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Tuning beneficial calcineurin phosphatase activation to counterα-synuclein toxicity in a yeast model of Parkinson’s disease

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Neural Regeneration Research 2025年第1期20卷 199-200页

作者： Srishti Chawla Mikael Molin thomas Nystrom Institute for Biomedicine Sahlgrenska AcademyCentre for Ageing and Health-AgeCapUniversity of GothenburgGothenburgSweden Department of Life Sciences Chalmers University of TechnologyGothenburgSweden

Calcineurin(CN)is a calcium-and calmodulindependent serine/threonine that has been studied in many model organisms including yeast,filamentous fungi,plants,and *** biological functions range from ion homeostasis and virulence in lower eukaryotes to T-cell activation in humans by human nuclear factors of activated *** is a heterodimeric protein consisting of a catalytic subunit,calcineurin A(Cna1p),which contains an active site with a dinuclear metal center,and a regulatory Ca^(2+) binding subunit called calcineurin B(Cnb1p)required to activate *** calcineurin B subunit has been highly conserved through evolution:For example,the mammalian calcineurin B shows 54%identity with calcineurin B from Saccharomyces cerevisiae.

关键词： activation dinuclear conserved

Microglia:a promising therapeutic target in spinal cord injury

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Neural Regeneration Research 2025年第2期20卷 454-463页

作者： Xiaowei Zha Guoli Zheng thomas Skutella Karl Kiening Andreas Unterberg Alexander Younsi Department of Neurosurgery Heidelberg University HospitalHeidelbergGermany Department of Neuroanatomy Institute for Anatomy and Cell BiologyHeidelberg UniversityHeidelbergGermany

Microglia are present throughout the central nervous system and are vital in neural repair,nutrition,phagocytosis,immunological regulation,and maintaining neuronal *** a healthy spinal cord,microglia are accountable for immune surveillance,however,when a spinal cord injury occurs,the microenvironment drastically changes,leading to glial scars and failed axonal *** this context,microglia vary their gene and protein expression during activation,and proliferation in reaction to the injury,influencing injury responses both favorably and unfavorably.A dynamic and multifaceted injury response is mediated by microglia,which interact directly with neurons,astrocytes,oligodendrocytes,and neural stem/progenitor *** a clear understanding of their essential nature and origin,the mechanisms of action and new functions of microglia in spinal cord injury require extensive *** review summarizes current studies on microglial genesis,physiological function,and pathological state,highlights their crucial roles in spinal cord injury,and proposes microglia as a therapeutic target.

关键词： astrocytes cytokines functional recovery immune regulation M1/M2 activation macrophages microglia neuroinflammation spinal cord injury therapy

Two-Dimensional Electrophoretic Analysis of Soluble Leaf Proteins of a Salt-sensitive （Triticum aestivum） and a Salt-tolerant （T. durum） Cultivar in Response to NaCI Stress

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Journal of Integrative Plant Biology 2007年第7期49卷 975-981页

作者： Mustafa yildiz Afyon Kocatepe University Faculty of Science and Arts Department of Biology Afyonkarahisar 03200 Turkey

In this research, 3-day-old etiolated wheat seedlings of Triticum aestivum L. cv. Ceyhan-99 （salt-sensitive） and T. durum Desf. cv. Firat-93 （salt-tolerant） were grown in control and salt （150 mmol/L NaCl） treatments at a 15/25℃ temperature regime in the light for 12 days. Soluble proteins extracted from the first leaf tissues of two cultivars were analyzed by twodimensional （2-D） electrophoresis in order to detect NaCl-induced changes. The soluble leaf protein profiles of cultivars were observed to be similar. However, quantitative differences in 74 proteins were detected in the salt treatment group, compared to the control. Among the 74 protein spots, 14 were common for two cultivars. As a result of NaCl treatment, two low-molecular-weight （LMW） proteins （28.9 and 30.0 kDa） and one intermediate-molecular-weight （IMW） protein （44.3 kDa） in cv. Ceyhan-99 and six LMW proteins （18.6, 19.4, 25.7, 25.9, 26 and 27.6 kDa） in cv. Firat-93 were newly synthesized. The newly synthesized proteins were specific to each cultivar. In the Firat-93 cultivar, four proteins with LMW （24.8-27.9 kDa） were completely lost in NaCl treatment. Moreover, these four protein spots were not observed in both protein profiles of cv. Ceyhan-99. Most of these proteins were in acidic character （pl 〈6.0-6.9） and low molecular weight （〈31.6 kDa）. It is suggested that the newly synthesized or completely lost LMW proteins may be important for cultivars differing in sensitivity towards NaCl.

关键词： NaCl stress soluble leaf proteins Triticum aestivum Triticum durum two-dimensional electrophoretic analysis.

Numerical Prediction of Form Factor and Wave Interference of A Trimaran for Different Outrigger Positions

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China Ocean Engineering 2022年第2期36卷 279-288页

作者： Ali DOGRUL Burak yildiz Department of Naval Architecture and Marine Engineering Turkish Naval AcademyNational Defense UniversityIstanbul 34940Turkey Department of Marine Engineering Operations Yildiz Technical UniversityIstanbul 34349Turkey

Trimaran hydrodynamics have been an important research topic in recent *** have even been chosen for naval surface *** this case,investigation of a trimaran with different outrigger positions is important and necessary for better hydrodynamic *** paper focuses on the numerical investigation of trimaran *** trimaran model used in this study is a 1/80 scale high-speed displacement frigate-type concept developed by the Center for Innovation in Ship Design(CISD)at Naval Surface Warfare Center,Carderock Division(NSWCCD).The numerical simulations were conducted for different outrigger positions at low and moderate Froude numbers by using commercial CFD software solving URANS equations.A verification and validation study was carried out for the numerical method in one configuration and one ship *** existing experimental results for the trimaran resistance in the literature were used for *** different outrigger positions were analyzed and the form factor of each configuration was calculated by the Prohaska *** total resistance was decomposed to its components using the form *** interference factor was calculated for each configuration in terms of total resistance,residual resistance and wave ***,wave profiles using the longitudinal wave cuts in different locations were obtained both numerically and *** was concluded that the outrigger position had different effects on the interference,total resistance and wave profile at different Froude *** was also shown that the CFD results were in good agreement with the experimental data in all *** conclusion,this study presents the results of interference effects for different trimaran configurations in terms of wave resistance in addition to the total resistance and residual *** numerical method was validated not only with the total resistance test data but also the longitudinal wave profiles a

关键词： CFD form factor wave interference wave profile outrigger trimaran

Computer-Based Modelling of Network Functions for Linear Dynamic Circuits Using Modified Nodal Approach

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Computer Modeling in Engineering & Sciences 2017年第3期113卷 261-274页

作者： Ali Bekir yildiz Engineering Faculty Department of Electrical EngineeringKocaeli UniversityTurkey

In this paper,a computer-based systematic and efficient formulation method is presented for obtaining the network functions of linear or linearized time-invariant dynamic *** method employs the modified nodal approach to obtain the system *** technique is based on developing a matrix formulation for modelling network *** using both symbolic manipulation of algebraic expressions and numeric processes,the network functions are expressed with a matrix-based *** examples are given to illustrate the features of the method.

关键词： Network functions modified nodal approach modelling.

Relationship between Exposure to Low Dose of x-ray and DNA Hypomethylation in Solid Tumors and Hematological Malignancies

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Biomedical and Environmental Sciences 2020年第7期33卷 528-537页

作者： YUKSEL Selin DINNER yildiz Department of Medical Biochemistry Cerrahpasa Medical FacultyIstanbul University-CerrahpasaIstanbulTurkey

X-rays are used in diagnostic and interventional radiology, and for treatment of certain benign and malignant diseases. Although these procedures utilize only low doses of radiation, the long term effects of exposure ... 详细信息

关键词： doses utilize malignant

Plume diagnostics of BUSTLab microwave electrothermal thruster using Langmuir and Faraday probes

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Plasma Science and Technology 2019年第4期21卷 145-154页

作者： M Serhan yildiz Murat CELIK Turkish Air Force Academy.Istanbul 34149.Turkey Bogazici University Islanbul 34342Turkey

This study presents the Langmuir and Faraday probe measurements conducted to determine the plume characteristics of the BUSTLab microwave electrothermal thruster(MET).The thruster,designed to operate at 2.45 GHz frequency,is run with helium,argon and nitrogen gases as the *** the measurements,the propellant volume flow rate and the delivered microwave power levels are *** with nitrogen gas revealed certain operation regimes where a very luminous plume is *** the use of in-house-built Langmuir probes and a Faraday probe with guard ring,thruster plume electron temperature,plasma density and ion current density values are measured,and the results are *** measurements show that MET thruster plume effects on spacecraft will likely be similar to those of the arcjet *** is observed that the measured plume ion flux levels are very low for the high volume flow rates used for the operation of this thruster.

关键词： microwave electrothermal thruster plasma diagnostics plume plasma faraday probe

Sleep as a window to understand and regulate Alzheimer's disease:emerging roles of thalamic reticular nucleus

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Neural Regeneration Research 2025年第6期20卷 1711-1712页

作者： Haoqi Sun Shiqian Shen Robert J.thomas M.Brandon Westover Can Zhang Department of Neurology Beth Israel Deaconess Medical CenterHarvard Medical SchoolBostonMAUSA Center for Translational Pain Research Department of AnesthesiaCritical Care and Pain MedicineMassachusetis General HospitalHarvard Medical SchoolBostonMAUSA Division of Pulmonary Critical Care and Sleep MedicineDepartment of MedicineBeth Israel Deaconess Medical CenterHarvard Medical SchoolBostonMAUSA Genetics and Aging Research Unit McCance Center for Brain HealthMass General Institute for Neurodegenerative DiseaseDepartment of NeurologyMassachusetts General HospitalHarvard Medical SchoolBostonMAUSA

Introduction:Alzheimer 's disease(AD) is a common neurodegenerative disorder and the primary cause of dementia. Considerable evidence supports the “amyloid hypothesis,” stating that the pathogenesis of AD is primarily caused by the deposition of amyloid-β(Aβ), which drives tau phosphorylation, neuroinflammation, and neurodegeneration in the brain. The amyloid hypothesis is strengthened by the significant and moderate benefit of lecanemab, a humanized antibody through an anti-amyloid mechanism,showing slowed clinical decline(van Dyck et al.,2023). The recent positive results of anti-amyloid trials have brought back focus on the amyloid hypothesis through biochemical, genetic, and pharmacological approaches(Zhang, 2023).

关键词： Alzheimer inflammation hypothesis

Continuous flow pyrolysis of virgin and waste polyolefins:a comparative study,process optimization and product characterization

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Frontiers of Chemical Science and Engineering 2024年第6期18卷 133-149页

作者： Ecrin Ekici Güray yildiz Magdalena Joka yildiz Monika Kalinowska ErolŞeker Jiawei Wang Karlsruhe Institute of Technology Institute of Catalysis Research and TechnologyEggenstein-Leopoldshafen 76344Germany Izmir Institute of Technology Faculty of EngineeringDepartment of Energy Systems EngineeringIzmir 35430Türkiye Department of Materials Engineering and Production Faculty of Mechanical EngineeringBialystok University of TechnologyBialystok 15-351Poland Department of Agricultural and Food Engineering and Environmental Development Institute of Civil Engineering and EnergeticsFaculty of Civil Engineering and Environmental SciencesBialystok University of Technology15-351 BialystokPoland Department of Chemistry Biology and BiotechnologyInstitute of Civil Engineering and EnergeticsFaculty of Civil Engineering and Environmental SciencesBialystok University of TechnologyBialystok 15-351Poland Izmir Institute of Technology Faculty of EngineeringDepartment of Chemical EngineeringIzmir 35430Türkiye Energy and Bioproducts Research Institute(EBRI) Aston UniversityBirmingham B47ETUnited Kingdom

Under optimal process conditions,pyrolysis of polyolefins can yield ca.90 wt%of liquid product,i.e.,combination of light oil fraction and heavier *** this work,the experimental findings reported in a selected group of publications concerning the non-catalytic pyrolysis of polyolefins were collected,reviewed,and compared with the ones obtained in a continuously operated bench-scale pyrolysis *** process parameters were used for the pyrolysis of waste and virgin counterparts of high-density polyethylene,low-density polyethylene,polypropylene and a defined mixture of those(i.e.,25:25:50 wt%,respectively).To mitigate temperature drops and enhance heat transfer,an increased feed intake is employed to create a hot melt plastic *** 1.5 g·min^(-1) feed intake,1.1 L·min^(-1) nitrogen flow rate,and a moderate pyrolysis temperature of 450℃,the formation of light hydrocarbons was favored,while wax formation was limited for polypropylene-rich *** of virgin plastics yielded more liquid(maximum 73.3 wt%)than that of waste plastics(maximum 66 wt%).Blending polyethylenes with polypropylene favored the production of liquids and increased the formation of gasoline-range *** products were mainly composed of C3 hydrocarbons,and no hydrogen production was detected due to moderate pyrolysis temperature.

关键词： waste plastics polyolefins chemical recycling pyrolysis alternative fuels waste-to-energy