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Successful rescue of disseminated Nocardia infection with multiple abscesses in a patient with membranous nephropathy after cardiopulmonary resuscitation:A three-year follow-up

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Journal of Biomedical Research 2024年第2期38卷 189-194,I0019,I0020页

作者： yili xu Hanyang Qian Wen Qian Li Dong Weiying Liu Yan Zhu Yaning Mei Yi xu Ling Wang Yi Xia xu Qi Huanping Mei xueqiang xu Huijuan Mao Changying Xing Ningning Wang Department of Nephrology the First Affiliated Hospital of Nanjing Medical UniversityJiangsu Province HospitalNanjingJiangsu 210029China Department of Nephrology Nanjing Tongren HospitalNanjingJiangsu 211102China Department of Image the First Affiliated Hospital of Nanjing Medical UniversityJiangsu Province HospitalNanjingJiangsu 210029China Department of Infectious Disease the First Affiliated Hospital of Nanjing Medical UniversityJiangsu Province HospitalNanjingJiangsu 210029China Department of Nephrology the Second Hospital of NanjingNanjingJiangsu 210029China Department of Microorganism the First Affiliated Hospital of Nanjing Medical UniversityJiangsu Province HospitalNanjingJiangsu 210029China Department of Hematology the First Affiliated Hospital of Nanjing Medical UniversityJiangsu Province HospitalNanjingJiangsu 210029China Department of Rheumatology and Immunology the First Affiliated Hospital of Nanjing Medical UniversityJiangsu Province HospitalNanjingJiangsu 210029China

Nocardiosis manifests as an opportunistic infection,primarily affecting individuals who are immunocompromised and susceptible to the *** present a case study of one patient with nephrotic syndrome and membranous nephropathy,who underwent treatment with prednisone and cyclosporine in *** early 2017,the patient was diagnosed with a"fungal infection"and discontinued the use of *** one month of anti-infection therapy,a cranial magnetic resonance imaging scan showed multiple abscesses in the right temporal *** diagnosis of nocardiosis was confirmed based on the presence of metastatic abscess masses,multiple lung and brain lesions,and a positive culture of Nocardia in the *** changed the anti-infection therapy to a combination of trimethoprim-sulfamethoxazole(TMP-SMX),minocycline,and ***,the patient experienced a sudden cardiac arrest and subsequently recovered after cardiopulmonary *** the five-month follow-up period following the discharge,the patient displayed an enhanced nutritional status and stable renal *** focal infection ultimately resolved during the subsequent three ***-infection caused by Nocardia should be considered in immunocompromised patients,and TMP-SMX is the preferred initial therapy;however,because of the high mortality rate,a long-term combination therapy with imipenem,cefotaxime,amikacin,and TMP-SMX is suggested.

关键词： Nocardia infection glomerulonephritis membranous nephrology cardiopulmonary resuscitation

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鱼类麻醉保活运输研究进展

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河北渔业 2024年第6期 41-46页

作者：董秀金徐一力吴冰许建和江苏海洋大学海洋科学与水产学院江苏连云港222005

为了解麻醉保活技术在活鱼运输中的应用和最新研究进展,对活鱼运输过程中麻醉剂的种类、麻醉保活效果的影响因素、麻醉对鱼体生理生化及组织结构的影响进行了总结。

关键词：鱼类麻醉剂保活运输影响因素

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丁香酚慢性麻醉对红鲫血液生理及肝脏hsp70和hsp90mRNA表达量的影响

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河北渔业 2024年第5期 17-21页

作者：吴冰董秀金徐一力许建和江苏海洋大学海洋科学与水产学院江苏连云港222005

为研究丁香酚慢性麻醉对红鲫(Carassius auratus)血液生理及肝脏中应激基因hsp70和hsp90mRNA相对表达量的影响,试验设置丁香酚处理组和对照组,用15 mg/L丁香酚处理平均体质量(61.9±3.66)g红鲫12 h。试验结果表明,经12 h麻醉后,试验组... 详细信息

为研究丁香酚慢性麻醉对红鲫(Carassius auratus)血液生理及肝脏中应激基因hsp70和hsp90mRNA相对表达量的影响,试验设置丁香酚处理组和对照组,用15 mg/L丁香酚处理平均体质量(61.9±3.66)g红鲫12 h。试验结果表明,经12 h麻醉后,试验组红鲫除游动变缓外,其它行为表现正常,未出现死亡现象;麻醉组红鲫血液中皮质醇含量、乳酸脱氢酶活力显著下降,而血糖和K^(+)、Na^(+)浓度却显著上升。基因定量结果显示,麻醉组红鲫肝脏中hsp70和hsp90mRNA相对表达量显著高于对照组。综上所述,15 mg/L丁香酚处理12 h内对红鲫未造成明显损伤,可用于其保活运输。

关键词：红鲫(Carassius auratus) 丁香酚血液生理 hsp70 hsp90

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Photoperiod Mediates the Effects of Temperature and Light Intensity on the Proliferation of Ulva prolifera

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Journal of Ocean University of China 2024年第1期23卷 255-263页

作者： JIANG Jianan YU Yanyan CHEN yili LI Yahe xu Nianjun Key Laboratory of Marine Biotechnology of Zhejiang Province School of Marine SciencesNingbo UniversityNingbo 315211China

In order to study the complex effects of photoperiod,temperature,and light intensity on the spore maturation and release number of Ulva prolifera,we cultured thalli segment(2–3 mm)under three different photoperiods(L:D=12:12,14:10 and 10:14),temperature(15℃(LT),25℃(MT)and 30℃(HT))and light intensity(100,200 and 400μmol m^(−2)s^(−1),noted as LL,ML and HL,respectively)*** the maturation time,spore release number and chlorophyll fluorescence were *** results suggested that:1)The spore maturation time was accelerated by higher temperature or higher light intensity from 62 h to 36 h,and changes in day length accelerated the spore maturation to a certain extent as compared with 12:12 light/dark cycle;2)Higher light intensity significantly decreased the chlorophyll fluorescence(Fv′/Fm′,NPQ,rETRmax andα)of the mature reproductive segment under 30℃with 12:12 light/dark *** when in the other photoperiods(10:14 and 14:10 conditions),the inhibitory effects of high light intensity were alleviated significantly;3)The optimum condition for the spore maturation and release was 12:12 light/dark cycle,25℃,400μmol m^(−2)s^(−1),with both shorter and longer photoperiod reducing the spore release number;4)Higher light intensity significantly increased the spore release number under 25℃,but these effects were alleviated by 30℃*** study is the first attempt to elucidate the coincidence effects of photoperiod,temperature and light intensity on the reproduction of Ulva,which would help to reveal the mechanism of the rapid proliferation of green tide.

关键词： light intensity maturation photoperiod reproduction temperature Ulva prolifera

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空转工况风力发电机组叶片失速振荡研究

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机电工程技术 2024年第3期53卷 95-98页

作者：张缘章培成王瑞良徐伊丽刘为李飞越运达能源科技集团股份有限公司杭州310012 浙江省风力发电技术重点实验室杭州310063

在风力发电机组吊装完成和高风速切出或故障切出时,机组保持在空转停机状态。在现场特定风况和特定机组状态组合下,叶片容易发生由动态失速导致的振荡现象,极大威胁叶片疲劳寿命和机组安全性。根据IEC 61400-1规范中的要求,机组处于空... 详细信息

在风力发电机组吊装完成和高风速切出或故障切出时,机组保持在空转停机状态。在现场特定风况和特定机组状态组合下,叶片容易发生由动态失速导致的振荡现象,极大威胁叶片疲劳寿命和机组安全性。根据IEC 61400-1规范中的要求,机组处于空转停机状态,应考虑极端风速模型(EWM)。针对叶片长度分别为92、97、112 m 3款叶片进行建模分析,研究机组发生失速振荡的内在规律和抑制手段。通过对机组在0~360°风向、场址极端风速以及降低风况条件进行Bladed仿真,发现3款机组均在1只叶片竖直向下位置附近、风向30°和330°附近容易发生叶片失速振荡现象。基于失速振荡发生较为集中的工况,通过调整桨距角能够实现对振荡幅值的抑制;针对不同气动外形,抑制效果有一定差别。

关键词：风力发电机叶片空转工况动态失速振荡桨距角

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SF_(6)回收净化处理系统保温性能测试平台设计

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安徽电气工程职业技术学院学报 2024年第3期29卷 34-40页

作者：黄海龙许一力杨娴苏晓东陈以明房超安徽新力电业科技有限责任公司安徽合肥230022 国网安徽省电力有限公司电力科学研究院安徽合肥230022

针对六氟化硫(SF_(6))气体回收、净化处理、回充、储运等循环再利用全过程生产作业过程中存在冷热损失问题,设计了SF_(6)气体循环再利用系统的保温性能测试平台。可实现在不同工况下的热损失特性研究,降低系统相关装备能耗水平,使其在... 详细信息

针对六氟化硫(SF_(6))气体回收、净化处理、回充、储运等循环再利用全过程生产作业过程中存在冷热损失问题,设计了SF_(6)气体循环再利用系统的保温性能测试平台。可实现在不同工况下的热损失特性研究,降低系统相关装备能耗水平,使其在极端环境下保持安全稳定和可靠耐久运行水平。

关键词： SF_(6)气体 SF_(6)回收回充净化处理工艺设计

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Flexible capacitive pressure sensor based on interdigital electrodes with porous microneedle arrays for physiological signal monitoring

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Nanotechnology and Precision Engineering 2024年第1期7卷 18-31页

作者： Jiahui xu Minghao Wang Minyi Jin Siyan Shang Chuner Ni yili Hu xun Sun Jun xu Bowen Ji Le Li Yuhua Cheng Gaofeng Wang School of Electronics&Information MOE Engineering Research Center of Smart Microsensors and MicrosystemsHangzhou Dianzi UniversityHangzhou 310018China Wenzhou Institute of Hangzhou Dianzi University Wenzhou 310018China Key Laboratory of Intelligent Operation and Maintenance Technology&Equipment for Urban Rail Transit of Zhejiang Province College of EngineeringInstitute of Precision Machinery and Smart StructureZhejiang Normal UniversityJinhua 321004China Institute of Guizhou Aerospace Measuring and Testing Technology Guiyang 550009China Unmanned System Research Institute Northwestern Polytechnical UniversityXi’an 710072China Research&Development Institute of Northwestern Polytechnical University in Shenzhen Shenzhen 518057China

Flexible pressure sensors have many potential applications in the monitoring of physiological signals because of their good biocompatibil-ity and ***,their relatively low sensitivity,linearity,and stability have hindered their large-scale commercial ***,aﬂexible capacitive pressure sensor based on an interdigital electrode structure with two porous microneedle arrays(MNAs)is *** porous substrate that constitutes the MNA is a mixed product of polydimethylsiloxane and *** to its porous and interdigital structure,the maximum sensitivity(0.07 kPa-1)of a porous MNA-based pressure sensor was found to be seven times higher than that of an imporous MNA pressure sensor,and it was much greater than that of aﬂat pressure sensor without a porous MNA ***-element analysis showed that the interdigital MNA structure can greatly increase the strain and improve the sensitivity of the *** addition,the porous MNA-based pressure sensor was found to have good stability over 1500 loading cycles as a result of its bilayer parylene-enhanced conductive electrode *** importantly,it was found that the sensor could accurately monitor the motion of aﬁnger,wrist joint,arm,face,abdomen,eye,and Adam’s ***,preliminary semantic recognition was achieved by monitoring the movement of the Adam’s ***,multiple pressure sensors were integrated into a 33 array to detect a spatial pressure distribu-×*** to the sensors reported in previous works,the interdigital electrode structure presented in this work improves sensitivity and stability by modifying the electrode layer rather than the dielectric layer.

关键词： Capacitive pressure sensor Microneedle array Porous PDMS Interdigital electrode

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通用型粘接剂对牙体组织粘接效果影响因素的研究进展

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口腔疾病防治 2022年第1期30卷 68-72页

作者：许屹立于皓福建医科大学口腔医学院·附属口腔医院修复科福建福州350002

近年来,通用型粘接剂因其操作简单、适用范围广等优点而被广泛运用于口腔治疗中。在实际临床操作中,酸蚀模式、涂布方法、粘接前预处理等因素可能影响其对牙体组织的粘接性能。本文归纳和分析可能影响通用型粘接剂粘接性能的因素,并以... 详细信息

近年来,通用型粘接剂因其操作简单、适用范围广等优点而被广泛运用于口腔治疗中。在实际临床操作中,酸蚀模式、涂布方法、粘接前预处理等因素可能影响其对牙体组织的粘接性能。本文归纳和分析可能影响通用型粘接剂粘接性能的因素,并以此为基础阐述如何进一步改善通用型粘接剂的粘接效果,以期为临床工作提供参考。现阶段研究表明,对于牙釉质粘接,通用型粘接剂的全酸蚀模式可取得更好的粘接效果;而对于牙本质粘接,全酸蚀和自酸蚀的粘接效果相近。延长粘接剂的涂布时间、双层涂布粘接剂、粘接前用水或乙醇润湿可提升粘接强度。0.2%氯己定和金属纳米粒子可有效抑制基质金属蛋白酶(matrix metallo⁃proteinases,MMPs)的激活,提高长期粘接效果。通用型粘接剂具有良好的稳定性和抗唾液污染能力,但抗血液污染能力不佳。酸蚀模式、涂布方法、粘接前预处理等因素均可影响粘接效果,临床操作中医师应注意以上因素。目前,通用型粘接剂仍存在对牙釉质自酸蚀粘接强度不佳、对龋病周围脱矿的牙体组织粘接能力下降等问题,仍有待进一步研究改进。

关键词：通用型粘接剂牙釉质牙本质全酸蚀自酸蚀粘接强度基质金属蛋白酶 10⁃甲基丙烯酰葵基二氢磷酸酯

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Genome-wide CRISPR screening identifies critical role of phosphatase and tensin homologous (PTEN) in sensitivity of acute myeloid leukemia to chemotherapy

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2024年第8期25卷 700-710页

作者： Liming LIN Jingjing TAO Ying MENG Yichao GAN Xin HE Shu LI Jiawei ZHANG Feiqiong GAO Dijia XIN Luyao WANG yili FAN Boxiao CHEN Zhimin LU Yang xu Department of Hematology the Second Affiliated HospitalZhejiang University School of MedicineHangzhou 310009China Zhejiang Provincial Key Laboratory of Pancreatic Disease the First Affiliated Hospital and Institute of Translational MedicineCancer CenterZhejiang University School of MedicineHangzhou 310029China Institute of Genetics Zhejiang UniversityHangzhou 310058China Division of Hematopoietic Stem Cell&Leukemia Research Beckman Research Institute of City of HopeDuarteCA 91010USA Department of Hematology Shanghai General HospitalShanghai Jiao Tong University School of MedicineShanghai 200025China

Although significant progress has been made in the development of novel targeted drugs for the treatment of acute myeloid leukemia(AML)in recent years,chemotherapy still remains the mainstay of treatment and the overall survival is poor in most ***,we demonstrated the antileukemia activity of a novel small molecular compound NL101,which is formed through the modification on bendamustine with a suberanilohydroxamic acid(SAHA)***101 suppresses the proliferation of myeloid malignancy cells and primary AML *** induces DNA damage and caspase 3-mediated apoptosis.A genome-wide clustered regularly interspaced short palindromic repeats(CRISPR)library screen revealed that phosphatase and tensin homologous(PTEN)gene is critical for the regulation of cell survival upon NL101 *** knockout or inhibition of PTEN significantly reduced NL101-induced apoptosis in AML and myelodysplastic syndrome(MDS)cells,accompanied by the activation of protein kinase B(AKT)signaling *** inhibition of mammalian target of rapamycin(mTOR)by rapamycin enhanced the sensitivity of AML cells to NL101-induced cell *** findings uncover PTEN protein expression as a major determinant of chemosensitivity to NL101 and provide a novel strategy to treat AML with the combination of NL101 and rapamycin.

关键词： Genome-wide clustered regularly interspaced short palindromic repeats(CRISPR)library Phosphatase and tensin homologous(PTEN) Rapamycin Acute myeloid leukemia(AML) Chemotherapy

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Contactin-associated protein-like 2(CNTNAP2)mutations impair the essentialα-secretase cleavages,leading to autism-like phenotypes

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Signal Transduction and Targeted Therapy 2024年第4期9卷 1625-1636页

作者： Qing Zhang Mengen Xing Zhengkai Bao Lu xu Yang Bai Wanqi Chen Wenhao Pan Fang Cai Qunxian Wang Shipeng Guo Jing Zhang Zhe Wang yili Wu Yun Zhang Jia-Da Li Weihong Song Oujiang Laboratory(Zhejiang Lab for Regenerative Medicine Vision and Brain Health)Zhejiang Key Laboratory of Alzheimer's DiseaseZhejiang Provincial Clinical Research Center for Mental DisordersSchool of Mental Health and Wenzhou Kangning HospitalThe Second Affiliated Hospital and Yuying Children's HospitalInstitute of AgingWenzhou Medical UniversityWenzhouZhejiang 325035China Townsend Family Laboratories Department of PsychiatryBrain Research CenterThe University of British Columbia2255 Wesbrook MallVancouverBC V6T 1Z3Canada Chongqing Key Laboratory of Translational Medical Research in Cognitive Development and Learning and Memory Disorders Ministry of Education Key Laboratory of Child Development and DisordersChildren's Hospital of Chongqing Medical UniversityChongqing 400014China Center for Medical Genetics Hunan Key Laboratory of Animal Models for Human DiseasesHunan Key Laboratory of Medical GeneticsHunan International Scientific and Technological Cooperation Base of Animal Models for Human DiseasesSchool of Life SciencesCentral South UniversityChangsha 410078 HunanChina The National Clinical Research Center for Geriatric Disease Xuanwu HospitalCapital Medical UniversityBeijing 100053Chin

Mutations in the Contactin-associated protein-like 2(CNTNAP2)gene are associated with autism spectrum disorder(ASD),and ectodomain shedding of the CNTNAP2 protein plays a role in its ***,key enzymes involved in the C-terminal cleavage of CNTNAP2 remain largely unknown,and the effect of ASD-associated mutations on this process and its role in ASD pathogenesis remain *** this report we showed that CNTNAP2 undergoes sequential cleavages by furin,ADAM10/17-dependent a-secretase and presenilindependent *** identified that the cleavage sites of ADAM10 and ADAM17 in CNTNAP2 locate at its C-terminal residue I79 and L96,and the main a-cleavage product C79 by ADAM10 is required for the subsequent y-secretase cleavage to generate CNTNAP2 intracellular domain(CICD).ASD-associated CNTNAP2 mutations impair the a-cleavage to generate C79,and the inhibition leads to ASDIlike repetitive and social behavior abnormalties in the Cntnap2l1254T knock-in ***,exogenous expression of 79 improves autism-ike phenotypes in the Cntnap2^(11254T) knock-in and Cntnap2^(-/-)knockout *** data demonstrates that the a-secretase is essential for CNTNAP2 processing and its *** study indicates that inhibition of the cleavage by pathogenic mutations underlies ASD pathogenesis,and upregulation of its C-terminal fragments could have therapeutical potentials for ASD treatment.

关键词： NAP2 cleavage subsequent

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