安全性。但OLV在应用过程中易造成肺损伤,常见的肺损伤类型有肺不张损伤、灌注性... 详细信息

单肺通气(OLV)是临床常见的一种通气技术,能够有效隔离患侧肺,实现对非手术侧肺通气的目的。目前,OLV广泛应用于各类大型手术中,有效提高了手术的有效性与安全性。但OLV在应用过程中易造成肺损伤,常见的肺损伤类型有肺不张损伤、灌注性肺损伤、氧化应激肺损伤、手术操作致肺损伤、高容量肺损伤,多种类型的肺损伤发病机制具有复杂性,根据肺损伤机制临床可制定吸入合适的氧浓度、选择有效的通气模式、潮气量、持续正压气道、呼气末正压等一系列肺保护策略,能够逐步提高氧合功能,减轻肺损伤,加速肺损伤组织的修复。

关键词：单肺通气肺损伤机制保护策略研究进展

Oncolytic virus-based hepatocellular carcinoma treatment:Current status,intravenous delivery strategies,and emerging combination therapeutic solutions

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Asian Journal of Pharmaceutical Sciences 2023年第1期18卷 4-26页

作者： Xinguo li Xiaonan Sun BingyuanWang yiling li Jing Tong The First Hospital of China Medical University Shenyang 110001China The 4th People’s Hospital of Shenyang Shenyang 110031China

Current treatments for advanced hepatocellular carcinoma(HCC)have limited success in improving patients’quality of life and prolonging life *** clinical need for more efficient and safe therapies has contributed to the exploration of emerging ***,there has been increased interest in oncolytic viruses(OVs)as a therapeutic modality for *** undergo selective replication in cancerous tissues and kill tumor ***,pexastimogene devacirepvec(Pexa-Vec)was granted an orphan drug status in HCC by the *** and Drug Administration(FDA)in ***,dozens of OVs are being tested in HCC-directed clinical and preclinical *** this review,the pathogenesis and current therapies of HCC are ***,we summarize multiple OVs as single therapeutic agents for the treatment of HCC,which have demonstrated certain efficacy and *** carrier cell-,bioengineered cell mimetic-or nonbiological vehicle-mediated OV intravenous delivery systems in HCC therapy are *** addition,we highlight the combination treatments between oncolytic virotherapy and other ***,the clinical challenges and prospects of OV-based biotherapy are discussed,with the aim of continuing to develop a fascinating approach in HCC patients.

关键词： Oncolytic viruses(OVs) OV intravenous delivery systems Combination treatments Advanced hepatocellular carcinoma (HCC) Pexa-Vec

Speech databases for mental disorders: A systematic review

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General Psychiatry 2019年第3期32卷 119-129页

作者： yiling li Yi lin Hongwei Ding Chunbo li School of Foreign Languages Shanghai Jiao Tong University Shanghai China Shanghai Key Laboratory of Psychotic Disorders Shanghai Mental Health Center School of Medicine Shanghai Jiao Tong University Shanghai China Center for Excellence in Brain Science and Intelligence Technology (CEBSIT) Chinese Academy of Sciences Shanghai China

Background The employment of clinical databases in the study of mental disorders is essential to the diagnosis and treatment of patients with mental illness. While text corpora obtain merely limited information of content, speech corpora capture tones, emotions, rhythms and many other signals beyond content. Hence, the design and development of speech corpora for patients with mental disorders is increasingly important. Aim This review aims to extract the existing speech corpora for mental disorders from online databases and peer-reviewed journals in order to demonstrate both achievements and challenges in this area. Methods The review first covers publications or resources worldwide, and then leads to the reports from China, followed by a comparison between Chinese and nonChinese regions. Results Most of the speech databases were recorded in Europe or the United States by audio or video. Some were even supplemented by brain images and Event- Related Potential (ERP) statistics. The corpora were mostly developed for patients with neurocognitive disorders like stutter and aphasia, and mental illness like dementia, while other types of mental illness such as bipolar disorder, anxiety, d即ression and autism were scarce in number in database development. Strengths and limitations The results demonstrated that database development of neurocognitive disorders in China is much scarcer than that in some European countries, but the existing databases pave an instructive road for psychiatric problems. Also, the methods and applications of databases from the leading countries are inspiring for Chinese scholars, who are searchi ng methods for developing a comprehensive resource for clinical studies.

关键词： Speech databases mental disorders A systematic review

The pathophysiological mechanism between hypopituitarism and nonalcoholic fatty liver disease

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iliVER 2022年第1期1卷 65-71页

作者： Xinhe Zhang Haoyu Tian yiling li Gastroenterology Department The First Affiliated Hospital of China Medical UniversityNo.155 North Nanjing StreetHeping DistrictShenyang 110001LiaoningChina The 3rd Clinical Department of China Medical University No.77 Puhe RoadShenyang North New AreaShenyang 110122LiaoningChina

Nonalcoholic fatty liver disease(NAFLD)is a common chronic metabolic liver disease *** is closely related to diseases of the cardiovascular system and chronic kidney *** can also occur secondary to many other *** research shows that patients with hypopituitarism have a high risk of developing *** the adenohypophysis is dominated by hypothalamic hormones,hormones are secreted to act on the corresponding tissues or *** is characterized by a decrease in the thyroid hormone,cortisol,and growth hormone *** this review,we analyzed the mechanisms related to NAFLD through thyroid secretion,growth hormone secretion,sex hormone,and prolactin axes in patients with hypopituitarism,which will provide information and a theoretical basis for clinical diagnosis and treatment.

关键词： Hypopituitarism NAFLD Pathophysiological mechanism

Targeting nuclear acid-mediated immunity in cancer immune checkpoint inhibitor therapies

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Signal Transduction and Targeted Therapy 2020年第1期5卷 235-248页

作者： Miaoqin Chen Shiman Hu yiling li Ting Ting Jiang Hongchuan Jin lifeng Feng Laboratory of Cancer Biology Key lab of Biotherapy in Zhejiang ProvinceCancer Institute of Zhejiang UniversitySir Run Run Shaw hospitalSchool of MedicineZhejiang UniversityHangzhouZhejiang 310016China Department of Radiation Oncology Sir Run Run Shaw HospitalMedical School of Zhejiang UniversityHangzhou 310016China

Cancer immunotherapy especially immune checkpoint inhibition has achieved unprecedented successes in cancer ***,there are many patients who failed to benefit from these therapies,highlighting the need for new combinations to increase the clinical efficacy of immune checkpoint *** this review,we summarized the latest discoveries on the combination of nucleic acid-sensing immunity and immune checkpoint inhibitors in cancer *** the critical role of nuclear acid-mediated immunity in maintaining the activation of T cell function,it seems that harnessing the nuclear acidmediated immunity opens up new strategies to enhance the effect of immune checkpoint inhibitors for tumor control.

关键词： immunity cancer therapies

A historical review of aggregation-induced emission from 2001 to 2020:A bibliometric analysis

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Aggregate

Aggregate 2022年第1期3卷 122-137页

作者： Qiming Xia Yiyin Zhang yiling li Yirun li Yixuan li Zhe Feng Xiaoxiao Fan Jun Qian Hui lin Department of General Surgery Sir Run Run Shaw HospitalSchool of MedicineZhejiang UniversityZhejiang ProvinceHangzhouP.R.China State Key Laboratory of Modern Optical Instrumentations Centre for Optical and Electromagnetic ResearchCollege of Optical Science and EngineeringInternational Research Center for Advanced PhotonicsZhejiang UniversityHangzhouP.R.China College of Biomedical Engineering and Instrument Science Zhejiang UniversityHangzhouP.R.China

Aggregation-induced emission(AIE)is a photophysical phenomenon that a certain group of luminescent materials that become highly luminous when aggregated in a bad solvent or solid *** year is the 20th anniversary since the AIE concept firstly proposed in *** advanced applications were gradually being explored,covering optics,electronics,energy,and bioscience and so *** present,bibliometrics can enlighten the researchers with comprehensive sights of the achievements and trends of a specific field,which is critical for academic ***,we presented a general bibliometric overview of AIE covering 20 years of *** the assistance of Web of Science Core Collection database and several bibliometric software tools,the annual publication and citation,most influential countries/regions,most contributing authors,journals and institutions,second near-infrared(NIR-Ⅱ)related hotspots,as well as the forecast of frontiers were demonstrated and systematically *** study summarizes the current research status in AIE research field and provides a reference for future research directions.

关键词： aggregation-induced emission(AIE) bibliometric analysis research trend second near-infrared(NIR-Ⅱ)

FRET-based two-photon benzo[a]phenothiazinium photosensitizer for fluorescence imaging-guided photodynamic therapy

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Chinese Chemical Letters 2024年第7期35卷 325-328页

作者： yiling li Zekun Gao Xiuxiu Yue Minhuan Lan Xiuli Zheng Benhua Wang Shuang Zhao Xiangzhi Song College of Chemistry&Chemical Engineering Central South UniversityChangsha 410083China Key Laboratory of Photochemical Conversion and Optoelectronic Materials and City U-CAS Joint Laboratory of Functional Materials and Devices Technical Institute of Physics and ChemistryChinese Academy of SciencesBeijing 100190China Department of Dermatology Xiangya HospitalCentral South UniversityChangsha 410083China

To overcome the conflict between the long-wavelength excitation and high singlet oxygen quantum yield of photosensitizers,we conjugated a two-photon fluorophore,tetrahydroquinoxaline coumarin(TQ),and an efficient photodynamic therapeutic agent,benzo[a]phenothiazinium(NBS-NH_(2)),through a hexamethylene linker to build a two-photon photosensitizer,*** TQ-NBS,TQ served as an energy donor and NBS-NH_(2) acted as an energy acceptor;and TQ-NBS was a F?rster resonance energy transfer(FRET)cassette with a 92.8%*** large two-photon absorption cross-section of TQ allowed photosensitizer TQ-NBS to work in a 900 nm two-photon excitation(TPE)mode,which greatly benefited the deep tissue penetration in PDT ***,the excellent phototoxicity and near-infrared fluorescence of NBS-NH2was kept in TQ-NBS under a TPE mode via a FRET *** TQ-NBS exhibited a high phototoxic efficacy in living cells and tumor-bearing mice.

关键词： Photodynamic therapy Two-photon excitation FRET-based photosensitizer Singlet oxygen Near-infrared fluorescence

Maize-soybean relay cropping increases soybean yield synergistically by extending the post-anthesis leaf stay-green period and accelerating grain filling

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The Crop Journal 2023年第6期11卷 1921-1930页

作者： yiling li Ping Chen Zhidan Fu Kai Luo Ping lin Chao Gao Shanshan liu Tian Pu Taiwen Yong Wenyu Yang College of Agronomy Sichuan Agricultural University/Key Laboratory of Crop Ecophysiology and Farming System in SouthwestMinistry of Agriculture and Rural Affairs/Sichuan Engineering Research Center for Crop Strip Intercropping SystemChengdu 611130SichuanChina

Relay cropping of Poaceae and Fabaceae promotes high yield and land-use efficiency by allowing a double ***,it is difficult to increase yield synergistically because of the reduced photosynthetic abilities of legume leaves under the shade of *** photosynthetic capacity in relay cropping systems is associated with ecological niche differentiation and photosynthetic compensation after restoration of normal *** conducted a field experiment in southwest China in 2020–2021 to evaluate the effects of three cropping patterns:maize–soybean relay cropping(IMS),monoculture maize(MM),and monoculture soybean(SS),and N application levels:no N application(NN:0 kg N ha^(−1)),reduced N(RN:180 kg N ha^(−1)),and conventional N(CN:240 kg N ha^(−1)).Compared to monocropping,relay cropping increased the stay-green traits of maize and soybean by 13%and 89%,*** cropping prolonged the leaf stay-green duration in the maize and soybean lag phase by almost 4 and 8 days,*** cropping maize(IM)increased the leaf area index(LAI)by 79.4%to 88.5%under NN and 55.5%to 148%under *** cropping soybean(IS)increased the LAI from 115%to 437%at days 40 to 50 after *** increased yield by 65.6%.IS increased yield by 9.7%.HI and system yield were at their highest values under *** the relay cropping system,reduced N application extended green leaf duration,increased photosynthesis inside the canopy at multiple levels,ultimately increases soybean yield synergistically.

关键词： Leaf stay-green Nitrogen reduction Maize-soybean relay cropping Yield