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Comparative proteomic analysis of plasma exosomes reveals the functional contribution of N-acetyl-alpha-glucosaminidase to Parkinson’s disease

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Neural Regeneration Research 2025年第10期20卷 2998-3012页

作者： yuan Zhao Yidan Zhang Xin Liu Jian Zhang Ya Gao Shuyue Li Cui Chang Xiang Liu Guofeng Yang Department of Geriatrics Second Hospital of Hebei Medical UniversityShijiazhuangHebei ProvinceChina Department of Neurosurgery The Second Hospital of Hebei Medical UniversityShijiazhuangHebei ProvinceChina

Parkinson’s disease is the second most common progressive neurodegenerative disorder,and few reliable biomarkers are available to track disease *** proteins,DNA,mRNA,and lipids carried by exosomes reflect intracellular changes,and thus can serve as biomarkers for a variety of *** this study,we investigated alterations in the protein content of plasma exosomes derived from patients with Parkinson’s disease and the potential therapeutic roles of these proteins in Parkinson’s *** a tandem mass tag-based quantitative proteomics approach,we characterized the proteomes of plasma exosomes derived from individual patients,identified exosomal protein signatures specific to patients with Parkinson’s disease,and identified N-acetyl-alpha-glucosaminidase as a differentially expressed protein.N-acetyl-alpha-glucosaminidase expression levels in exosomes from the plasma of patients and healthy controls were validated by enzyme-linked immunosorbent assay and western *** results demonstrated that the exosomal N-acetyl-alpha-glucosaminidase concentration was not only lower in Parkinson’s disease,but also decreased with increasing Hoehn-Yahr stage,suggesting that N-acetyl-alpha-glucosaminidase could be used to rapidly evaluate Parkinson’s disease ***,western blot and immunohistochemistry analysis showed that N-acetyl-alpha-glucosaminidase levels were markedly reduced both in cells treated with 1-methyl-4-phenylpyridinium and cells overexpressingα-synuclein compared with control ***,N-acetyl-alpha-glucosaminidase overexpression significantly increased cell viability and inhibitedα-synuclein expression in 1-methyl-4-phenylpyridinium-treated *** together,our findings demonstrate for the first time that exosomal N-acetyl-alpha-glucosaminidase may serve as a biomarker for Parkinson’s disease diagnosis,and that N-acetyl-alpha-glucosaminidase may reduceα-synuclein expression and 1-methyl-4-phenylpyridinium-induced n

关键词： biomarker diagnosis exosomes N-acetyl-alpha-glucosaminidase Parkinson’s disease proteomic α-synuclein

A promising approach for quantifying focal stroke modeling and assessing stroke progression:optical resolution photoacoustic microscopy photothrombosis

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Neural Regeneration Research 2025年第7期20卷 2029-2037页

作者： Xiao Liang Xingping Quan Xiaorui Geng Yujing Huang Yonghua Zhao Lei Xi Zhen yuan Ping Wang Bin Liu Faculty of Health Sciences University of MacaoMacao Special Administrative RegionChina Center for Cognitive and Brain Sciences University of MacaoMacao Special Administrative RegionChina Department of Biomedical Engineering Southern University of Science and TechnologyShenzhenGuangdong ProvinceChina State Key Laboratory of Quality Research in Chinese Medicine Institute of Chinese Medical SciencesUniversity of MacaoTaipaMacao Special Administrative RegionChina Department of Emergency Zhujiang HospitalSouthern Medical UniversityGuangzhouGuangdong ProvinceChina

To investigate the mechanisms underlying the onset and progression of ischemic stroke,some methods have been proposed that can simultaneously monitor and create embolisms in the animal cerebral ***,these methods often require complex systems and the effect of age on cerebral embolism has not been adequately studied,although ischemic stroke is strongly *** this study,we propose an optical-resolution photoacoustic microscopy-based visualized photothrombosis methodology to create and monitor ischemic stroke in mice simultaneously using a 532 nm pulsed *** observed the molding process in mice of different ages and presented age-dependent vascular embolism ***,we integrated optical coherence tomography angiography to investigate age-associated trends in cerebrovascular variability following a *** imaging data and quantitative analyses underscore the differential cerebrovascular responses to stroke in mice of different ages,thereby highlighting the technique's potential for evaluating cerebrovascular health and unraveling age-related mechanisms involved in ischemic strokes.

关键词： age-dependent cerebral cortex ischemic stroke mouse model optical coherence tomography angiography photoacoustic microscopy photothrombosis vascular imaging

Great reduction pratice of SUS304 in cold-rolling

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Baosteel Technical Research 2010年第S1期4卷 79-页

作者： LUO Jinsong,ZHENG Tao,yuan yilin and LIU Yajun Ningbo Baoxin Stainless Steel Co.,Ltd.,Ningbo 315807,Zhejiang,China

SUS304 stainless steel is typical of austenitic stainless steel,which organization is metastable austenite,easily appears work hardening in cold *** to the common process,the max reduction of cold rolling in one stage is below 80%,we try to rasie the max reduction to 90%in one stage (wecalled that "great reduction" ) from the view of cuting *** to the work hardening,great reduction brings lots of problem(the difficulty of flatness control,strip break..etc)。This article analyzed the great reduction from properity of SUS304 steel,mill types,flatness control,rolling technics etc,supplied the corresponding solutions,and formed a sophisticated great reduction theory. This article focuses on the unusual thermal crown of raw materials(ie,abnormal distribution of horizontal thickness) and the rolling force fluctuations in "great reduction" ***,the "distortion" phenomenon which caused by unusual thermal crown of raw materials is explained,wedge-shaped strip In coiling, because of a big difference in thickness on both sides,leads to different compressive stress on both sides of flatness roll,so that the flatness measurement is distorted;Second,the "strip shifting" phenomenon caused by wedge shape of strip is explained,we analysis the stress on both sides of the strip,concluded that the wedge-shaped strip on the coiler will shift to the thick side of the deviation,the amount of strip shifting is related to the wedge level;Because of the characteristics of SUS304,the strip is difficult to be rolled in the last few *** the strip breaking is easily occurred,we found the reasonable parameters(rolling speed, cooling oil,tension,etc) to solute that problem;The deviation of rolling force will cause the shape of the roll gap,thus affecting the shape control,especially in the head and tail part of the strip,It is important to minimize the deviation of rolling force;The "great reduction" process provide the favorable flatness(< 8I-unit) and thickness d

关键词： SUS304 great reduction mill types strip shape control

Exploration of Gas‑Dependent Self‑Adaptive Reconstruction Behavior of Cu_(2)O for Electrochemical CO_(2)Conversion to Multi‑Carbon Products

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Nano-Micro Letters 2025年第3期17卷 280-296页

作者： Chaoran Zhang Yichuan Gu Qu Jiang Ziyang Sheng Ruohan Feng Sihong Wang Haoyue Zhang Qianqing Xu Zijian yuan Fang Song State Key Laboratory of Metal Matrix Composites School of Materials Science and EngineeringShanghai Jiao Tong UniversityShanghai 200240People’s Republic of China

Structural reconstruction of electrocatalysts plays a pivotal role in catalytic performances for CO_(2)reduction reaction(CO_(2)RR),whereas the behavior is by far superficially ***,we report that CO_(2)accessibility results in a universal self-adaptive structural reconstruction from Cu_(2)O to Cu@CuxO composites,ending with feeding gas-dependent microstructures and catalytic *** CO_(2)-rich atmosphere favors reconstruction for CO_(2)RR,whereas the CO_(2)-deficient one prefers that for hydrogen evolution *** the assistance of spectroscopic analysis and theoretical calculations,we uncover a CO_(2)-induced passivation behavior by identifying a reductionresistant but catalytic active Cu(I)-rich amorphous layer stabilized by*CO ***,we find extra CO production is indispensable for the robust production of *** inverse correlation between durability and FECO/FEC2H4 is disclosed,suggesting that the selfstabilization process involving the absorption of*CO intermediates on Cu(I)sites is essential for durable *** by this insight,we design hollow Cu_(2)O nanospheres for durable and selective CO_(2)RR electrolysis in producing *** work recognizes the previously overlooked passivation reconstruction and self-stabilizing behavior and highlights the critical role of the local atmosphere in modulating reconstruction and catalytic processes.

关键词： CO_(2)reduction reaction Electrocatalysts Cu_(2)O Reconstruction Self-adaptive electrocatalysis

Investigation on optical sinc-shaped Nyquist pulse generation based on external modulation

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Optoelectronics Letters 2025年

作者： yuan Jin XU Xiuxiu State Key Laboratory of Media Convergence and Communication， Communication University of China

In this paper， a scheme for generating sinc-shaped optical Nyquist pulses based on external modulation is proposed. First， five flat optical frequency comb (OFC) lines are generated by a dual-parallel Mach-Zehnder modulator (DP-MZM) for optical carrier phase cancellation interference. Then， the phase-locked OFC is split into two paths， one of which is transmitted to a single-drive Mach-Zehnder modulator (SD-MZM) for the modulation of the even-order side-band suppression， and the other is used to remodulate the signal in order to obtain equally spaced comb lines. Eventually， equal frequency spaced phase-locked 15-line OFCs are generated and extremely narrow over-zero width Nyquist pulses are realized at 2.5GHz， 5GHz， 10GHz and 20GHz. The root-mean-square error (RMSE) is calculated for the generated Nyquist pulses which enables the verification of the signal quality.

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基于多特征融合的无人机天山假狼毒地上生物量估算

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新疆农业科学 2024年第10期61卷 2527-2536页

作者：侯正清颜安谢开云袁以琳夏雯秋肖淑婷张振飞孙哲新疆农业大学资源与环境学院乌鲁木齐830052 新疆农业大学草业学院乌鲁木齐830052 新疆农业大学计算机与信息工程学院乌鲁木齐830052

【目的】研究无人机多特征构建天山假狼毒地上生物量(AGB)估算模型的能力,为草地退化程度的分级提供参考依据。【方法】天山假狼毒(Diarthron tianschanicum)作为退化指示植物之一,其生长状况可反映草地退化程度。通过可见光高空间分辨... 详细信息

【目的】研究无人机多特征构建天山假狼毒地上生物量(AGB)估算模型的能力,为草地退化程度的分级提供参考依据。【方法】天山假狼毒(Diarthron tianschanicum)作为退化指示植物之一,其生长状况可反映草地退化程度。通过可见光高空间分辨率遥感影像提取光谱特征、纹理特征和天山假狼毒覆盖度,将三者分别作为输入量建立一元线性模型,三类特征融合构建多元逐步回归与人工神经网络模型,分析多特征融合估算天山假狼毒AGB的效果。【结果】(1)盛花期为天山假狼毒最佳覆盖度提取窗口期,利用RF算法构建的天山假狼毒提取模型效果较为理想,总体精度在81%以上。(2)光谱特征、纹理特征、覆盖度均与天山假狼毒AGB具有相关性,其中纹理特征cor_G相关性最高,达0.784。(3)对比单一植被指数、纹理特征、覆盖度及任意两种特征组合作为输入量,多特征融合估算天山假狼毒AGB的精度最高,R2、RMSE为0.870、15.383,并利用人工神经网络模型对此结论进行验证。【结论】融合光谱特征、纹理指数、覆盖度能有效提高天山假狼毒AGB估算精度。

关键词：无人机天山假狼毒生物量可见光覆盖度纹理特征

Assessing the corrosion protection property of coatings loaded with corrosion inhibitors using the real-time atmospheric corrosion monitoring technique

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International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 119-126页

作者： Xiaoxue Wang Lulu Jin Jinke Wang Rongqiao Wang Xiuchun Liu Kai Gao Jingli Sun Yong yuan Lingwei Ma Hongchang Qian Dawei Zhang School of Energy and Power Engineering Beihang UniversityBeijing 100191China Beijing Institute of Space Long March Vehicle Beijing 100076China National Materials Corrosion and Protection Data Center University of Science and Technology BeijingBeijing 100083China Institute of Materials Intelligent Technology Liaoning Academy of MaterialsShenyang 110004China Shanghai Spaceflight Precision Machinery Institute Shanghai 201600China

The atmospheric corrosion monitoring(ACM)technique has been widely employed to track the real-time corrosion behavior of metal ***,limited studies have applied ACM to the corrosion protection properties of organic *** study compared a bare epoxy coating with one containing zinc phosphate corrosion inhibitors,both applied on ACM sensors,to observe their corrosion protection properties over *** with artificial damage via scratches were exposed to immersion and alternating dry and wet environments,which allowed for monitoring galvanic corrosion currents in *** the corrosion tests,the ACM currents of the zinc phosphate/epoxy coating were considerably lower than those of the blank epoxy *** trend in ACM current variations closely matched the results obtained from regular electrochemical tests and surface *** alignment highlights the potential of the ACM technique in evaluating the corrosion protection capabilities of organic *** with the blank epoxy coating,the zinc phosphate/epoxy coating showed much-decreased ACM current values that confirmed the effective inhibition of zinc phosphate against steel corrosion beneath the damaged coating.

关键词： atmospheric corrosion monitoring technology corrosion inhibitor coating carbon steel corrosion protection

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时空降阶单元及其自适应分析初探

“新工科”背景下化学工程与工艺专业的发展前景分析

工程力学 2025年第1期42卷 10-19页

作者：袁驷袁全清华大学土木工程系土木工程安全与耐久教育部重点实验室北京100084

基于初值问题和边值问题中降阶单元的成功实现，进一步提出时空降阶单元，以弹性弦振动方程(波动方程)为例，构造了自适应有限元分析算法。时空降阶单元继承了初值和边值问题中降阶单元的所有优点，可以给出按最大模度量满足误差限的降... 详细信息

基于初值问题和边值问题中降阶单元的成功实现，进一步提出时空降阶单元，以弹性弦振动方程(波动方程)为例，构造了自适应有限元分析算法。时空降阶单元继承了初值和边值问题中降阶单元的所有优点，可以给出按最大模度量满足误差限的降阶单元的解答。该文对这一研究进展做一简要介绍，并给出包括若干强迫振动以及移动荷载反应的典型算例以展示本法的可行性、有效性和可靠性。

关键词：时空有限元弦振动方程降阶单元最大模自适应有限元法

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现代盐化工 2018年第3期45卷 95-96页

作者：刘广涵黄慧姿赵紫光齐一琳黄园河北农业大学理工学院河北黄骅061100

在国家创新体系与新一轮的科技革命推动的不断创新体系建设的大背景下,我国的工程教育面临着前所未有的挑战,急需培养一批具有关联能力、空间感知能力、想象力、学科交叉能力以及批评性思维能力的人才。化工专业作为传统的工科专业更应... 详细信息

在国家创新体系与新一轮的科技革命推动的不断创新体系建设的大背景下,我国的工程教育面临着前所未有的挑战,急需培养一批具有关联能力、空间感知能力、想象力、学科交叉能力以及批评性思维能力的人才。化工专业作为传统的工科专业更应该在新工科的大趋势下,紧跟时代步伐,加快优化人才培养的全新方式,使高校与社会需要实现更好的对接。

关键词：新工科化学工程与工艺教育