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Coal Seam Correlation in Terrestrial Basins by Sequence Stratigraphy and Its Implications for Paleoclimate and Paleoenvironment Evolution

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Journal of Earth Science 2023年第2期34卷 556-570页

作者： Haihai Hou Longyi Shao Yue tang Yanan Li Guodong Liang yilin Xin Jiaqiang Zhang College of Mining Liaoning Technical UniversityFuxin 123000China College of Geoscience and Surveying Engineering China University of Mining and TechnologyBeijing 100083China Oil&Gas Resource Survey Centre China Geological SurveyMinistry of Land and ResourcesBeijing100029China

Coal correlation cannot only guide coal and coalbed methane exploitation,but may also provide valuable information for the evolution of the paleoclimate and paleoenvironment during coalaccumulation *** is difficult to undertake coal correlation in a terrestrial basin due to multiple superimposed coal seams and a lack of effective marker *** this study,based on the analyses of coal-bearing sedimentary environments and the observations of field outcrops and drilling cores,three key sequence surfaces of the Middle Jurassic Xishanyao Formation were identified in the middle part of the southern Junggar *** third-order sequences(S.Ⅲ1,S.Ⅲ2 and S.Ⅲ3)and ten fourth-order sequences were divided within the Xishanyao *** coal correlation was finally identified,combined with the layered vertical pattern coal and its interval thickness,coal maceral,and coal quality *** terms of the coal correlation within a specific sequence set,the interval of the B2–B3 coals was approximately three times thicker than that of the B3–B5 coals,which was the main marker for regional coal correlation in the Lower Xishanyao ***,the phenomena of steadily developed B4 coal seam(2–3 m in thickness)across the Liuhuanggou coal mining area(eastern study region)and the large-small-large variation for intervals between the B8 and B9,B9 and B10,and B10 and B11 coal seams in the Manasi coal mining(western study region)were also an effective means for local coal *** vitrinite and sulphur content and decreasing inertinite content in a third-order sequence were found,which were likely to be closely related to lake level *** on the variation of coal macerals,the wildfire frequency gradually decreased from the bottom to the top of the Xishanyao *** predicted O2level of the S.Ⅲ1,S.Ⅲ2,and S.Ⅲ3 of the Xishanyao Formation was 26.36%,24.22%,and 22.51%,*** for global paleoclimate effects,the provenance dire

关键词： southern Junggar Basin low ranked coal coalbed methane coal seam correlation sequence stratigraphy sedimentology

磁共振弥散张量成像在创伤性脑损伤临床诊断和预后评估的应用价值

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医学影像学杂志 2020年第10期30卷 1765-1769页

作者：陈水斌汤奕林欧阳林罗爱芳肖玉辉中国人民解放军联勤保障部队第九〇九医院医学影像科厦门大学医学院医学影像研究所福建漳州363000

目的探讨磁共振弥散张量成像(DTI)在创伤性脑损伤(TBI)临床诊断和预后评估中的应用价值。方法15例有明确颅脑外伤患者为TBI组,均行头颅CT、常规MRI序列(包括T 1WI、T 2WI、FLAIR像)与DTI检查,测量脑内不同部位的FA值,并对患者脑外伤严... 详细信息

目的探讨磁共振弥散张量成像(DTI)在创伤性脑损伤(TBI)临床诊断和预后评估中的应用价值。方法15例有明确颅脑外伤患者为TBI组,均行头颅CT、常规MRI序列(包括T 1WI、T 2WI、FLAIR像)与DTI检查,测量脑内不同部位的FA值,并对患者脑外伤严重程度行格拉斯哥昏迷评分(GCS),评估患者病情严重程度;采用Pearson直线相关分析FA值与GCS评分,分析患者后遗症的发生与DTI、GCS评分和住院时间的相关性,选取志愿者15例为对照组。结果TBI组各ROI的FA值与对照组相比较均下降,差异有统计学意义(P0.05);TBI组的FA值与GCS存在明显相关性(P<0.05)。DTI异常与患者脑伤后遗症比较(P<0.05)为差异有统计学意义。结论FA值的变化与TBI患者的病情严重程度具有较强的相关性,DTI检查技术为临床TBI患者的早期确诊和病情严重程度的评估提供重要临床依据。

关键词：创伤性脑损伤磁共振成像弥散张量成像临床价值

The potential mechanism and clinical application value of remote ischemic conditioning in stroke

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Neural Regeneration Research 2025年第6期20卷 1613-1627页

作者： Yajun Zhu Xiaoguo Li Xingwei Lei Liuyang tang Daochen Wen Bo Zeng Xiaofeng Zhang Zichao Huang Zongduo Guo The First Affiliated Hospital of Chongqing Medical University ChongqingChina

Some studies have confirmed the neuroprotective effect of remote ischemic conditioning against stroke. Although numerous animal researches have shown that the neuroprotective effect of remote ischemic conditioning may be related to neuroinflammation, cellular immunity, apoptosis, and autophagy, the exact underlying molecular mechanisms are unclear. This review summarizes the current status of different types of remote ischemic conditioning methods in animal and clinical studies and analyzes their commonalities and differences in neuroprotective mechanisms and signaling pathways. Remote ischemic conditioning has emerged as a potential therapeutic approach for improving stroke-induced brain injury owing to its simplicity, non-invasiveness, safety, and patient tolerability. Different forms of remote ischemic conditioning exhibit distinct intervention patterns, timing, and application range. Mechanistically, remote ischemic conditioning can exert neuroprotective effects by activating the Notch1/phosphatidylinositol 3-kinase/Akt signaling pathway, improving cerebral perfusion, suppressing neuroinflammation, inhibiting cell apoptosis, activating autophagy, and promoting neural regeneration. While remote ischemic conditioning has shown potential in improving stroke outcomes, its full clinical translation has not yet been achieved.

关键词： Akt apoptosis autophagy cerebral perfusion cerebral vascular stenosis clinical transformation hemorrhagic stroke ischemic stroke neuroinflammation neuroprotection Notch1 PI3K remote ischemic conditioning stroke

The interaction between KIF21A and KANK1 regulates dendritic morphology and synapse plasticity in neurons

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Neural Regeneration Research 2025年第1期20卷 209-223页

作者： Shi-Yan Sun Lingyun Nie Jing Zhang Xue Fang Hongmei Luo Chuanhai Fu Zhiyi Wei Ai-Hui tang Hefei National Research Center for Physical Sciences at the Microscale CAS Key Laboratory of Brain Function and DiseaseMinistry of Education Key Laboratory for Membrane-less Organelles and Cellular DynamicsDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefeiAnhui ProvinceChina Institute of Artificial Intelligence Hefei Comprehensive National Science CenterHefeiAnhui ProvinceChina CAS Center for Excellence in Molecular Cell Sciences Division of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefeiAnhui ProvinceChina Department of Neurobiology School of Life SciencesSouthern University of Science and TechnologyShenzhenGuangdong ProvinceChina Brain Research Center Southern University of Science and TechnologyShenzhenGuangdong ProvinceChina

Morphological alterations in dendritic spines have been linked to changes in functional communication between neurons that affect learning and ***-4 KIF21A helps organize the microtubule-actin network at the cell cortex by interacting with KANK1;however,whether KIF21A modulates dendritic structure and function in neurons remains *** this study,we found that KIF21A was distributed in a subset of dendritic spines,and that these KIF21A-positive spines were larger and more structurally plastic than KIF21A-negative ***,the interaction between KIF21A and KANK1 was found to be critical for dendritic spine morphogenesis and synaptic *** of either KIF21A or KANK1 inhibited dendritic spine morphogenesis and dendritic branching,and these deficits were fully rescued by coexpressing full-length KIF21A or KANK1,but not by proteins with mutations disrupting direct binding between KIF21A and KANK1 or binding between KANK1 and *** down KIF21A in the hippocampus of rats inhibited the amplitudes of long-term potentiation induced by high-frequency stimulation and negatively impacted the animals’cognitive *** together,our findings demonstrate the function of KIF21A in modulating spine morphology and provide insight into its role in synaptic function.

关键词： actin cytoskeleton dendrite KANK1 KIF21A microtubule spine morphology spine synaptic plasticity talin1

Graphene meets biology

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Chinese Science Bulletin 2014年第13期59卷 1341-1354页

作者： Ning Li yilin Cheng Qin Song Ziyun Jiang Mingliang tang Guosheng Cheng Suzhou Key Laboratory of Nanobiomedicine & Division of Nanobiomedicine Suzhou Institute of Nano-Tech and NanoBionics Chinese Academy of Sciences

Graphene features a shining star in the material sciences since its discovery in *** application of graphene-family materials has been driven *** this paper,we overviewed the cutting-edge research in the biomedical application of graphene-based biomaterials,such as bio-sensing and bio-imaging,drug/gene delivery and scaffold for tissue *** emphasized on the effect of graphene substrates on cellular behaviors of adhesion,proliferation,and *** development of three-dimensional scaffolds based on graphenebased nanomaterials and the potential of these constructs in tissue engineering are *** perspectives and challenges are also addressed.

关键词：石墨生物学生物医学应用材料科学组织工程生物材料生物成像生物传感

Stochastic scheduling with compatible job families by an improved Q-learning algorithm 36

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Stochastic scheduling with compatible job families by an imp...

3D pCASL结合DWI评价脑外伤后灌注损伤

第36届中国控制会议

作者： yilin Xiao Qi Tan Lei Zhou Hao tang School of Electrical Engineering and Automation Hefei University of Technology

ISBN: (纸本)9781538629185

We consider a system that a single batch processing machine can serve compatible job families(jobs from different families can be processed together in the same batch). The system is characterized by random jobs arrival, random processing time and unlimited buffer capacities. Optimization scheduling method needs to be used with the objective to minimize average cycle time in the long run. First, the stochastic scheduling problem is modeled as a continuous time Markov decision process(CTMDP) with average-cost criteria. Then, a Q-learning algorithm combined with simulated annealing technique(SA-Q learning) is used to derive the optimal or near-optimal policy to schedule the batch processing machine. Computational simulations on randomly generated instances show the effectiveness of the method.

关键词： Batch scheduling compatible job families CTMDP SA-Q learning

来源： cnki会议评论

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医学影像学杂志 2022年第3期32卷 365-369页

作者：肖玉辉欧阳林陈水斌喻黎陈懿汤奕林中国人民解放军联勤保障部队第九〇九医院医学影像科厦门大学附属东南医院医学影像研究所福建漳州363000

目的探讨3D动脉自旋标记成像技术(3D pCASL)和DWI评价创伤性脑损伤(traumatic brain injury,TBI)中不同时期的灌注损伤。方法选取我院2019年6月~2020年6月入院CT诊断为TBI者50例,并在脑创伤急性期、亚急性期、慢性期完成常规MRI、3D pC... 详细信息

目的探讨3D动脉自旋标记成像技术(3D pCASL)和DWI评价创伤性脑损伤(traumatic brain injury,TBI)中不同时期的灌注损伤。方法选取我院2019年6月~2020年6月入院CT诊断为TBI者50例,并在脑创伤急性期、亚急性期、慢性期完成常规MRI、3D pCASL及DWI序列扫描。分析TBI患者脑挫伤区及周围水肿区、对侧镜像区的定量脑血流量(CBF),结合DWI和ADC图,评价TBI患者微循环改变情况并进行统计学分析。结果TBI患者行3D pCASL和DWI扫描可见脑挫伤区及周围水肿区CBF较对侧镜像区明显减低,呈低灌注状态,差异有统计学意义(P<0.05),外伤侧急性期、亚急性期和慢性期CBF值较对侧镜像区下降分别约54%、35%、47%;TBI不同时期挫伤周围水肿区与对侧镜像区比较eADC值降低,差异有统计学意义。结论3D pCASL序列对评价TBI患者不同时期脑挫伤区及周围水肿区脑血流灌注损伤情况,评估外伤后脑微循环改变情况,结合DWI和ADC图,检测缺血半暗带存在,能够明确显示脑血流灌注减低区域、范围。为临床医师治疗提供依据,降低其致残率及死亡率,促进患者康复和提高生存指数。

关键词：创伤性脑损伤磁共振成像动脉自旋标记扩散加权成像

Catalyst–Support Interaction in Polyaniline‑Supported Ni_(3)Fe Oxide to Boost Oxygen Evolution Activities for Rechargeable Zn‑Air Batteries

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Nano-Micro Letters 2025年第1期17卷 176-190页

作者： Xiaohong Zou Qian Lu Mingcong tang Jie Wu Kouer Zhang Wenzhi Li Yunxia Hu Xiaomin Xu Xiao Zhang Zongping Shao Liang An Department of Mechanical Engineering The Hong Kong Polytechnic UniversityHung HomKowloonHong Kong SARPeople’s Republic of China Jiangsu Key Laboratory of Atmospheric Environment Monitoring and Pollution Control Jiangsu Collaborative Innovation Center of Atmospheric Environment and Equipment TechnologySchool of Environmental Science and TechnologyNanjing University of Information Science and TechnologyNanjing 210044People’s Republic of China Department of Chemistry The Chinese University of Hong KongMa Lin BuildingShatinHong Kong SAR 999077People’s Republic of China WA School of Mines:Minerals Energy and Chemical Engineering(WASM‑MECE)Curtin UniversityPerthWA 6102Australia Research Institute for Advanced Manufacturing The Hong Kong Polytechnic UniversityHung HomKowloonHong Kong SARPeople’s Republic of China Research Institute for Smart Energy The Hong Kong Polytechnic UniversityHung HomKowloonHong Kong SARPeople’s Republic of China

Catalyst–support interaction plays a crucial role in improving the catalytic activity of oxygen evolution reaction(OER).Here we modulate the catalyst–support interaction in polyaniline-supported Ni_(3)Fe oxide(Ni_(3)Fe oxide/PANI)with a robust hetero-interface,which significantly improves oxygen evolution activities with an overpotential of 270 mV at 10 mA cm^(-2)and specific activity of 2.08 mA cm_(ECSA)^(-2)at overpotential of 300 mV,3.84-fold that of Ni_(3)Fe *** is revealed that the catalyst–support interaction between Ni_(3)Fe oxide and PANI support enhances the Ni–O covalency via the interfacial Ni–N bond,thus promoting the charge and mass transfer on Ni_(3)Fe *** the excellent activity and stability,rechargeable Zn-air batteries with optimum Ni_(3)Fe oxide/PANI are assembled,delivering a low charge voltage of 1.95 V to cycle for 400 h at 10 mA cm^(-2).The regulation of the effect of catalyst–support interaction on catalytic activity provides new possibilities for the future design of highly efficient OER catalysts.

关键词： Catalyst-support interaction Supported catalysts Heterointerface Oxygen evolution reaction Zn-air batteries

AAV mediated carboxyl terminus of Hsp70 interacting protein overexpression mitigates the cognitive and pathological phenotypes of APP/PS1 mice

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Neural Regeneration Research 2025年第1期20卷 253-264页

作者： Zhengwei Hu Jing Yang Shuo Zhang Mengjie Li Chunyan Zuo Chengyuan Mao Zhongxian Zhang Mibo tang Changhe Shi Yuming Xu Department of Neurology The First Affiliated Hospital of Zhengzhou UniversityZhengzhou UniversityZhengzhouHenan ProvinceChina Academy of Medical Sciences of Zhengzhou University ZhengzhouHenan ProvinceChina NHC Key Laboratory of Prevention and treatment of Cerebrovascular Diseases The First Affiliated Hospital of Zhengzhou UniversityZhengzhou UniversityZhengzhouHenan ProvinceChina Henan Key Laboratory of Cerebrovascular Diseases The First Affiliated Hospital of Zhengzhou UniversityZhengzhou UniversityZhengzhouHenan ProvinceChina Institute of Neuroscience Zhengzhou UniversityZhengzhouHenan ProvinceChina Sino-British Research Centre for Molecular Oncology National Centre for International Research in Cell and Gene TherapySchool of Basic Medical SciencesAcademy of Medical SciencesZhengzhou UniversityZhengzhouHenan ProvinceChina Department of Gerontology The First Affiliated Hospital of Zhengzhou UniversityZhengzhou UniversityZhengzhouHenan ProvinceChina

The E3 ubiquitin ligase,carboxyl terminus of heat shock protein 70(Hsp70)interacting protein(CHIP),also functions as a co-chaperone and plays a crucial role in the protein quality control *** this study,we aimed to investigate the neuroprotective effect of overexpressed CHIP on Alzheimer’s *** used an adeno-associated virus vector that can cross the blood-brain barrier to mediate CHIP overexpression in APP/PS1 mouse *** overexpression significantly ameliorated the performance of APP/PS1 mice in the Morris water maze and nest building tests,reduced amyloid-βplaques,and decreased the expression of both amyloid-βand phosphorylated *** also alleviated the concentration of microglia and astrocytes around *** APP/PS1 mice of a younger age,CHIP overexpression promoted an increase in ADAM10 expression and inhibitedβ-site APP cleaving enzyme 1,insulin degrading enzyme,and neprilysin *** of HSP70 and HSP40,which have functional relevance to CHIP,were also *** nuclei transcriptome sequencing in the hippocampus of CHIP overexpressed mice showed that the lysosomal pathway and oligodendrocyte-related biological processes were up-regulated,which may also reflect a potential mechanism for the neuroprotective effect of *** research shows that CHIP effectively reduces the behavior and pathological manifestations of APP/PS1 ***,overexpression of CHIP could be a beneficial approach for the treatment of Alzheimer’s disease.

关键词： adeno-associated virus Alzheimer’s disease APP/PS1 mice carboxyl terminus of Hsp70 interacting protein gene therapy