检索结果-南通市图书馆

Antibacterial mechanism of kojic acid and tea polyphenols against Escherichia coli O157:H7 through transcriptomic analysis

引用

Food Science and Human Wellness 2024年第2期13卷 736-747页

作者： yilin lin Ruifei Wang Xiaoqing li Keren Agyekumwaa Addo Meimei Fang Yehui Zhang Yigang Yu School of Food Sciences and Engineering South China University of TechnologyGuangzhou 510640China Sericulture&Agri-food Research Institute Guangdong Academy of Agricultural Sciences Key Laboratory of Functional FoodsMinistry of Agriculture and Rural AffairsGuangdong Key Laboratory of Agricultural Products ProcessingGuangzhou 510610China Research Center of Food Safety and Detection College of Food Science and EngineeringSouth China University of TechnologyGuangzhou 510640China

Escherichia coli O157:H7 is one of the major foodborne pathogenic bacterial that cause infectious diseases in *** previous found that a combination of kojic acid and tea polyphenols exhibited better activity against *** O157:H7 than using either *** study aimed to explore responses underlying the antibacterial mechanisms of kojic acid and tea polyphenols from the gene *** functional enrichment analysis by comparing kojic acid and tea polyphenols individually or synergistically against *** O157:H7 found that acid resistance systems in kojic acid were activated,and the cell membrane and genomic DNA were destructed in the cells,resulting in“oxygen starvation”.The oxidative stress response triggered by tea polyphenols inhibited both sulfur uptake and the synthesis of ATP,which affected the bacteria's life metabolic ***,we found that kojic acid combined with tea polyphenols hindered the uptake of iron that played an essential role in the synthesis of DNA,respiration,tricarboxylic acid *** results suggested that the iron uptake pathways may represent a novel approach for kojic acid and tea polyphenols synergistically against *** O157:H7 and provided a theoretical basis for bacterial pathogen control in the food industry.

关键词： Kojic acid Tea polyphenols Antibacterial mechanism Escherichia coli O157:H7 RNA-seq

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

考虑不同天气类型样本的光伏功率日内预测模型

引用

分布式能源 2024年第2期9卷 39-47页

作者：付雪姣吕可欣吴林林刘辉张扬帆李奕霖叶林华北电力科学研究院有限责任公司(国网冀北电网有限公司电力科学研究院) 北京市西城区100045 中国农业大学信息与电气工程学院北京市海淀区100083

太阳能具有清洁、安全、可再生的优点,光伏发电可减轻资源消耗,助力可持续发展,然而光伏功率易受天气影响,针对不同天气类型下光伏功率的预测也是一个研究难点。该研究着手于在不同天气类型下应用人工少数类过采样法(synthetic minority... 详细信息

太阳能具有清洁、安全、可再生的优点,光伏发电可减轻资源消耗,助力可持续发展,然而光伏功率易受天气影响,针对不同天气类型下光伏功率的预测也是一个研究难点。该研究着手于在不同天气类型下应用人工少数类过采样法(synthetic minority over-sampling technique,SMOTE)和机器学习进行光伏功率预测。首先,通过皮尔逊相关系数法选择出对光伏功率影响最大的气象因子;然后,根据重要程度较大的气象因子计算日照时数,通过给日照时数设定阈值进行划分,将天气分类为晴天、多云或阴天、覆雪,再通过SMOTE技术对各种天气类型下的样本进行扩充;最后,通过多种机器学习算法分别针对不同天气场景以及数据扩充前后构建光伏功率预测模型。通过案例分析可知,所提算法能对不同天气类型进行划分,并为不同天气类型下光伏功率预测存在的样本不平衡问题提供了一种解决方案,提升了不同天气场景下光伏功率的预测精度。

关键词：光伏发电功率预测机器学习人工少数类过采样法(SMOTE) 天气类型

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Key Technologies and Prospects for Electric Vehicles Within Emerging Power Systems: Insights from Five Aspects

引用

CSEE Journal of Power and Energy Systems 2024年第2期10卷 439-447页

作者： Yalun li Minggao Ouyang C.C.Chan Xueliang Sun Yonghua Song Wei Cai yilin Xie Yuqiong Mao Department of Electrical Engineering and School of Vehicle and MobilityTsinghua UniversityBeijing 100084China School of Vehicle and Mobility Tsinghua UniversityBeijing 100084China Department of Electrical and Electronic Engineering The University of Hong KongHong Kong 999077China Department of Mechanical and Materials Engineering University of Western OntarioLondonON N6A 3K7Canada State Key Laboratory of Internet of Things for Smart City University of MacaoTaipaMacao 999078China Department of Electrical Engineering Tsinghua UniversityBeijing 100084China School of Electrical and Electronic Engineering Harbin University of Science and TechnologyHarbin 150080China

The energy revolution requires coordination in energy consumption, supply, storage and institutional *** energy generation technologies, along with their associated costs, are already fully equipped for large-scale ***, energy storage remains a bottleneck, and solutions areneeded through the use of electric vehicles, which traditionallyplay the role of energy consumption in power systems. Toclarify the key technologies and institutions that support EVsas terminals for energy use, storage, and feedback, the CSEEJPES forum assembled renowned experts and scholars in relevantfields to deliver keynote reports and engage in discussions ontopics such as vehicle–grid integration technology, advancedsolid-state battery technology, high-performance electric motortechnology, and institutional innovation in the industry *** experts also provided prospects for energy storage andutilization technologies capable of decarbonizing new powersystems.

关键词： Electric vehicles engineering philosophy highpower density motor new power system solid state batteries vehicle grid integration.

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

ADAM8的表达对急性酒精性肝损伤小鼠的影响

引用

天津医药 2024年第4期52卷 346-350页

作者：杨孟利李三强张凯杰崔钦奕冯家阳李依林李昊远齐婧含河南科技大学基础医学与法医学院 471000

目的探究CRISPR/Cas9技术靶向抑制去整合素-金属蛋白酶8(ADAM8)在小鼠急性酒精性肝损伤中的作用及分子机制。方法 18只6~8周龄健康雌性昆明小鼠根据随机数字表法分为正常组、酒精组和质粒组,每组6只。正常组不做处理,质粒组采用水流动... 详细信息

目的探究CRISPR/Cas9技术靶向抑制去整合素-金属蛋白酶8(ADAM8)在小鼠急性酒精性肝损伤中的作用及分子机制。方法 18只6~8周龄健康雌性昆明小鼠根据随机数字表法分为正常组、酒精组和质粒组,每组6只。正常组不做处理,质粒组采用水流动力学注射法尾静脉注射利用CRISPR/Cas9技术抑制ADAM8基因的三合一重组质粒ADAM8-sgRNA3(3 g/kg),酒精组尾静脉注射等量生理盐水。酒精组和质粒组采用50%(V/V)分析纯乙醇一次性灌胃(14 mL/kg)诱导急性肝损伤。禁食16 h后进行眼球取血,检测丙氨酸转氨酶(ALT)和天冬氨酸转氨酶(AST)活性;苏木素-伊红(HE)和过碘酸-雪夫(PAS)染色检测肝脏损伤和糖原变化情况;蛋白免疫印迹法检测肝组织中ADAM8、细胞色素CYP450 2E1(CYP2E1)、热休克蛋白70(HSP70)及丝裂原活化蛋白激酶(MAPK)通路相关因子的表达。结果与正常组相比,酒精组ALT和AST升高,肝损伤评分增加,糖原含量减少,ADAM8、CYP2E1、磷酸化的细胞外调节蛋白激酶1/2(p-ERK1/2)、磷酸化的p38(p-p38)MAPK以及磷酸化的c-Jun氨基未端激酶(p-c-Jun)的表达升高,而HSP70的表达降低(P<0.05)。与酒精组相比,质粒组ALT和AST降低,肝损伤评分降低(P<0.05),糖原含量增多;ADAM8、CYP2E1、p-ERK1/2、p-p38 MAPK以及p-c-Jun的表达降低,HSP70的表达增加(P<0.05)。结论利用CRISPR/Cas9技术靶向抑制ADAM8的表达,可以通过MAPK信号通路改善小鼠急性酒精性肝损伤。

关键词： ADAM蛋白质类急性酒精性肝损伤丝裂原激活蛋白激酶类 CRISPR/Cas9

来源：

维普期刊数据库博看期刊

同方期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

加减参芪地黄汤治疗慢性肾脏病3-4期的临床研究

引用

基层中医药 2024年第1期3卷 16-21页

作者：任燕段星星董宏利李一林蒋春波周丽霞周岚南京中医药大学附属苏州市中医医院江苏苏州215000

目的探讨加减参芪地黄汤在慢性肾病3-4期患者临床治疗中的作用。方法将2019年1月至2023年5月在苏州市中医医院住院及门诊治疗的慢性肾病3-4期患者60例,按随机数字表分组,各30例。对照组在常规治疗的基础上辅以肾衰宁片口服,治疗组在常... 详细信息

目的探讨加减参芪地黄汤在慢性肾病3-4期患者临床治疗中的作用。方法将2019年1月至2023年5月在苏州市中医医院住院及门诊治疗的慢性肾病3-4期患者60例,按随机数字表分组,各30例。对照组在常规治疗的基础上辅以肾衰宁片口服,治疗组在常规治疗的基础上给予加减参芪地黄汤中药治疗。检测两组患者肌酐、尿素氮、尿酸等指标,比较两组患者中医证候积分及临床疗效。结果治疗组总有效率为86.67%,显著高于对照组(77.33%)(P<0.05)。治疗组治疗后血Scr、BUN、UA显著低于对照组,差异具有统计学意义(P<0.05)。治疗组倦怠乏力、食少纳呆、腰膝酸软、肢体困重等证候积分与对照组比较均有统计学差异(P<0.01或P<0.05)。结论加减参芪地黄汤对慢性肾病3-4期患者疗效良好,可降低血肌酐、尿素氮、尿酸,改善临床症状,延缓慢性肾脏病进展。

关键词：参芪地黄汤慢性肾脏病3-4期临床疗效

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

柔嫩艾美耳球虫重组Profilin蛋白对鸡的免疫保护效果评价

引用

北京农学院学报 2024年第2期39卷 66-72,78页

作者：刘倩琳李翌琳周爽武欣欣刘永宁段思彰安健张建军北京农学院动物科学技术学院北京102206

【目的】通过对柔嫩艾美耳球虫(***)Profilin基因进行原核表达和纯化,探明重组Profilin蛋白对鸡的免疫保护效果。【方法】设计合成Profilin基因特异性引物,提取***孢子化卵囊总RNA,反转录成cDNA,用PCR扩增获得Profilin基因后连接至pET-3... 详细信息

【目的】通过对柔嫩艾美耳球虫(***)Profilin基因进行原核表达和纯化,探明重组Profilin蛋白对鸡的免疫保护效果。【方法】设计合成Profilin基因特异性引物,提取***孢子化卵囊总RNA,反转录成cDNA,用PCR扩增获得Profilin基因后连接至pET-32a(+)载体构建重组质粒pET-32a(+)-Profilin,在IPTG诱导下进行表达并纯化。用重组Profilin蛋白免疫雏鸡,随后经口服感染柔嫩艾美耳球虫卵囊,测定和统计雏鸡存活率、平均增重、血便计数、每克粪便卵囊数、卵囊产量、盲肠病变,计算抗球虫指数,观察盲肠组织病理学变化并测定血清中IL-2、IL-10、TNF-α、sIgA的水平以评估重组Profilin蛋白的免疫保护效果。【结果】成功表达了重组Profilin蛋白,大小为39.1 kDa。免疫保护试验表明:Profilin重组蛋白组鸡只存活率、鸡只血便数和OPG相对于感染不免疫攻虫组显著减少(P0.05)。在攻虫后7 d,感染不免疫攻虫组血清中IL-2、TNF-α、IL-10以及sIgA水平相比于空白对照组均极显著升高(Plin蛋白可减少感染雏鸡的增重损失和卵囊排出,引发雏鸡体内的细胞免疫和体液免疫,具有一定的免疫保护效果。

关键词：柔嫩艾美耳球虫原核表达 Profilin 雏鸡免疫保护

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Interface engineering strategy via electron-defect trimethyl borate additive toward 4.7 V ultrahigh-nickel liNi_(0.9)Co_(0.05)Mn_(0.05)O_(2)battery

引用

Journal of Energy Chemistry 2024年第5期92卷 639-647页

作者： yilin Zhang Yuqing Chen Qiu He Jinlong Ke Wei Wang Jian-Fang Wu Peng Gao Yanhua li Jilei liu College of Materials Science and Engineering Hunan Joint International Laboratory of Advanced Materials and Technology for Clean EnergyHunan Province Key Laboratory for Advanced Carbon Materials and Applied TechnologyHunan UniversityChangsha 410082HunanChina College of Materials Science and Engineering Sichuan UniversityChengdu 610065SichuanChina School of Materials Science and Engineering Hunan Institute of TechnologyHengyang 421002HunanChina

The li metal battery with ultrahigh-nickel cathode(liNi_(x)M_(1-x)O_(2),M=Mn,Co,and x≥0.9)under high-voltage is regarded as one of the most promising approaches to fulfill the ambitious target of 400 Wh/***,the practical application is impeded by the instability of electrode/electrolyte interface and Ni-rich cathode *** we proposed an electron-defect electrolyte additive trimethyl borate(TMB)which is paired with the commercial carbonate electrolyte to construct highly conductive fluorine-and boron-rich cathode electrolyte interface(CEI)on liNi_(0.9)Co_(0.05)Mn_(0.05)O_(2)(NCM90)surface and solid electrolyte interphase(SEI)on lithium metal *** modified CEI effectively mitigates the structural transformation from layered to disordered rock-salt phase,and consequently alleviate the dissolution of transition metal ions(TMs)and its“cross-talk”effect,while the enhanced SEI enables stable lithium plating/striping and thus demonstrated good compatibility between electrolyte and lithium metal *** a result,the common electrolyte with 1 wt%TMB enables 4.7 V NCM90/li cell cycle stably over 100 cycles with 70%capacity *** work highlights the significance of the electron-defect boron compounds for designing desirable interfacial chemistries to achieve high performance NCM90/li battery under high voltage operation.

关键词： NCM90 batteries Electrolyte additive Trimethyl borate

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Lactobacillus plantarum J26 alleviates alcohol-induced oxidative liver injury by regulating the Nrf2 signaling pathway

引用

Food Science and Human Wellness 2024年第4期13卷 2068-2078页

作者： Hongxuan li Shasha Cheng Yuhong Wang yilin Sun Jiaxin Zhang Mingshuang Sun Chaoxin Man Yu Zhang Yujun Jiang Key Laboratory of Dairy Science Ministry of EducationCollege of Food Science and EngineeringNortheast Agricultural UniversityHarbin 150030China

Oxidative stress is one of the main ways to cause alcohol-induced liver injury,and alcoholic liver disease(ALD)has been a common health problem *** acid bacteria(LAB)is also considered as a potential treatment to alleviate alcohol-induced liver *** plantarum J26 is a LAB isolated from Chinese traditional fermented dairy products with excellent probiotic *** study aimed to establish a mice model of alcoholic liver injury through acute-on-chronic alcohol feeding and to study the alleviating effect of pre-intake of *** J26 on alcohol-induced oxidative liver injury and focus on its potential mechanism of alleviating *** results showed that pre-intake of *** J26 could improve liver pathological changes,reduce lipid accumulation,increase mitochondrial ATP and mitochondrial(mtDNA)levels,and alleviate liver *** addition,pre-intake *** J26 can improve the level of short-chain fatty acids(SCFAs)in the intestines in mice,short chain fatty acids can be used as a signaling molecule activation of nuclear factor E2-related factor 2(Nrf2)signaling pathway to alleviate liver oxidative stress,and maintain mitochondrial homeostasis by regulating the expression of genes related to mitochondrial dynamics and autophagy,thereby reducing cell apoptosis to alleviate alcohol-induced oxidative liver injury.

关键词： Alcoholic liver disease Probiotics Nuclear factor E2-related factor 2(Nrf2) Oxidative stress Short-chain fatty acids

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

一种高压压合的高频PCB层偏改善研究

引用

印制电路信息 2024年第2期32卷 42-45页

作者：唐海波李逸林生益电子股份有限公司广东东莞523127

对一种结构为“芯板+半固化片(PP)+芯板”的4层高频印制电路板(PCB)进行研究,鉴于其PP流动性较低,采用高压的方式压合,会导致严重的层间偏移问题。通过不同的排板方式,包括PIN钉定位压合工艺(PIN+LAM)、电磁热熔+PIN和铆钉+PIN 3种方法... 详细信息

对一种结构为“芯板+半固化片(PP)+芯板”的4层高频印制电路板(PCB)进行研究,鉴于其PP流动性较低,采用高压的方式压合,会导致严重的层间偏移问题。通过不同的排板方式,包括PIN钉定位压合工艺(PIN+LAM)、电磁热熔+PIN和铆钉+PIN 3种方法,研究不同排板方式对层偏的影响,结合层偏数据从原理上对不同的排板方式进行分析论证,为改善类似PCB层偏问题提供理论支持。

关键词：高频电磁热熔层压层偏

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Performance enhancement and active sites identification of Cu-Cd bimetallic oxide derived catalysts for electrochemical CO_(2) reduction

引用

Journal of Energy Chemistry 2024年第4期91卷 50-58页

作者： Cai Wang Xin Hu Bairong Chen Houan Ren Xiaoyu Wang yilin Zhang Xinyu Chen Yuping liu Qingxin Guan Wei li State Key Laboratory of Elemento-Organic Chemistry Key Laboratory of Adv.Energy Mater.Chemistry(Ministry of Education)College of ChemistryNankai UniversityTianjin 300071China

The development of earth-abundant electrocatalysts with high performance for electrochemical CO_(2)reduction(ECR)is of great ***-based catalysts have been widely investigated for ECR due to their unique ability to generate various carbonaceous products,but directing selectivity toward one certain product and identifying the real active sites during ECR are still full of ***,after the incorporation of CdO into CuO,the Cu_(0.5)Cd_(0.5)-O catalyst achieves a 10.3-fold enhancement for CO selectivity in comparison with CuO,and a CO faradic efficiency nearly 90%with a current density around20 mA cm^(-2)could maintain at least 60 ***,a wide CO/H_(2)ratio(0.07-10)is reached on Cu_(x)Cd_(1-x)-O catalysts by varying the Cu/Cd ratio,demonstrating the potential of syngas production using such *** results of ex situ XRD,XPS,and in situ Raman reveal that the real active sites of Cu_(0.5)Cd_(0.5)-O catalysts for CO production during ECR reaction are the reconstructed mixed phases of CuCd alloy and CdCO_(3).In situ FTIR and theoretical calculations further implicate the presence of Cd related species promotes the CO desorption and inhibits the H_(2)evolution,thus leading to an enhanced CO generation.

关键词： CO_(2)reduction Cu-Cd bimetallic Real active sites CO production

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：